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Conserved domains on  [gi|1327850489|ref|NP_001346560|]
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transcriptional repressor p66-alpha isoform 3 [Homo sapiens]

Protein Classification

P66_CC and GATA domain-containing protein( domain architecture ID 10964881)

protein containing domains Med21, P66_CC, and GATA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 137-176 2.30e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


:

Pssm-ID: 465178  Cd Length: 40  Bit Score: 72.84  E-value: 2.30e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1327850489 137 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 176
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 418-452 4.76e-08

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


:

Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 49.24  E-value: 4.76e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1327850489 418 CAQCKTDFTCRWREEKSGAI-MCENCMTTNQKKALK 452
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
Med21 super family cl12769
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 98-167 3.23e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


The actual alignment was detected with superfamily member pfam11221:

Pssm-ID: 463241  Cd Length: 134  Bit Score: 37.96  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850489  98 PPSPDVIVLSDNEQPSSPRV--------NGL----TTVALKETSTEAL------MKSSPEERERMIKQLKEELRLEEAKL 159
Cdd:pfam11221  32 PLPPNDPISPDKAPPQPEPEpdppeefeATQrelaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEER 111

                          90
                  ....*....|....*.
gi 1327850489 160 V--------LLKKLRQ 167
Cdd:pfam11221 112 QeavkekeeLLKKLDE 127
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 137-176 2.30e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 72.84  E-value: 2.30e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1327850489 137 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 176
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 418-452 4.76e-08

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 49.24  E-value: 4.76e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1327850489 418 CAQCKTDFTCRWREEKSGAI-MCENCMTTNQKKALK 452
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 98-167 3.23e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 37.96  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850489  98 PPSPDVIVLSDNEQPSSPRV--------NGL----TTVALKETSTEAL------MKSSPEERERMIKQLKEELRLEEAKL 159
Cdd:pfam11221  32 PLPPNDPISPDKAPPQPEPEpdppeefeATQrelaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEER 111

                          90
                  ....*....|....*.
gi 1327850489 160 V--------LLKKLRQ 167
Cdd:pfam11221 112 QeavkekeeLLKKLDE 127
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 137-176 2.30e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 72.84  E-value: 2.30e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1327850489 137 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 176
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 418-452 4.76e-08

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 49.24  E-value: 4.76e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1327850489 418 CAQCKTDFTCRWREEKSGAI-MCENCMTTNQKKALK 452
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 98-167 3.23e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 37.96  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850489  98 PPSPDVIVLSDNEQPSSPRV--------NGL----TTVALKETSTEAL------MKSSPEERERMIKQLKEELRLEEAKL 159
Cdd:pfam11221  32 PLPPNDPISPDKAPPQPEPEpdppeefeATQrelaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEER 111

                          90
                  ....*....|....*.
gi 1327850489 160 V--------LLKKLRQ 167
Cdd:pfam11221 112 QeavkekeeLLKKLDE 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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