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Conserved domains on  [gi|1386806202|ref|NP_001349914|]
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GAS2-like protein 1 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 2.46e-61

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 201.39  E-value: 2.46e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  18 PFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEA---------ARALAAARPARGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFF--EKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1386806202  89 AHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 2.25e-42

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 147.36  E-value: 2.25e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386806202 208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 283-662 2.47e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 2.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  283 PPQPRVCTfsPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEG----------PETPPRPRDQLPPHPRSRRYS 352
Cdd:PHA03247  2556 PPAAPPAA--PDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  353 GDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPalrsqsrdrlDRGRPRGAPGGRGaqlSVPSPAR 432
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP----------QRPRRRAARPTVG---SLTSLAD 2700

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  433 RARSQSREEQAvllvrrdrdgqhswvPRGRGSGGSGRSTPQTPRARSPAAPrLSRVSSPSPELGTTPASIFRTPLQLDPQ 512
Cdd:PHA03247  2701 PPPPPPTPEPA---------------PHALVSATPLPPGPAAARQASPALP-AAPAPPAVPAGPATPGGPARPARPPTTA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  513 QeqqlfrrleeeflANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGdSGRTANGLPG 592
Cdd:PHA03247  2765 G-------------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP-AASPAGPLPP 2830

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  593 PRSQALSSSSDEGSPCP---GMGGPLdAPGSPLACTEPSR-------TWARGRMDT--------------QPDRKPSRIP 648
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPpslPLGGSV-APGGDVRRRPPSRspaakpaAPARPPVRRlarpavsrstesfaLPPDQPERPP 2909

                          410
                   ....*....|....
gi 1386806202  649 TPRGPRRPSGPAEL 662
Cdd:PHA03247  2910 QPQAPPPPQPQPQP 2923
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 2.46e-61

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 201.39  E-value: 2.46e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  18 PFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEA---------ARALAAARPARGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFF--EKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1386806202  89 AHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 2.25e-42

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 147.36  E-value: 2.25e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386806202 208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 9.79e-40

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 140.28  E-value: 9.79e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1386806202  206 RNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 1.46e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 55.76  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  27 EAMKEDLAEWLNALYGLGLPGGGDGF-LTGLATGTTLCQHANAVTEAaralaaarpargvAFQAHSVVPGSFMARDNVAT 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRVTNfTTDLRDGLALCALLNKLAPG-------------LVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1386806202 106 FIGWCRVELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-662 2.47e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 2.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  283 PPQPRVCTfsPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEG----------PETPPRPRDQLPPHPRSRRYS 352
Cdd:PHA03247  2556 PPAAPPAA--PDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  353 GDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPalrsqsrdrlDRGRPRGAPGGRGaqlSVPSPAR 432
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP----------QRPRRRAARPTVG---SLTSLAD 2700

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  433 RARSQSREEQAvllvrrdrdgqhswvPRGRGSGGSGRSTPQTPRARSPAAPrLSRVSSPSPELGTTPASIFRTPLQLDPQ 512
Cdd:PHA03247  2701 PPPPPPTPEPA---------------PHALVSATPLPPGPAAARQASPALP-AAPAPPAVPAGPATPGGPARPARPPTTA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  513 QeqqlfrrleeeflANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGdSGRTANGLPG 592
Cdd:PHA03247  2765 G-------------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP-AASPAGPLPP 2830

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  593 PRSQALSSSSDEGSPCP---GMGGPLdAPGSPLACTEPSR-------TWARGRMDT--------------QPDRKPSRIP 648
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPpslPLGGSV-APGGDVRRRPPSRspaakpaAPARPPVRRlarpavsrstesfaLPPDQPERPP 2909

                          410
                   ....*....|....
gi 1386806202  649 TPRGPRRPSGPAEL 662
Cdd:PHA03247  2910 QPQAPPPPQPQPQP 2923
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 3.87e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 45.77  E-value: 3.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202   31 EDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPArgvafqahsvvPGSFMARDNVATFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAAS-----------LSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1386806202  111 RvELGVPEVLmFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 E-KLGGKVVL-FEPEDLVEgPKLILGVIWTL 98
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 4.35e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 44.53  E-value: 4.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1386806202  97 FMARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199    67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 2.46e-61

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 201.39  E-value: 2.46e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  18 PFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEA---------ARALAAARPARGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFF--EKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1386806202  89 AHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 2.25e-42

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 147.36  E-value: 2.25e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386806202 208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 23-151 2.86e-41

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 146.64  E-value: 2.86e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  23 EAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEAARALAAARPARG-----VAFQAHSVVPGSF 97
Cdd:cd21204     1 EEALLPMKEDLAEWLNDLLGDDLTPDNFL--DELRNGVVLCQLAQKIQEAAEKAREAGKKNGpppsyKLKCNENAKPGSF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1386806202  98 MARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21204    79 FARDNVANFLRWCR-KLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 9.79e-40

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 140.28  E-value: 9.79e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1386806202  206 RNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 23-152 1.13e-18

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 82.68  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  23 EAYVEAMKEDLAEWLNALYGLGLPGGGDGFLtgLATGTTLCQHANAVTEAARALAAARPARGVAFQAHSV-----VP-GS 96
Cdd:cd21267     2 EASLLPMKEDLALWLTNLLGKEITAESFMEK--LDNGALLCQLAETLQEKFKENSADANKPGKSLPVRKIpcranAPsGS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1386806202  97 FMARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21267    80 FFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 23-151 5.97e-16

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 74.87  E-value: 5.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  23 EAYVEAMKEDLAEWLNALYGLGLPGGGDGFLtgLATGTTLCQHANAVTEAARALAAARPARGVAFQA----HSVVPGSFM 98
Cdd:cd21269     1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEE--LDNGVLLCQLIGVLQSKIKECCSTEELKHFPMRKvpckKDAPSGSFF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1386806202  99 ARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21269    79 ARDNTANFLSWCR-AIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 30-145 5.61e-11

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 59.66  E-value: 5.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  30 KEDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAaarpargvafqaHSVVPGSFMARDNVATFIGW 109
Cdd:cd00014     1 EEELLKWINEVLGEELPVSITDLFESLRDGVLLCKLINKLSPGSIPKI------------NKKPKSPFKKRENINLFLNA 68

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1386806202 110 CRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd00014    69 CK-KLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 1.46e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 55.76  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  27 EAMKEDLAEWLNALYGLGLPGGGDGF-LTGLATGTTLCQHANAVTEAaralaaarpargvAFQAHSVVPGSFMARDNVAT 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRVTNfTTDLRDGLALCALLNKLAPG-------------LVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1386806202 106 FIGWCRVELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-662 2.47e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 2.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  283 PPQPRVCTfsPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEG----------PETPPRPRDQLPPHPRSRRYS 352
Cdd:PHA03247  2556 PPAAPPAA--PDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  353 GDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPalrsqsrdrlDRGRPRGAPGGRGaqlSVPSPAR 432
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP----------QRPRRRAARPTVG---SLTSLAD 2700

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  433 RARSQSREEQAvllvrrdrdgqhswvPRGRGSGGSGRSTPQTPRARSPAAPrLSRVSSPSPELGTTPASIFRTPLQLDPQ 512
Cdd:PHA03247  2701 PPPPPPTPEPA---------------PHALVSATPLPPGPAAARQASPALP-AAPAPPAVPAGPATPGGPARPARPPTTA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  513 QeqqlfrrleeeflANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGdSGRTANGLPG 592
Cdd:PHA03247  2765 G-------------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP-AASPAGPLPP 2830

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  593 PRSQALSSSSDEGSPCP---GMGGPLdAPGSPLACTEPSR-------TWARGRMDT--------------QPDRKPSRIP 648
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPpslPLGGSV-APGGDVRRRPPSRspaakpaAPARPPVRRlarpavsrstesfaLPPDQPERPP 2909

                          410
                   ....*....|....
gi 1386806202  649 TPRGPRRPSGPAEL 662
Cdd:PHA03247  2910 QPQAPPPPQPQPQP 2923
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 56-145 2.17e-06

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 46.59  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  56 LATGTTLCQHANAVTEAAralaaarparGVAFQAhsvVPGSFMARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKS 135
Cdd:cd21210    26 LKDGVVLCKLANRILPAD----------IRKYKE---SKMPFVQMENISAFLNAAR-KLGVPENDLFQTVDLFERKNPAQ 91

                          90
                  ....*....|
gi 1386806202 136 VVLCLLEVAR 145
Cdd:cd21210    92 VLQCLHALSR 101
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 3.87e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 45.77  E-value: 3.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202   31 EDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPArgvafqahsvvPGSFMARDNVATFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAAS-----------LSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1386806202  111 RvELGVPEVLmFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 E-KLGGKVVL-FEPEDLVEgPKLILGVIWTL 98
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 96-140 2.16e-05

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 44.14  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1386806202  96 SFMARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCL 140
Cdd:cd21206    64 QFRHTDNINHFLRALK-KIGLPKIFHFETTDLYEKKNIPKVIYCL 107
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 4.35e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 44.53  E-value: 4.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1386806202  97 FMARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199    67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
PHA03247 PHA03247
large tegument protein UL36; Provisional
 282-504 2.78e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  282 RPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQ-------LPPHPRSRRYSGD 354
Cdd:PHA03247  2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHalvsatpLPPGPAAARQASP 2733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  355 SDSSASSAQSGPLGTRSDdtGTGPRRERPSRRLTTGTPASPRRPPAlrsqsrdrldrGRPRGAPGGRGAQLSVPSPARRA 434
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPATP--GGPARPARPPTTAGPPAPAPPAAPAA-----------GPPRRLTRPAVASLSESRESLPS 2800

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  435 RSQSREEQAVLLVRrdrdgqhSWVPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIFR 504
Cdd:PHA03247  2801 PWDPADPPAAVLAP-------AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR 2863
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 95-145 5.23e-04

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 39.99  E-value: 5.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1386806202  95 GSFMARDNVATFIGWCRvELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd21207    58 MAFKLMENIENFLTACK-GYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 297-503 1.31e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  297 SPTTSPRPASPVPGSerrgsrPEMTPVSLRSTK---EGPETPPRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDD 373
Cdd:PHA03307   111 PSSPDPPPPTPPPAS------PPPSPAPDLSEMlrpVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETAR 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  374 TGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSVPSPARRARSQSREEQAVLLVRRDRDG 453
Cdd:PHA03307   185 APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1386806202  454 QHSWvPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIF 503
Cdd:PHA03307   265 LPTR-IWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPR 313
PHA03247 PHA03247
large tegument protein UL36; Provisional
 282-681 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  282 RPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPEtPPRPRDQlPPHPRSRRYSGDSDSSASS 361
Cdd:PHA03247  2597 RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP-PERPRDD-PAPGRVSRPRRARRLGRAA 2674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  362 AQSGPLgtrsddtgTGPRreRPSRRLTTGTPASPRRPPALRSQsrdrldrgrPRGAPGGRGAQLSVPSPARRARSQSREE 441
Cdd:PHA03247  2675 QASSPP--------QRPR--RRAARPTVGSLTSLADPPPPPPT---------PEPAPHALVSATPLPPGPAAARQASPAL 2735

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  442 QAVLLVRRDRDGqhswvPRGRGSGGSGRSTPQTPRARSPAAPRlSRVSSPSPELGTTPASIFRTPLQLDPqqeqqlfrrL 521
Cdd:PHA03247  2736 PAAPAPPAVPAG-----PATPGGPARPARPPTTAGPPAPAPPA-APAAGPPRRLTRPAVASLSESRESLP---------S 2800

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  522 EEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANGLPGPRSQALSS- 600
Cdd:PHA03247  2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPAr 2880

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  601 ---SSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHSVTPRAEP 677
Cdd:PHA03247  2881 ppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960


                   ....
gi 1386806202  678 DSWM 681
Cdd:PHA03247  2961 QPWL 2964
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 256-417 5.12e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 5.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  256 RVGGGWDTLEHYLDKHDPCRcSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETP 335
Cdd:PHA03307   763 LVPAKLAEALALLEPAEPQR-GAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGA 841

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  336 ---PRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRG 412
Cdd:PHA03307   842 aarPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGGP 921


                   ....*
gi 1386806202  413 RPRGA 417
Cdd:PHA03307   922 DPRGG 926
PHA03247 PHA03247
large tegument protein UL36; Provisional
 325-661 9.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 9.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  325 LRSTKEGPETPPRPRDQLPPHPRSrrySGDSDSSASSAQSGPLGTRSDDTGTGPRRERPsrRLTTGTPASPRRPPALRSQ 404
Cdd:PHA03247  2543 LASDDAGDPPPPLPPAAPPAAPDR---SVPPPRPAPRPSEPAVTSRARRPDAPPQSARP--RAPVDDRGDPRGPAPPSPL 2617

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  405 SRDRLDRGRPRGAPGGRGAQLSVPSPARR-ARSQSREEQAVLLVRRDRdgqHSWVPRGRGSGGSGRSTPQTPRARSPAAP 483
Cdd:PHA03247  2618 PPDTHAPDPPPPSPSPAANEPDPHPPPTVpPPERPRDDPAPGRVSRPR---RARRLGRAAQASSPPQRPRRRAARPTVGS 2694

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  484 RLSRVSSPSPELGTTPASIFRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAycss 563
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA---- 2770

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806202  564 sssssslsvlggkcgQPGDSGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRK 643
Cdd:PHA03247  2771 ---------------PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                          330
                   ....*....|....*...
gi 1386806202  644 PSRIPTPRGPRRPSGPAE 661
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPLG 2853
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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