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Conserved domains on  [gi|1339869065|ref|NP_001347448|]
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CD180 antigen isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-367 3.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065  88 NLQKHYFFNISSNT-FHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQiSASNFPSLTHLSIKGNtkR 166
Cdd:COG4886    94 DLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN--Q 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 167 LELGTGCLENLENLRELDLSHDDIETSDCcnlQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRLKVKDAq 246
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQLTDLPE- 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 247 spFQNLHLLKVLNLSHSLL-DISSEQlfdGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFT 325
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLtDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1339869065 326 SLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIL 367
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 29-57 2.67e-10

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


:

Pssm-ID: 408601  Cd Length: 29  Bit Score: 55.16  E-value: 2.67e-10
                          10        20
                  ....*....|....*....|....*....
gi 1339869065  29 SAVFQSLNFGGTQNLLVIFKGLKNSTIQS 57
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 357-431 7.04e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 7.04e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1339869065  357 NLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTL 431
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-367 3.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065  88 NLQKHYFFNISSNT-FHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQiSASNFPSLTHLSIKGNtkR 166
Cdd:COG4886    94 DLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN--Q 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 167 LELGTGCLENLENLRELDLSHDDIETSDCcnlQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRLKVKDAq 246
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQLTDLPE- 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 247 spFQNLHLLKVLNLSHSLL-DISSEQlfdGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFT 325
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLtDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1339869065 326 SLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIL 367
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 29-57 2.67e-10

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 55.16  E-value: 2.67e-10
                          10        20
                  ....*....|....*....|....*....
gi 1339869065  29 SAVFQSLNFGGTQNLLVIFKGLKNSTIQS 57
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR_8 pfam13855
Leucine rich repeat;
228-289 2.95e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 2.95e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1339869065 228 PQLELLDLAFTRLKVkDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHF 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 357-431 7.04e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 7.04e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1339869065  357 NLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTL 431
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-289 5.16e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 131 LKKLVLSANKFENLCQISasNFPSLTHLSIKGNT-KRLElgtgCLENLENLRELDLSHDDIETSDccnlQLRNLSHLQSL 209
Cdd:cd21340    26 LKVLYLYDNKITKIENLE--FLTNLTHLYLQNNQiEKIE----NLENLVNLKKLYLGGNRISVVE----GLENLTNLEEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 210 NLSYN----------EPLSLKTEAfkecPQLELLDLAFTRLkvkDAQSPFQNLHLLKVLNLSHSLLDISSE--QLFDGLP 277
Cdd:cd21340    96 HIENQrlppgekltfDPRSLAALS----NSLRVLNISGNNI---DSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                         170
                  ....*....|..
gi 1339869065 278 ALQHLNLQGNHF 289
Cdd:cd21340   169 SLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
385-434 1.57e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 1.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1339869065  385 NPLDCTCSNIYFLEWyKENMQKLEDTEDTLCENPPLLRG--VRLSDVTLSCS 434
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASPSSLRGplLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-265 1.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065  81 EMSVESINLQKHYFFNISSNTFHC--------FSGLQELDLTATHLS-ELPSgLVGLSTLKKLVLSANKFENLCQISASN 151
Cdd:PLN00113  419 ELPSEFTKLPLVYFLDISNNNLQGrinsrkwdMPSLQMLSLARNKFFgGLPD-SFGSKRLENLDLSRNQFSGAVPRKLGS 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 152 FPSLTHLSIKGNTKRLELGTGcLENLENLRELDLSHDdietsdccnlqlrnlshlqslNLSYNEPLSlkteaFKECPQLE 231
Cdd:PLN00113  498 LSELMQLKLSENKLSGEIPDE-LSSCKKLVSLDLSHN---------------------QLSGQIPAS-----FSEMPVLS 550

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1339869065 232 LLDLAFTRLKvKDAQSPFQNLHLLKVLNLSHSLL 265
Cdd:PLN00113  551 QLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHL 583
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-367 3.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065  88 NLQKHYFFNISSNT-FHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQiSASNFPSLTHLSIKGNtkR 166
Cdd:COG4886    94 DLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN--Q 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 167 LELGTGCLENLENLRELDLSHDDIETSDCcnlQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRLKVKDAq 246
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQLTDLPE- 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 247 spFQNLHLLKVLNLSHSLL-DISSEQlfdGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFT 325
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLtDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1339869065 326 SLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIL 367
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-382 2.22e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 2.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 111 LDLTATHLSELPSGLVGLSTLKKLVLSANKfenlcqiSASNFPSLTHLSIKGNtkRLELGTGCLENLENLRELDLSHDDI 190
Cdd:COG4886    78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN--QLTDLPEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 191 ETSDccnLQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRLKvkDAQSPFQNLHLLKVLNLSHSLL-DISS 269
Cdd:COG4886   149 TDLP---EPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQIT--DLPEPLGNLTNLEELDLSGNQLtDLPE 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 270 EqlFDGLPALQHLNLQGNhfpkgNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAftSLKMMNHVDLSHNRLTSSSIEALS 349
Cdd:COG4886   223 P--LANLTNLETLDLSNN-----QLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELE 293

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1339869065 350 HLKGIYLNLASNRISIILPSLLPILSQQRTINL 382
Cdd:COG4886   294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-387 5.06e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 5.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065  96 NISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLE 175
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 176 NLENLRELDLSHddietsdccNLQLRNLSHLQSLNLSYNEPLSLkTEAFKECPQLELLDLAFTRLkvKDAQSPFQNLHLL 255
Cdd:COG4886    94 DLTNLTELDLSG---------NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL--TDLPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 256 KVLNLSHSLL-DISSEqlFDGLPALQHLNLQGNHFpkGNIqkTNSLQTLGRLEILVLSFCDLSSIDQhAFTSLKMMNHVD 334
Cdd:COG4886   162 KSLDLSNNQLtDLPEE--LGNLTNLKELDLSNNQI--TDL--PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLD 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1339869065 335 LSHNRLTS-SSIEALSHLKgiYLNLASNRISIILPSLLpiLSQQRTINLRQNPL 387
Cdd:COG4886   235 LSNNQLTDlPELGNLTNLE--ELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQL 284
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 29-57 2.67e-10

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 55.16  E-value: 2.67e-10
                          10        20
                  ....*....|....*....|....*....
gi 1339869065  29 SAVFQSLNFGGTQNLLVIFKGLKNSTIQS 57
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR_8 pfam13855
Leucine rich repeat;
228-289 2.95e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 2.95e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1339869065 228 PQLELLDLAFTRLKVkDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHF 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-327 5.76e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 5.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 108 LQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLcQISASNFPSLTHLSIKGNT-KRLElgtgCLENLENLRELDLS 186
Cdd:COG4886   184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQlTDLP----ELGNLTNLEELDLS 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 187 HDDIETSDccnlQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLD 266
Cdd:COG4886   259 NNQLTDLP----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1339869065 267 ISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSL 327
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-316 2.42e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 2.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 106 SGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQIsaSNFPSLTHLSIKGNTKRlelGTGCLENLENLRELDL 185
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLT---DLPPLANLTNLKTLDL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 186 SHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLL 265
Cdd:COG4886   280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLL 359

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1339869065 266 DISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDL 316
Cdd:COG4886   360 SLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 357-431 7.04e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 7.04e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1339869065  357 NLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTL 431
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75
LRR_8 pfam13855
Leucine rich repeat;
305-363 7.25e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 305 RLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRI 363
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLrYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-289 5.16e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 131 LKKLVLSANKFENLCQISasNFPSLTHLSIKGNT-KRLElgtgCLENLENLRELDLSHDDIETSDccnlQLRNLSHLQSL 209
Cdd:cd21340    26 LKVLYLYDNKITKIENLE--FLTNLTHLYLQNNQiEKIE----NLENLVNLKKLYLGGNRISVVE----GLENLTNLEEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 210 NLSYN----------EPLSLKTEAfkecPQLELLDLAFTRLkvkDAQSPFQNLHLLKVLNLSHSLLDISSE--QLFDGLP 277
Cdd:cd21340    96 HIENQrlppgekltfDPRSLAALS----NSLRVLNISGNNI---DSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                         170
                  ....*....|..
gi 1339869065 278 ALQHLNLQGNHF 289
Cdd:cd21340   169 SLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 154-342 8.19e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 8.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 154 SLTHLSIkgNTKRLElGTGCLENLENLRELDLSHDDIETsdCCNLQlrNLSHLQSLNLSYNEpLSlKTEAFKECPQLELL 233
Cdd:cd21340     3 RITHLYL--NDKNIT-KIDNLSLCKNLKVLYLYDNKITK--IENLE--FLTNLTHLYLQNNQ-IE-KIENLENLVNLKKL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 234 DLAFTRLKVKDAqspFQNLHLLKVLNLSHSLLDISSEQLFDG------LPALQHLNLQGNhfpkgNIQKTNSLQTLGRLE 307
Cdd:cd21340    74 YLGGNRISVVEG---LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNISGN-----NIDSLEPLAPLRNLE 145

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1339869065 308 ILVLSFCDLSSIDQ--HAFTSLKMMNHVDLSHNRLTS 342
Cdd:cd21340   146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK 182
LRRCT smart00082
Leucine rich repeat C-terminal domain;
385-434 1.57e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 1.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1339869065  385 NPLDCTCSNIYFLEWyKENMQKLEDTEDTLCENPPLLRG--VRLSDVTLSCS 434
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASPSSLRGplLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
129-190 6.50e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 6.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1339869065 129 STLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLeLGTGCLENLENLRELDLSHDDI 190
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-265 1.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065  81 EMSVESINLQKHYFFNISSNTFHC--------FSGLQELDLTATHLS-ELPSgLVGLSTLKKLVLSANKFENLCQISASN 151
Cdd:PLN00113  419 ELPSEFTKLPLVYFLDISNNNLQGrinsrkwdMPSLQMLSLARNKFFgGLPD-SFGSKRLENLDLSRNQFSGAVPRKLGS 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 152 FPSLTHLSIKGNTKRLELGTGcLENLENLRELDLSHDdietsdccnlqlrnlshlqslNLSYNEPLSlkteaFKECPQLE 231
Cdd:PLN00113  498 LSELMQLKLSENKLSGEIPDE-LSSCKKLVSLDLSHN---------------------QLSGQIPAS-----FSEMPVLS 550

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1339869065 232 LLDLAFTRLKvKDAQSPFQNLHLLKVLNLSHSLL 265
Cdd:PLN00113  551 QLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 153-349 8.13e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 8.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 153 PSLTHLSIKGN-TKRLELGTGC----LENLENLRELDLSHDDIETSDCCNLQ-LRNLSHLQSLNLSYNE----PLSLKTE 222
Cdd:cd00116    51 PSLKELCLSLNeTGRIPRGLQSllqgLTKGCGLQELDLSDNALGPDGCGVLEsLLRSSSLQELKLNNNGlgdrGLRLLAK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 223 AFKEC-PQLELLDLAFTRLKV---KDAQSPFQNLHLLKVLNLS-HSLLDISSEQLFDGLPA---LQHLNLQGNhfpkgni 294
Cdd:cd00116   131 GLKDLpPALEKLVLGRNRLEGascEALAKALRANRDLKELNLAnNGIGDAGIRALAEGLKAncnLEVLDLNNN------- 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1339869065 295 qktnslqTLGRLEILVLSfcdlssidqHAFTSLKMMNHVDLSHNRLTSSSIEALS 349
Cdd:cd00116   204 -------GLTDEGASALA---------ETLASLKSLEVLNLGDNNLTDAGAAALA 242
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 103-269 2.33e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 103 HCFSGLQELDLTATHLS-----ELPSGLVGLSTLKKLVLSANK-----FENLCQISASNfPSLTHLSIKGNTKRLELG-- 170
Cdd:cd00116   134 DLPPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGigdagIRALAEGLKAN-CNLEVLDLNNNGLTDEGAsa 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 171 -TGCLENLENLRELDLSHDDIETSDCCNL--QLRNLSH-LQSLNLSYNE--PLSLKT--EAFKECPQLELLDLAFTRLKV 242
Cdd:cd00116   213 lAETLASLKSLEVLNLGDNNLTDAGAAALasALLSPNIsLLTLSLSCNDitDDGAKDlaEVLAEKESLLELDLRGNKFGE 292

                         170       180
                  ....*....|....*....|....*..
gi 1339869065 243 KDAQSPFQNLHLLKVLNLSHSLLDISS 269
Cdd:cd00116   293 EGAQLLAESLLEPGNELESLWVKDDSF 319
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 108-387 3.31e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 108 LQELDLTATHLS-ELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNtkrlELGTGCLENL---ENLREL 183
Cdd:PLN00113  286 LISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN----KFSGEIPKNLgkhNNLTVL 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 184 DLSHDD----IETSDCCNLQLRNLShLQSLNLSYNEPLSLKTeafkeCPQLELLDLAFTRLKvKDAQSPFQNLHLLKVLN 259
Cdd:PLN00113  362 DLSTNNltgeIPEGLCSSGNLFKLI-LFSNSLEGEIPKSLGA-----CRSLRRVRLQDNSFS-GELPSEFTKLPLVYFLD 434

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339869065 260 LSHS-----------------LLDISSEQLFDGLP------ALQHLNLQGNHFpKGNIqkTNSLQTLGRLEILVLSFCDL 316
Cdd:PLN00113  435 ISNNnlqgrinsrkwdmpslqMLSLARNKFFGGLPdsfgskRLENLDLSRNQF-SGAV--PRKLGSLSELMQLKLSENKL 511

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1339869065 317 SSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRISIILPSLLPILSQQRTINLRQNPL 387
Cdd:PLN00113  512 SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLsQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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