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Conserved domains on  [gi|1386635392|ref|NP_001349820|]
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alpha/beta-tubulin-N-acetyltransferase 9 isoform 2 [Mus musculus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11447364)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 56-134 1.16e-13

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 66.18  E-value: 1.16e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386635392  56 MVGDVNLFLTDLEDPTlGEIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFKQVA 134
Cdd:COG1670    73 LIGVVGLYDIDRANRS-AEIGYWLA-PAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEG 149
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 56-134 1.16e-13

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 66.18  E-value: 1.16e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386635392  56 MVGDVNLFLTDLEDPTlGEIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFKQVA 134
Cdd:COG1670    73 LIGVVGLYDIDRANRS-AEIGYWLA-PAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEG 149
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-131 3.20e-12

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 61.59  E-value: 3.20e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386635392  53 ESCMVGDVNLFLTDlEDPTLGEIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFK 131
Cdd:pfam13302  63 DTGFIGSIGLYDID-GEPERAELGYWLG-PDYWGKGYATEAVRALLEYAFEELGLPRLVARIDPENTASRRVLEKLGFK 139
PRK15130 PRK15130
spermidine N1-acetyltransferase; Provisional
 74-131 1.58e-05

spermidine N1-acetyltransferase; Provisional


Pssm-ID: 237916  Cd Length: 186  Bit Score: 44.02  E-value: 1.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1386635392  74 EIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFK 131
Cdd:PRK15130   85 EFQIIIS-PEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFE 141
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 56-134 1.16e-13

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 66.18  E-value: 1.16e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386635392  56 MVGDVNLFLTDLEDPTlGEIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFKQVA 134
Cdd:COG1670    73 LIGVVGLYDIDRANRS-AEIGYWLA-PAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEG 149
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-131 3.20e-12

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 61.59  E-value: 3.20e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1386635392  53 ESCMVGDVNLFLTDlEDPTLGEIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFK 131
Cdd:pfam13302  63 DTGFIGSIGLYDID-GEPERAELGYWLG-PDYWGKGYATEAVRALLEYAFEELGLPRLVARIDPENTASRRVLEKLGFK 139
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 20-130 1.23e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386635392  20 EYEMQCSWCEDEDKCTFIVLDAEKWqaqprppeescmVGDVNLFLTDLEDPTlGEIEVMIAEPSYRRQGLGTEASLLIMS 99
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGEL------------VGFASLSIIDDEPPV-GEIEGLAVAPEYRGKGIGTALLQALLE 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1386635392 100 YGVtKLGLTKFEAKIGQENEPSIRMFQKLHF 130
Cdd:pfam00583  87 WAR-ERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
73-134 3.70e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 45.37  E-value: 3.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1386635392  73 GEIEVMIAePSYRRQGLGTeaslLIMSYGVT---KLGLTKFEAKIGQENEPSIRMFQKLHFKQVA 134
Cdd:COG1247    82 AEESIYVD-PDARGRGIGR----ALLEALIErarARGYRRLVAVVLADNEASIALYEKLGFEEVG 141
PRK15130 PRK15130
spermidine N1-acetyltransferase; Provisional
 74-131 1.58e-05

spermidine N1-acetyltransferase; Provisional


Pssm-ID: 237916  Cd Length: 186  Bit Score: 44.02  E-value: 1.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1386635392  74 EIEVMIAePSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFK 131
Cdd:PRK15130   85 EFQIIIS-PEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFE 141
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 58-130 2.50e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 38.46  E-value: 2.50e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1386635392  58 GDVNLFLTDLEDPTLGEIEVMIAEPSYRRQGLGteaSLLI--MSYGVTKLGLTKFeAKIGQENEPSIRMFQKLHF 130
Cdd:pfam08445   7 GDTGELAAWCLRLPGGELGALQTLPEHRRRGLG---SRLVaaLARGIAERGITPF-AVVVAGNTPSRRLYEKLGF 77
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 64-134 7.35e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 37.33  E-value: 7.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1386635392  64 LTDLEDPTLGEIEVMIAEPSYRRQGLGT----EASLLIMSYGVTKLGLTkfeakIGQENEPSIRMFQKLHFKQVA 134
Cdd:COG0456     5 LGLVDGGDEAEIEDLAVDPEYRGRGIGRalleAALERARERGARRLRLE-----VREDNEAAIALYEKLGFEEVG 74
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 29-133 9.55e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 38.11  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386635392  29 EDEDKCTFIVLDAEKwqaqpRPpeescmVGDVNLFLTDleDPTlGEIEVMIAEPSYRRQGLGTEasLLI--MSYGVTKlG 106
Cdd:COG0454    29 GSLAGAEFIAVDDKG-----EP------IGFAGLRRLD--DKV-LELKRLYVLPEYRGKGIGKA--LLEalLEWARER-G 91

                          90       100
                  ....*....|....*....|....*..
gi 1386635392 107 LTKFEAKIGQENEPSIRMFQKLHFKQV 133
Cdd:COG0454    92 CTALELDTLDGNPAAIRFYERLGFKEI 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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