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Conserved domains on  [gi|1572047503|ref|NP_001355366|]
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Serpentine Receptor, class T [Caenorhabditis elegans]

Protein Classification

class Z serpentine receptor( domain architecture ID 5111)

class Z serpentine receptor (Srz) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srz super family cl10995
Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis ...
 58-331 1.61e-35

Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.


The actual alignment was detected with superfamily member pfam10325:

Pssm-ID: 431214  Cd Length: 264  Bit Score: 130.40  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503  58 ILLAIFASLLSLLTFPIYFKVFRKNKAKEQESPIYPILQHFHR--------FVCFMLIVILSYPFQTVSLFFWPNMNIQT 129
Cdd:pfam10325   1 LLLLIILLIIYLLIFPFYVYVFKLNRERDKKTLLFPITNHFYKmvkisyflFIFLIVILILIFFFSSKNSIIGFIFLLLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503 130 IYYMYQFLMSTvsPIFNFLLAILALQRFLIFFLPDFEKFFSFKSKTWKVFIILLYFTFFIVNAGMVYAkgdWEAQNYTML 209
Cdd:pfam10325  81 FLILYILYIIT--QVFHLLIFLLAIQRFLIYFFPSTEKYVLISQKYLHKYIWILYLVFVLKDLILFLL---YVITFSKSL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503 210 EWEVgyngtevlavIDEAYTTVYFSLEAIAILSTALYCPIFVSVRQKIHLISLAQSKPDRYIRYQAVVICASKMFFIVLL 289
Cdd:pfam10325 156 GWET----------IKYVYLIIFIILNILLFLSALLYIPIMISIRKLSHLASAQLNKPQKYIFWQTITVLIFKSIYIPLF 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1572047503 290 FYNQIIGTKFASERKIGMLLqnwSNFGTTPLIIQISYLLCNK 331
Cdd:pfam10325 226 IFIFLIDFLSEFLIFSIISI---TDILTTPLIIQLSYLGCNK 264
 
Name Accession Description Interval E-value
7TM_GPCR_Srz pfam10325
Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis ...
 58-331 1.61e-35

Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.


Pssm-ID: 431214  Cd Length: 264  Bit Score: 130.40  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503  58 ILLAIFASLLSLLTFPIYFKVFRKNKAKEQESPIYPILQHFHR--------FVCFMLIVILSYPFQTVSLFFWPNMNIQT 129
Cdd:pfam10325   1 LLLLIILLIIYLLIFPFYVYVFKLNRERDKKTLLFPITNHFYKmvkisyflFIFLIVILILIFFFSSKNSIIGFIFLLLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503 130 IYYMYQFLMSTvsPIFNFLLAILALQRFLIFFLPDFEKFFSFKSKTWKVFIILLYFTFFIVNAGMVYAkgdWEAQNYTML 209
Cdd:pfam10325  81 FLILYILYIIT--QVFHLLIFLLAIQRFLIYFFPSTEKYVLISQKYLHKYIWILYLVFVLKDLILFLL---YVITFSKSL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503 210 EWEVgyngtevlavIDEAYTTVYFSLEAIAILSTALYCPIFVSVRQKIHLISLAQSKPDRYIRYQAVVICASKMFFIVLL 289
Cdd:pfam10325 156 GWET----------IKYVYLIIFIILNILLFLSALLYIPIMISIRKLSHLASAQLNKPQKYIFWQTITVLIFKSIYIPLF 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1572047503 290 FYNQIIGTKFASERKIGMLLqnwSNFGTTPLIIQISYLLCNK 331
Cdd:pfam10325 226 IFIFLIDFLSEFLIFSIISI---TDILTTPLIIQLSYLGCNK 264
 
Name Accession Description Interval E-value
7TM_GPCR_Srz pfam10325
Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis ...
 58-331 1.61e-35

Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.


Pssm-ID: 431214  Cd Length: 264  Bit Score: 130.40  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503  58 ILLAIFASLLSLLTFPIYFKVFRKNKAKEQESPIYPILQHFHR--------FVCFMLIVILSYPFQTVSLFFWPNMNIQT 129
Cdd:pfam10325   1 LLLLIILLIIYLLIFPFYVYVFKLNRERDKKTLLFPITNHFYKmvkisyflFIFLIVILILIFFFSSKNSIIGFIFLLLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503 130 IYYMYQFLMSTvsPIFNFLLAILALQRFLIFFLPDFEKFFSFKSKTWKVFIILLYFTFFIVNAGMVYAkgdWEAQNYTML 209
Cdd:pfam10325  81 FLILYILYIIT--QVFHLLIFLLAIQRFLIYFFPSTEKYVLISQKYLHKYIWILYLVFVLKDLILFLL---YVITFSKSL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047503 210 EWEVgyngtevlavIDEAYTTVYFSLEAIAILSTALYCPIFVSVRQKIHLISLAQSKPDRYIRYQAVVICASKMFFIVLL 289
Cdd:pfam10325 156 GWET----------IKYVYLIIFIILNILLFLSALLYIPIMISIRKLSHLASAQLNKPQKYIFWQTITVLIFKSIYIPLF 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1572047503 290 FYNQIIGTKFASERKIGMLLqnwSNFGTTPLIIQISYLLCNK 331
Cdd:pfam10325 226 IFIFLIDFLSEFLIFSIISI---TDILTTPLIIQLSYLGCNK 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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