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Conserved domains on  [gi|1398331578|ref|NP_001351090|]
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L-seryl-tRNA(Sec) kinase isoform 2 [Mus musculus]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
20-293 0e+00

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member TIGR03575:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 340  Bit Score: 519.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  20 LCVLCGLPAAGKSTFARALALRLRRERGWAVGVLSYDDVLPLALPDCDGTQPRPSQWKMFRQELLKHLECFLVAVISGAQ 99
Cdd:TIGR03575   1 LCVLCGLPAAGKSTLARSLSATLRRERGWAVAVITYDDIIPEAAFELDQSRPLPSQWKQFRQELLKYLEHFLVAVINGSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 MSAPPNRTEAVWEDFITCLKSQDLMIFPTALEAQPCHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 179
Cdd:TIGR03575  81 LSAPPGKTEGMWEDFVDCLKEQGLIISSGASEAQGCHSLTKPAVSRPLCLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 180 LDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWEHNSLIIQSSACSLEASLEVTGLLLTALENPIKCVEDNT 259
Cdd:TIGR03575 161 LDCPVESCLLRNKQRPVPLPDETIQLMGRKIEKPNPEKNAWEHNSLVIQSSACISEDSLEVTDLLNTALENPIKCVEENL 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1398331578 260 EQKETDRIICSTNILHKADETLRRTVSQTMREAK 293
Cdd:TIGR03575 241 EQKETDRIICSTNILHQADQTLRRIISQTMREAK 274
 
Name Accession Description Interval E-value
selen_PSTK_euk TIGR03575
L-seryl-tRNA(Sec) kinase, eukaryotic; Members of this protein are L-seryl-tRNA(Sec) kinase. ...
20-293 0e+00

L-seryl-tRNA(Sec) kinase, eukaryotic; Members of this protein are L-seryl-tRNA(Sec) kinase. This enzyme is part of a two-step pathway in Eukaryota and Archaea for performing selenocysteine biosynthesis by changing serine misacylated on selenocysteine-tRNA to selenocysteine. This enzyme performs the first step, phosphorylation of the OH group of the serine side chain. This family represents eukaryotic proteins with this activity.


Pssm-ID: 188340 [Multi-domain]  Cd Length: 340  Bit Score: 519.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  20 LCVLCGLPAAGKSTFARALALRLRRERGWAVGVLSYDDVLPLALPDCDGTQPRPSQWKMFRQELLKHLECFLVAVISGAQ 99
Cdd:TIGR03575   1 LCVLCGLPAAGKSTLARSLSATLRRERGWAVAVITYDDIIPEAAFELDQSRPLPSQWKQFRQELLKYLEHFLVAVINGSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 MSAPPNRTEAVWEDFITCLKSQDLMIFPTALEAQPCHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 179
Cdd:TIGR03575  81 LSAPPGKTEGMWEDFVDCLKEQGLIISSGASEAQGCHSLTKPAVSRPLCLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 180 LDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWEHNSLIIQSSACSLEASLEVTGLLLTALENPIKCVEDNT 259
Cdd:TIGR03575 161 LDCPVESCLLRNKQRPVPLPDETIQLMGRKIEKPNPEKNAWEHNSLVIQSSACISEDSLEVTDLLNTALENPIKCVEENL 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1398331578 260 EQKETDRIICSTNILHKADETLRRTVSQTMREAK 293
Cdd:TIGR03575 241 EQKETDRIICSTNILHQADQTLRRIISQTMREAK 274
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
20-239 5.16e-15

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 71.68  E-value: 5.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  20 LCVLCGLPAAGKSTFARALALRLRRErGWAVGVLSYDDvlplalpdcdgtqprpsqwkmFRQELLKHlecflvavisgaq 99
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRLYAE-GIAVALLHSDD---------------------FRRFLVNE------------- 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 mSAPPNRTEAVWEDFITClksqdlmifptaleaqpchlLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLAR-KYSLGFcqL 178
Cdd:COG4088    51 -SFPKETYEEVVEDVRTT--------------------TADNALDNGYSVIVDGTFYYRSWQRDFRNLAKhKAPIHI--I 107
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331578 179 FLDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWehnsLIIQSSACSLEASLE 239
Cdd:COG4088   108 YLKAPLETALRRNRERGEPIPERVIARMYRKFDKPGTKDRPD----LVIDTTEDSVSETLD 164
KTI12 pfam08433
Chromatin associated protein KTI12; This is a family of chromatin associated proteins which ...
138-293 7.98e-14

Chromatin associated protein KTI12; This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II. The Elongator complex has histone acetyltransferase activity.


Pssm-ID: 400643  Cd Length: 269  Bit Score: 70.02  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 138 LAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLKRNGERSQP--LPDETIQLMGRKIEKPNP 215
Cdd:pfam08433  61 AVKRDLSKNTIVIVDSLNYIKGFRYELYCIAKAARTTYCVIHCKAPLDLCRKWNEERGQKsrYPDELLDALIQRYEEPNS 140
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1398331578 216 eKNAWEHNSLIIQssacSLEASLEVTGLLLTALENPIKCVEDNTEQKETDriicSTNILHKADETLRRTVSQTMREAK 293
Cdd:pfam08433 141 -KNRWDSPLFTVL----SDDETLPLDEIWKALIEKQPLPPNQATQLKPLS----ETNFLQELDKETQDIVSEILKAQQ 209
 
Name Accession Description Interval E-value
selen_PSTK_euk TIGR03575
L-seryl-tRNA(Sec) kinase, eukaryotic; Members of this protein are L-seryl-tRNA(Sec) kinase. ...
20-293 0e+00

L-seryl-tRNA(Sec) kinase, eukaryotic; Members of this protein are L-seryl-tRNA(Sec) kinase. This enzyme is part of a two-step pathway in Eukaryota and Archaea for performing selenocysteine biosynthesis by changing serine misacylated on selenocysteine-tRNA to selenocysteine. This enzyme performs the first step, phosphorylation of the OH group of the serine side chain. This family represents eukaryotic proteins with this activity.


Pssm-ID: 188340 [Multi-domain]  Cd Length: 340  Bit Score: 519.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  20 LCVLCGLPAAGKSTFARALALRLRRERGWAVGVLSYDDVLPLALPDCDGTQPRPSQWKMFRQELLKHLECFLVAVISGAQ 99
Cdd:TIGR03575   1 LCVLCGLPAAGKSTLARSLSATLRRERGWAVAVITYDDIIPEAAFELDQSRPLPSQWKQFRQELLKYLEHFLVAVINGSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 MSAPPNRTEAVWEDFITCLKSQDLMIFPTALEAQPCHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 179
Cdd:TIGR03575  81 LSAPPGKTEGMWEDFVDCLKEQGLIISSGASEAQGCHSLTKPAVSRPLCLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 180 LDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWEHNSLIIQSSACSLEASLEVTGLLLTALENPIKCVEDNT 259
Cdd:TIGR03575 161 LDCPVESCLLRNKQRPVPLPDETIQLMGRKIEKPNPEKNAWEHNSLVIQSSACISEDSLEVTDLLNTALENPIKCVEENL 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1398331578 260 EQKETDRIICSTNILHKADETLRRTVSQTMREAK 293
Cdd:TIGR03575 241 EQKETDRIICSTNILHQADQTLRRIISQTMREAK 274
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
20-239 5.16e-15

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 71.68  E-value: 5.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  20 LCVLCGLPAAGKSTFARALALRLRRErGWAVGVLSYDDvlplalpdcdgtqprpsqwkmFRQELLKHlecflvavisgaq 99
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRLYAE-GIAVALLHSDD---------------------FRRFLVNE------------- 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 mSAPPNRTEAVWEDFITClksqdlmifptaleaqpchlLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLAR-KYSLGFcqL 178
Cdd:COG4088    51 -SFPKETYEEVVEDVRTT--------------------TADNALDNGYSVIVDGTFYYRSWQRDFRNLAKhKAPIHI--I 107
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331578 179 FLDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWehnsLIIQSSACSLEASLE 239
Cdd:COG4088   108 YLKAPLETALRRNRERGEPIPERVIARMYRKFDKPGTKDRPD----LVIDTTEDSVSETLD 164
KTI12 pfam08433
Chromatin associated protein KTI12; This is a family of chromatin associated proteins which ...
138-293 7.98e-14

Chromatin associated protein KTI12; This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II. The Elongator complex has histone acetyltransferase activity.


Pssm-ID: 400643  Cd Length: 269  Bit Score: 70.02  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 138 LAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLKRNGERSQP--LPDETIQLMGRKIEKPNP 215
Cdd:pfam08433  61 AVKRDLSKNTIVIVDSLNYIKGFRYELYCIAKAARTTYCVIHCKAPLDLCRKWNEERGQKsrYPDELLDALIQRYEEPNS 140
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1398331578 216 eKNAWEHNSLIIQssacSLEASLEVTGLLLTALENPIKCVEDNTEQKETDriicSTNILHKADETLRRTVSQTMREAK 293
Cdd:pfam08433 141 -KNRWDSPLFTVL----SDDETLPLDEIWKALIEKQPLPPNQATQLKPLS----ETNFLQELDKETQDIVSEILKAQQ 209
COG4639 COG4639
Predicted kinase [General function prediction only];
22-213 4.69e-11

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 59.46  E-value: 4.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  22 VLCGLPAAGKSTFAralalrlrreRGWAVG--VLSYDDvlplalpdcdgtqprpsqwkmFRQELlkhlecFLVAVISGAQ 99
Cdd:COG4639     6 VLIGLPGSGKSTFA----------RRLFAPteVVSSDD---------------------IRALL------GGDENDQSAW 48
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 msappnrtEAVWEdfitclksqdlmifptalEAqpcHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 179
Cdd:COG4639    49 --------GDVFQ------------------LA---HEIARARLRAGRLTVVDATNLQREARRRLLALARAYGALVVAVV 99
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1398331578 180 LDCPLETCLKRNGERSQPLPDETIQLMGRKIEKP 213
Cdd:COG4639   100 LDVPLEVCLARNAARDRQVPEEVIRRMLRRLRRP 133
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
150-200 5.63e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.90  E-value: 5.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1398331578 150 VLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLKRNGERSQPLPD 200
Cdd:COG0645    74 ILDATFLRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGD 124
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
20-213 1.40e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 38.44  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578  20 LCVLCGLPAAGKSTFARALALRLRRERgwavgvLSYDDvlplalpdcdgtqprpsqwkMFRQellkhlecflVAVISGAQ 99
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELGAVR------LSSDD--------------------ERKR----------LFGEGRPS 44
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331578 100 MSAPPNRTEAVWEdfitCLksqdlmifptaleaqpcHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLF 179
Cdd:pfam13671  45 ISYYTDATDRTYE----RL-----------------HELARIALRAGRPVILDATNLRRDERARLLALAREYGVPVRIVV 103
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1398331578 180 LDCPLETCLKRN------GERSQPLPDETIQLMGRKIEKP 213
Cdd:pfam13671 104 FEAPEEVLRERLaararaGGDPSDVPEEVLDRQKARFEPP 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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