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Conserved domains on  [gi|1292371398|ref|NP_001345580|]
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protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5 [Mus musculus]

Protein Classification

protein-L-isoaspartate O-methyltransferase family protein( domain architecture ID 1000299)

protein-L-isoaspartate O-methyltransferase (PIMT) family protein catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Gene Ontology:  GO:0051998|GO:0036211

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCMT super family cl30237
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
1-185 9.51e-99

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


The actual alignment was detected with superfamily member pfam01135:

Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 284.26  E-value: 9.51e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVI 76
Cdd:pfam01135  25 MLAVDREEFVpesfKSYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPaG 156
Cdd:pfam01135 103 SIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRLVIPVGP-N 176

                         170       180
                  ....*....|....*....|....*....
gi 1292371398 157 GNQMLEQYDKLQDGSVKMKPLMGVIYVPL 185
Cdd:pfam01135 177 GNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
1-185 9.51e-99

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 284.26  E-value: 9.51e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVI 76
Cdd:pfam01135  25 MLAVDREEFVpesfKSYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPaG 156
Cdd:pfam01135 103 SIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRLVIPVGP-N 176

                         170       180
                  ....*....|....*....|....*....
gi 1292371398 157 GNQMLEQYDKLQDGSVKMKPLMGVIYVPL 185
Cdd:pfam01135 177 GNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 1-192 2.35e-65

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 200.05  E-value: 2.35e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVI 76
Cdd:TIGR00080  29 LLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELL--ELKPGMKVLEIGTGSGYQAAVLAEIVGRDGLVV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPag 156
Cdd:TIGR00080 107 SIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKEGGILVMPVGE-- 179

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1292371398 157 GNQMLEQYDKlQDGSVKMKPLMGVIYVPLTDKEKQW 192
Cdd:TIGR00080 180 YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 1-186 9.29e-50

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 159.87  E-value: 9.29e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGnsgKVI 76
Cdd:COG2518    18 MRAVPRELFVpealRELAYADRALPIGHGQTISQPYIVARMLEAL--DLKPGDRVLEIGTGSGYQAAVLARLAG---RVY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPaG 156
Cdd:COG2518    93 SVERDPELAERARERLAA-----LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRLVAPVGE-G 166

                         170       180       190
                  ....*....|....*....|....*....|
gi 1292371398 157 GNQMLEQYDKLQDGsVKMKPLMGVIYVPLT 186
Cdd:COG2518   167 GVQRLVLITRTGDG-FERESLFEVRFVPLR 195
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 9-189 1.76e-48

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 157.10  E-value: 1.76e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   9 YAKSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDS 88
Cdd:PRK13942   40 YLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL--DLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  89 ITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAggNQMLEQYDKlQ 168
Cdd:PRK13942  118 KKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPKPLIEQLKDGGIMVIPVGSY--SQELIRVEK-D 189

                         170       180
                  ....*....|....*....|.
gi 1292371398 169 DGSVKMKPLMGVIYVPLTDKE 189
Cdd:PRK13942  190 NGKIIKKKLGEVAFVPLIGKN 210
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 50-152 2.86e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.04  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  50 KALDVGSGSGILTACFARmvGNSGKVIGIDhikelVDDSITNVKKDDPMLLSSGRVRLVVGDGRMG-YAEEAPYDAIHVG 128
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVD-----ISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1292371398 129 AAAPVV---PQALIDQ----LKPGGRLILPV 152
Cdd:cd02440    74 PPLHHLvedLARFLEEarrlLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
1-185 9.51e-99

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 284.26  E-value: 9.51e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVI 76
Cdd:pfam01135  25 MLAVDREEFVpesfKSYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPaG 156
Cdd:pfam01135 103 SIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRLVIPVGP-N 176

                         170       180
                  ....*....|....*....|....*....
gi 1292371398 157 GNQMLEQYDKLQDGSVKMKPLMGVIYVPL 185
Cdd:pfam01135 177 GNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 1-192 2.35e-65

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 200.05  E-value: 2.35e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVI 76
Cdd:TIGR00080  29 LLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELL--ELKPGMKVLEIGTGSGYQAAVLAEIVGRDGLVV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPag 156
Cdd:TIGR00080 107 SIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKEGGILVMPVGE-- 179

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1292371398 157 GNQMLEQYDKlQDGSVKMKPLMGVIYVPLTDKEKQW 192
Cdd:TIGR00080 180 YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 1-186 9.29e-50

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 159.87  E-value: 9.29e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGnsgKVI 76
Cdd:COG2518    18 MRAVPRELFVpealRELAYADRALPIGHGQTISQPYIVARMLEAL--DLKPGDRVLEIGTGSGYQAAVLARLAG---RVY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  77 GIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPaG 156
Cdd:COG2518    93 SVERDPELAERARERLAA-----LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRLVAPVGE-G 166

                         170       180       190
                  ....*....|....*....|....*....|
gi 1292371398 157 GNQMLEQYDKLQDGsVKMKPLMGVIYVPLT 186
Cdd:COG2518   167 GVQRLVLITRTGDG-FERESLFEVRFVPLR 195
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 9-189 1.76e-48

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 157.10  E-value: 1.76e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   9 YAKSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDS 88
Cdd:PRK13942   40 YLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL--DLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  89 ITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAggNQMLEQYDKlQ 168
Cdd:PRK13942  118 KKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPKPLIEQLKDGGIMVIPVGSY--SQELIRVEK-D 189

                         170       180
                  ....*....|....*....|.
gi 1292371398 169 DGSVKMKPLMGVIYVPLTDKE 189
Cdd:PRK13942  190 NGKIIKKKLGEVAFVPLIGKN 210
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-189 3.95e-41

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 138.03  E-value: 3.95e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398   1 MLATDRS--------HYAksnpYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGns 72
Cdd:PRK00312   30 IEATPRElfvpeafkHKA----YENRALPIGCGQTISQPYMVARMTELL--ELKPGDRVLEIGTGSGYQAAVLAHLVR-- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  73 gKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPV 152
Cdd:PRK00312  102 -RVFSVERIKTLQWEAKRRLKQ-----LGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLEQLKEGGILVAPV 175

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1292371398 153 GpaGGNQMLEQYDKLQDGSVKMKPLMGVIYVPLTDKE 189
Cdd:PRK00312  176 G--GEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGE 210
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 15-185 2.60e-28

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 104.89  E-value: 2.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  15 YMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKK 94
Cdd:PRK13944   42 YEDRPLPLFAGATISAPHMVAMMCELI--EPRPGMKILEVGTGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIER 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  95 ddpmLLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGnQMLEQYDKLQDGsVKM 174
Cdd:PRK13944  120 ----LGYWGVVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSALVRQLKDGGVLVIPVEEGVG-QVLYKVVKRGEK-VEK 193

                         170
                  ....*....|.
gi 1292371398 175 KPLMGVIYVPL 185
Cdd:PRK13944  194 RAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 27-152 1.45e-20

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 87.81  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  27 TISAPHMHAYALELLfdQLHEGAKALDVGSGsGILTACFARMVGNSGKVIGIDHIKELVDDSitnvkkdDPMLLSSG--R 104
Cdd:TIGR04364  64 SVSAPHIQAMMLEQA--GVEPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDRA-------RACLAAAGypQ 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1292371398 105 VRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPV 152
Cdd:TIGR04364 134 VTVVLADAEAGVPELAPYDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 26-152 4.85e-19

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 82.97  E-value: 4.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  26 ATISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRV 105
Cdd:PRK13943   61 STSSQPSLMALFMEWV--GLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRR-----LGIENV 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1292371398 106 RLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPV 152
Cdd:PRK13943  134 IFVCGDGYYGVPEFAPYDVIFVTVGVDEVPETWFTQLKEGGRVIVPI 180
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 45-149 4.03e-13

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 65.57  E-value: 4.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  45 LHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKddpmLLSSGRVRLVVGDGRMGYAEEaPYDA 124
Cdd:COG2519    89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER----FGLPDNVELKLGDIREGIDEG-DVDA 163

                          90       100
                  ....*....|....*....|....*..
gi 1292371398 125 IHVGAAAP--VVPQAlIDQLKPGGRLI 149
Cdd:COG2519   164 VFLDMPDPweALEAV-AKALKPGGVLV 189
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 45-157 3.82e-11

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 60.84  E-value: 3.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  45 LHEGAKALDVGSGSGILTACFARMVGnsgkvigidhikelvDDSITNVKKDdPMLLSSGRVRL---------VVGDGRMG 115
Cdd:TIGR04188 105 VEDGHRVLEIGTGTGYSAALLCHRLG---------------DDNVTSVEVD-PGLAARAASALaaagyaptvVTGDGLLG 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1292371398 116 YAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVG---PAGG 157
Cdd:TIGR04188 169 HPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSgwlYGGG 213
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 39-150 7.24e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 54.64  E-value: 7.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  39 ELLFDQLHEGAKALDVGSGSGILTACFARMvgnsG-KVIGIDhikeLVDDSITNVKKddpmLLSSGRVRLVVGDGRMGYA 117
Cdd:COG2227    16 ALLARLLPAGGRVLDVGCGTGRLALALARR----GaDVTGVD----ISPEALEIARE----RAAELNVDFVQGDLEDLPL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1292371398 118 EEAPYDAI-------HVGAAAPVVpQALIDQLKPGGRLIL 150
Cdd:COG2227    84 EDGSFDLVicsevleHLPDPAALL-RELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-150 9.91e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.29  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  47 EGAKALDVGSGSGILTACFARMVGNsGKVIGIDhikeLVDDSITNVKKDDPmllssgRVRLVVGDGRmGYAEEAPYDAIH 126
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPG-ARVTGVD----LSPEMLARARARLP------NVRFVVADLR-DLDPPEPFDLVV 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 1292371398 127 VGAA------APVVPQALIDQLKPGGRLIL 150
Cdd:COG4106    69 SNAAlhwlpdHAALLARLAAALAPGGVLAV 98
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
38-150 1.94e-09

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 55.56  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  38 LELLFDQLHEGAKALDVGSGSGILtACFARMVGNsGKVIGIDhIKEL-VDDSITNVKKDDpmllSSGRVRLVVGDGRmgy 116
Cdd:COG2264   139 LEALEKLLKPGKTVLDVGCGSGIL-AIAAAKLGA-KRVLAVD-IDPVaVEAARENAELNG----VEDRIEVVLGDLL--- 208

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1292371398 117 aEEAPYDAIhVgA---AAPVVPQA--LIDQLKPGGRLIL 150
Cdd:COG2264   209 -EDGPYDLV-V-AnilANPLIELApdLAALLKPGGYLIL 244
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-146 6.05e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 6.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  52 LDVGSGSGILTACFARMVGnsGKVIGIDHIKELVDDSITNVKKDDPmllssgRVRLVVGDGRMGYAEEAPYDAIHVGAAA 131
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGL------NVEFVQGDAEDLPFPDGSFDLVVSSGVL 73

                          90       100
                  ....*....|....*....|...
gi 1292371398 132 PVVPQALIDQ--------LKPGG 146
Cdd:pfam13649  74 HHLPDPDLEAalreiarvLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 37-150 7.78e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 52.24  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  37 ALELLFD--QLHEGAKALDVGSGSGILTACFARMVGnsGKVIGID-------HIKELVDDsitnvkkddpmLLSSGRVRL 107
Cdd:COG2230    39 KLDLILRklGLKPGMRVLDIGCGWGGLALYLARRYG--VRVTGVTlspeqleYARERAAE-----------AGLADRVEV 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1292371398 108 VVGDGRmGYAEEAPYDAI-------HVGAAA-PVVPQALIDQLKPGGRLIL 150
Cdd:COG2230   106 RLADYR-DLPADGQFDAIvsigmfeHVGPENyPAYFAKVARLLKPGGRLLL 155
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 37-180 1.25e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 52.61  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  37 ALELLFDQLHEGAKALDVGSGSGILTACFARMVGnsGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGD-GRMG 115
Cdd:COG0500    16 ALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAK-----AGLGNVEFLVADlAELD 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1292371398 116 YAEEAPYDAI-------HVgaaAPVVPQALID----QLKPGGRLILPVGPAGGNQMLEQYDKLQDGSVKMKPLMGV 180
Cdd:COG0500    89 PLPAESFDLVvafgvlhHL---PPEEREALLRelarALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLR 161
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 34-150 2.05e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 51.15  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  34 HAYALELLfdQLHEGAKALDVGSGSGILTACFARMvgnSGKVIGIDHIKELVDDSITNVKKDDPmllssgRVRLVVGDG- 112
Cdd:COG2226    11 REALLAAL--GLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGL------NVEFVVGDAe 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1292371398 113 RMGYAEEApYDAIHVGAAAPVVP--QALIDQ----LKPGGRLIL 150
Cdd:COG2226    80 DLPFPDGS-FDLVISSFVLHHLPdpERALAEiarvLKPGGRLVV 122
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 28-152 5.01e-08

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 49.64  E-value: 5.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  28 ISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNsGKVIGIDHIKELVDdsitnvkkddpmLLSSGRVRL 107
Cdd:TIGR02469   2 MTKREVRALTLAKL--RLRPGDVLWDIGAGTGSVTIEAARLVPN-GRVYAIERNPEALD------------LIERNLRRF 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1292371398 108 VVGDGR--MGYAEEAPY------DAIHVGAAA---PVVPQALIDQLKPGGRLILPV 152
Cdd:TIGR02469  67 GVSNIVivEGDAPEAPEallpdpDAVFVGGSGgllQEILEAVERRLRPGGRIVLNA 122
PRK08317 PRK08317
hypothetical protein; Provisional
 35-150 1.27e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.94  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  35 AYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKDDPmllssgRVRLVVGDG-R 113
Cdd:PRK08317    9 ARTFELL--AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAGLGP------NVEFVRGDAdG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1292371398 114 MGYAEEApYDAI-------HVGAaapvvPQALIDQ----LKPGGRLIL 150
Cdd:PRK08317   81 LPFPDGS-FDAVrsdrvlqHLED-----PARALAEiarvLRPGGRVVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 50-152 2.86e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.04  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  50 KALDVGSGSGILTACFARmvGNSGKVIGIDhikelVDDSITNVKKDDPMLLSSGRVRLVVGDGRMG-YAEEAPYDAIHVG 128
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVD-----ISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1292371398 129 AAAPVV---PQALIDQ----LKPGGRLILPV 152
Cdd:cd02440    74 PPLHHLvedLARFLEEarrlLKPGGVLVLTL 104
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 45-150 9.69e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.64  E-value: 9.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  45 LHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDgrmgyAEEAP--- 121
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK-----LGFDNVEFEQGD-----IEELPell 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1292371398 122 ----YD------AIHVGAAAPVVPQALIDQLKPGGRLIL 150
Cdd:pfam13847  71 eddkFDvvisncVLNHIPDPDKVLQEILRVLKPGGRLII 109
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 48-150 1.59e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 47.07  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  48 GAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDdsitNVKKDDPMLLSSGRVRLVVGDgrmgyAEEAPY----- 122
Cdd:PRK00216   52 GDKVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLA----VGREKLRDLGLSGNVEFVQGD-----AEALPFpdnsf 122

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1292371398 123 DAIHVGAAAPVVPQalIDQ--------LKPGGRL-IL 150
Cdd:PRK00216  123 DAVTIAFGLRNVPD--IDKalremyrvLKPGGRLvIL 157
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 37-152 4.10e-06

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 45.56  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  37 ALELLFDQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKDDPMllssGRVRLVVGDGRMGY 116
Cdd:PRK00377   30 ALALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEKFGVL----NNIVLIKGEAPEIL 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1292371398 117 AEEAP-YDAIHVGAAA---PVVPQALIDQLKPGGRLILPV 152
Cdd:PRK00377  106 FTINEkFDRIFIGGGSeklKEIISASWEIIKKGGRIVIDA 145
arsM PRK11873
arsenite methyltransferase;
42-85 8.32e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.94  E-value: 8.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1292371398  42 FDQLHEGAKALDVGSGSGIltACF--ARMVGNSGKVIGIDHIKELV 85
Cdd:PRK11873   72 LAELKPGETVLDLGSGGGF--DCFlaARRVGPTGKVIGVDMTPEML 115
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 52-150 9.52e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.65  E-value: 9.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  52 LDVGSGSGILTACFARMVGNsgkVIGIDHIKELVDDSITNVKKDDpmllssgrVRLVVGDG-RMGYAEEApYDAIHVGAA 130
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR---VTGVDISPEMLELAREKAPREG--------LTFVVGDAeDLPFPDNS-FDLVLSSEV 68

                          90       100
                  ....*....|....*....|....*.
gi 1292371398 131 A---PVVPQAL--IDQ-LKPGGRLIL 150
Cdd:pfam08241  69 LhhvEDPERALreIARvLKPGGILII 94
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
38-150 9.78e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 44.76  E-value: 9.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  38 LELLFDQLHEGAKALDVGSGSGILtACFARMVGNsGKVIGIDhIKEL-VDDSITNVKKDDpmllssgrVRLVVGDGrmgy 116
Cdd:PRK00517  110 LEALEKLVLPGKTVLDVGCGSGIL-AIAAAKLGA-KKVLAVD-IDPQaVEAARENAELNG--------VELNVYLP---- 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1292371398 117 AEEAPYDAIhVgA---AAPVVpqALIDQ----LKPGGRLIL 150
Cdd:PRK00517  175 QGDLKADVI-V-AnilANPLL--ELAPDlarlLKPGGRLIL 211
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
47-149 1.57e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 43.97  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  47 EGAKALDVGSGSGILTACFARMVGNSGKVIGIDhikelVDDSITNVKKDDPMLLSSGRVRLVVGDGRMGYAEEAPYDAIH 126
Cdd:pfam01209  42 RGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLD-----INENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSFDIVT 116

                          90       100
                  ....*....|....*....|....*....
gi 1292371398 127 VGAA---APVVPQALIDQ---LKPGGRLI 149
Cdd:pfam01209 117 ISFGlrnFPDYLKVLKEAfrvLKPGGRVV 145
PRK14968 PRK14968
putative methyltransferase; Provisional
 39-79 5.93e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 5.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1292371398  39 ELLFDQLHE--GAKALDVGSGSGILTACFARmvgNSGKVIGID 79
Cdd:PRK14968   13 FLLAENAVDkkGDRVLEVGTGSGIVAIVAAK---NGKKVVGVD 52
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 44-146 7.49e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 41.32  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  44 QLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKDDpmllSSGRVRLVVGDGR--MGYAEEAP 121
Cdd:COG4122    13 RLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAG----LADRIRLILGDALevLPRLADGP 88

                          90       100
                  ....*....|....*....|....*...
gi 1292371398 122 YDAIHVGAAAPVVP---QALIDQLKPGG 146
Cdd:COG4122    89 FDLVFIDADKSNYPdylELALPLLRPGG 116
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 39-150 1.24e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.94  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  39 ELLFDQL--HEGAKALDVGSGSGILTACFARMVGNSgKVIGIDhIKEL-VDDSITNVKKDDPmllssGRVRLVVGDGRMG 115
Cdd:COG2813    39 RLLLEHLpePLGGRVLDLGCGYGVIGLALAKRNPEA-RVTLVD-VNARaVELARANAAANGL-----ENVEVLWSDGLSG 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1292371398 116 YAEEaPYDAI------HVGAAAPV-VPQALIDQ----LKPGGRLIL 150
Cdd:COG2813   112 VPDG-SFDLIlsnppfHAGRAVDKeVAHALIADaarhLRPGGELWL 156
PLN02366 PLN02366
spermidine synthase
 95-146 2.47e-04

spermidine synthase


Pssm-ID: 215208 [Multi-domain]  Cd Length: 308  Bit Score: 40.78  E-value: 2.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1292371398  95 DDPmllssgRVRLVVGDGR--MGYAEEAPYDAIHVGAAAPVVP-QALIDQ---------LKPGG 146
Cdd:PLN02366  143 DDP------RVNLHIGDGVefLKNAPEGTYDAIIVDSSDPVGPaQELFEKpffesvaraLRPGG 200
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
32-150 7.66e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.83  E-value: 7.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  32 HMHAYALELLFDQlhEGAKALDVGSGSGILTACFARMVGnsgKVIGIDHIKELVDdsITNVKKDDpmllssgrVRLVVGD 111
Cdd:COG4976    33 LLAEELLARLPPG--PFGRVLDLGCGTGLLGEALRPRGY---RLTGVDLSEEMLA--KAREKGVY--------DRLLVAD 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1292371398 112 GRMGYAEEAPYDAI-------HVGAAAPVVpQALIDQLKPGGRLIL 150
Cdd:COG4976    98 LADLAEPDGRFDLIvaadvltYLGDLAAVF-AGVARALKPGGLFIF 142
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
35-150 2.59e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 37.29  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  35 AYALELLfdQLHEGAKALDVGSGSGILTACFARMVGNSgKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRM 114
Cdd:PRK08287   21 ALALSKL--ELHRAKHLIDVGAGTGSVSIEAALQFPSL-QVTAIERNPDALRLIKENRQR-----FGCGNIDIIPGEAPI 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1292371398 115 GYAEEApyDAIHVGAAAPVVpQALID----QLKPGGRLIL 150
Cdd:PRK08287   93 ELPGKA--DAIFIGGSGGNL-TAIIDwslaHLHPGGRLVL 129
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 35-150 5.20e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 37.07  E-value: 5.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  35 AYALELLfdQLHEGAKALDVGSGSGILTACFARMvGNSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRM 114
Cdd:COG2242   237 ALTLAKL--ALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARR-----FGVPNVEVVEGEAPE 308

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1292371398 115 GYAEEAPYDAIHVG----AAAPVVpQALIDQLKPGGRLIL 150
Cdd:COG2242   309 ALADLPDPDAVFIGgsggNLPEIL-EACWARLRPGGRLVA 347
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 42-150 6.26e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.03  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1292371398  42 FDQLHEGaKALDVGSGSGILTACFARMVGNsGKVIGIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGyAEEAP 121
Cdd:pfam05175  27 LPKDLSG-KVLDLGCGAGVLGAALAKESPD-AELTMVDINARALESARENLAANGLE-----NGEVVASDVYSG-VEDGK 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1292371398 122 YDAI------HVG-AAAPVVPQALI----DQLKPGGRLIL 150
Cdd:pfam05175  99 FDLIisnppfHAGlATTYNVAQRFIadakRHLRPGGELWI 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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