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Conserved domains on  [gi|1475409166|ref|NP_001352687|]
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ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 200-293 1.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  200 PEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVvTRYKVEWSmsEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 279
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....
gi 1475409166  280 NMKGWGPAQTTTPA 293
Cdd:cd00063     78 NGGGESPPSESVTV 91
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
63-127 4.58e-07

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.58e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1475409166   63 NFQGNEAMFEAVEQQDMDAVQILLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 200-293 1.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  200 PEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVvTRYKVEWSmsEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 279
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....
gi 1475409166  280 NMKGWGPAQTTTPA 293
Cdd:cd00063     78 NGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
203-286 2.78e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 2.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  203 PTNVCLMVTSSTSLTVSFQEPLSVNAaVVTRYKVEWSMSEDFSPLAgEIIMDNlQTLRCTITGLTMGQQYFVQVSAYNMK 282
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWN-EITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1475409166  283 GWGP 286
Cdd:pfam00041   80 GEGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 200-285 1.85e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 1.85e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166   200 PEMPTNVCLMVTSSTSLTVSFQEPLSvnaAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 279
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD---DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1475409166   280 NMKGWG 285
Cdd:smart00060   78 NGAGEG 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-127 4.58e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.58e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1475409166   63 NFQGNEAMFEAVEQQDMDAVQILLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-127 3.16e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 3.16e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1475409166   66 GNEAMFEAVEQQDMDAVQILLyqytpEELDLNtPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGA 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
199-280 6.66e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.84  E-value: 6.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  199 APEMPTNVCLMVTSSTSLTVSFQeplSVNAAVVTRYKVEWSMSED--FSPLAgeiimdNLQTLRCTITGLTMGQQYFVQV 276
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGDgpFTKVA------TVTTTSYTDTGLTNGTTYYYRV 302


                   ....
gi 1475409166  277 SAYN 280
Cdd:COG3401    303 TAVD 306
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 200-293 1.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  200 PEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVvTRYKVEWSmsEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 279
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....
gi 1475409166  280 NMKGWGPAQTTTPA 293
Cdd:cd00063     78 NGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
203-286 2.78e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 2.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  203 PTNVCLMVTSSTSLTVSFQEPLSVNAaVVTRYKVEWSMSEDFSPLAgEIIMDNlQTLRCTITGLTMGQQYFVQVSAYNMK 282
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWN-EITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1475409166  283 GWGP 286
Cdd:pfam00041   80 GEGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 200-285 1.85e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 1.85e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166   200 PEMPTNVCLMVTSSTSLTVSFQEPLSvnaAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 279
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD---DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1475409166   280 NMKGWG 285
Cdd:smart00060   78 NGAGEG 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-127 4.58e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.58e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1475409166   63 NFQGNEAMFEAVEQQDMDAVQILLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-127 2.38e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 2.38e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1475409166   63 NFQGNEAMFEAVEQQDMDAVQILLYQytpeELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEA----GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-127 5.10e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 5.10e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1475409166   62 VNFQGNEAMFEAVEQQDMDAVQILLyqytpeEL--DLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLL------EAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-127 3.16e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 3.16e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1475409166   66 GNEAMFEAVEQQDMDAVQILLyqytpEELDLNtPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGA 85
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-123 2.26e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 2.26e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1475409166   66 GNEAMFEAVEQQDMDAVQILLYQytpeELDLNTPNSEGLTPLDIAIMTNNVPIARILL 123
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
70-123 2.48e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.87  E-value: 2.48e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1475409166   70 MFEAVEQQDMDAVQILLYqytpEELDLNTPNSEGLTPLDIAIMTNNVPIARILL 123
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLE----NGADANLQDKNGRTALHLAAKNGHLEIVKLLL 50
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
199-280 6.66e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.84  E-value: 6.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  199 APEMPTNVCLMVTSSTSLTVSFQeplSVNAAVVTRYKVEWSMSED--FSPLAgeiimdNLQTLRCTITGLTMGQQYFVQV 276
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGDgpFTKVA------TVTTTSYTDTGLTNGTTYYYRV 302


                   ....
gi 1475409166  277 SAYN 280
Cdd:COG3401    303 TAVD 306
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
199-280 1.06e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.07  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166  199 APEMPTNVCLMVTSSTSLTVSFQEPLSVNaavVTRYKVEWSMSEDFSPlagEIIMDNLQTLRCTITGLTMGQQYFVQVSA 278
Cdd:COG3401    326 PPAAPSGLTATAVGSSSITLSWTASSDAD---VTGYNVYRSTSGGGTY---TKIAETVTTTSYTDTGLTPGTTYYYKVTA 399


                   ..
gi 1475409166  279 YN 280
Cdd:COG3401    400 VD 401
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-129 1.48e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 1.48e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409166   62 VNFQGNEAMFEAVEQQDMDAVQILLyqytpeEL--DLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARE 129
Cdd:COG0666    182 RDNDGETPLHLAAENGHLEIVKLLL------EAgaDVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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