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Conserved domains on  [gi|1446042973|ref|NP_001352201|]
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zinc finger and SCAN domain-containing protein 10 isoform 4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-592 2.08e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 218 DERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRG--FQRRASLVQHLLAHAQ-------DQKPPC---APESK 285
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNnpsdlnsKSLPLSnskASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 286 AEAPPLTDV---LCSHCGQSFQRRSSLKRHLR--IHARDKD----RRSSEGSGSRRRDSDRRPFVCSDCGKAFRRSEHLv 356
Cdd:COG5048   110 LSSSSSNSNdnnLLSSHSLPPSSRDPQLPDLLsiSNLRNNPlpgnNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 357 aHRRVHTGERPFSCQACGRSFTQSSQLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQT 436
Cdd:COG5048   189 -SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 437 QDLARHQRSHTGE-------KPCRCSECGEGFSQSAHLARHQR--IHTGE--KPHACD--TCGHRFRNSSNLARHRRSHT 503
Cdd:COG5048   268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 504 GERPYSCQTCGRSFRRN------AHLRRHLATHAEPGQEQAEPPQECVecgKSFSRSCNLLRHLLVHTGARPYSC--TQC 575
Cdd:COG5048   348 SISPAKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCI---RNFKRDSNLSLHIITHLSFRPYNCknPPC 424

                         410
                  ....*....|....*..
gi 1446042973 576 GRSFSRNSHLLRHLRTH 592
Cdd:COG5048   425 SKSFNRHYNLIPHKKIH 441
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 3-132 3.17e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973   3 PVSGGHGATGVPEPAPGALRPLAAAGSAHQETDPGAAGPQgPSPWPEESSRDQELAAvlecltfedvpenkAWPAHPLGF 82
Cdd:PRK07764  397 AAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPA-PAPAPPSPAGNAPAGG--------------APSPPPAAA 461

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1446042973  83 GSRTPDKEEFKQEEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAA 132
Cdd:PRK07764  462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-592 2.08e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 218 DERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRG--FQRRASLVQHLLAHAQ-------DQKPPC---APESK 285
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNnpsdlnsKSLPLSnskASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 286 AEAPPLTDV---LCSHCGQSFQRRSSLKRHLR--IHARDKD----RRSSEGSGSRRRDSDRRPFVCSDCGKAFRRSEHLv 356
Cdd:COG5048   110 LSSSSSNSNdnnLLSSHSLPPSSRDPQLPDLLsiSNLRNNPlpgnNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 357 aHRRVHTGERPFSCQACGRSFTQSSQLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQT 436
Cdd:COG5048   189 -SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 437 QDLARHQRSHTGE-------KPCRCSECGEGFSQSAHLARHQR--IHTGE--KPHACD--TCGHRFRNSSNLARHRRSHT 503
Cdd:COG5048   268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 504 GERPYSCQTCGRSFRRN------AHLRRHLATHAEPGQEQAEPPQECVecgKSFSRSCNLLRHLLVHTGARPYSC--TQC 575
Cdd:COG5048   348 SISPAKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCI---RNFKRDSNLSLHIITHLSFRPYNCknPPC 424

                         410
                  ....*....|....*..
gi 1446042973 576 GRSFSRNSHLLRHLRTH 592
Cdd:COG5048   425 SKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*
gi 1446042973 383 LVSHQRVHTGEKPYACPQCGKRFVR 407
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 366-417 1.08e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1446042973 366 RPFsCQACGRSFTQSSQLVSHQRvhtgEKPYACPQCGKRFVRRASLARHLLT 417
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-132 3.17e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973   3 PVSGGHGATGVPEPAPGALRPLAAAGSAHQETDPGAAGPQgPSPWPEESSRDQELAAvlecltfedvpenkAWPAHPLGF 82
Cdd:PRK07764  397 AAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPA-PAPAPPSPAGNAPAGG--------------APSPPPAAA 461

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1446042973  83 GSRTPDKEEFKQEEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAA 132
Cdd:PRK07764  462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-592 2.08e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 218 DERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRG--FQRRASLVQHLLAHAQ-------DQKPPC---APESK 285
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNnpsdlnsKSLPLSnskASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 286 AEAPPLTDV---LCSHCGQSFQRRSSLKRHLR--IHARDKD----RRSSEGSGSRRRDSDRRPFVCSDCGKAFRRSEHLv 356
Cdd:COG5048   110 LSSSSSNSNdnnLLSSHSLPPSSRDPQLPDLLsiSNLRNNPlpgnNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 357 aHRRVHTGERPFSCQACGRSFTQSSQLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQT 436
Cdd:COG5048   189 -SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 437 QDLARHQRSHTGE-------KPCRCSECGEGFSQSAHLARHQR--IHTGE--KPHACD--TCGHRFRNSSNLARHRRSHT 503
Cdd:COG5048   268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973 504 GERPYSCQTCGRSFRRN------AHLRRHLATHAEPGQEQAEPPQECVecgKSFSRSCNLLRHLLVHTGARPYSC--TQC 575
Cdd:COG5048   348 SISPAKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCI---RNFKRDSNLSLHIITHLSFRPYNCknPPC 424

                         410
                  ....*....|....*..
gi 1446042973 576 GRSFSRNSHLLRHLRTH 592
Cdd:COG5048   425 SKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*
gi 1446042973 383 LVSHQRVHTGEKPYACPQCGKRFVR 407
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 570-592 3.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|...
gi 1446042973 570 YSCTQCGRSFSRNSHLLRHLRTH 592
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 366-417 1.08e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1446042973 366 RPFsCQACGRSFTQSSQLVSHQRvhtgEKPYACPQCGKRFVRRASLARHLLT 417
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-233 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*
gi 1446042973 209 LKLHMRTHTDERPHACHLCGHRFRQ 233
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 340-362 2.26e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.26e-03
                          10        20
                  ....*....|....*....|...
gi 1446042973 340 FVCSDCGKAFRRSEHLVAHRRVH 362
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 508-530 2.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|...
gi 1446042973 508 YSCQTCGRSFRRNAHLRRHLATH 530
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-132 3.17e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973   3 PVSGGHGATGVPEPAPGALRPLAAAGSAHQETDPGAAGPQgPSPWPEESSRDQELAAvlecltfedvpenkAWPAHPLGF 82
Cdd:PRK07764  397 AAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPA-PAPAPPSPAGNAPAGG--------------APSPPPAAA 461

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1446042973  83 GSRTPDKEEFKQEEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAA 132
Cdd:PRK07764  462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
529-592 3.35e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1446042973 529 THAEPGQEQAEPPQECVECGKSFSRSCNLLRHLLVHTGARPYSCTQCGR--SFSRNSHLLRHLRTH 592
Cdd:COG5048    21 KSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-433 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|....
gi 1446042973 410 SLARHLLTHGGPRPHHCTQCGKSF 433
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-159 6.72e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973   3 PVSGGHGATGVPEPAPG-----ALRPLAAAGSAHQETDPGAAGPQGPSPWPEESSRDQELAAVLECLTFEDVPENKAWPA 77
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSgppeeAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446042973  78 HPLGfGSRTPDKEEFKQEEPkGAAWPTPIlAESQADSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEilevkvAEGVP 157
Cdd:PRK07764  670 PAKA-GGAAPAAPPPAPAPA-APAAPAGA-APAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAA------DDPVP 740


                  ..
gi 1446042973 158 EP 159
Cdd:PRK07764  741 LP 742
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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