nuclear factor 1 X-type isoform 8 [Homo sapiens]
Protein Classification
nuclear factor I( domain architecture ID 12106891)
nuclear factor I (NFI) is a CCAAT-box-binding protein active in transcription and DNA replication
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| CTF_NFI | pfam00859 | CTF/NF-I family transcription modulation region; |
212-417 | 1.03e-98 | ||||
CTF/NF-I family transcription modulation region; : Pssm-ID: 459967 [Multi-domain] Cd Length: 288 Bit Score: 297.21 E-value: 1.03e-98
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| NfI_DNAbd_pre-N | pfam10524 | Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ... |
8-45 | 2.57e-20 | ||||
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication. : Pssm-ID: 463134 Cd Length: 41 Bit Score: 83.42 E-value: 2.57e-20
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| MH1 super family | cl45991 | MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related ... |
67-169 | 5.40e-17 | ||||
MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localization signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx. The actual alignment was detected with superfamily member pfam03165: Pssm-ID: 460833 Cd Length: 103 Bit Score: 76.26 E-value: 5.40e-17
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| Name | Accession | Description | Interval | E-value | ||||
| CTF_NFI | pfam00859 | CTF/NF-I family transcription modulation region; |
212-417 | 1.03e-98 | ||||
CTF/NF-I family transcription modulation region; Pssm-ID: 459967 [Multi-domain] Cd Length: 288 Bit Score: 297.21 E-value: 1.03e-98
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| NfI_DNAbd_pre-N | pfam10524 | Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ... |
8-45 | 2.57e-20 | ||||
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication. Pssm-ID: 463134 Cd Length: 41 Bit Score: 83.42 E-value: 2.57e-20
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| MH1 | pfam03165 | MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related ... |
67-169 | 5.40e-17 | ||||
MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localization signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx. Pssm-ID: 460833 Cd Length: 103 Bit Score: 76.26 E-value: 5.40e-17
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| DWA | smart00523 | Domain A in dwarfin family proteins; |
66-167 | 5.00e-16 | ||||
Domain A in dwarfin family proteins; Pssm-ID: 214708 Cd Length: 109 Bit Score: 73.57 E-value: 5.00e-16
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| ROM1 | COG5422 | RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
231-439 | 7.82e-03 | ||||
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 38.72 E-value: 7.82e-03
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| Name | Accession | Description | Interval | E-value | ||||
| CTF_NFI | pfam00859 | CTF/NF-I family transcription modulation region; |
212-417 | 1.03e-98 | ||||
CTF/NF-I family transcription modulation region; Pssm-ID: 459967 [Multi-domain] Cd Length: 288 Bit Score: 297.21 E-value: 1.03e-98
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| NfI_DNAbd_pre-N | pfam10524 | Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ... |
8-45 | 2.57e-20 | ||||
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication. Pssm-ID: 463134 Cd Length: 41 Bit Score: 83.42 E-value: 2.57e-20
|
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| MH1 | pfam03165 | MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related ... |
67-169 | 5.40e-17 | ||||
MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localization signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx. Pssm-ID: 460833 Cd Length: 103 Bit Score: 76.26 E-value: 5.40e-17
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| DWA | smart00523 | Domain A in dwarfin family proteins; |
66-167 | 5.00e-16 | ||||
Domain A in dwarfin family proteins; Pssm-ID: 214708 Cd Length: 109 Bit Score: 73.57 E-value: 5.00e-16
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| ROM1 | COG5422 | RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
231-439 | 7.82e-03 | ||||
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 38.72 E-value: 7.82e-03
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| Blast search parameters | ||||
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