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Conserved domains on  [gi|1384865971|ref|NP_001349765|]
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zinc finger protein ZFPM2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 44-154 6.05e-75

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


:

Pssm-ID: 380993  Cd Length: 111  Bit Score: 242.48  E-value: 6.05e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865971   44 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYS 123
Cdd:cd19216      1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1384865971  124 KGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 154
Cdd:cd19216     81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 44-154 6.05e-75

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 242.48  E-value: 6.05e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865971   44 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYS 123
Cdd:cd19216      1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1384865971  124 KGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 154
Cdd:cd19216     81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 44-154 6.05e-75

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 242.48  E-value: 6.05e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865971   44 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYS 123
Cdd:cd19216      1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1384865971  124 KGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 154
Cdd:cd19216     81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 44-151 1.06e-29

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 114.36  E-value: 1.06e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865971   44 WDGPGELEVFQKDG----ERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQV-----------PMVLTAGPKWLLDVT 108
Cdd:cd19201      1 LSLPGELELRKPSQdagrSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKVeaqgskggeglLLLTEDSGTWLKLVR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1384865971  109 WQGvEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDS 151
Cdd:cd19201     81 SAD-DEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 44-147 6.35e-22

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 91.77  E-value: 6.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865971   44 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQ---VPMVLTAGPKWLLDVTwQGVEDNKNNCI 120
Cdd:cd19215      1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEEspaVTLLLVDEDCWLRRLP-LVSTEAEANCT 79

                           90       100
                   ....*....|....*....|....*..
gi 1384865971  121 VYSKGGQLWCTTTKAISEGEELIAFVV 147
Cdd:cd19215     80 IYRKGDAIWCKTTKPVPEGELLSAILV 106
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 47-145 2.24e-06

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 46.42  E-value: 2.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865971   47 PGELEVFQ---KDGERKIQSRQQLPVGTTWGPFPGK---MDLNNNSLKTKAQvpmvltagpkwlldvtwqgvednknNCI 120
Cdd:cd10534      2 PAGLELVLssiPEGGLGVFARRTIPAGTRFGPLEGVvnwMRFVRPARNEEEQ-------------------------NLV 56

                           90       100
                   ....*....|....*....|....*
gi 1384865971  121 VYSKGGQLWCTTTKAISEGEELIAF 145
Cdd:cd10534     57 AYQHGGQIYFRTTRDIPPGEELLVW 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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