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Conserved domains on  [gi|1388591255|ref|NP_001350131|]
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ATPase MORC2A isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 6.42e-63

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


:

Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 208.80  E-value: 6.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQI 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1388591255   98 GQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 135
Cdd:cd16931     81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-542 4.93e-17

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 75.42  E-value: 4.93e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1388591255  495 TTIQCDLCLKWRTLPFQLSSVETdyPDTWVCSMNPDPEQDRCEASEQK 542
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 239-451 3.94e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 3.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  239 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 309
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  310 eskartlEVRMGgdltrdsrvmlrqvqntaitlrreadvkkRIKDAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 389
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388591255  390 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 624-741 8.05e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 8.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPRPSTQlRKTSVISLP-----KPPTTAARGETSTSRLLQ----PTEAPRKPANPPIKTVPRPTPPVHTPP 694
Cdd:PHA03247  2877 APARPPVRRLARPAVS-RSTESFALPpdqpeRPPQPQAPPPPQPQPQPPpppqPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1388591255  695 LSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVS 741
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 6.42e-63

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 208.80  E-value: 6.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQI 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1388591255   98 GQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 135
Cdd:cd16931     81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-169 3.56e-42

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 150.56  E-value: 3.56e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255   29 LFGALAELVDNARDADATRIDIYAERREDlrGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGNGLKSG 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEVNKNRG--GGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1388591255  108 SMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiDEVIVPLPTWnartREPITDNVEKFAIET 169
Cdd:pfam13589   79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-542 4.93e-17

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 75.42  E-value: 4.93e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1388591255  495 TTIQCDLCLKWRTLPFQLSSVETdyPDTWVCSMNPDPEQDRCEASEQK 542
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 239-451 3.94e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 3.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  239 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 309
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  310 eskartlEVRMGgdltrdsrvmlrqvqntaitlrreadvkkRIKDAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 389
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388591255  390 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 624-741 8.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 8.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPRPSTQlRKTSVISLP-----KPPTTAARGETSTSRLLQ----PTEAPRKPANPPIKTVPRPTPPVHTPP 694
Cdd:PHA03247  2877 APARPPVRRLARPAVS-RSTESFALPpdqpeRPPQPQAPPPPQPQPQPPpppqPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1388591255  695 LSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVS 741
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
35-79 6.33e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.49  E-value: 6.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1388591255   35 ELVDNARDADATRIDIYAErredlRGGFML-CFLDDGAGMDPSDAA 79
Cdd:COG0323     30 ELVENAIDAGATRIEVEIE-----EGGKSLiRVTDNGCGMSPEDLP 70
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 624-733 7.94e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 7.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPrPSTQLRKtsvisLPKPPTTAARGETSTSRLLQ-PTEAPRKPANPPIKTVPRPTPP-VHTPPLSLIPSS 701
Cdd:pfam03154  348 APLSMPHIKPP-PTTPIPQ-----LPNPQSHKHPPHLSGPSPFQmNSNLPPPPALKPLSSLSTHHPPsAHPPPLQLMPQS 421

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1388591255  702 KSLREVPAQKAIKTPVVKKPePPVKQSVATSG 733
Cdd:pfam03154  422 QQLPPPPAQPPVLTQSQSLP-PPAASHPPTSG 452
mutL PRK00095
DNA mismatch repair endonuclease MutL;
35-79 1.42e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 42.51  E-value: 1.42e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1388591255   35 ELVDNARDADATRIDIYAErredlRGGfmlcfL------DDGAGMDPSDAA 79
Cdd:PRK00095    29 ELVENALDAGATRIDIEIE-----EGG-----LklirvrDNGCGISKEDLA 69
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 6.42e-63

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 208.80  E-value: 6.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQI 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1388591255   98 GQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 135
Cdd:cd16931     81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-169 3.56e-42

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 150.56  E-value: 3.56e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255   29 LFGALAELVDNARDADATRIDIYAERREDlrGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGNGLKSG 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEVNKNRG--GGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1388591255  108 SMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiDEVIVPLPTWnartREPITDNVEKFAIET 169
Cdd:pfam13589   79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-542 4.93e-17

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 75.42  E-value: 4.93e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1388591255  495 TTIQCDLCLKWRTLPFQLSSVETdyPDTWVCSMNPDPEQDRCEASEQK 542
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 239-451 3.94e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 3.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  239 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 309
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  310 eskartlEVRMGgdltrdsrvmlrqvqntaitlrreadvkkRIKDAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 389
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388591255  390 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 624-741 8.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 8.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPRPSTQlRKTSVISLP-----KPPTTAARGETSTSRLLQ----PTEAPRKPANPPIKTVPRPTPPVHTPP 694
Cdd:PHA03247  2877 APARPPVRRLARPAVS-RSTESFALPpdqpeRPPQPQAPPPPQPQPQPPpppqPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1388591255  695 LSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVS 741
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 35-83 1.11e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 44.35  E-value: 1.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1388591255   35 ELVDNARDADATRIDIYAErredlRGGfmLCFL---DDGAGMDPSDAASVIQ 83
Cdd:cd16926     20 ELVENSIDAGATRIDVEIE-----EGG--LKLIrvtDNGSGISREDLELAFE 64
PHA03247 PHA03247
large tegument protein UL36; Provisional
 624-727 1.65e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETSTSR--LLQPTEAPRKPANPP---IKTVPRPTPPVHTPPLSL- 697
Cdd:PHA03247  2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPaaALPPAASPAGPLPPPtsaQPTAPPPPPGPPPPSLPLg 2853

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1388591255  698 ---IPSSKSLREVPAQKAIKTPVVkKPEPPVKQ 727
Cdd:PHA03247  2854 gsvAPGGDVRRRPPSRSPAAKPAA-PARPPVRR 2885
PHA03247 PHA03247
large tegument protein UL36; Provisional
 623-727 2.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  623 NAPSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETS---------TSRllQPTEAPRKPANPPIKTVPRPTPPVHTP 693
Cdd:PHA03247  2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApggdvrrrpPSR--SPAAKPAAPARPPVRRLARPAVSRSTE 2896

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1388591255  694 PLSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQ 727
Cdd:PHA03247  2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
35-79 6.33e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.49  E-value: 6.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1388591255   35 ELVDNARDADATRIDIYAErredlRGGFML-CFLDDGAGMDPSDAA 79
Cdd:COG0323     30 ELVENAIDAGATRIEVEIE-----EGGKSLiRVTDNGCGMSPEDLP 70
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 624-733 7.94e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 7.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPrPSTQLRKtsvisLPKPPTTAARGETSTSRLLQ-PTEAPRKPANPPIKTVPRPTPP-VHTPPLSLIPSS 701
Cdd:pfam03154  348 APLSMPHIKPP-PTTPIPQ-----LPNPQSHKHPPHLSGPSPFQmNSNLPPPPALKPLSSLSTHHPPsAHPPPLQLMPQS 421

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1388591255  702 KSLREVPAQKAIKTPVVKKPePPVKQSVATSG 733
Cdd:pfam03154  422 QQLPPPPAQPPVLTQSQSLP-PPAASHPPTSG 452
mutL PRK00095
DNA mismatch repair endonuclease MutL;
35-79 1.42e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 42.51  E-value: 1.42e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1388591255   35 ELVDNARDADATRIDIYAErredlRGGfmlcfL------DDGAGMDPSDAA 79
Cdd:PRK00095    29 ELVENALDAGATRIDIEIE-----EGG-----LklirvrDNGCGISKEDLA 69
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 624-732 2.36e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  624 APSRPPSIQTPRPSTQLRkTSVISLPKPPTTAARGETSTSrllqPTEAPRKPANPPIKTVPRPTP-----PVHTPPLSLI 698
Cdd:PRK14951   379 KTPARPEAAAPAAAPVAQ-AAAAPAPAAAPAAAASAPAAP----PAAAPPAPVAAPAAAAPAAAPaaapaAVALAPAPPA 453

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1388591255  699 PSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATS 732
Cdd:PRK14951   454 QAAPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK11633 PRK11633
cell division protein DedD; Provisional
 647-733 2.74e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 40.37  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  647 SLP-KPP---TTAARGETSTSRLLQPTEAPRKPANPPIKTVPRPTPPVHtpplsliPSSKSLREVPAQKAIKTPVVKKPE 722
Cdd:PRK11633    62 ALPtQPPegaAEAVRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPK-------PVEKPKPKPKPQQKVEAPPAPKPE 134

                           90
                   ....*....|...
gi 1388591255  723 --PPVKQSVATSG 733
Cdd:PRK11633   135 pkPVVEEKAAPTG 147
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 628-725 6.20e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 40.18  E-value: 6.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  628 PPSIQTPRPSTQLRK-TSVISLPKPPTTaarGETSTSRLLQPTEAPRKPanPPIKTVPRPTP-------PVHTPPLSLIP 699
Cdd:pfam15279  203 PPSIPQPNSPLSNPMlPGIGPPPKPPRN---LGPPSNPMHRPPFSPHHP--PPPPTPPGPPPglpppppRGFTPPFGPPF 277

                           90       100
                   ....*....|....*....|....*.
gi 1388591255  700 SSKSLREVPAQKAIKTPVVKKPEPPV 725
Cdd:pfam15279  278 PPVNMMPNPPEMNFGLPSLAPLVPPV 303
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 626-727 6.73e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  626 SRPPSIQTPRPstqlrktsvisLPKPPTTAARGETSTSRLLQPTEAPRKPanppiktvPRPTPPVHTPPLSLIPSSKSLR 705
Cdd:pfam03154  169 TQPPVLQAQSG-----------AASPPSPPPPGTTQAATAGPTPSAPSVP--------PQGSPATSQPPNQTQSTAAPHT 229

                           90       100
                   ....*....|....*....|..
gi 1388591255  706 EVPAQKAIKTPVVKKPEPPVKQ 727
Cdd:pfam03154  230 LIQQTPTLHPQRLPSPHPPLQP 251
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 621-723 7.08e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  621 IKNAPSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETSTSRLLQPTEAPRKPANP----PIKTVPRPTPPVHTPPLS 696
Cdd:pfam03154  282 LQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPpreqPLPPAPLSMPHIKPPPTT 361

                           90       100
                   ....*....|....*....|....*...
gi 1388591255  697 LIPsskslrEVPAQKAIKTPV-VKKPEP 723
Cdd:pfam03154  362 PIP------QLPNPQSHKHPPhLSGPSP 383
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 620-724 7.86e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 7.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  620 VIKNAPSRPPSIQTPRPSTQLRKtsvislPKPPTTAARGETSTS-RLLQPTEAPRKPANPPIKTVPR-PTPPVHtpplsl 697
Cdd:PTZ00449   574 TLSKKPEFPKDPKHPKDPEEPKK------PKRPRSAQRPTRPKSpKLPELLDIPKSPKRPESPKSPKrPPPPQR------ 641

                           90       100
                   ....*....|....*....|....*...
gi 1388591255  698 iPSSKSLREVPaqKAIKTPVV-KKPEPP 724
Cdd:PTZ00449   642 -PSSPERPEGP--KIIKSPKPpKSPKPP 666
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
552-725 8.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 8.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  552 KDPKTQeeKQKQLTEKIRQ------QQEKLEALQKTTPIRSQADL-------KKLPLEVT------TRPIEEPVRRPQRP 612
Cdd:PRK14971   298 KDAATL--QLLEVGESIRQryleqaQKCPMSFLYRALKLCNQCDLnyrasknKRLLVELTliqlaqLTQKGDDASGGRGP 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388591255  613 RSPPLPAVIKNAPSRPPSIQTpRPSTQLRKTSVISLPK--PPTTAARGETSTSRLLQPTEAPRKPA-NPPIKTVPRPTPP 689
Cdd:PRK14971   376 KQHIKPVFTQPAAAPQPSAAA-AASPSPSQSSAAAQPSapQSATQPAGTPPTVSVDPPAAVPVNPPsTAPQAVRPAQFKE 454

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1388591255  690 VHTPPLSLIPSSKSLREVPAQKAIKTPVVKKPEPPV 725
Cdd:PRK14971   455 EKKIPVSKVSSLGPSTLRPIQEKAEQATGNIKEAPT 490
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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