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Conserved domains on  [gi|1483453057|ref|NP_001353199|]
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protein archease isoform 13 [Homo sapiens]

Protein Classification

archease( domain architecture ID 1771)

archease catalyzes the activation of the RNA ligase RtcB, which joins RNA molecules to form phosphodiester bonds

CATH:  3.55.10.10
Gene Ontology:  GO:0072669|GO:0046872|GO:0006388
SCOP:  4003521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Archease super family cl00606
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 54-93 4.10e-13

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


The actual alignment was detected with superfamily member pfam01951:

Pssm-ID: 469838  Cd Length: 136  Bit Score: 60.24  E-value: 4.10e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEEN-PEVFVIIDI 93
Cdd:pfam01951  96 YGEPFDPEKHEPKTEVKAVTYHELRIEKEDGgWEAQVVVDI 136
 
Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 54-93 4.10e-13

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 426527  Cd Length: 136  Bit Score: 60.24  E-value: 4.10e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEEN-PEVFVIIDI 93
Cdd:pfam01951  96 YGEPFDPEKHEPKTEVKAVTYHELRIEKEDGgWEAQVVVDI 136
ARCH COG1371
Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and ...
 54-93 1.16e-09

Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440982  Cd Length: 139  Bit Score: 51.33  E-value: 1.16e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEENP-EVFVIIDI 93
Cdd:COG1371    99 RGEPLDPERHEFKVEVKAVTYHELRVEQEDGGwRAQVVVDV 139
Archease PRK00407
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 54-93 9.38e-06

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 179008  Cd Length: 139  Bit Score: 41.16  E-value: 9.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEENP-EVFVIIDI 93
Cdd:PRK00407   99 WGEKFDPEIHERRTVVKAMTYHDMEIEKEDGCwMAQFVVDI 139
 
Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 54-93 4.10e-13

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 426527  Cd Length: 136  Bit Score: 60.24  E-value: 4.10e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEEN-PEVFVIIDI 93
Cdd:pfam01951  96 YGEPFDPEKHEPKTEVKAVTYHELRIEKEDGgWEAQVVVDI 136
ARCH COG1371
Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and ...
 54-93 1.16e-09

Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440982  Cd Length: 139  Bit Score: 51.33  E-value: 1.16e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEENP-EVFVIIDI 93
Cdd:COG1371    99 RGEPLDPERHEFKVEVKAVTYHELRVEQEDGGwRAQVVVDV 139
Archease PRK00407
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 54-93 9.38e-06

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 179008  Cd Length: 139  Bit Score: 41.16  E-value: 9.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483453057  54 WGEEFSLSKHPQGTEVKAITYSAMQVYNEENP-EVFVIIDI 93
Cdd:PRK00407   99 WGEKFDPEIHERRTVVKAMTYHDMEIEKEDGCwMAQFVVDI 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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