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Conserved domains on  [gi|1371981716|ref|NP_001348539|]
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kinesin light chain 1 isoform 1K [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
210-435 2.00e-27

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 110.87  E-value: 2.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG0457     5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRekvlgkdhPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIy 369
Cdd:COG0457    72 ---DPDDAEALNNLGLALQALGRYEEALEDYDKALELD--------PDDAEALYNLGLALLELGRYDEAIEAYERALEL- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981716 370 qtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREE 435
Cdd:COG0457   140 -------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLA 198
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 35-149 1.70e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716   35 LEALKNEHNSILQSLLET-LKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQ-VMMALSNHLNAVESEKQKLRAQVRR 112
Cdd:TIGR02168  234 LEELREELEELQEELKEAeEELEELTAELQELEEKLEELRLEVSELEEEIEELQkELYALANEISRLEQQKQILRERLAN 313

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1371981716  113 LCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLE 149
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK 350
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
210-435 2.00e-27

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 110.87  E-value: 2.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG0457     5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRekvlgkdhPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIy 369
Cdd:COG0457    72 ---DPDDAEALNNLGLALQALGRYEEALEDYDKALELD--------PDDAEALYNLGLALLELGRYDEAIEAYERALEL- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981716 370 qtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREE 435
Cdd:COG0457   140 -------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLA 198
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 212-417 2.79e-20

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 94.99  E-value: 2.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 212 RLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHD--HPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTL 289
Cdd:NF040586  433 TLRLRFHLANALRSLGRYEEARELDEDTLERQRRVLGLGedHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVF 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 GRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIY 369
Cdd:NF040586  513 GEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERY 592

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1371981716 370 QTKL-GPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRaHEREFG 417
Cdd:NF040586  593 REVLgGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYER-YRRRFG 640
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 226-421 6.67e-20

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 93.83  E-value: 6.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 226 QGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAI--REKTLGRDHPAVAATLNNL 303
Cdd:NF040586  405 RGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEARELDEDTLERqrRVLGLGEDHPHTLMTAGGL 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 304 AVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKT 383
Cdd:NF040586  485 GADLRALGRFREALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLS 564

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1371981716 384 KNNLASCYLKQGKFKQAETLYKEILTRaHEREFGSVDD 421
Cdd:NF040586  565 ANNLARDLRELGRYAEALDLLEEALER-YREVLGGPDH 601
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 227-417 1.68e-18

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 89.59  E-value: 1.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 227 GRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVL 306
Cdd:NF040586  492 GRFREALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARD 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 307 YGKRGKYKEAEPLCKRALEIREKVL-GKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKTKN 385
Cdd:NF040586  572 LRELGRYAEALDLLEEALERYREVLgGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDTLAAAL 651

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1371981716 386 NLASCYLKQGKFKQAETLYKEILTRaHEREFG 417
Cdd:NF040586  652 SLANDLRALGDADEARELAREVLDR-YRRVLG 682
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 205-414 5.59e-18

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 87.67  E-value: 5.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 205 GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKT-SGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALA 283
Cdd:NF040586  554 LGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYE 633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 284 IREKTLGRDHP-AVAATLNnLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYY 362
Cdd:NF040586  634 RYRRRFGPDHPdTLAAALS-LANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELA 712

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1371981716 363 QRALGIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQA--ETLYKEILTRAHER 414
Cdd:NF040586  713 EAALEGLRERLGPDHPYTLAAAVNLANDLAALGDLDAAlgEEALERLRRLLGED 766
TPR_12 pfam13424
Tetratricopeptide repeat;
296-370 6.59e-18

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 78.20  E-value: 6.59e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1371981716 296 VAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQ 370
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 205-380 2.92e-16

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 82.27  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 205 GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPD-VATMLNiLALVYRDQNKYKDAANLLNDALA 283
Cdd:NF040586  597 GGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtLAAALS-LANDLRALGDADEARELAREVLD 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 284 IREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE-------------------------------------- 325
Cdd:NF040586  676 RYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALEglrerlgpdhpytlaaavnlandlaalgdldaalgeea 755

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981716 326 --------IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNV 380
Cdd:NF040586  756 lerlrrllGEDLRAGPDHPDTLACAANLALDLRATGRTEEAEELRADTLARLRRVLGPDHPDT 818
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 211-405 4.76e-10

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 60.04  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 211 ARLRTlhNLVIQYASQGRYEvavplckQALEDLEKTSGHDhPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektlg 290
Cdd:TIGR02521  31 AKIRV--QLALGYLEQGDLE-------VAKENLDKALEHD-PDDYLAYLALALYYQQLGELEKAEDSFRRALTL------ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 291 rdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEirekvlGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIyq 370
Cdd:TIGR02521  95 --NPNNGDVLNNYGTFLCQQGKYEQAMQQFEQAIE------DPLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQI-- 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1371981716 371 tklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYK 405
Cdd:TIGR02521 165 ------DPQRPESLLELAELYYLRGQYKDARAYLE 193
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 306-420 2.48e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 50.30  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 306 LYgKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEV---------------------EY---- 360
Cdd:NF040586  402 LY-LRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAreldedtlerqrrvlglgedhPHtlmt 480

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981716 361 ------------YYQRAL-------GIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRaHEREFGSVD 420
Cdd:NF040586  481 agglgadlralgRFREALeldeetlERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRR-RRRVLGPDH 558
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 35-149 1.70e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716   35 LEALKNEHNSILQSLLET-LKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQ-VMMALSNHLNAVESEKQKLRAQVRR 112
Cdd:TIGR02168  234 LEELREELEELQEELKEAeEELEELTAELQELEEKLEELRLEVSELEEEIEELQkELYALANEISRLEQQKQILRERLAN 313

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1371981716  113 LCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLE 149
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK 350
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 218-298 2.20e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 44.14  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 218 NLVIQYASQGRYEVAvpLCKQALEDLE------KTSGHDHPDV-ATMLNiLALVYRDQNKYKDAANLLNDALAIREKTLG 290
Cdd:NF040586  736 NLANDLAALGDLDAA--LGEEALERLRrllgedLRAGPDHPDTlACAAN-LALDLRATGRTEEAEELRADTLARLRRVLG 812


                  ....*...
gi 1371981716 291 RDHPAVAA 298
Cdd:NF040586  813 PDHPDTVA 820
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 297-329 6.52e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.43  E-value: 6.52e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1371981716  297 AATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 29-161 8.05e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.54  E-value: 8.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716   29 KQVIQGLEALKNEHNSILQSLLETLkclkkDDESNLVEEKSSMIRKSLEMLElglSEAQVMMALSNHLNAV-ESEKQKLR 107
Cdd:smart00787 139 MKLLEGLKEGLDENLEGLKEDYKLL-----MKELELLNSIKPKLRDRKDALE---EELRQLKQLEDELEDCdPTELDRAK 210

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1371981716  108 AQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKkhLEFMNQLKKYDDDI 161
Cdd:smart00787 211 EKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKK--SELNTEIAEAEKKL 262
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 62-147 6.84e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 39.45  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716  62 SNLVEEKSSMIR--KSLEMLELGLSEA-QVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSV 138
Cdd:pfam09726 388 NNQLSKPDALVRleQDIKKLKAELQASrQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTV 467

                          90
                  ....*....|...
gi 1371981716 139 AQLE----EEKKH 147
Cdd:pfam09726 468 QQLEkrlkAEQEA 480
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 295-416 9.90e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 38.10  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 295 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPdvAKQ---LNNLA----LLCQNQGKYEEVEYY------ 361
Cdd:cd24145   145 EVGAFLEELATAYDLYGRFCLALPLYMQALSLKGQILLSQAN--CHSlvlMNNEAaelaLHALRKPLSSTLIEAsrlpqk 222

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371981716 362 ------------YQRALGIYQTKLGPD-----DPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREF 416
Cdd:cd24145   223 srdqlleaalkwAQKALDVAKSIKPKDrdpecDQACALALYNLGVIAEMLGNLDEARKLYKEAISLAKELGF 294
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
210-435 2.00e-27

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 110.87  E-value: 2.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG0457     5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRekvlgkdhPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIy 369
Cdd:COG0457    72 ---DPDDAEALNNLGLALQALGRYEEALEDYDKALELD--------PDDAEALYNLGLALLELGRYDEAIEAYERALEL- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981716 370 qtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREE 435
Cdd:COG0457   140 -------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLA 198
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 212-417 2.79e-20

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 94.99  E-value: 2.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 212 RLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHD--HPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTL 289
Cdd:NF040586  433 TLRLRFHLANALRSLGRYEEARELDEDTLERQRRVLGLGedHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVF 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 GRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIY 369
Cdd:NF040586  513 GEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERY 592

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1371981716 370 QTKL-GPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRaHEREFG 417
Cdd:NF040586  593 REVLgGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYER-YRRRFG 640
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 226-421 6.67e-20

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 93.83  E-value: 6.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 226 QGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAI--REKTLGRDHPAVAATLNNL 303
Cdd:NF040586  405 RGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEARELDEDTLERqrRVLGLGEDHPHTLMTAGGL 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 304 AVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKT 383
Cdd:NF040586  485 GADLRALGRFREALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLS 564

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1371981716 384 KNNLASCYLKQGKFKQAETLYKEILTRaHEREFGSVDD 421
Cdd:NF040586  565 ANNLARDLRELGRYAEALDLLEEALER-YREVLGGPDH 601
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 208-411 1.23e-19

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 92.75  E-value: 1.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 208 EIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKtsGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrek 287
Cdd:COG3914    33 EAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAA--AAALLLLAALLELAALLLQALGRYEEALALYRRALAL--- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 288 tlgrdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALG 367
Cdd:COG3914   108 -----NPDNAEALFNLGNLLLALGRLEEALAALRRALAL--------NPDFAEAYLNLGEALRRLGRLEEAIAALRRALE 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1371981716 368 IyqtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRA 411
Cdd:COG3914   175 L--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 227-417 1.68e-18

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 89.59  E-value: 1.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 227 GRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVL 306
Cdd:NF040586  492 GRFREALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARD 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 307 YGKRGKYKEAEPLCKRALEIREKVL-GKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKTKN 385
Cdd:NF040586  572 LRELGRYAEALDLLEEALERYREVLgGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDTLAAAL 651

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1371981716 386 NLASCYLKQGKFKQAETLYKEILTRaHEREFG 417
Cdd:NF040586  652 SLANDLRALGDADEARELAREVLDR-YRRVLG 682
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 205-414 5.59e-18

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 87.67  E-value: 5.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 205 GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKT-SGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALA 283
Cdd:NF040586  554 LGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYE 633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 284 IREKTLGRDHP-AVAATLNnLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYY 362
Cdd:NF040586  634 RYRRRFGPDHPdTLAAALS-LANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELA 712

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1371981716 363 QRALGIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQA--ETLYKEILTRAHER 414
Cdd:NF040586  713 EAALEGLRERLGPDHPYTLAAAVNLANDLAALGDLDAAlgEEALERLRRLLGED 766
TPR_12 pfam13424
Tetratricopeptide repeat;
296-370 6.59e-18

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 78.20  E-value: 6.59e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1371981716 296 VAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQ 370
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
TPR_12 pfam13424
Tetratricopeptide repeat;
253-329 6.03e-17

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 75.50  E-value: 6.03e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981716 253 DVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 205-380 2.92e-16

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 82.27  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 205 GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPD-VATMLNiLALVYRDQNKYKDAANLLNDALA 283
Cdd:NF040586  597 GGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtLAAALS-LANDLRALGDADEARELAREVLD 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 284 IREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE-------------------------------------- 325
Cdd:NF040586  676 RYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALEglrerlgpdhpytlaaavnlandlaalgdldaalgeea 755

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981716 326 --------IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNV 380
Cdd:NF040586  756 lerlrrllGEDLRAGPDHPDTLACAANLALDLRATGRTEEAEELRADTLARLRRVLGPDHPDT 818
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 210-413 2.02e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.69  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEdlektsghDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG2956    73 PDRAEALLELAQDYLKAGLLDRAEELLEKLLE--------LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL----- 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIy 369
Cdd:COG2956   140 ---GPENAHAYCELAELYLEQGDYDEAIEALEKALKL--------DPDCARALLLLAELYLEQGDYEEAIAALERALEQ- 207

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1371981716 370 qtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHE 413
Cdd:COG2956   208 -------DPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS 244
TPR_12 pfam13424
Tetratricopeptide repeat;
212-287 1.42e-14

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 68.95  E-value: 1.42e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981716 212 RLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREK 287
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 223-413 2.68e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 73.22  E-value: 2.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 223 YASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTlgrdhpavAATLNN 302
Cdd:COG2956    52 YRRRGEYDRAIRIHQKLLER--------DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDD--------AEALRL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 303 LAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIyqtklgpdDPNVAK 382
Cdd:COG2956   116 LAEIYEQEGDWEKAIEVLERLLKL--------GPENAHAYCELAELYLEQGDYDEAIEALEKALKL--------DPDCAR 179

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1371981716 383 TKNNLASCYLKQGKFKQAETLYKEILTRAHE 413
Cdd:COG2956   180 ALLLLAELYLEQGDYEEAIAALERALEQDPD 210
TPR_10 pfam13374
Tetratricopeptide repeat;
296-337 4.23e-14

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 66.37  E-value: 4.23e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1371981716 296 VAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
Cdd:pfam13374   1 TASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
TPR_12 pfam13424
Tetratricopeptide repeat;
337-411 1.24e-13

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 66.26  E-value: 1.24e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1371981716 337 DVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRA 411
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 261-413 4.14e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.75  E-value: 4.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 261 LALVYRDQNKYKDAANLLNDALAIrektlgrdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAK 340
Cdd:COG4783    10 LAQALLLAGDYDEAEALLEKALEL--------DPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL--------DPDEPE 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981716 341 QLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNVAktkNNLASCYLKQGKFKQAETLYKEILTRAHE 413
Cdd:COG4783    74 ARLNLGLALLKAGDYDEALALLEKAL-----KLDPEHPEAY---LRLARAYRALGRPDEAIAALEKALELDPD 138
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 211-369 6.65e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.98  E-value: 6.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 211 ARLRTLHNLVIQYASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektlg 290
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALEL--------DPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL------ 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981716 291 rdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEirekvLGKDHPDVakqLNNLALLCQNQGKYEEVEYYYQRALGIY 369
Cdd:COG4783    68 --DPDEPEARLNLGLALLKAGDYDEALALLEKALK-----LDPEHPEA---YLRLARAYRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 222-414 1.12e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.79  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 222 QYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKY-KDAANLLNDALAIREKTLGRDHPAVAATL 300
Cdd:COG3914     2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALaEAAAAALLALAAGEAAAAAAALLLLAALL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 301 NNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNV 380
Cdd:COG3914    82 ELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL-----ALNPDFAEA 148

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1371981716 381 AktkNNLASCYLKQGKFKQAETLYKEILTRAHER 414
Cdd:COG3914   149 Y---LNLGEALRRLGRLEEAIAALRRALELDPDN 179
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 249-411 8.43e-12

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 63.44  E-value: 8.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 249 HDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIre 328
Cdd:COG5010     6 GFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL-- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 329 kvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNVAktkNNLASCYLKQGKFKQAETLYKEIL 408
Cdd:COG5010    84 ------DPNNPELYYNLALLYSRSGDKDEAKEYYEKAL-----ALSPDNPNAY---SNLAALLLSLGQDDEAKAALQRAL 149


                  ...
gi 1371981716 409 TRA 411
Cdd:COG5010   150 GTS 152
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
218-405 1.92e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.78  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 218 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIRektlgrdhPAVA 297
Cdd:COG4785    36 ALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELD--------PDLA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 298 ATLNNLAVLYGKRGKYKEAEPLCKRALEIRekvlgkdhPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDD 377
Cdd:COG4785   108 EAYNNRGLAYLLLGDYDAALEDFDRALELD--------PDYAYAYLNRGIALYYLGRYELAIADLEKAL-----ELDPND 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1371981716 378 P-------------NVAKTKNNL----ASCYLKQGKFKQAETLYK 405
Cdd:COG4785   175 PeralwlylaerklDPEKALALLledwATAYLLQGDTEEARELFK 219
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
306-408 8.49e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.64  E-value: 8.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 306 LYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYyQRALGIyqtklgpdDPNVAKTKN 385
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALEL--------DPDNADALNNLGLLLLEQGRYDEAIAL-EKALKL--------DPNNAEALL 63

                          90       100
                  ....*....|....*....|...
gi 1371981716 386 NLASCYLKQGKFKQAETLYKEIL 408
Cdd:COG3063    64 NLAELLLELGDYDEALAYLERAL 86
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
210-370 9.45e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 9.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIRektl 289
Cdd:COG0457    73 PDDAEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERALELD---- 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 grdhPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIY 369
Cdd:COG0457   141 ----PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTL 216


                  .
gi 1371981716 370 Q 370
Cdd:COG0457   217 A 217
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 260-415 1.15e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.44  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 260 ILALVYRDQNKYKDAANLLNDALAIrektlgrdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVA 339
Cdd:COG2956    13 FKGLNYLLNGQPDKAIDLLEEALEL--------DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLER--------DPDRA 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981716 340 KQLNNLALLCQNQGKYEEVEYYYQRALGIyqtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHERE 415
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLLEL--------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA 144
TPR_10 pfam13374
Tetratricopeptide repeat;
254-294 2.09e-10

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 55.97  E-value: 2.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1371981716 254 VATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHP 294
Cdd:pfam13374   1 TASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHP 41
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
264-366 3.70e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 56.72  E-value: 3.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 264 VYRDQNKYKDAANLLNDALAIrektlgrdHPAVAATLNNLAVLYGKRGKYKEAEPLcKRALEIrekvlgkdHPDVAKQLN 343
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALEL--------DPDNADALNNLGLLLLEQGRYDEAIAL-EKALKL--------DPNNAEALL 63

                          90       100
                  ....*....|....*....|...
gi 1371981716 344 NLALLCQNQGKYEEVEYYYQRAL 366
Cdd:COG3063    64 NLAELLLELGDYDEALAYLERAL 86
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 295-411 4.14e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.89  E-value: 4.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 295 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLG 374
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALEL--------DPDNPEAFALLGEILLQLGDLDEAIVLLHEAL-----ELD 68

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1371981716 375 PDDPNVAktkNNLASCYLKQGKFKQAETLYKEILTRA 411
Cdd:COG4783    69 PDEPEAR---LNLGLALLKAGDYDEALALLEKALKLD 102
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 211-405 4.76e-10

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 60.04  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 211 ARLRTlhNLVIQYASQGRYEvavplckQALEDLEKTSGHDhPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektlg 290
Cdd:TIGR02521  31 AKIRV--QLALGYLEQGDLE-------VAKENLDKALEHD-PDDYLAYLALALYYQQLGELEKAEDSFRRALTL------ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 291 rdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEirekvlGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIyq 370
Cdd:TIGR02521  95 --NPNNGDVLNNYGTFLCQQGKYEQAMQQFEQAIE------DPLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQI-- 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1371981716 371 tklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYK 405
Cdd:TIGR02521 165 ------DPQRPESLLELAELYYLRGQYKDARAYLE 193
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 210-368 6.31e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 6.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG5010     9 RLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL----- 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGI 368
Cdd:COG5010    84 ---DPNNPELYYNLALLYSRSGDKDEAKEYYEKALAL--------SPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 238-388 1.17e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.55  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 238 QALEDLEKTSGHDHPDVATMLNiLALVYRDQNKYKDAANLLNDALAIRektlgrdhPAVAATLNNLAVLYGKRGKYKEAE 317
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLL-LGRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAE 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1371981716 318 PLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNVAKTKNNLA 388
Cdd:COG4235    72 ELLERALAL--------DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLL-----ALLPADAPARLLEASIA 129
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
223-331 3.66e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 54.02  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 223 YASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLlNDALAIrektlgrdHPAVAATLNN 302
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALEL--------DPDNADALNNLGLLLLEQGRYDEAIAL-EKALKL--------DPNNAEALLN 64

                          90       100
                  ....*....|....*....|....*....
gi 1371981716 303 LAVLYGKRGKYKEAEPLCKRALEIREKVL 331
Cdd:COG3063    65 LAELLLELGDYDEALAYLERALELDPSAL 93
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 261-480 1.08e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 261 LALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKdHPDVAK 340
Cdd:COG3914     1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAA-LLLLAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 341 QLNNLALLCQNQGKYEEVEYYYQRALGIyqtklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILtraherefgSVD 420
Cdd:COG3914    80 LLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL---------ALN 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981716 421 DENKPIWM---HAEEREeckGKQKDGSAFgeyggWYKACKVDsPTVTTTLKNLGALYRRQGKF 480
Cdd:COG3914   143 PDFAEAYLnlgEALRRL---GRLEEAIAA-----LRRALELD-PDNAEALNNLGNALQDLGRL 196
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 291-411 1.84e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 1.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 291 RDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRekvlgkdhPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIyq 370
Cdd:COG4235    11 AANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERALAL-- 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1371981716 371 tklgpdDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRA 411
Cdd:COG4235    81 ------DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 210-366 4.61e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 4.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEdlektsghDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG2956   141 PENAHAYCELAELYLEQGDYDEAIEALEKALK--------LDPDCARALLLLAELYLEQGDYEEAIAALERALEQ----- 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIrekvlgkdHPDVAkQLNNLALLCQNQGKYEEVEYYYQRAL 366
Cdd:COG2956   208 ---DPDYLPALPRLAELYEKLGDPEEALELLRKALEL--------DPSDD-LLLALADLLERKEGLEAALALLERQL 272
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 309-410 2.68e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.22  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 309 KRGKYKEAEPLCKRALEirekvLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYqtklgPDDPNVAKTKNNLA 388
Cdd:COG1729     5 KAGDYDEAIAAFKAFLK-----RYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRY-----PDSPKAPDALLKLG 74

                          90       100
                  ....*....|....*....|..
gi 1371981716 389 SCYLKQGKFKQAETLYKEILTR 410
Cdd:COG1729    75 LSYLELGDYDKARATLEELIKK 96
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 250-409 3.54e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.16  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 250 DHPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektlgrdHPAVAATLNNLAVLYGKRgKYKEAEPLCKRALEIRek 329
Cdd:TIGR02917 765 THPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKK--------APDNAVVLNNLAWLYLEL-KDPRALEYAERALKLA-- 833

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 330 vlgkdhPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIyqtklGPDDPNVaktKNNLASCYLKQGKFKQAETLYKEILT 409
Cdd:TIGR02917 834 ------PNIPAILDTLGWLLVEKGEADRALPLLRKAVNI-----APEAAAI---RYHLALALLATGRKAEARKELDKLLN 899
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
261-434 3.57e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.45  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 261 LALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRekvlgkdhPDVAK 340
Cdd:COG4785    37 LAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELD--------PDLAE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 341 QLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNVaktKNNLASCYLKQGKFKQAEtlykEILTRAHerEFGSVD 420
Cdd:COG4785   109 AYNNRGLAYLLLGDYDAALEDFDRAL-----ELDPDYAYA---YLNRGIALYYLGRYELAI----ADLEKAL--ELDPND 174

                         170
                  ....*....|....
gi 1371981716 421 DENkPIWMHAEERE 434
Cdd:COG4785   175 PER-ALWLYLAERK 187
TPR_10 pfam13374
Tetratricopeptide repeat;
213-253 6.30e-07

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 45.96  E-value: 6.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1371981716 213 LRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPD 253
Cdd:pfam13374   2 ASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
210-366 1.18e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.53  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDlektsghdHPDVATMLNILALVYRDQNKYKDAANLLNDALAIRektl 289
Cdd:COG4785    70 PDLAQLYYERGVAYDSLGDYDLAIADFDQALEL--------DPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD---- 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 290 grdhPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREK----------VLGKDHPDVAKQL--NNLALLCQNQGKYEE 357
Cdd:COG4785   138 ----PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNdperalwlylAERKLDPEKALALllEDWATAYLLQGDTEE 213


                  ....*....
gi 1371981716 358 VEYYYQRAL 366
Cdd:COG4785   214 ARELFKLAL 222
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 237-411 1.56e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 237 KQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLgrdhPAVAAtlnnLAVLYGKRGKYKEA 316
Cdd:TIGR02917 107 QQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSL----YAKLG----LAQLALAENRFDEA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 317 EPLCKRALEIrekvlgkdHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNVaktKNNLASCYLKQGK 396
Cdd:TIGR02917 179 RALIDEVLTA--------DPGNVDALLLKGDLLLSLGNIELALAAYRKAI-----ALRPNNIAV---LLALATILIEAGE 242

                         170
                  ....*....|....*
gi 1371981716 397 FKQAETLYKEILTRA 411
Cdd:TIGR02917 243 FEEAEKHADALLKKA 257
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 306-420 2.48e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 50.30  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 306 LYgKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEV---------------------EY---- 360
Cdd:NF040586  402 LY-LRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAreldedtlerqrrvlglgedhPHtlmt 480

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981716 361 ------------YYQRAL-------GIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRaHEREFGSVD 420
Cdd:NF040586  481 agglgadlralgRFREALeldeetlERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRR-RRRVLGPDH 558
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 210-326 3.10e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.72  E-value: 3.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEdlektsghDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREktl 289
Cdd:COG4783    35 PDNPEAFALLGEILLQLGDLDEAIVLLHEALE--------LDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDP--- 103

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1371981716 290 grDHPAVaatLNNLAVLYGKRGKYKEAEPLCKRALEI 326
Cdd:COG4783   104 --EHPEA---YLRLARAYRALGRPDEAIAALEKALEL 135
TPR_10 pfam13374
Tetratricopeptide repeat;
338-379 4.26e-06

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 43.64  E-value: 4.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1371981716 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPN 379
Cdd:pfam13374   1 TASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 210-326 5.85e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.77  E-value: 5.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEdLEktsghdhPDVATMLNILALVYRDQNKYKDAANLLNDALAIrektl 289
Cdd:COG4235    14 PNDAEGWLLLGRAYLRLGRYDEALAAYEKALR-LD-------PDNADALLDLAEALLAAGDTEEAEELLERALAL----- 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1371981716 290 grdHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEI 326
Cdd:COG4235    81 ---DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 261-326 6.15e-06

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 43.86  E-value: 6.15e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981716 261 LALVYRDQNKYKDAANLLNDALAirektLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEI 326
Cdd:pfam13432   3 LARAALRAGDYDDAAAALEAALA-----RFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRA 63
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 321-413 2.95e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.84  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 321 KRALEIREKVlgKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALgiyqtKLGPDDPNVaktKNNLASCYLKQGKFKQA 400
Cdd:COG4235     1 EAIARLRQAL--AANPNDAEGWLLLGRAYLRLGRYDEALAAYEKAL-----RLDPDNADA---LLDLAEALLAAGDTEEA 70

                          90
                  ....*....|...
gi 1371981716 401 ETLYKEILTRAHE 413
Cdd:COG4235    71 EELLERALALDPD 83
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 210-428 3.61e-05

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 46.15  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKtsgHDHPDVATM-LNILALVYRDQNKYKDAANLLNDALAIREKT 288
Cdd:pfam17874  37 LARGLATFVLGEAYLCLGDLDAALQAMREAEALARR---ADSPHVTLWaLLQQGEILRAQGRLHQALETYQQALQLARDH 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 289 LGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVlgkdHPDVAKQLN-NLALLCQNQGKYEEVEYYYQRALG 367
Cdd:pfam17874 114 GLQHLPLHGFLLVGLADLLYEWNDLEEAEQHAQQGIQLGRQW----EPDAAVDAYvLLARIALAQGELEEALTLLRRAEL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 368 IYQTK----------------------------------LGPDDPN---VAKTKNNLASCYLKQGKFKQAETLYKEILTR 410
Cdd:pfam17874 190 LARQSffhvdwlanaervrvrlwlargdlraavrwlraaEPPSDADnhfLERELRNLARVLLALGRFDDALSLLERLQNL 269

                         250
                  ....*....|....*...
gi 1371981716 411 AheREFGSVDDENKpIWM 428
Cdd:pfam17874 270 A--EQLGRVRSLIE-NLI 284
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 265-389 1.07e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.90  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 265 YRDQNKYKDAANLLNDALAirektLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEirekvLGKDHPDVAKQLNN 344
Cdd:COG1729     3 LLKAGDYDEAIAAFKAFLK-----RYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLK-----RYPDSPKAPDALLK 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1371981716 345 LALLCQNQGKYEEVEYYYQRALGIYqtklgPDDPNVAKTKNNLAS 389
Cdd:COG1729    73 LGLSYLELGDYDKARATLEELIKKY-----PDSEAAKEARARLAR 112
TPR_1 pfam00515
Tetratricopeptide repeat;
297-329 1.27e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 1.27e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1371981716 297 AATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 35-149 1.70e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716   35 LEALKNEHNSILQSLLET-LKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQ-VMMALSNHLNAVESEKQKLRAQVRR 112
Cdd:TIGR02168  234 LEELREELEELQEELKEAeEELEELTAELQELEEKLEELRLEVSELEEEIEELQkELYALANEISRLEQQKQILRERLAN 313

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1371981716  113 LCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLE 149
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK 350
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 218-298 2.20e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 44.14  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 218 NLVIQYASQGRYEVAvpLCKQALEDLE------KTSGHDHPDV-ATMLNiLALVYRDQNKYKDAANLLNDALAIREKTLG 290
Cdd:NF040586  736 NLANDLAALGDLDAA--LGEEALERLRrllgedLRAGPDHPDTlACAAN-LALDLRATGRTEEAEELRADTLARLRRVLG 812


                  ....*...
gi 1371981716 291 RDHPAVAA 298
Cdd:NF040586  813 PDHPDTVA 820
TPR_7 pfam13176
Tetratricopeptide repeat;
299-334 2.62e-04

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 38.29  E-value: 2.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1371981716 299 TLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD 334
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALALAKDPYDRE 36
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 297-329 6.52e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.43  E-value: 6.52e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1371981716  297 AATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 29-161 8.05e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.54  E-value: 8.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716   29 KQVIQGLEALKNEHNSILQSLLETLkclkkDDESNLVEEKSSMIRKSLEMLElglSEAQVMMALSNHLNAV-ESEKQKLR 107
Cdd:smart00787 139 MKLLEGLKEGLDENLEGLKEDYKLL-----MKELELLNSIKPKLRDRKDALE---EELRQLKQLEDELEDCdPTELDRAK 210

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1371981716  108 AQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKkhLEFMNQLKKYDDDI 161
Cdd:smart00787 211 EKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKK--SELNTEIAEAEKKL 262
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 302-378 8.34e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 38.09  E-value: 8.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981716 302 NLAVLYGKRGKYKEAEPLCKRALEirekvLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYqtklgPDDP 378
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALA-----RFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAA-----PGDP 68
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 223-284 9.02e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 38.09  E-value: 9.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371981716 223 YASQGRYEVAVPLCKQALEdlektSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAI 284
Cdd:pfam13432   7 ALRAGDYDDAAAALEAALA-----RFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRA 63
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
210-289 1.71e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 210 PARLRTLHNLVIQYASQGRYEVAVPLcKQALEdlektsghDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTL 289
Cdd:COG3063    23 PDNADALNNLGLLLLEQGRYDEAIAL-EKALK--------LDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSAL 93
TPR_1 pfam00515
Tetratricopeptide repeat;
339-366 3.20e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.47  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*...
gi 1371981716 339 AKQLNNLALLCQNQGKYEEVEYYYQRAL 366
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKAL 28
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 10-149 4.59e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 4.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716   10 YIKEEKLEKLT-QDEIISKTKQVIQGLEALKNEHNSILQSLLETlKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQV 88
Cdd:TIGR02169  748 SLEQEIENVKSeLKELEARIEELEEDLHKLEEALNDLEARLSHS-RIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTL 826

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371981716   89 MMA-LSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLE 149
Cdd:TIGR02169  827 EKEyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK 888
TPR_10 pfam13374
Tetratricopeptide repeat;
380-417 5.76e-03

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 34.79  E-value: 5.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1371981716 380 VAKTKNNLASCYLKQGKFKQAETLYKEILTRaHEREFG 417
Cdd:pfam13374   1 TASSLNNLANALRAQGRYDEAEELLEEALAI-RERVLG 37
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 62-147 6.84e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 39.45  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716  62 SNLVEEKSSMIR--KSLEMLELGLSEA-QVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSV 138
Cdd:pfam09726 388 NNQLSKPDALVRleQDIKKLKAELQASrQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTV 467

                          90
                  ....*....|...
gi 1371981716 139 AQLE----EEKKH 147
Cdd:pfam09726 468 QQLEkrlkAEQEA 480
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 295-416 9.90e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 38.10  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981716 295 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPdvAKQ---LNNLA----LLCQNQGKYEEVEYY------ 361
Cdd:cd24145   145 EVGAFLEELATAYDLYGRFCLALPLYMQALSLKGQILLSQAN--CHSlvlMNNEAaelaLHALRKPLSSTLIEAsrlpqk 222

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371981716 362 ------------YQRALGIYQTKLGPD-----DPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREF 416
Cdd:cd24145   223 srdqlleaalkwAQKALDVAKSIKPKDrdpecDQACALALYNLGVIAEMLGNLDEARKLYKEAISLAKELGF 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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