endothelial cell-specific chemotaxis regulator isoform 2 precursor [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ECSCR super family | cl24401 | Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis ... |
139-200 | 1.53e-17 | ||
Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells. The actual alignment was detected with superfamily member pfam15820: Pssm-ID: 292448 Cd Length: 104 Bit Score: 74.79 E-value: 1.53e-17
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| Name | Accession | Description | Interval | E-value | ||
| ECSCR | pfam15820 | Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis ... |
139-200 | 1.53e-17 | ||
Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells. Pssm-ID: 292448 Cd Length: 104 Bit Score: 74.79 E-value: 1.53e-17
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| Name | Accession | Description | Interval | E-value | ||
| ECSCR | pfam15820 | Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis ... |
139-200 | 1.53e-17 | ||
Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells. Pssm-ID: 292448 Cd Length: 104 Bit Score: 74.79 E-value: 1.53e-17
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