NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1585245696|ref|NP_001355769|]
View 

transmembrane protein 8B isoform 3 [Mus musculus]

Protein Classification

TMEM8 family protein( domain architecture ID 10572301)

TMEM8 family protein is a DUF3522 domain-containing protein; similar to Homo sapiens transmembrane protein 8B, post-GPI attachment to proteins factor 6 and protein myomaker

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3522 pfam12036
Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. ...
 704-874 1.60e-50

Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.


:

Pssm-ID: 463441  Cd Length: 183  Bit Score: 175.93  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696 704 MFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDqpgIVVFCIMDYDVLQFC-------DFLGSLMSVWVTVIAMARLQ 776
Cdd:pfam12036  15 AFLPAIYVALKRRYHFEAFVYTFTMFFSFMYHACD---SGVFCFMKYDVLQLCegdwhrlDNIGSILSFWVTFVYLADFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696 777 PVIKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRrrhcypptWRRWLFYLCPG--SLIAGSAVL 854
Cdd:pfam12036  92 EVLKRFLHYFGLLLTAIAQEKDPWNLWNTLIPILIGLLILIVSWLLRRRL--------PRYNTQYLLPGllLLALALIFF 163

                         170       180
                  ....*....|....*....|
gi 1585245696 855 LYAFVETRDNYFYIHSIWHM 874
Cdd:pfam12036 164 LYGLDETNDNYRIVHSLWHI 183
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2-154 1.53e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696   2 AQPLSRPLILSQFQP---WPPATPSPRFPNLS----RPRPVSQRMSRSRSPLQPRSLPPAWPLSPPRPLFHPL--SQFPA 72
Cdd:pfam03154 198 GPTPSAPSVPPQGSPatsQPPNQTQSTAAPHTliqqTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPP 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696  73 QHLTLSHSPRLLKPLAQPQPL-LQSPSHPLLPSHLLPLFEPRCSVQR-HPKKAQSLPPSLCLPKSLPLGPRlshtlPLSQ 150
Cdd:pfam03154 278 MPHSLQTGPSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRiHTPPSQSQLQSQQPPREQPLPPA-----PLSM 352


                  ....
gi 1585245696 151 PRLR 154
Cdd:pfam03154 353 PHIK 356
 
Name Accession Description Interval E-value
DUF3522 pfam12036
Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. ...
 704-874 1.60e-50

Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.


Pssm-ID: 463441  Cd Length: 183  Bit Score: 175.93  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696 704 MFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDqpgIVVFCIMDYDVLQFC-------DFLGSLMSVWVTVIAMARLQ 776
Cdd:pfam12036  15 AFLPAIYVALKRRYHFEAFVYTFTMFFSFMYHACD---SGVFCFMKYDVLQLCegdwhrlDNIGSILSFWVTFVYLADFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696 777 PVIKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRrrhcypptWRRWLFYLCPG--SLIAGSAVL 854
Cdd:pfam12036  92 EVLKRFLHYFGLLLTAIAQEKDPWNLWNTLIPILIGLLILIVSWLLRRRL--------PRYNTQYLLPGllLLALALIFF 163

                         170       180
                  ....*....|....*....|
gi 1585245696 855 LYAFVETRDNYFYIHSIWHM 874
Cdd:pfam12036 164 LYGLDETNDNYRIVHSLWHI 183
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2-154 1.53e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696   2 AQPLSRPLILSQFQP---WPPATPSPRFPNLS----RPRPVSQRMSRSRSPLQPRSLPPAWPLSPPRPLFHPL--SQFPA 72
Cdd:pfam03154 198 GPTPSAPSVPPQGSPatsQPPNQTQSTAAPHTliqqTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPP 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696  73 QHLTLSHSPRLLKPLAQPQPL-LQSPSHPLLPSHLLPLFEPRCSVQR-HPKKAQSLPPSLCLPKSLPLGPRlshtlPLSQ 150
Cdd:pfam03154 278 MPHSLQTGPSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRiHTPPSQSQLQSQQPPREQPLPPA-----PLSM 352


                  ....
gi 1585245696 151 PRLR 154
Cdd:pfam03154 353 PHIK 356
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-92 4.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696   12 SQFQPWPPATPS-PRFPNLSRPRPVSQRMSRSRSPLQPRSLPPawPLSPPRPLFHPLSQFPAQHLTLSHSPRLLKPLAQP 90
Cdd:PHA03247  2868 SRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQPERPPQ--PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945


                   ..
gi 1585245696   91 QP 92
Cdd:PHA03247  2946 TT 2947
 
Name Accession Description Interval E-value
DUF3522 pfam12036
Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. ...
 704-874 1.60e-50

Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.


Pssm-ID: 463441  Cd Length: 183  Bit Score: 175.93  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696 704 MFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDqpgIVVFCIMDYDVLQFC-------DFLGSLMSVWVTVIAMARLQ 776
Cdd:pfam12036  15 AFLPAIYVALKRRYHFEAFVYTFTMFFSFMYHACD---SGVFCFMKYDVLQLCegdwhrlDNIGSILSFWVTFVYLADFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696 777 PVIKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRrrhcypptWRRWLFYLCPG--SLIAGSAVL 854
Cdd:pfam12036  92 EVLKRFLHYFGLLLTAIAQEKDPWNLWNTLIPILIGLLILIVSWLLRRRL--------PRYNTQYLLPGllLLALALIFF 163

                         170       180
                  ....*....|....*....|
gi 1585245696 855 LYAFVETRDNYFYIHSIWHM 874
Cdd:pfam12036 164 LYGLDETNDNYRIVHSLWHI 183
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2-154 1.53e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696   2 AQPLSRPLILSQFQP---WPPATPSPRFPNLS----RPRPVSQRMSRSRSPLQPRSLPPAWPLSPPRPLFHPL--SQFPA 72
Cdd:pfam03154 198 GPTPSAPSVPPQGSPatsQPPNQTQSTAAPHTliqqTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPP 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696  73 QHLTLSHSPRLLKPLAQPQPL-LQSPSHPLLPSHLLPLFEPRCSVQR-HPKKAQSLPPSLCLPKSLPLGPRlshtlPLSQ 150
Cdd:pfam03154 278 MPHSLQTGPSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRiHTPPSQSQLQSQQPPREQPLPPA-----PLSM 352


                  ....
gi 1585245696 151 PRLR 154
Cdd:pfam03154 353 PHIK 356
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 3-151 3.88e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696   3 QPLS-RPLILSQFQPwPPATPSPRFPNlsrprPVSQRMSRSRSPLQPRSLPPAWPlspPRPLFHPLSQFPAQHLTLSHSP 81
Cdd:pfam03154 343 QPLPpAPLSMPHIKP-PPTTPIPQLPN-----PQSHKHPPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPP 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696  82 ---------RLLKPLAQPQPLLQSPSHPLLPSHLLPLFEPRCSVQRHPKKAQSLPPSLCLPKSLPLGP--RLSHTLPLSQ 150
Cdd:pfam03154 414 plqlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPptSTSSAMPGIQ 493


                  .
gi 1585245696 151 P 151
Cdd:pfam03154 494 P 494
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-92 4.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1585245696   12 SQFQPWPPATPS-PRFPNLSRPRPVSQRMSRSRSPLQPRSLPPawPLSPPRPLFHPLSQFPAQHLTLSHSPRLLKPLAQP 90
Cdd:PHA03247  2868 SRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQPERPPQ--PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945


                   ..
gi 1585245696   91 QP 92
Cdd:PHA03247  2946 TT 2947
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH