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Conserved domains on  [gi|1390157501|ref|NP_001350382|]
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RE1-silencing transcription factor [Homo sapiens]

Protein Classification

zf-H2C2_2 and zf-H2C2_5 domain-containing protein( domain architecture ID 12143203)

zf-H2C2_2 and zf-H2C2_5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 599-767 1.01e-07

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 56.63  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  599 EPVEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQME-----GAQ-----IRPAPD--EPVQMEVVQEGPAQKEL 666
Cdd:PRK10263   318 EPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAwqpvpGPQtgepvIAPAPEgyPQQSQYAQPAVQYNEPL 397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  667 LPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAPMQ-VVQKEPVQMELSPPMEVVQKEP- 744
Cdd:PRK10263   398 QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQsTFAPQSTYQTEQTYQQPAAQEPl 477

                          170       180
                   ....*....|....*....|....
gi 1390157501  745 -VQIELSPPMEVVQKEPVKIELSP 767
Cdd:PRK10263   478 yQQPQPVEQQPVVEPEPVVEETKP 501
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 2.17e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 2.17e-06
                           10        20
                   ....*....|....*....|....*.
gi 1390157501  318 HLTRHMRTHSGEKPFKCDQCSYVASN 343
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
304-328 5.80e-06

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.69  E-value: 5.80e-06
                           10        20
                   ....*....|....*....|....*
gi 1390157501  304 YKCELCPYSSSQKTHLTRHMRTHSG 328
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-315 3.61e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.61e-05
                           10        20
                   ....*....|....*....|....*.
gi 1390157501  290 NYVQHVRTHTGERPYKCELCPYSSSQ 315
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
363-383 9.77e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.53  E-value: 9.77e-04
                           10        20
                   ....*....|....*....|.
gi 1390157501  363 CPHCDYKTADRSNFKKHVELH 383
Cdd:pfam13909    3 CSQCDYSTAWKSNLKRHLRKH 23
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 599-767 1.01e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 56.63  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  599 EPVEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQME-----GAQ-----IRPAPD--EPVQMEVVQEGPAQKEL 666
Cdd:PRK10263   318 EPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAwqpvpGPQtgepvIAPAPEgyPQQSQYAQPAVQYNEPL 397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  667 LPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAPMQ-VVQKEPVQMELSPPMEVVQKEP- 744
Cdd:PRK10263   398 QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQsTFAPQSTYQTEQTYQQPAAQEPl 477

                          170       180
                   ....*....|....*....|....
gi 1390157501  745 -VQIELSPPMEVVQKEPVKIELSP 767
Cdd:PRK10263   478 yQQPQPVEQQPVVEPEPVVEETKP 501
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 2.17e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 2.17e-06
                           10        20
                   ....*....|....*....|....*.
gi 1390157501  318 HLTRHMRTHSGEKPFKCDQCSYVASN 343
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
304-328 5.80e-06

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.69  E-value: 5.80e-06
                           10        20
                   ....*....|....*....|....*
gi 1390157501  304 YKCELCPYSSSQKTHLTRHMRTHSG 328
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-315 3.61e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.61e-05
                           10        20
                   ....*....|....*....|....*.
gi 1390157501  290 NYVQHVRTHTGERPYKCELCPYSSSQ 315
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-381 2.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 2.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  302 RPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCSYVASNQHEVTRHARQVHNGPKPLNC---PHCDYKTADRSNF 376
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslPLSNSKASSSSLS 111


                   ....*
gi 1390157501  377 KKHVE 381
Cdd:COG5048    112 SSSSN 116
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 598-828 3.71e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.37  E-value: 3.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  598 KEPVEKgSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQME--GAQIRPAPDEPVQMEVVQEGPAQKELLP-PVEPAQ 674
Cdd:NF033839   285 KEPGNK-KPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEkpKPEVKPQPEKPKPEVKPQLETPKPEVKPqPEKPKP 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  675 MVGAQIVLAHMELPPPMETAQTEVAQM--GPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVVQKEPVQielsPP 752
Cdd:NF033839   364 EVKPQPEKPKPEVKPQPETPKPEVKPQpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEK----PK 439

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390157501  753 MEVV-QKEPVKIELSPPIEVVQKEpVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPiSKKPPLRKDkKEKSNMQS 828
Cdd:NF033839   440 PEVKpQPEKPKPEVKPQPETPKPE-VKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKP-STPNNLSKD-KQPSNQAS 513
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
363-383 9.77e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.53  E-value: 9.77e-04
                           10        20
                   ....*....|....*....|.
gi 1390157501  363 CPHCDYKTADRSNFKKHVELH 383
Cdd:pfam13909    3 CSQCDYSTAWKSNLKRHLRKH 23
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 595-817 1.60e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  595 PPQKEPVEKGSAQMDP--PQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIR----PAPDEPVQMEVVQEGPAQKELLP 668
Cdd:pfam03154  186 PPPPGTTQAATAGPTPsaPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHpqrlPSPHPPLQPMTQPPPPSQVSPQP 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  669 PVEPAQmvgaqivlaHMELPPPMETAQTEVAQMG-PAPMEP----AQMEVAQVESAPMQVVQKEPVQMELSPPMEVV--- 740
Cdd:pfam03154  266 LPQPSL---------HGQMPPMPHSLQTGPSHMQhPVPPQPfpltPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQlqs 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  741 QKEPVQIELSP-PMEVVQKEPVKIELSPPIEVVQ--KEPVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLR 817
Cdd:pfam03154  337 QQPPREQPLPPaPLSMPHIKPPPTTPIPQLPNPQshKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQ 416
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 605-831 2.46e-03

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 41.84  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  605 SAQMDPPQMGPAPTEAVQKGPVQVEPPPP----MEHAQMEGAQIR------PAPDEPVQMEVVQEGPAQKELLP--PVEP 672
Cdd:cd22540    152 QAIITPVQVLQQPQQAHKPVPIKPAPLQTsntnSASLQVPGNVIKlqsggnVALTLPVNNLVGTQDGATQLQLAaaPSKP 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  673 AQMVGAQiVLAHMELPPPM---------ETAQTEVAQMG--------PAPMEPAQMEVAQVesapMQVVQKEPVQMELSP 735
Cdd:cd22540    232 SKKIRKK-SAQAAQPAVTVaeqvetvliETTADNIIQAGnnllivqsPGTGQPAVLQQVQV----LQPKQEQQVVQIPQQ 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  736 PMEVVQkepVQIELSPPMEVVQKEPVKIELSPPievvqkEPVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPP 815
Cdd:cd22540    307 ALRVVQ---AASATLPTVPQKPLQNIQIQNSEP------TPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVT 377

                          250
                   ....*....|....*....
gi 1390157501  816 LR---KDKKEKSNMQSERA 831
Cdd:cd22540    378 ANngtGTSKPNYNVRKERT 396
ZnF_C2H2 smart00355
zinc finger;
304-326 3.01e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 3.01e-03
                            10        20
                    ....*....|....*....|...
gi 1390157501   304 YKCELCPYSSSQKTHLTRHMRTH 326
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 599-767 1.01e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 56.63  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  599 EPVEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQME-----GAQ-----IRPAPD--EPVQMEVVQEGPAQKEL 666
Cdd:PRK10263   318 EPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAwqpvpGPQtgepvIAPAPEgyPQQSQYAQPAVQYNEPL 397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  667 LPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAPMQ-VVQKEPVQMELSPPMEVVQKEP- 744
Cdd:PRK10263   398 QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQsTFAPQSTYQTEQTYQQPAAQEPl 477

                          170       180
                   ....*....|....*....|....
gi 1390157501  745 -VQIELSPPMEVVQKEPVKIELSP 767
Cdd:PRK10263   478 yQQPQPVEQQPVVEPEPVVEETKP 501
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 2.17e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 2.17e-06
                           10        20
                   ....*....|....*....|....*.
gi 1390157501  318 HLTRHMRTHSGEKPFKCDQCSYVASN 343
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
304-328 5.80e-06

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.69  E-value: 5.80e-06
                           10        20
                   ....*....|....*....|....*
gi 1390157501  304 YKCELCPYSSSQKTHLTRHMRTHSG 328
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
PHA03378 PHA03378
EBNA-3B; Provisional
 599-749 8.27e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.07  E-value: 8.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  599 EPVEKGSAQMDPPQMGPA----PTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPAQkelLPPVEPAQ 674
Cdd:PHA03378   675 QPSPTGANTMLPIQWAPGtmqpPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGR---ARPPAAAP 751

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390157501  675 MVGAQIVLAHMELPPPmETAQTEVAQMGPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVVQKEPVQIEL 749
Cdd:PHA03378   752 GRARPPAAAPGRARPP-AAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQIL 825
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-315 3.61e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.61e-05
                           10        20
                   ....*....|....*....|....*.
gi 1390157501  290 NYVQHVRTHTGERPYKCELCPYSSSQ 315
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
rne PRK10811
ribonuclease E; Reviewed
 619-773 3.77e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.11  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  619 EAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPAQKElLPPVEPAQmvGAQIVLAHMELPPPMETAQTEV 698
Cdd:PRK10811   862 EEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEE-VVVVETTH--PEVIAAPVTEQPQVITESDVAV 938

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390157501  699 AQMGPAPMEPAQMEVAQVESapmqVVQKEPVQMELSPPMEVVQKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQ 773
Cdd:PRK10811   939 AQEVAEHAEPVVEPQDETAD----IEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEA 1009
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 304-326 8.04e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 8.04e-05
                           10        20
                   ....*....|....*....|...
gi 1390157501  304 YKCELCPYSSSQKTHLTRHMRTH 326
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-381 2.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 2.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  302 RPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCSYVASNQHEVTRHARQVHNGPKPLNC---PHCDYKTADRSNF 376
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslPLSNSKASSSSLS 111


                   ....*
gi 1390157501  377 KKHVE 381
Cdd:COG5048    112 SSSSN 116
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 595-776 3.36e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 3.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  595 PPQKEPVEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPdepvQMEVVQEGPAQKELLPPVEPAQ 674
Cdd:PRK10263   366 PQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQP----YYAPAPEQPAQQPYYAPAPEQP 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  675 MVGAQIVLAHMELP-PPMETAQTEVAQMGPAPMEPAQMEVAQVEsaPMQVVQKEPVQMELS---PPM----EVVQKEPVQ 746
Cdd:PRK10263   442 VAGNAWQAEEQQSTfAPQSTYQTEQTYQQPAAQEPLYQQPQPVE--QQPVVEPEPVVEETKparPPLyyfeEVEEKRARE 519

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1390157501  747 IE-----LSPPMEVVqKEPVKIELSPPIEVVQKEP 776
Cdd:PRK10263   520 REqlaawYQPIPEPV-KEPEPIKSSLKAPSVAAVP 553
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 598-828 3.71e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.37  E-value: 3.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  598 KEPVEKgSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQME--GAQIRPAPDEPVQMEVVQEGPAQKELLP-PVEPAQ 674
Cdd:NF033839   285 KEPGNK-KPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEkpKPEVKPQPEKPKPEVKPQLETPKPEVKPqPEKPKP 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  675 MVGAQIVLAHMELPPPMETAQTEVAQM--GPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVVQKEPVQielsPP 752
Cdd:NF033839   364 EVKPQPEKPKPEVKPQPETPKPEVKPQpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEK----PK 439

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390157501  753 MEVV-QKEPVKIELSPPIEVVQKEpVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPiSKKPPLRKDkKEKSNMQS 828
Cdd:NF033839   440 PEVKpQPEKPKPEVKPQPETPKPE-VKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKP-STPNNLSKD-KQPSNQAS 513
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 625-778 6.49e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.70  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  625 PVQVEPPPPMEHAQMEGAQIRPAPDEPVQmevVQEGPAQKELLPPVEPAQMVgaqivlahmeLPPPMETAQTEVAQMGPA 704
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTA---AVAPPQAPAVPPPPASAPQQ----------APAVPLPETTSQLLAARQ 427

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390157501  705 PMEPAQMEVAQVESAPMQVVQKEPVQmelSPPMEVVQKEPVQIELSPpmEVVQKEPVKIELSPPIEVVQKEPVQ 778
Cdd:PRK07994   428 QLQRAQGATKAKKSEPAAASRARPVN---SALERLASVRPAPSALEK--APAKKEAYRWKATNPVEVKKEPVAT 496
rne PRK10811
ribonuclease E; Reviewed
 617-784 9.18e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.49  E-value: 9.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  617 PTEAVQKGPVQVEPPPPMEHAQMEGAQIR-PAPDEPVQMEVVQEGPAQkellPPVEPAQMVGAQIVLAhmelpPPMETAQ 695
Cdd:PRK10811   846 PVVRPQDVQVEEQREAEEVQVQPVVAEVPvAAAVEPVVSAPVVEAVAE----VVEEPVVVAEPQPEEV-----VVVETTH 916

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  696 TEVAQmGPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVVQKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQKE 775
Cdd:PRK10811   917 PEVIA-APVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVT 995


                   ....*....
gi 1390157501  776 PVQMELSPP 784
Cdd:PRK10811   996 AVEPEVAPA 1004
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
363-383 9.77e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.53  E-value: 9.77e-04
                           10        20
                   ....*....|....*....|.
gi 1390157501  363 CPHCDYKTADRSNFKKHVELH 383
Cdd:pfam13909    3 CSQCDYSTAWKSNLKRHLRKH 23
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 606-748 1.58e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.49  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  606 AQMDPPQmGPAPTeAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPvqmevvqEGPAQKELLPPVEPAQMVGAqivlahm 685
Cdd:PRK14950   366 PQPAKPT-AAAPS-PVRPTPAPSTRPKAAAAANIPPKEPVRETATP-------PPVPPRPVAPPVPHTPESAP------- 429

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390157501  686 elPPPMETAQTEVAQMGPAPMEPAQMEVA---------QVESAPMQVVQKEPVQmelSPPMEVVQK---EPVQIE 748
Cdd:PRK14950   430 --KLTRAAIPVDEKPKYTPPAPPKEEEKAliadgdvleQLEAIWKQILRDVPPR---SPAVQALLSsgvRPVSVE 499
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 595-817 1.60e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  595 PPQKEPVEKGSAQMDP--PQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIR----PAPDEPVQMEVVQEGPAQKELLP 668
Cdd:pfam03154  186 PPPPGTTQAATAGPTPsaPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHpqrlPSPHPPLQPMTQPPPPSQVSPQP 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  669 PVEPAQmvgaqivlaHMELPPPMETAQTEVAQMG-PAPMEP----AQMEVAQVESAPMQVVQKEPVQMELSPPMEVV--- 740
Cdd:pfam03154  266 LPQPSL---------HGQMPPMPHSLQTGPSHMQhPVPPQPfpltPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQlqs 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  741 QKEPVQIELSP-PMEVVQKEPVKIELSPPIEVVQ--KEPVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLR 817
Cdd:pfam03154  337 QQPPREQPLPPaPLSMPHIKPPPTTPIPQLPNPQshKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQ 416
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 615-774 1.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.55  E-value: 1.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  615 PAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPAQKELLPPVEP-AQMVGA--QIVLAHMELPPPm 691
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETtSQLLAArqQLQRAQGATKAK- 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  692 etAQTEVAQMGPAPMEPAQMEVAQVESAPmQVVQKEPvqmelsPPMEVVQKEPVQIELSPPMEVVQKEPVK--IELSPPI 769
Cdd:PRK07994   440 --KSEPAAASRARPVNSALERLASVRPAP-SALEKAP------AKKEAYRWKATNPVEVKKEPVATPKALKkaLEHEKTP 510


                   ....*
gi 1390157501  770 EVVQK 774
Cdd:PRK07994   511 ELAAK 515
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
604-794 1.74e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  604 GSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPAQKELLPPVEPAQMVGAQIVLA 683
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA 449

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  684 HMELPP--PMETAQTEVAQMGPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPmEVVQKEPVQIELSPPMEVVQ--KE 759
Cdd:PRK12323   450 PAPAPAaaPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP-EFASPAPAQPDAAPAGWVAEsiPD 528

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1390157501  760 PVKIELSPPIEVVQKEPVQMELSPPMGVVQKEPAQ 794
Cdd:PRK12323   529 PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 661-794 2.00e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.16  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  661 PAQKELLPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMePAQMEVAQVESAPMQVVQKEPVQMELSPPMEVV 740
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASA-PQQAPAVPLPETTSQLLAARQQLQRAQGATKAK 439

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390157501  741 QKEPVQIELSPPMEVVQKEPVKIELSP---PIEVVQKEPVQMELSPPMGVVQKEPAQ 794
Cdd:PRK07994   440 KSEPAAASRARPVNSALERLASVRPAPsalEKAPAKKEAYRWKATNPVEVKKEPVAT 496
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 605-831 2.46e-03

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 41.84  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  605 SAQMDPPQMGPAPTEAVQKGPVQVEPPPP----MEHAQMEGAQIR------PAPDEPVQMEVVQEGPAQKELLP--PVEP 672
Cdd:cd22540    152 QAIITPVQVLQQPQQAHKPVPIKPAPLQTsntnSASLQVPGNVIKlqsggnVALTLPVNNLVGTQDGATQLQLAaaPSKP 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  673 AQMVGAQiVLAHMELPPPM---------ETAQTEVAQMG--------PAPMEPAQMEVAQVesapMQVVQKEPVQMELSP 735
Cdd:cd22540    232 SKKIRKK-SAQAAQPAVTVaeqvetvliETTADNIIQAGnnllivqsPGTGQPAVLQQVQV----LQPKQEQQVVQIPQQ 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  736 PMEVVQkepVQIELSPPMEVVQKEPVKIELSPPievvqkEPVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPP 815
Cdd:cd22540    307 ALRVVQ---AASATLPTVPQKPLQNIQIQNSEP------TPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVT 377

                          250
                   ....*....|....*....
gi 1390157501  816 LR---KDKKEKSNMQSERA 831
Cdd:cd22540    378 ANngtGTSKPNYNVRKERT 396
ZnF_C2H2 smart00355
zinc finger;
304-326 3.01e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 3.01e-03
                            10        20
                    ....*....|....*....|...
gi 1390157501   304 YKCELCPYSSSQKTHLTRHMRTH 326
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-414 3.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 3.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  271 FPRKVYTCGKCNYFSDRKNNYVQHVRT--HTGE--RPYKC--ELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCSY--- 339
Cdd:COG5048    285 GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSkfs 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  340 --VASNQHEVTRHARQVHNGPKPLNCPHCDYK-TADRSNFKKHVELHVN--PRQFNCPVCdYAASKKCNLQYHFKSKHPT 414
Cdd:COG5048    365 plLNNEPPQSLQQYKDLKNDKKSETLSNSCIRnFKRDSNLSLHIITHLSfrPYNCKNPPC-SKSFNRHYNLIPHKKIHTN 443
PHA03379 PHA03379
EBNA-3A; Provisional
 600-784 4.64e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 41.20  E-value: 4.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  600 PVEKGSAQMDPPQMGPAPtEAVQK-------GPVQVEPPPPM---------EHAQMEG---AQIRPAPDEPVQMEVVQEG 660
Cdd:PHA03379   408 ASEPTYGTPRPPVEKPRP-EVPQSletatshGSAQVPEPPPVhdlepgplhDQHSMAPcpvAQLPPGPLQDLEPGDQLPG 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  661 PAQKELLPPVePAQMVGAQIVlahmelpPPMETAQTEVAQMGPAPMEPAQMEVAQV---ESAPMQVVQKEPVQMELSPPM 737
Cdd:PHA03379   487 VVQDGRPACA-PVPAPAGPIV-------RPWEASLSQVPGVAFAPVMPQPMPVEPVpvpTVALERPVCPAPPLIAMQGPG 558

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  738 EVVQKEPVQIELSP------PMEVVQKEPVKIELS-------PPIEVVQKEPVQMELSPP 784
Cdd:PHA03379   559 ETSGIVRVRERWRPapwtpnPPRSPSQMSVRDRLArlraeaqPYQASVEVQPPQLTQVSP 618
rne PRK10811
ribonuclease E; Reviewed
 605-753 5.17e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.18  E-value: 5.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157501  605 SAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPaqkellPPVEPAQMVGAQIVLAH 684
Cdd:PRK10811   872 EVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPVTEQP------QVITESDVAVAQEVAEH 945

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390157501  685 ME---LPPPMETAQTEVAQMgpAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVVQKEPVQIEL-----SPPM 753
Cdd:PRK10811   946 AEpvvEPQDETADIEEAAET--AEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVehnhaTAPM 1020
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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