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Conserved domains on  [gi|1327850528|ref|NP_001346644|]
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uncharacterized protein LOC72128 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
10-69 1.03e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.45  E-value: 1.03e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528   10 VSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSLGCCVIKPELILMLEREFGPW 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-616 4.35e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 271 KPYECVECSKTFYCKSYLIRHqSRTHSREKPYECT--ECTKTFYCKSDLTRHQTTHSGEKPFECNECSKTFYYKSDlanh 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRH-IRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS---- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 349 qktHTDDNPYECKECRKTFCSKSSLNQHHR---IHTGEKPYE--CNECKKSFNSKSNLTEHQRRTHTREKPyecNECWKS 423
Cdd:COG5048   107 ---SSSLSSSSSNSNDNNLLSSHSLPPSSRdpqLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 424 FYCRSELTNHQRTHTVERYYECKECRKnFYCKSNLNQHQRTHTGEKPYECKDCNKAFYCKSNLNQHQRTHTGEKPFACKD 503
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 504 CSKAFYCKSSLVKHQKIHSGE-------KPYECEECRKTFFQKSDLTRHQRT--HTGE--KPYEC--KDCSKTFYCKSNL 570
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1327850528 571 NQHQRTHTHEKPYECKECRETFYSKSELTEHQRTHTDEKPYVMFNI 616
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
10-69 1.03e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.45  E-value: 1.03e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528   10 VSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSLGCCVIKPELILMLEREFGPW 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.95e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.95e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1327850528   9 SVSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSLG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-49 2.16e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 2.16e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1327850528  10 VSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSL 49
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-616 4.35e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 271 KPYECVECSKTFYCKSYLIRHqSRTHSREKPYECT--ECTKTFYCKSDLTRHQTTHSGEKPFECNECSKTFYYKSDlanh 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRH-IRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS---- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 349 qktHTDDNPYECKECRKTFCSKSSLNQHHR---IHTGEKPYE--CNECKKSFNSKSNLTEHQRRTHTREKPyecNECWKS 423
Cdd:COG5048   107 ---SSSLSSSSSNSNDNNLLSSHSLPPSSRdpqLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 424 FYCRSELTNHQRTHTVERYYECKECRKnFYCKSNLNQHQRTHTGEKPYECKDCNKAFYCKSNLNQHQRTHTGEKPFACKD 503
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 504 CSKAFYCKSSLVKHQKIHSGE-------KPYECEECRKTFFQKSDLTRHQRT--HTGE--KPYEC--KDCSKTFYCKSNL 570
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1327850528 571 NQHQRTHTHEKPYECKECRETFYSKSELTEHQRTHTDEKPYVMFNI 616
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-510 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 1327850528 485 NLNQHQRTHTGEKPFACKDCSKAFYC 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
10-69 1.03e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.45  E-value: 1.03e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528   10 VSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSLGCCVIKPELILMLEREFGPW 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.95e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.95e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1327850528   9 SVSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSLG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-49 2.16e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 2.16e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1327850528  10 VSFEDIAVFFTWEEWQDLDIAQKLLYRDVMLENYSSLVSL 49
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-616 4.35e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 271 KPYECVECSKTFYCKSYLIRHqSRTHSREKPYECT--ECTKTFYCKSDLTRHQTTHSGEKPFECNECSKTFYYKSDlanh 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRH-IRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS---- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 349 qktHTDDNPYECKECRKTFCSKSSLNQHHR---IHTGEKPYE--CNECKKSFNSKSNLTEHQRRTHTREKPyecNECWKS 423
Cdd:COG5048   107 ---SSSLSSSSSNSNDNNLLSSHSLPPSSRdpqLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 424 FYCRSELTNHQRTHTVERYYECKECRKnFYCKSNLNQHQRTHTGEKPYECKDCNKAFYCKSNLNQHQRTHTGEKPFACKD 503
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 504 CSKAFYCKSSLVKHQKIHSGE-------KPYECEECRKTFFQKSDLTRHQRT--HTGE--KPYEC--KDCSKTFYCKSNL 570
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1327850528 571 NQHQRTHTHEKPYECKECRETFYSKSELTEHQRTHTDEKPYVMFNI 616
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-585 4.24e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 215 YECEECRKSFHRKANLIRHQrRTHSREKPYEC--IECGKTFYCKSDVTRHQRRTH-------------------SREKPY 273
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHI-RSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnnpsdlnskslplsnskasSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 274 ECVECSKTFYCKSYLIRHQSRthSREKPYECTECTKTFYCKSDLTRHQTTHSGEKPFE-----CNECSKTFYYKSDLANH 348
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSR--DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpaNSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 349 QKTHTDDNPYECKECRKTFcSKSSLNQHHRIHTGEKPYECNEC-----------KKSFNSKSNLTEHQRRTHTREKPYEc 417
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSY-SIPSSSSDQNLENSSSSLPLTTNsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTA- 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 418 NECWKSFYCRSELTNHQRTHTveryYECKECRKNFYCKSNLNQHQRT--HTGE--KPYEC--KDCNKAFYCKSNLNQHQR 491
Cdd:COG5048   269 SSQSSSPNESDSSSEKGFSLP----IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 492 THTGEKPFACKDCS-------KAFYCKSSLVKHQKIHSGEKPYECE--ECRKTFFQKSDLTRHQRTHTGEKPYECKD--C 560
Cdd:COG5048   345 LHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNppC 424

                         410       420
                  ....*....|....*....|....*
gi 1327850528 561 SKTFYCKSNLNQHQRTHTHEKPYEC 585
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-545 2.76e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 291 HQSRTHSREKPYECTEcTKTFYCKSDLTRHQTTHSGEKPFECNECSKTFYYKSDLANHQKTHTDDNPYECKECRKTFCSK 370
Cdd:COG5048   189 SSNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 371 SSLNQHHRIHTGE-------KPYECNECKKSFNSKSNLTEHQRRT-HTRE--KPYECNE--CWKSFYCRSELTNHQRTHT 438
Cdd:COG5048   268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 439 VERYYECKECRKNFYCKSNLN-------QHQRTHTGEKPYEC--KDCNKAFYCKSNLNQHQRTHTGEKP--FACKDCSKA 507
Cdd:COG5048   348 SISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1327850528 508 FYCKSSLVKHQKIHSGEKPYECeECRKTFFQKSDLTRH 545
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-510 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 1327850528 485 NLNQHQRTHTGEKPFACKDCSKAFYC 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-512 1.24e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 223 SFHRKANLIRHQRRTHSREKPYECIECGKTFYCKSDVTRHQRRTHSReKPYECVECSKTFYCKSYLIRHQSRTHSR---- 298
Cdd:COG5048   203 SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS-SSDSSSSASESPRSSLPTASSQSSSPNEsdss 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 299 -----EKPYECTECTKTFYCKSDLTRHQ--TTHSGE--KPFECNE--CSKTFYYKSDLANHQKTHTDDNPYECKECRKTF 367
Cdd:COG5048   282 sekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 368 CSKSSLN-------QHHRIHTGEKPYEC--NECKKSFNSKSNLTEHqRRTHTREKPYECnecwksfycrseltnhqrtht 438
Cdd:COG5048   362 KFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH-IITHLSFRPYNC--------------------- 419

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1327850528 439 veryyeckecrKNFYCKSNLNQHqrthtgekpyeckdcnkafyckSNLNQHQRTHTGEKPFACKDCSKAFYCKS 512
Cdd:COG5048   420 -----------KNPPCSKSFNRH----------------------YNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-566 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 1327850528 541 DLTRHQRTHTGEKPYECKDCSKTFYC 566
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-482 1.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 1327850528 457 NLNQHQRTHTGEKPYECKDCNKAFYC 482
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
372-397 2.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1327850528 372 SLNQHHRIHTGEKPYECNECKKSFNS 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 495-579 4.62e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 495 GEKPFACK--DCSKAfYCKSSLVKHQKIHSgekpyeceECRKTFFQKSDLTRHQRTHTGEKPYECKDCSKTFyckSNLN- 571
Cdd:COG5189   346 DGKPYKCPveGCNKK-YKNQNGLKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY---KNLNg 413


                  ....*....
gi 1327850528 572 -QHQRTHTH 579
Cdd:COG5189   414 lKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 467-550 7.12e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850528 467 GEKPYECK--DCNKAFYCKSNLNQHqRTHtgekpfacKDCSKAFYCKSSLVKHQKIHSGEKPYECEECRKTFFQKSDLTR 544
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1327850528 545 HqRTHT 550
Cdd:COG5189   417 H-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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