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Conserved domains on  [gi|1306255355|ref|NP_001345850|]
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4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 68-353 4.27e-153

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member PLN02809:

Pssm-ID: 469727  Cd Length: 289  Bit Score: 432.58  E-value: 4.27e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  68 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANR 147
Cdd:PLN02809    3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 148 PIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS 227
Cdd:PLN02809   83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 228 CDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAAL 307
Cdd:PLN02809  163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1306255355 308 GAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLW 353
Cdd:PLN02809  243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 68-353 4.27e-153

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 432.58  E-value: 4.27e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  68 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANR 147
Cdd:PLN02809    3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 148 PIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS 227
Cdd:PLN02809   83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 228 CDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAAL 307
Cdd:PLN02809  163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1306255355 308 GAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLW 353
Cdd:PLN02809  243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 71-352 9.03e-148

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 418.65  E-value: 9.03e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  71 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIA 150
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 151 AGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 230
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 231 sVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAV 310
Cdd:TIGR01474 161 -AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1306255355 311 GAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNL 352
Cdd:TIGR01474 240 ALLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 78-350 1.33e-119

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 346.76  E-value: 1.33e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  78 MRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTF 157
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 158 QSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPsVCLPLY 237
Cdd:cd13959    81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPL-PALLLY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 238 FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAVgAHLTHQ 317
Cdd:cd13959   160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAA-AHLLWQ 238

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1306255355 318 IYTLDIHRPE-DCWNKFISNRTLGLIVFLGIVLG 350
Cdd:cd13959   239 EHRLDLPDPLrSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 72-349 1.55e-73

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 229.73  E-value: 1.55e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  72 QPYLRLMRLDKPIGTWLLYLPCTWSIGLAAepGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAA 151
Cdd:COG0382     1 RAYLRLLRLDRPIGILLLLWPTLWALFLAA--GGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 152 GDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 230
Cdd:COG0382    79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 231 SVcLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSG-FSVAMLGALSLVGVNSGQTAPYYAALGA 309
Cdd:COG0382   159 SA-WLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1306255355 310 VGAHL-THQIYTLD--IHRPEDCWNKFISNRTLGLIVFLGIVL 349
Cdd:COG0382   238 ALLLLyLSQLWLLRprKKDPARALKLFKLNMLLGLLLFLGIAL 280
UbiA pfam01040
UbiA prenyltransferase family;
97-333 2.07e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 156.23  E-value: 2.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  97 IGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLC 176
Cdd:pfam01040   7 AGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALGLLLLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 177 LNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVcLPLYFSGVMWTLIYDTIYAHQD 255
Cdd:pfam01040  87 LNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA-LLLALALFLWTWAIALANDLRD 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1306255355 256 KRDDVLIGLKSTALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKF 333
Cdd:pfam01040 166 REDDRKAGIKTLPVVLGRKAARILLaLLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDPKKDAKAF 244
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 68-353 4.27e-153

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 432.58  E-value: 4.27e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  68 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANR 147
Cdd:PLN02809    3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 148 PIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS 227
Cdd:PLN02809   83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 228 CDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAAL 307
Cdd:PLN02809  163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1306255355 308 GAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLW 353
Cdd:PLN02809  243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 71-352 9.03e-148

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 418.65  E-value: 9.03e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  71 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIA 150
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 151 AGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 230
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 231 sVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAV 310
Cdd:TIGR01474 161 -AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1306255355 311 GAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNL 352
Cdd:TIGR01474 240 ALLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 78-350 1.33e-119

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 346.76  E-value: 1.33e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  78 MRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTF 157
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 158 QSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPsVCLPLY 237
Cdd:cd13959    81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPL-PALLLY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 238 FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAVgAHLTHQ 317
Cdd:cd13959   160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAA-AHLLWQ 238

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1306255355 318 IYTLDIHRPE-DCWNKFISNRTLGLIVFLGIVLG 350
Cdd:cd13959   239 EHRLDLPDPLrSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 72-349 1.55e-73

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 229.73  E-value: 1.55e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  72 QPYLRLMRLDKPIGTWLLYLPCTWSIGLAAepGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAA 151
Cdd:COG0382     1 RAYLRLLRLDRPIGILLLLWPTLWALFLAA--GGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 152 GDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 230
Cdd:COG0382    79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 231 SVcLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSG-FSVAMLGALSLVGVNSGQTAPYYAALGA 309
Cdd:COG0382   159 SA-WLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1306255355 310 VGAHL-THQIYTLD--IHRPEDCWNKFISNRTLGLIVFLGIVL 349
Cdd:COG0382   238 ALLLLyLSQLWLLRprKKDPARALKLFKLNMLLGLLLFLGIAL 280
UbiA pfam01040
UbiA prenyltransferase family;
97-333 2.07e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 156.23  E-value: 2.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  97 IGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLC 176
Cdd:pfam01040   7 AGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALGLLLLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 177 LNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVcLPLYFSGVMWTLIYDTIYAHQD 255
Cdd:pfam01040  87 LNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA-LLLALALFLWTWAIALANDLRD 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1306255355 256 KRDDVLIGLKSTALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKF 333
Cdd:pfam01040 166 REDDRKAGIKTLPVVLGRKAARILLaLLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDPKKDAKAF 244
ubiA PRK12873
4-hydroxybenzoate polyprenyltransferase;
71-353 2.64e-41

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 171787 [Multi-domain]  Cd Length: 294  Bit Score: 146.73  E-value: 2.64e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  71 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAaePGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIA 150
Cdd:PRK12873    7 LSPWFELLRWNKPTGRLILLIPAGWSLWLT--PSAPPSLLLLLLIILGGLAVSGAGCIANDLWDRRIDRKVERTKNRPLA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 151 AGDISTFQSFVFLGGQLTLALGVLLCL----NYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKG 226
Cdd:PRK12873   85 RGKISLKTAYSLLIVLLLLSLFVVLSLpqpsRNLCLSLAFLALPPILIYPSAKRWFAYPQAILALCWGFAVLIPWAAAEG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 227 SCDPSVclPLYFS---GVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPY 303
Cdd:PRK12873  165 SLNGGW--PLLFCwlaTLLWTFGFDTVYAMADRRDDAKIGLNSSALSLGSNALKTVQICYFLTSIFLALAAFIAQVGFIF 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1306255355 304 YAAlgAVGAHLTHQIYTLDIHRPEDCWNKF---ISNRT-LGLIVFLGIVLGNLW 353
Cdd:PRK12873  243 WPF--WLIASIGMQRDILKLFPEKQSIKTIgnhFSNQViLGSLLLLGLILARGG 294
ubiA_other TIGR01475
putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this ...
 106-353 1.33e-27

putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this model represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273646  Cd Length: 282  Bit Score: 109.75  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 106 FPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALG 185
Cdd:TIGR01475  32 LPGLKTLILILIAAVSARTAAMAFNRIIDRAIDARNPRTKNRPLVSGLISKKEARTMIILSLALFLSASYFLNPLAFILS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 186 AGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVCLPLYFSGV-MWTLIYDTIYAHQDKRDDVLIGL 264
Cdd:TIGR01475 112 PLVLLVLIIYPYTKRFTFLCHYVLGSTYGLAPLAGWVAVIGTISFFLVAWLLGIGVgFWIAGFDLIYAIQDYEFDRKNGL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 265 KSTALRFGENTKPWLSGFS-VAMLGALSLVGVNSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKFIS-NRTLGLI 342
Cdd:TIGR01475 192 HSIPARFGIKAALKIASLShVITFILLLLVGFYVGNGYIALLALILIGLILAYEHYIVDPGDQSKIQRAFFYaNGFLSIT 271

                         250
                  ....*....|.
gi 1306255355 343 VFLGIVLGNLW 353
Cdd:TIGR01475 272 FLIGVIIDVLL 282
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 79-350 1.49e-16

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 78.93  E-value: 1.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  79 RLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGtGAILMRGAGCTINDMWDQDYDKKvtRTANRPIAAGDISTFQ 158
Cdd:cd13956     2 RLMRPYTLLYVLAPALAGAALAGAFAGPLPALLLLALL-AVFLGAGAGYALNDYTDRELDAI--NKPDRPLPSGRLSPRQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 159 SFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLA-LGLTFNWGALLGWSAIKGSCDPSVCLPLY 237
Cdd:cd13956    79 ALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGWGvLGYATGLALLPGLGAVAAGGLVPLALLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 238 FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAhLTH 316
Cdd:cd13956   159 LVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAaGLLLAALILVVLLAVAGLLGPLALLALLAVAL-LAL 237

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1306255355 317 QIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLG 350
Cdd:cd13956   238 RARFARADRLPALPRGFLLLAVYRLLLFAALLLA 271
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 78-230 8.33e-14

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 70.93  E-value: 8.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  78 MRLDKPIGTWLLYLpcTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTF 157
Cdd:cd13957     1 LELTKPRITLLVLL--TALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 158 QSFVFLGGQLTLALGVL-LCLNYYSIALGAGSLLL-VITYPLMKRISYWpqlalgltFN--WGA-------LLGWSAIKG 226
Cdd:cd13957    79 HALIFGLVLGILGLALLaLFVNPLTALLGLLGIFLyVFVYTPLKKRTTP--------LNtvIGGiagaippLIGWAAATG 150


                  ....
gi 1306255355 227 SCDP 230
Cdd:cd13957   151 SLDL 154
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
129-353 1.37e-13

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 70.42  E-value: 1.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 129 INDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLA 208
Cdd:PRK12874   66 FNRLVDRDIDKDNPRTANRPSVDGRISVKSMVLFIVLNALIFIGVSYFINPLAFKLSFPFLIVLGGYSYFKRFSSLAHLV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 209 LGLTFNWGALLGWSAIKGSCDP-SVCLPLyfsGVM-WTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFS--V 284
Cdd:PRK12874  146 LGLSLGLAPIAGVVAVLGEIPLwSVFLAL---GVMfWVAGFDLLYSLQDMEFDKKRGLHSIPSKFGEKATLFISRLFhlL 222

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 285 AMLGALSLVGV-NSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWnkFISNRTLGLIVFLGIVLGNLW 353
Cdd:PRK12874  223 AVLFWLLFVWCaHLGLFAYLGVIVSALILLYEHYLVRKDFKKIDKAF--FTLNGYLGIVFFIFIVLDVLF 290
ubiA PRK12886
prenyltransferase; Reviewed
 108-314 1.60e-13

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 70.10  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 108 DWYMLSLFGTgailmRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAG 187
Cdd:PRK12886   45 DWILMAMVGA-----RTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPLCLYLSPP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 188 SLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVCLpLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKST 267
Cdd:PRK12886  120 ALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIRGTIELPAIL-LGLAVLFWVAGFDILYALQDLEFDRKEGLHSI 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1306255355 268 ALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHL 314
Cdd:PRK12886  199 PAKLGVNGSLWIArVFHLLMIGFLFALGISAGLGPWFLAGLAVTGILL 246
ubiA PRK13106
prenyltransferase; Reviewed
 74-349 7.33e-13

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 68.21  E-value: 7.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  74 YLRLMRLDKPigtwLLYLPCTWSIGLAAEPGcFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGD 153
Cdd:PRK13106   18 ILRFLRIEQT----FFSLPMAYLGAFVAIKG-IPPISTLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRPLVTGA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 154 ISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVC 233
Cdd:PRK13106   93 IKISEAKALITAGLILFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLASIQGLAVFSGAVAVLGLYANSLI 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 234 LPLY-------FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPwLSGFSVAMLGALSLVGVNSGQTAPYYAA 306
Cdd:PRK13106  173 QVLLrvpwlfvIGTILWAAGFDLYNHIPDAEFDREMGLHSFAVVLGKWALT-FAGLNQLFSVVLDLLGDLYYGLGPIAIA 251

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1306255355 307 LGAVGAHLTHQIYTLdIHRPEDCWNKFISNRTLGLIVFLGIVL 349
Cdd:PRK13106  252 ATILHGLIMAYAYYL-ASKKGDFGRAFYYNIYSSIVLGLGIII 293
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 99-230 7.93e-12

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 65.16  E-value: 7.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  99 LAAEPGCFPDWYML-SLFGTGaiLMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCL 177
Cdd:PRK04375   34 LLAPPGVPPLLLLLlTLLGIA--LVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPREALIFGLVLGVLGFLLLGLF 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1306255355 178 -NYYSIALGAGSLLL-VITYPL-MKRISywPQ------LAlgltfnwGA---LLGWSAIKGSCDP 230
Cdd:PRK04375  112 vNPLAAWLTLAGIFFyVVVYTLwLKRRT--PQniviggAA-------GAmppLIGWAAVTGSLSW 167
ubiA PRK12876
prenyltransferase; Reviewed
 89-273 2.15e-11

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 64.00  E-value: 2.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  89 LYLPCTwSIGLAAEPGcfpdWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTfqSFVFLGGQLT 168
Cdd:PRK12876   31 LSLPEI-SFSLFSLGG----IKTISLGGSAFFCARTVGIIVNQIIDCAIDKKNPRTSSRVLPAKLLSI--NFSMLLLTLC 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 169 LALGVLLC--LNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGScdpSVCLPLYFSGVMWTLI 246
Cdd:PRK12876  104 SFLFLSLCwlLNPLCFSLAVLSTLLMIIYPYTKRVTFLCHWILGLVYYLAILMNFFAIIET---PLSFSLFCMASLWGIS 180

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1306255355 247 Y-------DTIYAHQDKRDDVLIGLKSTALRFGE 273
Cdd:PRK12876  181 FgmiiaanDIIYAIQDLEFDRKEGLFSIPARFGE 214
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
107-328 4.21e-10

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 60.12  E-value: 4.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 107 PDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGA 186
Cdd:PRK12888   36 VHWADLLLVTVAMVGARTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRTAWTGALVALAVFLGAAALLNPLCLALAP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 187 GSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCD-PSVCLPLYFSgvMWTLIYDTIYAHQDKRDDVLIGLK 265
Cdd:PRK12888  116 LAVAPLVVYPYAKRFTNFPHAILGLAQAVGPVGAWIAVTGTWSwPAVLLGLAVG--LWIGGFDLIYACQDAEVDRRIGVR 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1306255355 266 STALRFGENTKPWLSGFS-VAMLGALSLVGVNSGQTAPYYAALGAVGAHLthqIYTLDIHRPED 328
Cdd:PRK12888  194 SVPARFGVRAALWASRVAhVVTFALFVWFGLAVGFGALWWIGLAITAGAF---AYEHAIVSPTD 254
ubiA PRK12895
prenyltransferase; Reviewed
 99-350 1.56e-06

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 49.04  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  99 LAAEPGCFPDWYMLSLFGtgAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLN 178
Cdd:PRK12895   28 IAAGHYIHPIKILLILIA--AVSARTSAMSINRIEGLRYDMINPRKKDWALVSGRIKMREAIAFTIIFIAIFEICTFLLN 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 179 YYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS--CDPSVCLpLYFSGVMWTLIYDTIYAHQDK 256
Cdd:PRK12895  106 RLVFILSPIVIFLFIIDPFLKRYTAWRHIYMGSIIGLGVLAGYLAVIPAfpYNLLIYI-IFISSSLWIAGFDIIYVIPDI 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 257 RDDVLIGLKSTALRFGENTKPWLSGF---SVAMLGALSLVGVNsgqTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKF 333
Cdd:PRK12895  185 EYDKINGLKTIMNTYGIKNGLYISDIfhiSSLILFWISGIYIR---TLWYLAALIIIYTLVIYQHLIIDPRNPINKRMSF 261

                         250
                  ....*....|....*...
gi 1306255355 334 I-SNRTLGLIVFLGIVLG 350
Cdd:PRK12895  262 FnANSFIGFVFLIGIILS 279
PLN02776 PLN02776
prenyltransferase
 128-238 5.12e-04

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 41.65  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 128 TINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVllclNYYSIALGAGSLLL-VITYPLMKRI 201
Cdd:PLN02776   47 TLNQVFEVKNDSKMKRTMRRPLPSGRISvphavAWAVVVGAAGVALLAYKT----NMLTAGLGAGNILLyAFVYTPLKQI 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1306255355 202 SYWPqlalgltfNW-GA-------LLGWSAIKGSCDP-SVCLP--LYF 238
Cdd:PLN02776  123 HPAN--------TWvGAvvgaippLMGWAAASGQLDAgAMVLAaaLYF 162
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 129-224 7.87e-04

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 40.92  E-value: 7.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 129 INDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPL-MKRISYWPQL 207
Cdd:cd13963    52 LNDLLDLEADRLHPTKRNRPIASGRLSIPAALALAVVLLLAGLALALLLSPAFLLVLLAYLVLNLAYSLkLKRIPLLDVF 131

                          90
                  ....*....|....*..
gi 1306255355 208 ALGLTFNWGALLGWSAI 224
Cdd:cd13963   132 VIAAGFVLRVLAGAVAI 148
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 73-310 3.73e-03

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 38.64  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355  73 PYLRLMRLDKP----IGTWLLYlpctwsIGLAAEPGCFPDWYMLSLFGTGAILMrGAGCTINDMWDQDYDKkVTRTaNRP 148
Cdd:cd13961     1 AYLELIRPPNLlmaaLAQYLGA------LFALGPLLSLNDLELLLLFLSVFLIA-AAGYIINDYFDVEIDR-INKP-DRP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 149 IAAGDIStfQSFVFLGGQLTLALGVLL--CLNYYSIALGAGSLLLVITYP-LMKRISYWPQLA----LGLTFNWGALLGW 221
Cdd:cd13961    72 IPSGRIS--RREALILSILLNALGLILafLLSPLALLIALLNSLLLWLYShKLKRTPLIGNLLvallTGLPFLFGGLAAG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1306255355 222 SAIKGSCDPSVCLPLYfsgvmwTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTA 301
Cdd:cd13961   150 NLLLIILLLALFAFLI------TLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLLGGLG 223


                  ....*....
gi 1306255355 302 PYYAALGAV 310
Cdd:cd13961   224 ILYLILIII 232
ubiA PRK12882
prenyltransferase; Reviewed
 120-195 7.09e-03

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 37.64  E-value: 7.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1306255355 120 ILMRGAGCTINDMWDQDYDkKVTRtANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITY 195
Cdd:PRK12882   48 FLATGAGNAINDYFDREID-RINR-PDRPIPSGAVSPRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLY 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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