NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1609559110|ref|NP_001356380|]
View 

WD repeat-containing protein 74 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
17-329 3.50e-130

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


:

Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 376.57  E-value: 3.50e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  17 TGILKGVNLQRKQ--AANFTAG--GQPRREEAVSALCWGT-GGETQMLVGCADRTVKHFSTEDG----IFQ--GQRHCPG 85
Cdd:cd22857     1 LGLVKVVEARGKQeeAAPKVVDrwGGPDKSKAVQALSIADrESEPLLAVARKNGTVEVLDPENGdllaSFSdsEPATKLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  86 GEGMFRGLAQADGTLITCVDSGILRVWH-DKDKDTSSDPLLELRVGPGVCRMRQDPaHPHVVATGGKENALKIWDLQGSE 164
Cdd:cd22857    81 EEDHFVGLHLFSGTLLTCTSKGSLRSTKlPDDSTASSSPTAWVCLGGNLLCMRVDP-NENYFAFGGKEVELNVWDLEEKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 165 EPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRVYDPASpQRRPVLETTYGEYPLTAMTLTPGGNSV 242
Cdd:cd22857   160 GKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 243 IVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRgLEHKVYLKSQLNCLLLSG 321
Cdd:cd22857   239 YVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDS 317

                  ....*...
gi 1609559110 322 RDNWEDEP 329
Cdd:cd22857   318 SFSPEEEA 325
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
17-329 3.50e-130

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 376.57  E-value: 3.50e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  17 TGILKGVNLQRKQ--AANFTAG--GQPRREEAVSALCWGT-GGETQMLVGCADRTVKHFSTEDG----IFQ--GQRHCPG 85
Cdd:cd22857     1 LGLVKVVEARGKQeeAAPKVVDrwGGPDKSKAVQALSIADrESEPLLAVARKNGTVEVLDPENGdllaSFSdsEPATKLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  86 GEGMFRGLAQADGTLITCVDSGILRVWH-DKDKDTSSDPLLELRVGPGVCRMRQDPaHPHVVATGGKENALKIWDLQGSE 164
Cdd:cd22857    81 EEDHFVGLHLFSGTLLTCTSKGSLRSTKlPDDSTASSSPTAWVCLGGNLLCMRVDP-NENYFAFGGKEVELNVWDLEEKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 165 EPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRVYDPASpQRRPVLETTYGEYPLTAMTLTPGGNSV 242
Cdd:cd22857   160 GKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 243 IVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRgLEHKVYLKSQLNCLLLSG 321
Cdd:cd22857   239 YVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDS 317

                  ....*...
gi 1609559110 322 RDNWEDEP 329
Cdd:cd22857   318 SFSPEEEA 325
WD40 COG2319
WD40 repeat [General function prediction only];
34-304 2.27e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  34 TAGGQPRR-----EEAVSALCWGTGGETqMLVGCADRTVKHFSTEDGifQGQRHCPGGEGMFRGLA-QADG-TLITCVDS 106
Cdd:COG2319   107 LATGLLLRtltghTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAfSPDGkLLASGSDD 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 107 GILRVWHDkdkdTSSDPLLELRVGPGVCRmrqDPA-HP--HVVATGGKENALKIWDLQGSEEPvfRAKNVRNDWldlrvp 183
Cdd:COG2319   184 GTVRLWDL----ATGKLLRTLTGHTGAVR---SVAfSPdgKLLASGSADGTVRLWDLATGKLL--RTLTGHSGS------ 248
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 184 IWDqdIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLG 263
Cdd:COG2319   249 VRS--VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1609559110 264 CLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGL 304
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
258-296 1.56e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1609559110  258 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 296
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
17-329 3.50e-130

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 376.57  E-value: 3.50e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  17 TGILKGVNLQRKQ--AANFTAG--GQPRREEAVSALCWGT-GGETQMLVGCADRTVKHFSTEDG----IFQ--GQRHCPG 85
Cdd:cd22857     1 LGLVKVVEARGKQeeAAPKVVDrwGGPDKSKAVQALSIADrESEPLLAVARKNGTVEVLDPENGdllaSFSdsEPATKLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  86 GEGMFRGLAQADGTLITCVDSGILRVWH-DKDKDTSSDPLLELRVGPGVCRMRQDPaHPHVVATGGKENALKIWDLQGSE 164
Cdd:cd22857    81 EEDHFVGLHLFSGTLLTCTSKGSLRSTKlPDDSTASSSPTAWVCLGGNLLCMRVDP-NENYFAFGGKEVELNVWDLEEKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 165 EPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRVYDPASpQRRPVLETTYGEYPLTAMTLTPGGNSV 242
Cdd:cd22857   160 GKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 243 IVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRgLEHKVYLKSQLNCLLLSG 321
Cdd:cd22857   239 YVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDS 317

                  ....*...
gi 1609559110 322 RDNWEDEP 329
Cdd:cd22857   318 SFSPEEEA 325
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
18-323 4.59e-94

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 284.91  E-value: 4.59e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  18 GILKGVNLQRKQAANFTAGGQP---------RREEAVSALCWGTGGETQMLVGCADR--TVKHFSTEDG-------IFQG 79
Cdd:cd22850     1 GSLKEVVCNRGTDTSVQDAAQPkvvethlseGLSNAVQRLSLVDRSDPLLLVARRNGngEVYVLSPVDGelfellsSIEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  80 QRHCPGGEGmFRGLAQ-ADGTLITCVD-SGILRVWHDKDKDTSSDPL-LELRVGPGVCRMRQDPAHPHVVATGGKENALK 156
Cdd:cd22850    81 LTRSKEEDK-FVGLHLlRSLGLLTCATkSGLLHIIDLEDSKKDSLEVkAPLTLPGFLSAFRVNPTDEGVFAYGGKENDLK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 157 IWDL---QGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGS----QKLVTCTGYHQVRVYDPASpQRRPVlettYGEYP 229
Cdd:cd22850   160 LWDLekdFLKLKQIWKAKNVKNDRLDLRVPVWITAITFLPPDdhrkFKFVTGTRYGQVRLYDTSA-GRRPV----FSEKP 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 230 LTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPS--KPLLASCGLDRVLRIHRIQNPRgLEH 306
Cdd:cd22850   235 IKKPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRLLGKYGgSITGAVRHPElfDPYLASGGLDRYLRVFDIETRE-LLA 313
                         330
                  ....*....|....*...
gi 1609559110 307 KVYLKSQ-LNCLLLSGRD 323
Cdd:cd22850   314 KVYLGKQiLTVVVLDDEE 331
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
90-359 2.87e-46

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 163.16  E-value: 2.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  90 FRGLAQ--ADGTLITCVDSGILRVWHDKDKDTSSDPL-LELRVGPGVCRmRQDPAHPHVVATGGKENALKIWDLQGSEEP 166
Cdd:cd22858   104 FVSLIVleSLGIILAATKSGLVHIIDLEDDLFKIKPHeVKAPLEFIQAF-DLNPTDPGVFAYGGKENDLKIVELFSDKKK 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 167 ------VFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ------KLVTCTGYHQVRVYDpASPQRRPVLETTYGEYPLTAMT 234
Cdd:cd22858   183 ffklkqIWEAKNVKNDRLDLRVPIWITGILFLKPSPskgfdyKFITVTRYGHLRKYD-TTHGRKPIKSYKLLPKPELTEP 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 235 LTpggnSVIVGNTHGQLAE-----IDLR--------QGRLLGCLKG--LAGSVRGLQCHPSKpLLASCGLDRVLRIHRIQ 299
Cdd:cd22858   262 LT----ELIISDTHSLIAKlslitTDSKksvsagdgKGRLLGKYGGgdITGAVSAVDVFEDK-YLATGGLDRYLRVFDLE 336
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1609559110 300 NpRGLEHKVYLKSQLN-CLLLSGRDnwEDEPQEPQEPN---KVPLEDTETD--ELWASLEAAAKRK 359
Cdd:cd22858   337 T-RELLAKVYVGSKISsVLLLDDED--IELPESEKKKKkkkKRKEEEEEEDdeELWNELEEKKKKR 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
45-302 1.94e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  45 VSALCWGTGGETqMLVGCADRTVKHFSTEDGI----FQGQRHcpggeGMFRGLAQADGT-LITCVDSGILRVWhdkdkDT 119
Cdd:cd00200    12 VTCVAFSPDGKL-LATGSGDGTIKVWDLETGEllrtLKGHTG-----PVRDVAASADGTyLASGSSDKTIRLW-----DL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 120 SSDPLLELRVG--PGVCRMRQDPaHPHVVATGGKENALKIWDL-QGSEEPVFRAKNvrnDWLdlrvpiwdQDIQFLPGSQ 196
Cdd:cd00200    81 ETGECVRTLTGhtSYVSSVAFSP-DGRILSSSSRDKTIKVWDVeTGKCLTTLRGHT---DWV--------NSVAFSPDGT 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 197 KLVTCTGYHQVRVYDPASPQRRPVLETTYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQ 276
Cdd:cd00200   149 FVASSSQDGTIKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226
                         250       260
                  ....*....|....*....|....*.
gi 1609559110 277 CHPSKPLLASCGLDRVLRIHRIQNPR 302
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
34-304 2.27e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  34 TAGGQPRR-----EEAVSALCWGTGGETqMLVGCADRTVKHFSTEDGifQGQRHCPGGEGMFRGLA-QADG-TLITCVDS 106
Cdd:COG2319   107 LATGLLLRtltghTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAfSPDGkLLASGSDD 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 107 GILRVWHDkdkdTSSDPLLELRVGPGVCRmrqDPA-HP--HVVATGGKENALKIWDLQGSEEPvfRAKNVRNDWldlrvp 183
Cdd:COG2319   184 GTVRLWDL----ATGKLLRTLTGHTGAVR---SVAfSPdgKLLASGSADGTVRLWDLATGKLL--RTLTGHSGS------ 248
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 184 IWDqdIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLG 263
Cdd:COG2319   249 VRS--VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1609559110 264 CLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGL 304
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
42-300 3.82e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  42 EEAVSALCWGTGGETqMLVGCADRTVKHFSTEDGifQGQRHCPGGEGMFRGLA-QADG-TLITCVDSGILRVWhdkdkDT 119
Cdd:COG2319   162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAfSPDGkLLASGSADGTVRLW-----DL 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 120 SSDPLLELRVGPGvcRMRQDPA-HP--HVVATGGKENALKIWDLQGSEEPVFRAKNVRndwldlrvPIWDqdIQFLPGSQ 196
Cdd:COG2319   234 ATGKLLRTLTGHS--GSVRSVAfSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSG--------GVNS--VAFSPDGK 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 197 KLVTCTGYHQVRVYDPASPQRRPVLETtyGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQ 276
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379
                         250       260
                  ....*....|....*....|....
gi 1609559110 277 CHPSKPLLASCGLDRVLRIHRIQN 300
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
143-302 1.95e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 143 PHVVATGGKENALKIWDLQGSEEPVFRAKNVRndwldlrvPIWdqDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLE 222
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTG--------AVR--SVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 223 TtyGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 302
Cdd:COG2319   160 G--HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
229-302 4.73e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 4.73e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1609559110 229 PLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 302
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
187-263 5.83e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 187 QDIQFLPGSQKL-VTCTGYHQVRVYDPASpqRRPVLETTYGEYPlTAMTLTPGGNSVIVGNTHGQ-----LAEIDLRQGR 260
Cdd:COG3391   113 RGLAVDPDGGRLyVADSGNGRVSVIDTAT--GKVVATIPVGAGP-HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGK 189

                  ...
gi 1609559110 261 LLG 263
Cdd:COG3391   190 VVA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
258-296 1.56e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1609559110  258 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 296
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
42-211 5.25e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.47  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110  42 EEAVSALCWGTGGetQMLV-GCADRTVKHFSTEDGIFQGQrhCPGGEGMFRGLAQ-ADG-TLITCVDSGILRVWhdkdkD 118
Cdd:cd00200   135 TDWVNSVAFSPDG--TFVAsSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVAFsPDGeKLLSSSSDGTIKLW-----D 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 119 TSSDPLLELRVG--PGVCRMRQDPaHPHVVATGGKENALKIWDLQgSEEPVFRAKNVRNdwldlrvPIWDqdIQFLPGSQ 196
Cdd:cd00200   206 LSTGKCLGTLRGheNGVNSVAFSP-DGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN-------SVTS--LAWSPDGK 274
                         170
                  ....*....|....*
gi 1609559110 197 KLVTCTGYHQVRVYD 211
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
166-302 5.88e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559110 166 PVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETtyGEYPLTAMTLTPGGNSVIVG 245
Cdd:COG2319    19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG--HTAAVLSVAFSPDGRLLASA 96
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1609559110 246 NTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 302
Cdd:COG2319    97 SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH