NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1390435878|ref|NP_001350449|]
View 

major facilitator superfamily domain-containing protein 8 isoform 2 [Homo sapiens]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-440 1.43e-138

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 402.36  E-value: 1.43e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA-----------S 186
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPAlqaaftpigypG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 187 TDEAQVPQGNIDQVAV--------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIIL 246
Cdd:cd17326   161 YVIGIKLRFNMYTAPAwlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 247 AALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspme 325
Cdd:cd17326   241 AVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG---------------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 326 ddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFI 405
Cdd:cd17326   287 ---------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFV 339

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1390435878 406 SQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 440
Cdd:cd17326   340 TAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-440 1.43e-138

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 402.36  E-value: 1.43e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA-----------S 186
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPAlqaaftpigypG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 187 TDEAQVPQGNIDQVAV--------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIIL 246
Cdd:cd17326   161 YVIGIKLRFNMYTAPAwlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 247 AALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspme 325
Cdd:cd17326   241 AVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG---------------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 326 ddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFI 405
Cdd:cd17326   287 ---------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFV 339

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1390435878 406 SQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 440
Cdd:cd17326   340 TAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-292 4.84e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.03  E-value: 4.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA------ 185
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLlgglla 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 186 ------------------------------STDEAQVPQGNIDQV----AVVAINVLFFVTLFIFALFETIITPLTMDMY 231
Cdd:COG2814   159 dlfgwrwvflvnavlallalllllrllpesRPAARARLRGSLRELlrrpRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390435878 232 AWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGN 292
Cdd:COG2814   239 GLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
42-402 1.88e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.21  E-value: 1.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 122 AYlhipaSHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGPAStdeAQVPQGNIDQV 200
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLL---GGLLASLFGWR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 201 AVVAINVLFFVTLFIFALF--------------ETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKK 266
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLprpppeskrpkpaeEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 267 IGERAILLGGLIVVWVGFFILLPWGNQFPKIQwedlhNNSIPNTTFGEIIIGLWkspmeddnerptgcsieqAWCLYTPV 346
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG-----RRRRLLLALLLLILAAL------------------GLLLLSLT 288

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1390435878 347 IHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGP 402
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-440 1.43e-138

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 402.36  E-value: 1.43e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA-----------S 186
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPAlqaaftpigypG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 187 TDEAQVPQGNIDQVAV--------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIIL 246
Cdd:cd17326   161 YVIGIKLRFNMYTAPAwlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 247 AALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspme 325
Cdd:cd17326   241 AVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG---------------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 326 ddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFI 405
Cdd:cd17326   287 ---------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFV 339

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1390435878 406 SQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 440
Cdd:cd17326   340 TAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 42-434 4.11e-60

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 199.73  E-value: 4.11e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIWPYLQKI-DPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 121 YAYlhipaSHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPASTDEAQVPQGNIDQV 200
Cdd:cd17330    81 LGL-----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 201 AVVA----------------INVLFFVTLFI---FALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGV- 260
Cdd:cd17330   156 LVAAalallnlvlvlfflppLRRLLLVYFLIalaFAGLESVFSLFLKDRFGFSPSQI----GLLLALVGIAGILAQLLLi 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 261 KLLSKKIGERAILLGGLIVVWVGFFiLLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqaw 340
Cdd:cd17330   232 PRLAKRLGERKLLRLGLLLAIIGLL-LLPFASSVP--------------------------------------------- 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 341 clytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSL 420
Cdd:cd17330   266 ----------LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335

                         410
                  ....*....|....
gi 1390435878 421 VCGIIVLTITLLGV 434
Cdd:cd17330   336 AAGLLLIALFLLSL 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-437 6.03e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 88.02  E-value: 6.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLG--ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 122 AYLHIPashnkYYMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGPA--------------- 185
Cdd:cd17325    79 AFATSY-----WQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLlgglladalgyrapf 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 186 ----------------------STDEAQVPQGNIDQV---------AVVAINVLFFVTLFIFALFETIITPLTMDMYAWT 234
Cdd:cd17325   154 lvcaalallalvlallllpeprPPPNKRAVSAARLRSglrlllrdrRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 235 QEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVwVGFFILLPWGNQFPkiqwedlhnnsipnttfge 314
Cdd:cd17325   234 PAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS-AVALLLLPLATSFW------------------- 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 315 iiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASG 394
Cdd:cd17325   290 ------------------------------------LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1390435878 395 SGARILGPMFISQVYAHWGPRWAFsLVCGIIVLTITLLGVVYK 437
Cdd:cd17325   334 SLGMVLGPLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-292 4.84e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.03  E-value: 4.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA------ 185
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLlgglla 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 186 ------------------------------STDEAQVPQGNIDQV----AVVAINVLFFVTLFIFALFETIITPLTMDMY 231
Cdd:COG2814   159 dlfgwrwvflvnavlallalllllrllpesRPAARARLRGSLRELlrrpRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390435878 232 AWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGN 292
Cdd:COG2814   239 GLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
42-402 1.88e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.21  E-value: 1.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 122 AYlhipaSHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGPAStdeAQVPQGNIDQV 200
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLL---GGLLASLFGWR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 201 AVVAINVLFFVTLFIFALF--------------ETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKK 266
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLprpppeskrpkpaeEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 267 IGERAILLGGLIVVWVGFFILLPWGNQFPKIQwedlhNNSIPNTTFGEIIIGLWkspmeddnerptgcsieqAWCLYTPV 346
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG-----RRRRLLLALLLLILAAL------------------GLLLLSLT 288

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1390435878 347 IHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGP 402
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-185 4.37e-12

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 67.25  E-value: 4.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIsvaanCLY 121
Cdd:cd17390     1 LYLVGFLDLFGVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLL-----TAL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390435878 122 AYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA 185
Cdd:cd17390    74 GYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPV 137
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 35-184 1.63e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.51  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390435878 115 VAanclyAYLHIPASHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17325   276 AV-----ALLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-439 7.70e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.19  E-value: 7.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  33 KSRWRSIRILYLTMFLSSVGFSVVMMsIWPYLQK---IDPTAdtsfLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIV 109
Cdd:COG2271     6 RYRWRILALLFLAYFLNYLDRSNLSV-AAPPLQAdlgLSAAQ----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 110 SILISVAANCLYAYlhipaSHNKYYMLVARGLLGIG-AGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPASTd 188
Cdd:COG2271    81 GLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 189 eaqvpQGNIDQ-------------------VAVVAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIILAAl 249
Cdd:COG2271   155 -----GWLLAAfgwraaflilglpglllalLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLA- 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 250 gveAVVIFLGVKLLSKKIGERaillgGLIVVWVGFFILLPwgnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddne 329
Cdd:COG2271   229 ---GIVGSLLGGWLSDRLGRR-----RKLVLAIGLLLAAL---------------------------------------- 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 330 rptgcsieqAWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVY 409
Cdd:COG2271   261 ---------ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331

                         410       420       430
                  ....*....|....*....|....*....|
gi 1390435878 410 AHWGPRWAFSLVCGIIVLTITLLGVVYKRL 439
Cdd:COG2271   332 DATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 59-223 1.04e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 56.90  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  59 SIWPYLQKIDPTA--DTSFLGWVIAS-YSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYM 135
Cdd:cd17389    46 DWFRDAIGAPDERryNSVLFGGLIGSlFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWA-----VSRSFTIF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 136 LVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA-----STDEAQVPQGNIDQVAVVAINVLFF 210
Cdd:cd17389   121 LLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMigayfASFTRSLGEVFFSMPALFALVLALA 200

                         170
                  ....*....|....
gi 1390435878 211 VTLFIFALF-ETII 223
Cdd:cd17389   201 DLLFIFFFLpETLP 214
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 39-287 2.05e-08

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 56.10  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  39 IRILYLTMFLSSVGFSVvMMSIWPYL--QKIDPTAD-TSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISV 115
Cdd:cd17388     1 LIFILVTVLLDAMGIGL-IMPVLPTLlrEFVGDSADaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 116 AAnclyaYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA---------- 185
Cdd:cd17388    80 LD-----YLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPAlggllgeisp 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 186 ---------------------------------STDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPL----TM 228
Cdd:cd17388   155 rapflvaaglnglnfllglfvlpeslpperrraFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTwvlfTE 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 229 DMYAWTQEQavlyNGIILAALGVEAVVI-FLGVKLLSKKIGERAILLGGLIVVWVGFFIL 287
Cdd:cd17388   235 DRFDWSPTM----VGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLL 290
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 33-184 3.72e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.82  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  33 KSRWRSIRILYLTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0477    10 RRRRRALLALALGTFLEGLDFTIVNVAL-PSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1390435878 113 ISVAANCLYAYLHIPAShnkyyMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:COG0477    88 LFGLASLLCGLAPSPEL-----LIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 41-287 7.38e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 7.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  41 ILYLTMFLSSVGFSVVMMSIwPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17473     3 TLLLASTLTVMAGAAIAPAL-PAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 121 YAYLhipashNKYY-MLVARGLLGIGAGNVAVVrsytagATSL-------QERTSSMANISMCQALG------------- 179
Cdd:cd17473    82 GLFL------DSLYaLLASRALLGIGVAGIMTL------ATALigdyfegEERAKMLGLQSAAMSLGgvvflllggalae 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 180 -------------FILGPAS----TDEAQVPQGNIDQVAVVA-------INVLFFVTLFIFALFETIITPLTMDMYAwTQ 235
Cdd:cd17473   150 igwrapflvyllaLPVLILVllflPEPARKSKSAASPGAATAaalpwkrVLPIYFLAFLAMLLFYVIPIQLPFLLQE-RG 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1390435878 236 EQAVLYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFIL 287
Cdd:cd17473   229 GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 43-432 1.86e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.73  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  43 YLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYA 122
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 123 YLHIPAShnkyyMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGPASTDEAqVPQGNIDQVA 201
Cdd:cd06174    80 FAPSFWL-----LLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL-ASSLGFGWRA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 202 VVAINVLFFVTLFIFALF---------------ETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKK 266
Cdd:cd06174   154 VFLIAAALALLAAILLLLvvpdppesarakneeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 267 IGERAILLGGLIVVWVGFFILLpwgnQFPKIQWEDLHNNSIPNTTFGEIIIGLwkspmeddnerptgcsieqAWCLYTPV 346
Cdd:cd06174   234 GGLSVAVAGLLLSLFGLAGALG----SLLLGLLSDRLIGRKPLLLIGLLLMAL-------------------GLALLLLA 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 347 IHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYA-HWGPRWAFSLVCGII 425
Cdd:cd06174   291 PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLL 370


                  ....*..
gi 1390435878 426 VLTITLL 432
Cdd:cd06174   371 LLAAILL 377
Sugar_tr pfam00083
Sugar (and other) transporter;
71-147 1.88e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.96  E-value: 1.88e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1390435878  71 ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLyayLHIPASHNKYYML-VARGLLGIGAG 147
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVL---QGAAKGKWSVYQLiVGRVLVGIGVG 117
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 36-218 6.05e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 6.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  36 WRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPrKEPLIVSILISV 115
Cdd:cd17473   196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG-GGSAALIGLALAIASLAGAIGALLFGRLKRRLG-KRRLLAIGFALM 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 116 AAnclyAYLHIPASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPASTDEAQVPQ 194
Cdd:cd17473   274 AL----GFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349

                         170       180
                  ....*....|....*....|....
gi 1390435878 195 GNIDQVAVVAINVLFFVTLFIFAL 218
Cdd:cd17473   350 GGLSGAFLILGVLALVLAIVLLLL 373
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 42-288 6.28e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 47.94  E-value: 6.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIwpylqkidPT-----ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17502     1 LMLALFLAALDQTIVATAL--------PTivaefGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFEL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 117 ANCLYAylhipASHNKYYMLVARGLLGIGAGNVAVVrSYTAGA--TSLQERTSSMANISMCQALGFILGP----ASTDEA 190
Cdd:cd17502    73 GSLLCG-----LAPNMTMLIVGRAIQGIGGGGLMSL-AFIIIAdlVPPRERGKYQGYIGAVFGIASVAGPliggAFTDHL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 191 --------QVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPLTMdMYAWTQEQAVLYNGIILAALGVEAVV-IFLGVK 261
Cdd:cd17502   147 swrwcfyiNLPIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPL-YFQLVLGDSATKSGVRLLPLIIGLVIgSIISGA 225

                         250       260
                  ....*....|....*....|....*..
gi 1390435878 262 LLSKKIGERAILLGGLIVVWVGFFILL 288
Cdd:cd17502   226 LISKTGRYKPLIVIGTILMSVGAGLLT 252
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 44-320 1.94e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.40  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  44 LTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAY 123
Cdd:cd17321     3 LAVFLAALDVTIVNVAL-PTIAR-DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 124 lhipaSHNKYYMLVARGLLGIGAG-----NVAVVRSYTAGAtslqERTSSMANISMCQALGFILGP----ASTDEA---- 190
Cdd:cd17321    81 -----APSLAFLIAARALQGIGAAaimpaSLALIAATFPGE----RRGRALGLWGAVVGIGAALGPllggLLLELFgwrw 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 191 ----QVPqgnidqVAVVAI---------NVLFFVTLFIFALFETIITPLTMDMYAWTQEQAvlynGIILAALGVE-AVVI 256
Cdd:cd17321   152 ifliNVP------IGLVALllartfsgaVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA----GLALLPLALAmLVAA 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390435878 257 FLGVKLLsKKIGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlHNNSIPNTTFGEIIIGLW 320
Cdd:cd17321   222 PLAGRLA-DRFGPRLVLVAGLLLTAVGLLLLALLG-----------ADSSVWLLLPGLVLLGLG 273
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 39-432 4.19e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 4.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAAN 118
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQ-QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 119 CLYAYLHIPAshnkyymLVARGLLGIGAGN---VAVVRSYTAGATSLQERTSSMANISMCQALGFILGPAstdeAQVPQG 195
Cdd:cd17329    80 ALLGFAHSPW-------LFAIALVLTGFGGglfEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPL----LGGLLL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 196 NIDQVAVVAINVLFFVTLFIFALFETIITPLTMDMYAWTQE----QAVLYNGIILAALGVEAVVIFLGVKLLS------- 264
Cdd:cd17329   149 LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEIlrgyKIVLRDRAFLLFLLASFLISLIYFQLEStlpvyvv 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 265 --KKIGERAI----LLGGLIVVwVGFFILLPWGNQFpkiqwedlhnNSIPNTTFGEIIIGLWKSpmeddnerptgcsieq 338
Cdd:cd17329   229 eiLGLGESLLglllALNALLIV-LLQFPVARLVERF----------RLRKILMIGILLFAIGFA---------------- 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 339 awcLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAF 418
Cdd:cd17329   282 ---VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358

                         410
                  ....*....|....
gi 1390435878 419 sLVCGIIVLTITLL 432
Cdd:cd17329   359 -LILAALGLIAAAL 371
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 77-183 4.72e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.23  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  77 GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNV-AVVRSY 155
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA-----LAPSFALLLLARALAGLAHGGFwAIAAAY 111

                          90       100
                  ....*....|....*....|....*...
gi 1390435878 156 TAGATSLQERTSSMANISMCQALGFILG 183
Cdd:cd17324   112 AADLVPPEKRGRAIGLVFSGLTLGLVLG 139
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
35-179 5.06e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 5.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV-LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1390435878 115 VAANCLYAYLHIPAShnkyyMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALG 179
Cdd:COG2814   284 ALGLLLLALAGSLWL-----LLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-185 9.61e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 9.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  37 RSIRILYLTMFLSSVGFSVVMMSIwPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALL-LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390435878 117 ANCLYAYLHipaSHNKYYMLVARGLLGIGAGNVAVV-RSYTAGATSLQERTSS-------MANISMCQALGFILGPA 185
Cdd:COG2211   307 GLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLpWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGA 380
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-219 1.17e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.07  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0738     4 KNYRRALIAIYLLFFLWGFATALWG-PLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 113 ISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAG--NVAVvrsyTAGATSLQERTSSmANISMCQA---LGFILGPAST 187
Cdd:COG0738    82 LMALGLLLFAL-----APSYPLLLLALFLLGLGLGllDVAA----NPYVAALGPETAA-SRLNLLHAffsLGALLGPLLG 151

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1390435878 188 DEAQVPQGNIDQVAVVAINVLFFVTLFIFALF 219
Cdd:COG0738   152 GLLILLGLSLSWHLPYLILAVLLLLLALLFLR 183
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 42-185 2.14e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.35  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSflGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA--GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390435878 122 AYLHIPAShnkyyMLVARGLLGIGAGNVAVVRS-YTAGATSLQERTSSMANISMCQALGFILGPA 185
Cdd:cd17489    79 LLATSVAL-----LLVLRLIHGIGWGAFTTAAAtLVADIIPPSRRGEGIGYYGLATTLAMALGPA 138
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 38-287 2.33e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 43.36  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  38 SIRILYLTMFLSSVGFSVvMMSIWPYL-QKIDptADTSFLGWVIASYSLGQMVASPIFGLWSN-YRPRKEpLIVSILisv 115
Cdd:cd17331     1 VLLIVHLNIVLYATCYWL-QQPVLPYLtKKLG--VDSVVFGYLQTTFSVLQLVGGPLFGRFGDlFGPRAA-LVLSFL--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 116 AANCLYAYLhipASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILG------------ 183
Cdd:cd17331    74 SSALSYLLL---AFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGsflgglltkkfg 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 184 -----------------------PASTDEAQVPQGNIDQVAVVAINVLFFVTL-----------------FIFALFETII 223
Cdd:cd17331   151 eqaaalvaavgsllsivlvilliPSNTKSKREKEAKESASPPSVFNLKEILRLlrlpgvaflllvkllsgLPIGMFQSMF 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390435878 224 TPLTMDMYAWTQEQavlyNGIILAALGV-EAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFIL 287
Cdd:cd17331   231 SLVAMDFFGLTPEE----NGYLMSYAGVlGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
348-432 2.57e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 348 HLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVL 427
Cdd:COG2814    97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF-LVNAVLAL 175


                  ....*
gi 1390435878 428 TITLL 432
Cdd:COG2814   176 LALLL 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-185 4.61e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.41  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  30 EHYKSRWRSIRILYLTMFLSSVGFSVV-MMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLI 108
Cdd:cd06174   194 KLLKRVLKNPGLWLLLLAIFLVNLAYYsFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1390435878 109 VSILISVAANCLYAYLHIPashnKYYMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGPA 185
Cdd:cd06174   274 LIGLLLMALGLALLLLAPS----LLLLLLLLLLLGFGLGGLLPLSfALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL 347
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 42-185 7.77e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.38  E-value: 7.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVM--MSIW--PYLQkidptADTSFLGWVIASYSLGQMVASPIFGLWSNYR-PRKEPLIVSILISVA 116
Cdd:cd17471     1 LLLATLLTGLAGAFVLpyLSLFltEELG-----ASPLQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILLALLAGAL 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390435878 117 ANCLYAYLHIpashnkYYMLVARGLLGIGAGNVAV------VRSYtAGATSLQERTSSMANISMCQALGFILGPA 185
Cdd:cd17471    76 GYLLFAFLRN------YWVLLLVGVVLLSLGAAAFpqlfalAREY-ADRSSGRDATLFNSVLRAAFSLAWVIGPP 143
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 342-435 1.08e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 342 LYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLV 421
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156

                          90
                  ....*....|....
gi 1390435878 422 CGIIVLTITLLGVV 435
Cdd:cd17489   157 AVLALLALLLVFLV 170
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 37-218 1.40e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPtADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLG-YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 117 ANCLYAYLHIPAShnKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERT-SSMANISMCQALGFILGPA---------S 186
Cdd:cd17321   247 GLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAgAASGILNTARQLGGALGVAllgalltagL 324

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1390435878 187 TDEAQVPQGNIDQVAVVAINVLFFVTLFIFAL 218
Cdd:cd17321   325 SANLGDSGVAALLSAAAAAFAAGFHLAFLVAA 356
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 42-293 1.46e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  42 LYLTMFLSSVGFSVVMM--SIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANC 119
Cdd:cd17474     1 LYAVFFATLLAVLGVSIvdPILPAIAE-ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 120 LYAylhipASHNKYYMLVARGLLGIGAG-----NVAVVRSYTAGAtslqERTSSMANISMCQALGFILGPA--------- 185
Cdd:cd17474    80 LCG-----LSDSFALLLAGRALQGIGAAglgplALTLIGDLFEGG----ERAKAMGLYEAALGLGIAVGPLlggllaais 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 186 ------------------------STDEAQVPQGNIDQVAVVAIN------VLFFVTLFIFALFETIIT--PLTMDMyaw 233
Cdd:cd17474   151 wrypffllaalipvaflailfllpEPKEKAKSSSATKLRDLKKALrgrgllTFLVSAFLYFFLYFAFLTylPFLLEL--- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390435878 234 TQEQAVLYNGIILAALGVE-AVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGNQ 293
Cdd:cd17474   228 LYGISPIIIGLLFAGWSVLlALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL 288
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-185 1.47e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17324   198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDV-PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1390435878 117 ANCLYAYLHIPAShnkyyMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPA 185
Cdd:cd17324   277 LLLLTLLGPSPLL-----LLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAA 340
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 89-275 1.90e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 40.34  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  89 VASPIFGLWSNYRPRKEPLIVSI---LISVAANCLYAYLHIPASHNKYYM-LVARGLLGIGAGNVAVVRSYTAGATSLQE 164
Cdd:cd17386    45 FSSLFLGSWSDRYGRKPPLLMSLvglLLSSLILVLIVYFTTVPSVWWFYLsAIPLALFGGFTAFLSASFAYISDISSEKK 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 165 RTSSMANISMCQALGFILGPASTDEAQVPQGNIDQVAVVA-------INVLFFVTLFIFALFETIITPLTMD-----MY- 231
Cdd:cd17386   125 RTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAalllialLYILFFLTLLILLLLAAFLTIFVLSgesdvLYl 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1390435878 232 ------AWTQEQAVLYNGiilAALGVEAVVIFLGVKLLSKKIGERAILLG 275
Cdd:cd17386   205 fvlekfAWNVKDFSYFST---LGSLIYLTGMLGGVLLLRCLLKMSDSTLA 251
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 72-152 2.79e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.86  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  72 DTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNVAV 151
Cdd:cd17315    32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA-----LAPNVWVLIVGRFLLGLGVGLASV 106


                  .
gi 1390435878 152 V 152
Cdd:cd17315   107 L 107
MFS_1 pfam07690
Major Facilitator Superfamily;
37-184 3.01e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG--LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1390435878 117 ANCLYAYLHIPASHNKYYMLVArgLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALL--LLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-215 3.02e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.48  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQkiDPTADTSFL-----GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSI 111
Cdd:cd17504   177 RNVLLANITALLAGFGMFMVFQLLPQLLQ--LPTPTGFGLgiteaGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 112 LISVAANCLYAYLHIPASHnkyyMLVARGLLGIGAGN----------VAVVRSYTAGATSLqerTSSMANISMcqALGFI 181
Cdd:cd17504   255 VISAVGLLLLALLHSSLWA----LVVALLLIGIGLGLafaslpnivvESVPPDRTGIATGM---NTVLRTIGS--AIGPA 325

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1390435878 182 LGPA-------STDEAQVPQGNIDQVAVVAINVLFFVTLFI 215
Cdd:cd17504   326 IAGAilttytvSITSGGVPTEGAYVLAFLIGAALALAALLL 366
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 40-432 3.08e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  40 RILYLTMFLSSVGFSVVMMSIWPYLQKIdpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANC 119
Cdd:cd06173     2 RLLWLAQLLSALGDWIFTVALPWLVLQL--TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 120 LYAYLHIPASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPAStdeAQVPQGNID 198
Cdd:cd06173    80 VLALLALLGSLSLWLLLVLAFLLGIASAfFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPAL---GGLLVALLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 199 QVAVVAINVLFFVTLFIFALF------------ETIITPLTMDMYAWTQEQAVLYNGIILAAL--GVEAVVIFLGVKLLS 264
Cdd:cd06173   157 PGGAFAINALSFLLSALLLLFirrpppaapgesSSLLLRDLREGLRYLRRSPLLRLLLLALALfaLLGGALTVLLPLLAK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 265 KKIGERAILLGGL-IVVWVGFFI---LLPWGNQfpkiqwedlHNNSIPNTTFGEIIIGLwkspmeddnerptgCSIEQAW 340
Cdd:cd06173   237 EVLGGGAAGYGLLlAAFGVGALLgalLLGRLSK---------RRRRGRLLLIGALLLGL--------------ALLVLGL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 341 clytpVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsL 420
Cdd:cd06173   294 -----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF-L 367

                         410
                  ....*....|..
gi 1390435878 421 VCGIIVLTITLL 432
Cdd:cd06173   368 LAGALLLLAALL 379
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 71-295 3.62e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.48  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  71 ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNVA 150
Cdd:cd17503    28 ASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG-----LAPNLASLIIFRILQGFGGGVLI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 151 -VVRSYTAGATSLQERTSSMANISMCQALGFILGPAS----TDEA--------QVPQGNIDQVAVVAINV---------- 207
Cdd:cd17503   103 pLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLggwlTDNLswrwifyiNLPIGILALLLAPLLDLrlfkdrnftl 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 208 -LFFVTLFIFALFET-IITPLtmdMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFF 285
Cdd:cd17503   183 gLLLSFLLGLGLFGAmFLLPL---YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259

                         250
                  ....*....|
gi 1390435878 286 ILLPWGNQFP 295
Cdd:cd17503   260 LLAFLTPDTS 269
MFS_1 pfam07690
Major Facilitator Superfamily;
339-432 5.06e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878 339 AWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAF 418
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                          90
                  ....*....|....
gi 1390435878 419 SLVCGIIVLTITLL 432
Cdd:pfam07690 155 LILAILSLLAAVLL 168
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 73-184 5.11e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.12  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  73 TSFL-GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAGNvAV 151
Cdd:cd17472    30 TPTLiGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAY-----ATSIYGLILGRALQGSGAIS-SV 103

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1390435878 152 VRSYTAGATSLQERTSSMA----NISMCQALGFILGP 184
Cdd:cd17472   104 VMALLADLTREENRTKAMAligaSIGIAFAISMVLGP 140
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 35-152 6.46e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 38.74  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390435878  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFlgWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17332   219 KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV--LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1390435878 115 VAANCLYAYLHipaSHNKYYMLVARGLLGIGAGNVAVV 152
Cdd:cd17332   297 ILGLLLLFFLP---PGNLVLILVLAVLAGIGYGGANLL 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH