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Conserved domains on  [gi|1401565944|ref|NP_001351215|]
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aquaporin-4 isoform M23 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 3.18e-82

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 247.23  E-value: 3.18e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944   9 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  88 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944 168 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 3.18e-82

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 247.23  E-value: 3.18e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944   9 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  88 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944 168 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 14-229 3.63e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.43  E-value: 3.63e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTINWGGTEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 93
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  94 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVT 164
Cdd:cd00333    80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1401565944 165 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:cd00333   160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 18-226 1.98e-65

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.45  E-value: 1.98e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  18 AEFLAMLIFVLLSLGSTI---NWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 94
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  95 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 172
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1401565944 173 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 12-230 1.51e-59

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 189.95  E-value: 1.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  12 FWKAVTAEFLAMLIFVLLSLGSTINWGGTekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 91
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  92 KSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 163
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1401565944 164 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-230 2.70e-43

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 148.55  E-value: 2.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTINWGG--TEKPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 90
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  91 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTmvhGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 169
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVA---AGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1401565944 170 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 3.18e-82

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 247.23  E-value: 3.18e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944   9 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  88 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944 168 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 14-229 3.63e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.43  E-value: 3.63e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTINWGGTEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 93
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  94 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVT 164
Cdd:cd00333    80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1401565944 165 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:cd00333   160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 18-226 1.98e-65

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.45  E-value: 1.98e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  18 AEFLAMLIFVLLSLGSTI---NWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 94
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  95 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 172
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1401565944 173 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 12-230 1.51e-59

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 189.95  E-value: 1.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  12 FWKAVTAEFLAMLIFVLLSLGSTINWGGTekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 91
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  92 KSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 163
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1401565944 164 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-230 2.70e-43

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 148.55  E-value: 2.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTINWGG--TEKPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 90
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  91 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTmvhGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 169
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVA---AGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1401565944 170 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 14-230 3.31e-42

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 145.70  E-value: 3.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTINW-----GGTEKPLPVDMVLISLCFGLSIATMVQCfgHISGGHINPAVTVAMVCTRKI 88
Cdd:PLN00027   21 KAALAEFISTLIFVFAGEGSGMAFnkltdNGSTTPAGLVAAALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  89 SIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTmvhGNLTAGHGLLVELIITFQLVFTIFASC-DSKRTDVTGSI 167
Cdd:PLN00027   99 TLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLS---SGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGIIA 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1401565944 168 ALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00027  176 PIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 14-230 4.32e-37

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 132.01  E-value: 4.32e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTINWGGTeKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 93
Cdd:PRK05420    3 KKLAAEFFGTFWLVFGGCGSAVLAAAF-PELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  94 VFYIAAQCLGAIIGAGILYLVtppsVVGGLGVTMVHGNLTA-GHG------------LLVELIITFQLVFTIFASCDsKR 160
Cdd:PRK05420   82 VPYIIAQVVGGIAAAAVLYLI----ASGKAGFDLAGSGFASnGYGehspggysllaaLVCEVVLTAFFLLVILGATD-KR 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1401565944 161 TDVtGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNW--ENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PRK05420  157 APA-GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 4-232 2.78e-35

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 128.10  E-value: 2.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944   4 FKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTInwgGTEKPLPVD------MVLISLCFGLSIATMVQCFGHISGGHINPA 77
Cdd:PLN00167   13 FQQSVTRNALRSYLAEFISTFFFVFAAVGSAM---SSRKLMPDAasdpssLLIVAIANAFALSSAVYIAANISGGHVNPA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  78 VTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTppsVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCD 157
Cdd:PLN00167   90 VTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGD 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1401565944 158 SKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 232
Cdd:PLN00167  167 PRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00026 PLN00026
aquaporin NIP; Provisional
 14-235 1.44e-31

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 119.20  E-value: 1.44e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  14 KAVTAEFLAMLIFVLLSLGSTI---NWGGTEKPLPvdmvlISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 90
Cdd:PLN00026   72 RKLGAEFVGTFILIFAATAGPIvnqKYDGAETLIG-----NAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  91 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVhgnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-L 169
Cdd:PLN00026  147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSV----STGQAFALEFIITFNLLFVVTAVATDTRA--VGELAgI 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1401565944 170 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 235
Cdd:PLN00026  221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 51-229 2.29e-29

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 113.08  E-value: 2.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  51 ISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL---VTPPSVVGGLGVTm 127
Cdd:PLN00182   78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLmfnVTPEAFFGTTPTD- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944 128 vhgnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE 206
Cdd:PLN00182  157 -----SSGQALVAEIIISFLLMFVISGVATDSRA--VGELAgIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK 229

                         170       180
                  ....*....|....*....|...
gi 1401565944 207 NHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:PLN00182  230 GIWVYIVGPFVGIIAGGFVYNLI 252
PLN00184 PLN00184
aquaporin NIP1; Provisional
 12-229 3.25e-27

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 107.41  E-value: 3.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  12 FWKAVTAEFLAMLIFVLLSLGSTINwgGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 91
Cdd:PLN00184   53 FLQKLIAEVLGTYFLVFTGCASVVV--NMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  92 KSVFYIAAQCLGAIIGAGILYLV--TPPSVVGGLGVTMVhGNLTAGHGL---LVELIITFQLVFTIFASCDSKRTdvTGS 166
Cdd:PLN00184  131 QVPAYVISQVIGSTLAAATLRLLfgLDHDVCSGKHDVFI-GSSPVGSDLqafVMEFIVTFYLMFIISGVATDNRA--IGE 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1401565944 167 IA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:PLN00184  208 LAgLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 56-226 5.30e-21

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 90.30  E-value: 5.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  56 GLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGIlylvtppsvvgGLGVTMVHGNLTAG 135
Cdd:PLN00183   86 GLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITAQTVGSVLATYV-----------GVSVYGVKADLMTT 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944 136 HGLL-------VELIITFQLVFtIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENH 208
Cdd:PLN00183  155 KPAQgcssafwVEFIATFIVMF-LAASLTSQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDI 233

                         170
                  ....*....|....*...
gi 1401565944 209 WIYWVGPIIGAVLAGGLY 226
Cdd:PLN00183  234 WIYITAPTIGAVAGALMF 251
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 13-235 5.65e-21

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 90.57  E-value: 5.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  13 WKAVTAEFLAMliFVLLSLGSTINwgGTEKPLPVDMVLISLCFGLSIATMVQCF--GHISGGHINPAVTVAMVCTRKISI 90
Cdd:PTZ00016   50 VREYVAEFLGT--FVLLFFGEGVV--ATTHTVGNNGDYLAITIGWGLGVTFGLLvsAGISGGHLNPAVTLGNAVFGKFPW 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944  91 AKSVFYIAAQCLGAIIGAGILYLV----------------TPPSVVGGLGVTMVHGNLTagHGLLVELIITFQLVFTIFA 154
Cdd:PTZ00016  126 KKLPGYFVAQLLGAFVGAACVYGLyygffkdhgipelpweTMANGFAGVFATYPREGNF--YAIFSELILTAILLLVILA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401565944 155 SCDSKRTDVTGSIALAIGFSV-AIGHLFAINyTGASMNPARSFGP----AVIMGN----WENH--WIYWVGPIIGAVLAG 223
Cdd:PTZ00016  204 ITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevftKDNYyfWVPLVAPFVGAVLGM 282

                         250
                  ....*....|..
gi 1401565944 224 GLYEYVFCPDVE 235
Cdd:PTZ00016  283 FLYDKFIPPLIE 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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