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Conserved domains on  [gi|1276317715|ref|NP_001344780|]
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SLIT and NTRK-like protein 3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-212 1.03e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  94 YTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNVIKRIeSGAFRNL 173
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1276317715 174 SKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVL 212
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
LRR_8 pfam13855
Leucine rich repeat;
433-493 3.18e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 3.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276317715 433 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
399-564 7.82e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 7.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 399 NNISEL---LPRPLNAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVqDGAFINLPNLKSLFLNGNDIEKLtPG 475
Cdd:COG4886   123 NQLTDLpeeLANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 476 MFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPtdAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNa 554
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNlTNLEELDLSNNQLTDLPPLANLTNLK- 275

                         170
                  ....*....|
gi 1276317715 555 ivQIDLNENP 564
Cdd:COG4886   276 --TLDLSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-598 1.28e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1276317715  563 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENL 598
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSL 36
LRRCT smart00082
Leucine rich repeat C-terminal domain;
233-271 3.80e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 3.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1276317715  233 NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGK 271
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-212 1.03e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  94 YTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNVIKRIeSGAFRNL 173
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1276317715 174 SKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVL 212
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
LRR_8 pfam13855
Leucine rich repeat;
106-162 3.71e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 3.71e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1276317715 106 SINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 162
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
433-493 3.18e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 3.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276317715 433 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-564 7.82e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 7.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 399 NNISEL---LPRPLNAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVqDGAFINLPNLKSLFLNGNDIEKLtPG 475
Cdd:COG4886   123 NQLTDLpeeLANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 476 MFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPtdAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNa 554
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNlTNLEELDLSNNQLTDLPPLANLTNLK- 275

                         170
                  ....*....|
gi 1276317715 555 ivQIDLNENP 564
Cdd:COG4886   276 --TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-497 3.64e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 399 NNISELlPRPL----NAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKSLFLNGNDIEKLTP 474
Cdd:COG4886   192 NQITDL-PEPLgnltNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                          90       100
                  ....*....|....*....|...
gi 1276317715 475 GMfrGLQSLHYLYFEFNVIREIQ 497
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 382-486 3.04e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 382 LHINDLGLTVnckergfnnIsELLPRPLNAKKLYLSSNLIQKIyrSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKS 461
Cdd:cd21340     7 LYLNDKNITK---------I-DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                          90       100
                  ....*....|....*....|....*
gi 1276317715 462 LFLNGNDIEKLTpgmfrGLQSLHYL 486
Cdd:cd21340    73 LYLGGNRISVVE-----GLENLTNL 92
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-598 1.28e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1276317715  563 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENL 598
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSL 36
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-207 3.73e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  59 HIHCDSKgftNISQITEFwsRPFK----LYLQRN---SMRRLYTNSFL-HLNnavsinLGNNALQDIQTgaFNGLKILKR 130
Cdd:cd21340     6 HLYLNDK---NITKIDNL--SLCKnlkvLYLYDNkitKIENLEFLTNLtHLY------LQNNQIEKIEN--LENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 131 LYLHENKLDV---------------------------FRNDTFLGL-ESLEYLQADYNVIKRIESgaFRNLSKLRVLILN 182
Cdd:cd21340    73 LYLGGNRISVveglenltnleelhienqrlppgekltFDPRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                         170       180
                  ....*....|....*....|....*....
gi 1276317715 183 DNLI----PVLPTnLFKAVSLTHLDLRGN 207
Cdd:cd21340   151 NNQIsdleELLDL-LSSWPSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
233-271 3.80e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 3.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1276317715  233 NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGK 271
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-212 1.03e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  94 YTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNVIKRIeSGAFRNL 173
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1276317715 174 SKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVL 212
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-212 3.32e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 3.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  82 KLYLQRNSMRRLyTNSFLHLNNAVSINLGNNALQDIQTgAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNV 161
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1276317715 162 IKRIeSGAFRNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVL 212
Cdd:COG4886   194 ITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-212 3.52e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 3.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  82 KLYLQRNSMRRLyTNSFLHLNNAVSINLGNNALQDIQTgAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNV 161
Cdd:COG4886   163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1276317715 162 IKRIESgaFRNLSKLRVLILNDNLIPVLPtNLFKAVSLTHLDLRGNRLKVL 212
Cdd:COG4886   240 LTDLPE--LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
106-162 3.71e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 3.71e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1276317715 106 SINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 162
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
128-186 1.54e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.54e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1276317715 128 LKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLI 186
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
433-493 3.18e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 3.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276317715 433 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
410-469 2.12e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.12e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 410 NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDI 469
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-564 7.82e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 7.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 399 NNISEL---LPRPLNAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVqDGAFINLPNLKSLFLNGNDIEKLtPG 475
Cdd:COG4886   123 NQLTDLpeeLANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 476 MFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPtdAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNa 554
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNlTNLEELDLSNNQLTDLPPLANLTNLK- 275

                         170
                  ....*....|
gi 1276317715 555 ivQIDLNENP 564
Cdd:COG4886   276 --TLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
151-209 1.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 151 SLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKA-VSLTHLDLRGNRL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-497 3.64e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 399 NNISELlPRPL----NAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKSLFLNGNDIEKLTP 474
Cdd:COG4886   192 NQITDL-PEPLgnltNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                          90       100
                  ....*....|....*....|...
gi 1276317715 475 GMfrGLQSLHYLYFEFNVIREIQ 497
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-212 3.90e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 3.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  91 RRLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYlhenKLDVFRNDTFLGLESLEYLQADYNVIKRIESgAF 170
Cdd:COG4886    58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----ELDLSGNEELSNLTNLESLDLSGNQLTDLPE-EL 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1276317715 171 RNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVL 212
Cdd:COG4886   133 ANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL 174
LRR_8 pfam13855
Leucine rich repeat;
457-505 1.00e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 1.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1276317715 457 PNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMP 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-605 2.92e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 399 NNISELlPRPL----NAKKLYLSSNLIQKIyrSDFWNFSSLDLLHLGNNRISYVQDGAfiNLPNLKSLFLNGNDIEKLTp 474
Cdd:COG4886   215 NQLTDL-PEPLanltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK- 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 475 gmfrgLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNA 554
Cdd:COG4886   289 -----LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1276317715 555 IVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRT 605
Cdd:COG4886   364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 382-486 3.04e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 382 LHINDLGLTVnckergfnnIsELLPRPLNAKKLYLSSNLIQKIyrSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKS 461
Cdd:cd21340     7 LYLNDKNITK---------I-DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                          90       100
                  ....*....|....*....|....*
gi 1276317715 462 LFLNGNDIEKLTpgmfrGLQSLHYL 486
Cdd:cd21340    73 LYLGGNRISVVE-----GLENLTNL 92
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-598 1.28e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1276317715  563 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENL 598
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSL 36
LRR_8 pfam13855
Leucine rich repeat;
82-138 1.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1276317715  82 KLYLQRNSMRRLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKL 138
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-207 3.73e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  59 HIHCDSKgftNISQITEFwsRPFK----LYLQRN---SMRRLYTNSFL-HLNnavsinLGNNALQDIQTgaFNGLKILKR 130
Cdd:cd21340     6 HLYLNDK---NITKIDNL--SLCKnlkvLYLYDNkitKIENLEFLTNLtHLY------LQNNQIEKIEN--LENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 131 LYLHENKLDV---------------------------FRNDTFLGL-ESLEYLQADYNVIKRIESgaFRNLSKLRVLILN 182
Cdd:cd21340    73 LYLGGNRISVveglenltnleelhienqrlppgekltFDPRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                         170       180
                  ....*....|....*....|....*....
gi 1276317715 183 DNLI----PVLPTnLFKAVSLTHLDLRGN 207
Cdd:cd21340   151 NNQIsdleELLDL-LSSWPSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
233-271 3.80e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 3.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1276317715  233 NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGK 271
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-233 1.07e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  99 LHLNNavsinlgnNALQDIqtGAFNGLKILKRLYLHENKLDVFRN-DTFLGLESLeYLQadYNVIKRIESgaFRNLSKLR 177
Cdd:cd21340     7 LYLND--------KNITKI--DNLSLCKNLKVLYLYDNKITKIENlEFLTNLTHL-YLQ--NNQIEKIEN--LENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 178 VLILNDNLIPVL-----PTNL-----------------FK-------AVSLTHLDLRGNRLKVLFYRGMLdhigRSLMEL 228
Cdd:cd21340    72 KLYLGGNRISVVeglenLTNLeelhienqrlppgekltFDprslaalSNSLRVLNISGNNIDSLEPLAPL----RNLEQL 147


                  ....*
gi 1276317715 229 QLEEN 233
Cdd:cd21340   148 DASNN 152
LRR_8 pfam13855
Leucine rich repeat;
174-234 1.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276317715 174 SKLRVLILNDNLIPVLPTNLFKAVS-LTHLDLRGNRLKVLfYRGMLDHIgRSLMELQLEENP 234
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTL-SPGAFSGL-PSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
380-563 2.27e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 380 CNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRisyvqdgAFINLPNL 459
Cdd:COG4886    43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715 460 KSLFLNGNDIEKLtPGMFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNY 539
Cdd:COG4886   116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                         170       180
                  ....*....|....*....|....
gi 1276317715 540 FLYLPVAgvLEHLNAIVQIDLNEN 563
Cdd:COG4886   194 ITDLPEP--LGNLTNLEELDLSGN 215
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 88-207 9.46e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317715  88 NSMRRLYTNSFLHLNNAVSINLGNNaLQDIQTGAFNGLKiLKRLYLHENkldvfrndtflglesleylqadynvIKRIES 167
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-------------------------LTSIGE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1276317715 168 GAFRNLSKLRVLILNDNLIpVLPTNLFKAVSLTHLDLRGN 207
Cdd:pfam13306  73 YAFSNCSNLKSITLPSNLT-SIGSYAFSNCSLKSITIPSS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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