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Conserved domains on  [gi|1390435880|ref|NP_001350450|]
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major facilitator superfamily domain-containing protein 8 isoform 3 [Homo sapiens]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-402 4.40e-112

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 333.41  E-value: 4.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 118 NCLYAYLHIPASHNKYYMLVARGLLGIGA------------ASTDE-----------AQV------------------PQ 156
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAgnvavlrayvaaASTLKdrtramavisaAQAlgfivgpalqaaftpigyPG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 157 GNIDQVAV----------------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIIL 208
Cdd:cd17326   161 YVIGIKLRfnmytapawlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 209 AALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspme 287
Cdd:cd17326   241 AVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG---------------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 288 ddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFI 367
Cdd:cd17326   287 ---------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFV 339

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1390435880 368 SQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 402
Cdd:cd17326   340 TAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-402 4.40e-112

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 333.41  E-value: 4.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 118 NCLYAYLHIPASHNKYYMLVARGLLGIGA------------ASTDE-----------AQV------------------PQ 156
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAgnvavlrayvaaASTLKdrtramavisaAQAlgfivgpalqaaftpigyPG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 157 GNIDQVAV----------------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIIL 208
Cdd:cd17326   161 YVIGIKLRfnmytapawlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 209 AALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspme 287
Cdd:cd17326   241 AVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG---------------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 288 ddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFI 367
Cdd:cd17326   287 ---------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFV 339

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1390435880 368 SQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 402
Cdd:cd17326   340 TAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-147 8.00e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.99  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1390435880 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAA 147
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAG 113
MFS_1 pfam07690
Major Facilitator Superfamily;
42-364 1.44e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 122 AYlhipaSHNKYYMLVARGLLGIGAASTD-------EAQVPQGNIDQVavvaiNVLFFVTLFIFALFETIITPLTMDMYA 194
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALFpaalaliADWFPPEERGRA-----LGLVSAGFGLGAALGPLLGGLLASLFG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 195 WtqEQAVLYNGIILAALGV-----------------EAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGNQFP 257
Cdd:pfam07690 150 W--RAAFLILAILSLLAAVllllprpppeskrpkpaEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 258 KIQ-WEDLHNNSIPN-----TTFGEIIIGLWKSPMEDDNERPTGCSI----EQAWCLYTPVIHLAQFLTSAVLIGLGYPV 327
Cdd:pfam07690 228 EVLgLSALLAGLLLGlggllGAIGRLLLGRLSDRLGRRRRLLLALLLlilaALGLLLLSLTLSSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1390435880 328 CNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGP 364
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-402 4.40e-112

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 333.41  E-value: 4.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 118 NCLYAYLHIPASHNKYYMLVARGLLGIGA------------ASTDE-----------AQV------------------PQ 156
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAgnvavlrayvaaASTLKdrtramavisaAQAlgfivgpalqaaftpigyPG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 157 GNIDQVAV----------------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIIL 208
Cdd:cd17326   161 YVIGIKLRfnmytapawlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 209 AALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspme 287
Cdd:cd17326   241 AVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG---------------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 288 ddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFI 367
Cdd:cd17326   287 ---------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFV 339

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1390435880 368 SQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 402
Cdd:cd17326   340 TAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 42-396 3.81e-41

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 148.88  E-value: 3.81e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  42 LYLTMFLSSVGFSVVMMSIWPYLQKI-DPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 121 YAYlhipaSHNKYYMLVARGLLGIGAASTDEAQ------------------------------------VPQGNIDQVAV 164
Cdd:cd17330    81 LGL-----SRNLWLLFLARFLDGLTGGNVSVAQayiaditdeeerakafgiisaafglgfilgpalggfLSTPYGYALPF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 165 VAINVLFFVTL---------------------FIFALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGV- 222
Cdd:cd17330   156 LVAAALALLNLvlvlfflpplrrlllvyfliaLAFAGLESVFSLFLKDRFGFSPSQI----GLLLALVGIAGILAQLLLi 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 223 KLLSKKIGERAILLGGLIVVWVGFFiLLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqaw 302
Cdd:cd17330   232 PRLAKRLGERKLLRLGLLLAIIGLL-LLPFASSVP--------------------------------------------- 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 303 clytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSL 382
Cdd:cd17330   266 ----------LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335

                         410
                  ....*....|....
gi 1390435880 383 VCGIIVLTITLLGV 396
Cdd:cd17330   336 AAGLLLIALFLLSL 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-399 3.58e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.13  E-value: 3.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLG--ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 122 AYLHIPashnkYYMLVARGLLGIGAA------------------------------------------------------ 147
Cdd:cd17325    79 AFATSY-----WQLLLARFLQGLASAavwpaamaliadiappeergramgifssaiglgfligpllgglladalgyrapf 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 148 ----------------------STDEAQVPQGNIDQV---------AVVAINVLFFVTLFIFALFETIITPLTMDMYAWT 196
Cdd:cd17325   154 lvcaalallalvlallllpeprPPPNKRAVSAARLRSglrlllrdrRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 197 QEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVwVGFFILLPWGNQFPkiqwedlhnnsipnttfge 276
Cdd:cd17325   234 PAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS-AVALLLLPLATSFW------------------- 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 277 iiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASG 356
Cdd:cd17325   290 ------------------------------------LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1390435880 357 SGARILGPMFISQVYAHWGPRWAFsLVCGIIVLTITLLGVVYK 399
Cdd:cd17325   334 SLGMVLGPLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-147 8.00e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.99  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1390435880 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAA 147
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAG 113
MFS_1 pfam07690
Major Facilitator Superfamily;
42-364 1.44e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 122 AYlhipaSHNKYYMLVARGLLGIGAASTD-------EAQVPQGNIDQVavvaiNVLFFVTLFIFALFETIITPLTMDMYA 194
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALFpaalaliADWFPPEERGRA-----LGLVSAGFGLGAALGPLLGGLLASLFG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 195 WtqEQAVLYNGIILAALGV-----------------EAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGNQFP 257
Cdd:pfam07690 150 W--RAAFLILAILSLLAAVllllprpppeskrpkpaEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 258 KIQ-WEDLHNNSIPN-----TTFGEIIIGLWKSPMEDDNERPTGCSI----EQAWCLYTPVIHLAQFLTSAVLIGLGYPV 327
Cdd:pfam07690 228 EVLgLSALLAGLLLGlggllGAIGRLLLGRLSDRLGRRRRLLLALLLlilaALGLLLLSLTLSSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1390435880 328 CNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGP 364
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 33-147 4.94e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.88  E-value: 4.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  33 KSRWRSIRILYLTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0477    10 RRRRRALLALALGTFLEGLDFTIVNVAL-PSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1390435880 113 ISVAANCLYAYLHIPAShnkyyMLVARGLLGIGAA 147
Cdd:COG0477    88 LFGLASLLCGLAPSPEL-----LIAARALQGIGAG 117
Sugar_tr pfam00083
Sugar (and other) transporter;
71-146 1.01e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 47.65  E-value: 1.01e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390435880  71 ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLyayLHIPASHNKYYML-VARGLLGIGA 146
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVL---QGAAKGKWSVYQLiVGRVLVGIGV 116
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
38-254 2.06e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  38 SIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTAD-TSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:COG2814    97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 117 AnCLYAYLHIPASHnkyymlvargllgiGAASTDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPLTMDMYAWT 196
Cdd:COG2814   177 A-LLLLLRLLPESR--------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1390435880 197 QEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGN 254
Cdd:COG2814   242 ASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 35-147 3.44e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1390435880 115 VAanclyAYLHIPASHNKYYMLVARGLLGIGAA 147
Cdd:cd17325   276 AV-----ALLLLPLATSFWLLLLLLALLGLGLG 303
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-401 1.22e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  33 KSRWRSIRILYLTMFLSSVGFSVVMMsIWPYLQK---IDPTAdtsfLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIV 109
Cdd:COG2271     6 RYRWRILALLFLAYFLNYLDRSNLSV-AAPPLQAdlgLSAAQ----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 110 SILISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAASTdeaqvpqgnidQVAVVAINVLFF--------VTLFIFA-- 179
Cdd:COG2271    81 GLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGF-----------FPAALKLIAEWFppkergraLGIFNAGgp 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 180 ---LFETIITPLTMDMYAWtqeQAVLYNGIILAALGveAVVIFLgvkllskkigerAILLGGLIVVWVGFFILLpWGNQF 256
Cdd:COG2271   145 lggALAPPLLGWLLAAFGW---RAAFLILGLPGLLL--ALLRFW------------LLALAYFLVYFALYGFLT-WLPTY 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 257 pkiqWEDLHNNSIPNT-----------TFGEIIIGLWKSPMEDDNERPTGCS---IEQAWCLYTPVIHLAQFLTSAVLIG 322
Cdd:COG2271   207 ----LVEVRGLSLAQAglllslpflagIVGSLLGGWLSDRLGRRRKLVLAIGlllAALALLLLALLPSPALAIALLFLAG 282

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1390435880 323 LGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRL 401
Cdd:COG2271   283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
310-394 1.72e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.42  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 310 HLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVL 389
Cdd:COG2814    97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF-LVNAVLAL 175


                  ....*
gi 1390435880 390 TITLL 394
Cdd:COG2814   176 LALLL 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 43-150 3.12e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.80  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  43 YLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYA 122
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100
                  ....*....|....*....|....*...
gi 1390435880 123 YLHIPAShnkyyMLVARGLLGIGAASTD 150
Cdd:cd06174    80 FAPSFWL-----LLLGRFLLGLGSGLID 102
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
35-149 3.29e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV-LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1390435880 115 VAANCLYAYLHIPAShnkyyMLVARGLLGIGAAST 149
Cdd:COG2814   284 ALGLLLLALAGSLWL-----LLLALFLLGFGFGLL 313
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-144 3.71e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIsvaanCLY 121
Cdd:cd17390     1 LYLVGFLDLFGVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLL-----TAL 73

                          90       100
                  ....*....|....*....|...
gi 1390435880 122 AYLHIPASHNKYYMLVARGLLGI 144
Cdd:cd17390    74 GYVLLGFSTSLALLFLSRIPLGI 96
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-149 3.83e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  37 RSIRILYLTMFLSSVGFSVVMMSIwPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALL-LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1390435880 117 ANCLYAYLHipaSHNKYYMLVARGLLGIGAAST 149
Cdd:COG2211   307 GLLLLFFLG---PGNLWLLLVLAALAGIGLGAI 336
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 68-249 4.15e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 42.21  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  68 DPTADTSFLGWVIASYSLGqMVASPIFGLW-SNYRPRKEPLIVSILISVAANCLyAYLHIPaSHNKYYMLVARGLLGIGA 146
Cdd:cd17331   116 DPGERAAALGRLGLSYGIG-MVVGSFLGGLlTKKFGEQAAALVAAVGSLLSIVL-VILLIP-SNTKSKREKEAKESASPP 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 147 ASTDEAQVpqGNIDQVAVVAINVLF-FVTLFIFALFETIITPLTMDMYAWTQEQavlyNGIILAALGV-EAVVIFLGVKL 224
Cdd:cd17331   193 SVFNLKEI--LRLLRLPGVAFLLLVkLLSGLPIGMFQSMFSLVAMDFFGLTPEE----NGYLMSYAGVlGMVVQGLLVGP 266

                         170       180
                  ....*....|....*....|....*
gi 1390435880 225 LSKKIGERAILLGGLIVVWVGFFIL 249
Cdd:cd17331   267 LTKRFGERSLLKLSVALLAIGYLLL 291
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 77-147 5.84e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 5.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390435880  77 GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAA 147
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA-----LAPSFALLLLARALAGLAHG 102
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-150 7.04e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.38  E-value: 7.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0738     4 KNYRRALIAIYLLFFLWGFATALWG-PLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1390435880 113 ISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAASTD 150
Cdd:COG0738    82 LMALGLLLFAL-----APSYPLLLLALFLLGLGLGLLD 114
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
76-400 8.03e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.40  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  76 LGWVIASYSLGQMVASPIFG-LWSNYRPRKEPLIVSILISVAANCLYAYLHIPASHNKyyMLVARGLLGIGAASTDeaqv 154
Cdd:COG2223   131 LGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA--AAAKASLRDQLEALRD---- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 155 pqgnidqVAVVAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAI 234
Cdd:COG2223   205 -------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA----GLLAALFALLGALGRPLGGWLSDRIGGRRV 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 235 LLGGLIVVWVGFFILLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaQF 314
Cdd:COG2223   274 LLIVFALMALGLLLLALALGSLW-------------------------------------------------------LF 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 315 LTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWG-PRWAFSLVCGIIVLTITL 393
Cdd:COG2223   299 LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378


                  ....*..
gi 1390435880 394 LGVVYKR 400
Cdd:COG2223   379 TLLLYRR 385
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 304-397 9.39e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 304 LYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLV 383
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156

                          90
                  ....*....|....
gi 1390435880 384 CGIIVLTITLLGVV 397
Cdd:cd17489   157 AVLALLALLLVFLV 170
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-149 2.43e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.84  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17324   198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDV-PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1390435880 117 ANCLYAYLHIPAShnkyyMLVARGLLGIGAAST 149
Cdd:cd17324   277 LLLLTLLGPSPLL-----LLVGLVLWGLGFFAA 304
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 40-394 2.70e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  40 RILYLTMFLSSVGFSVVMMSIWPYLQKIdpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANC 119
Cdd:cd06173     2 RLLWLAQLLSALGDWIFTVALPWLVLQL--TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 120 LYAYLHIPASHNKYYMLVARGLLGIGAASTD---EAQVPQgNIDQVAVVAINVLFFVTLFIFALFETIITPLtmdMYAWT 196
Cdd:cd06173    80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGparQALLPE-LVPKEQLVRANALNSLATQLARIIGPALGGL---LVALL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 197 QEQAVLYNGIILAALGVeAVVIFLGVKLLSKKIGERAI-----------------LLGGLIVVWVGFFILLPWGNQFPKI 259
Cdd:cd06173   156 GPGGAFAINALSFLLSA-LLLLFIRRPPPAAPGESSSLllrdlreglrylrrsplLRLLLLALALFALLGGALTVLLPLL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 260 QWEDLHNNSIPNTTF----------GEIIIGLWKSPMEDDNERPTGCSIEQAWCLYTPVIH-LAQFLTSAVLIGLGYPVC 328
Cdd:cd06173   235 AKEVLGGGAAGYGLLlaafgvgallGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPsLWLLLAALFLLGLAGGLF 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1390435880 329 NLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVLTITLL 394
Cdd:cd06173   315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF-LLAGALLLLAALL 379
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 36-146 3.27e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  36 WRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPrKEPLIVSILISV 115
Cdd:cd17473   196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG-GGSAALIGLALAIASLAGAIGALLFGRLKRRLG-KRRLLAIGFALM 273

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1390435880 116 AAnclyAYLHIPASHNKYYMLVARGLLGIGA 146
Cdd:cd17473   274 AL----GFLLLALASGLWVVLLGAILAGLGF 300
MFS_1 pfam07690
Major Facilitator Superfamily;
301-394 3.97e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 301 AWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAF 380
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                          90
                  ....*....|....
gi 1390435880 381 SLVCGIIVLTITLL 394
Cdd:pfam07690 155 LILAILSLLAAVLL 168
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 77-249 5.21e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 38.77  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  77 GWVIASYSLGqMVASPIFGLW-SNYRPRKePLIVSILISvAANCLYAYLHIPASHNKYymlvARGLLGIGAAStdeaqvP 155
Cdd:cd17388   129 GLLGAAFGLG-FIAGPALGGLlGEISPRA-PFLVAAGLN-GLNFLLGLFVLPESLPPE----RRRAFRWRRAN------P 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880 156 QGNIDQVAVVAINVLFFVTLFIFALFETIITPL----TMDMYAWTQEQavlyNGIILAALGVEAVVI-FLGVKLLSKKIG 230
Cdd:cd17388   196 FGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTwvlfTEDRFDWSPTM----VGLSLAVFGLLHALFqAFVTGPIAKRLG 271

                         170
                  ....*....|....*....
gi 1390435880 231 ERAILLGGLIVVWVGFFIL 249
Cdd:cd17388   272 EKRAILLGLAADALGFLLL 290
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 35-149 7.59e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 38.35  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFlgWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17332   219 KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV--LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1390435880 115 VAANCLYAYLHipaSHNKYYMLVARGLLGIGAAST 149
Cdd:cd17332   297 ILGLLLLFFLP---PGNLVLILVLAVLAGIGYGGA 328
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 39-127 8.69e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 37.98  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAAN 118
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQ-QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79


                  ....*....
gi 1390435880 119 CLYAYLHIP 127
Cdd:cd17329    80 ALLGFAHSP 88
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-147 9.74e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 37.94  E-value: 9.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435880  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQkiDPTADTSFL-----GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSI 111
Cdd:cd17504   177 RNVLLANITALLAGFGMFMVFQLLPQLLQ--LPTPTGFGLgiteaGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1390435880 112 LISVAANCLYAYLHIPASHnkyyMLVARGLLGIGAA 147
Cdd:cd17504   255 VISAVGLLLLALLHSSLWA----LVVALLLIGIGLG 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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