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Conserved domains on  [gi|1331036862|ref|NP_001346765|]
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uncharacterized protein LOC381933 isoform 4 [Mus musculus]

Protein Classification

calponin homology domain-containing protein( domain architecture ID 10533622)

calponin homology (CH) domain-containing protein may bind actin filament (F-actin) or serve a regulatory function

CATH:  1.10.418.10
Gene Ontology:  GO:0008017
PubMed:  12186940|11911887

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_2 pfam06294
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
 22-113 2.98e-46

CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.


:

Pssm-ID: 461871  Cd Length: 91  Bit Score: 149.12  E-value: 2.98e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036862  22 LCAWLDRLPLSRPKRHLARDFSDGVLVAEIVKHFRPRLVDLHSYVPACSTDQKLSNWSLLnRKVFRKLHLCISDNDIQRV 101
Cdd:pfam06294   1 LLKWLQSLDLSRPVRNIARDFSDGFLVAEILSRYYPKLVDLHNYSPGSSVAAKLNNWETL-EKVLKKLGIKLSKEDIEDL 79

                          90
                  ....*....|..
gi 1331036862 102 VSNRPGVIESIL 113
Cdd:pfam06294  80 ANGKPGAAERLL 91
 
Name Accession Description Interval E-value
CH_2 pfam06294
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
 22-113 2.98e-46

CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.


Pssm-ID: 461871  Cd Length: 91  Bit Score: 149.12  E-value: 2.98e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036862  22 LCAWLDRLPLSRPKRHLARDFSDGVLVAEIVKHFRPRLVDLHSYVPACSTDQKLSNWSLLnRKVFRKLHLCISDNDIQRV 101
Cdd:pfam06294   1 LLKWLQSLDLSRPVRNIARDFSDGFLVAEILSRYYPKLVDLHNYSPGSSVAAKLNNWETL-EKVLKKLGIKLSKEDIEDL 79

                          90
                  ....*....|..
gi 1331036862 102 VSNRPGVIESIL 113
Cdd:pfam06294  80 ANGKPGAAERLL 91
 
Name Accession Description Interval E-value
CH_2 pfam06294
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
 22-113 2.98e-46

CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.


Pssm-ID: 461871  Cd Length: 91  Bit Score: 149.12  E-value: 2.98e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036862  22 LCAWLDRLPLSRPKRHLARDFSDGVLVAEIVKHFRPRLVDLHSYVPACSTDQKLSNWSLLnRKVFRKLHLCISDNDIQRV 101
Cdd:pfam06294   1 LLKWLQSLDLSRPVRNIARDFSDGFLVAEILSRYYPKLVDLHNYSPGSSVAAKLNNWETL-EKVLKKLGIKLSKEDIEDL 79

                          90
                  ....*....|..
gi 1331036862 102 VSNRPGVIESIL 113
Cdd:pfam06294  80 ANGKPGAAERLL 91
CAMSAP_CH pfam11971
CAMSAP CH domain; This domain is the N-terminal CH domain from the CAMSAP proteins.
 23-90 9.16e-15

CAMSAP CH domain; This domain is the N-terminal CH domain from the CAMSAP proteins.


Pssm-ID: 432229  Cd Length: 85  Bit Score: 67.71  E-value: 9.16e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036862  23 CAWLDRLPLSRPKRHLARDFSDGVLVAEIVKHFRPRLVDLHSY--VPACSTDQKLSNWSLLNRKVFRKLH 90
Cdd:pfam11971   1 PLSQRSLPLSPPVEDLLRDLSDGCALAALIHFYCPQLIDLEDIclKESMSLADSLYNIQLLQEFCQRHLG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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