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Conserved domains on  [gi|1274095713|ref|NP_001344483|]
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histone deacetylase complex subunit SAP130 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
635-1040 0e+00

Histone deacetylase complex subunit SAP130 C-terminus;


:

Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 549.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  635 AQGSSPRPSILRKKPATDGmavrktllppqppdvatprvessmrsasgsprpagAKPKSEVHVSIATPVTVSLETISNQN 714
Cdd:pfam16014    1 ALGSSPRPSILRKKPATEG-----------------------------------AKPKPDIHVAVAPPVTVAVEALPGQN 45
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  715 AEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVTPP----ITTIAATPTLSApVGGTPSTVLGPPVPE 790
Cdd:pfam16014   46 SEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLPAAMAVTPPipasMANVVAPPTQPA-ASSTAACAVSSVLPE 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  791 IKVKEEAEPVDITRpvsTVPPLATNTVSPSLALLASNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKS 870
Cdd:pfam16014  125 IKIKQEAEPMDTSQ---SVPPLTPTSISPALTSLANNLSVPAGDLLPGASPRKKPRKQQHVISTEEGEMMETNSTDEEKS 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  871 AAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSC 950
Cdd:pfam16014  202 APKPLTSRAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKGTLQDMANQKGVTC 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  951 RAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLD 1030
Cdd:pfam16014  282 RAQGWKIHLCAAQLLQLTNLEHDVYSRLTTLQEGLIPKKKAGTDDDLHRINELIQGNMQRCKLVMDQITEARDSMMKVLD 361
                          410
                   ....*....|
gi 1274095713 1031 HKDRVLKLLN 1040
Cdd:pfam16014  362 HKDRVLKLLN 371
PHA03247 super family cl33720
large tegument protein UL36; Provisional
417-886 1.20e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  417 PRIQPDYPPERSSLIPiSGHRASPNPVAMETRNDNRPSVPVQfqyflPTYPPSAYPlaahTYTPITSSVSTIRQYPVSAQ 496
Cdd:PHA03247  2641 HPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQ-----RPRRRAARP----TVGSLTSLADPPPPPPTPEP 2710
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  497 APNSTITAqtgvgvastvhlNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGtsgiqPAPIGTPGIHSAAPINTQGL 576
Cdd:PHA03247  2711 APHALVSA------------TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTTAGPPAPAPPA 2773
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  577 QPAAmanqQPQPEGKTSAVVLADGATivaNPISNPFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATdgmav 656
Cdd:PHA03247  2774 APAA----GPPRRLTRPAVASLSESR---ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP----- 2841
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  657 rktllPPQPPDVATPR----VESSMRSASGSPRPAGAKPKSEVHVSIATPVTVSLETiSNQNAEQPTVAVPPTAQQPPPT 732
Cdd:PHA03247  2842 -----PPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPP 2915
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  733 IPSMIAAASPPSQPAIALSTIPGAVPVTPPITTIAATPtlsAPVGGTPSTVLGP------PVPEIKVKEEAEPVDItrPV 806
Cdd:PHA03247  2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG---EPSGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREA--PA 2990
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  807 STVPPLaTNTVSPSLALLASNLSMPPSDLPPGASprkkpRKQQHVIS--TEEGDMMETNSTDDEKSAAKSLLVKAEKRKS 884
Cdd:PHA03247  2991 SSTPPL-TGHSLSRVSSWASSLALHEETDPPPVS-----LKQTLWPPddTEDSDADSLFDSDSERSDLEALDPLPPEPHD 3064

                   ..
gi 1274095713  885 PP 886
Cdd:PHA03247  3065 PF 3066
PHA03247 super family cl33720
large tegument protein UL36; Provisional
98-492 1.18e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713   98 PPAHLTPA---------VPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSLPPKVPGQVTVTMESS-IPQASAIPVATISG 167
Cdd:PHA03247  2551 PPPPLPPAappaapdrsVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSpLPPDTHAPDPPPPS 2630
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  168 QQGHPSNLHHIMTTNVQMSIIRSNAPGPP------------LHIGASHLPRGAAAAAVMSS-SKVTTVLRPTSQLPNAAT 234
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlgRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEP 2710
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  235 AQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPV-ITTTAAHAADSTLSRPTLSIQHPPSAAISIQRPAQSR 313
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  314 DVTTRITLPS------HPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTLPSTTTAGSVSHTQAPtstiVTMTM 387
Cdd:PHA03247  2791 LSESRESLPSpwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD----VRRRP 2866
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  388 PSHSSHATAVTTSNIPVAKVvpqqithtsPRIQPDYPPERSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPTYP 467
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRL---------ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          410       420
                   ....*....|....*....|....*
gi 1274095713  468 PSAYPLAAHTYTPITSSVSTIRQYP 492
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
635-1040 0e+00

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 549.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  635 AQGSSPRPSILRKKPATDGmavrktllppqppdvatprvessmrsasgsprpagAKPKSEVHVSIATPVTVSLETISNQN 714
Cdd:pfam16014    1 ALGSSPRPSILRKKPATEG-----------------------------------AKPKPDIHVAVAPPVTVAVEALPGQN 45
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  715 AEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVTPP----ITTIAATPTLSApVGGTPSTVLGPPVPE 790
Cdd:pfam16014   46 SEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLPAAMAVTPPipasMANVVAPPTQPA-ASSTAACAVSSVLPE 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  791 IKVKEEAEPVDITRpvsTVPPLATNTVSPSLALLASNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKS 870
Cdd:pfam16014  125 IKIKQEAEPMDTSQ---SVPPLTPTSISPALTSLANNLSVPAGDLLPGASPRKKPRKQQHVISTEEGEMMETNSTDEEKS 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  871 AAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSC 950
Cdd:pfam16014  202 APKPLTSRAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKGTLQDMANQKGVTC 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  951 RAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLD 1030
Cdd:pfam16014  282 RAQGWKIHLCAAQLLQLTNLEHDVYSRLTTLQEGLIPKKKAGTDDDLHRINELIQGNMQRCKLVMDQITEARDSMMKVLD 361
                          410
                   ....*....|
gi 1274095713 1031 HKDRVLKLLN 1040
Cdd:pfam16014  362 HKDRVLKLLN 371
PHA03247 PHA03247
large tegument protein UL36; Provisional
417-886 1.20e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  417 PRIQPDYPPERSSLIPiSGHRASPNPVAMETRNDNRPSVPVQfqyflPTYPPSAYPlaahTYTPITSSVSTIRQYPVSAQ 496
Cdd:PHA03247  2641 HPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQ-----RPRRRAARP----TVGSLTSLADPPPPPPTPEP 2710
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  497 APNSTITAqtgvgvastvhlNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGtsgiqPAPIGTPGIHSAAPINTQGL 576
Cdd:PHA03247  2711 APHALVSA------------TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTTAGPPAPAPPA 2773
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  577 QPAAmanqQPQPEGKTSAVVLADGATivaNPISNPFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATdgmav 656
Cdd:PHA03247  2774 APAA----GPPRRLTRPAVASLSESR---ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP----- 2841
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  657 rktllPPQPPDVATPR----VESSMRSASGSPRPAGAKPKSEVHVSIATPVTVSLETiSNQNAEQPTVAVPPTAQQPPPT 732
Cdd:PHA03247  2842 -----PPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPP 2915
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  733 IPSMIAAASPPSQPAIALSTIPGAVPVTPPITTIAATPtlsAPVGGTPSTVLGP------PVPEIKVKEEAEPVDItrPV 806
Cdd:PHA03247  2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG---EPSGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREA--PA 2990
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  807 STVPPLaTNTVSPSLALLASNLSMPPSDLPPGASprkkpRKQQHVIS--TEEGDMMETNSTDDEKSAAKSLLVKAEKRKS 884
Cdd:PHA03247  2991 SSTPPL-TGHSLSRVSSWASSLALHEETDPPPVS-----LKQTLWPPddTEDSDADSLFDSDSERSDLEALDPLPPEPHD 3064

                   ..
gi 1274095713  885 PP 886
Cdd:PHA03247  3065 PF 3066
PHA03247 PHA03247
large tegument protein UL36; Provisional
558-849 3.00e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  558 APIGTPGiHSAAPINTQGLQPAAMANQQPQPEGKTSAVVLADGATIVANPISNPFSAApaATTVVQTHSQSASTNTPAQG 637
Cdd:PHA03247  2600 APVDDRG-DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDP--APGRVSRPRRARRLGRAAQA 2676
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  638 SSPrPSILRKKPATDGMAVRKTLLPPQPPdvatprvessmrsasgsPRPAGAKPKSEVHVSIATPVTVSletiSNQNAEQ 717
Cdd:PHA03247  2677 SSP-PQRPRRRAARPTVGSLTSLADPPPP-----------------PPTPEPAPHALVSATPLPPGPAA----ARQASPA 2734
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  718 PTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVT--PPITTIAATPTLSAPVGGTPSTVLGPPVPEIKVKE 795
Cdd:PHA03247  2735 LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgpPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1274095713  796 EAEPVDITRPVSTVPPLATNT-VSPSLALLASNLSMPP-SDLPPGASPRKKPRKQQ 849
Cdd:PHA03247  2815 AAALPPAASPAGPLPPPTSAQpTAPPPPPGPPPPSLPLgGSVAPGGDVRRRPPSRS 2870
PHA03247 PHA03247
large tegument protein UL36; Provisional
98-492 1.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713   98 PPAHLTPA---------VPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSLPPKVPGQVTVTMESS-IPQASAIPVATISG 167
Cdd:PHA03247  2551 PPPPLPPAappaapdrsVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSpLPPDTHAPDPPPPS 2630
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  168 QQGHPSNLHHIMTTNVQMSIIRSNAPGPP------------LHIGASHLPRGAAAAAVMSS-SKVTTVLRPTSQLPNAAT 234
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlgRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEP 2710
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  235 AQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPV-ITTTAAHAADSTLSRPTLSIQHPPSAAISIQRPAQSR 313
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  314 DVTTRITLPS------HPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTLPSTTTAGSVSHTQAPtstiVTMTM 387
Cdd:PHA03247  2791 LSESRESLPSpwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD----VRRRP 2866
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  388 PSHSSHATAVTTSNIPVAKVvpqqithtsPRIQPDYPPERSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPTYP 467
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRL---------ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          410       420
                   ....*....|....*....|....*
gi 1274095713  468 PSAYPLAAHTYTPITSSVSTIRQYP 492
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQP 2962
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
453-829 4.23e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 4.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  453 PSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQ-YPVSAQAPNSTI-TAQTGVGVASTVHLNPMQLMTvdashar 530
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQgSPATSQPPNQTQsTAAPHTLIQQTPTLHPQRLPS------- 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  531 hiqgiqPAPISTQGIQPAPIGTSGIQPAPigTPGIHSAAPINTQGLQPAAMANQQPQPEgktsavvladgATIVANPISN 610
Cdd:pfam03154  245 ------PHPPLQPMTQPPPPSQVSPQPLP--QPSLHGQMPPMPHSLQTGPSHMQHPVPP-----------QPFPLTPQSS 305
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  611 PFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATDG-MAVRKTLLPPQPPDVATPRVESSMRSASGS------ 683
Cdd:pfam03154  306 QSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPApLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSgpspfq 385
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  684 -----PRPAGAKPKSEV---HVSIATPVTVSLETISNQ----NAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIAL- 750
Cdd:pfam03154  386 mnsnlPPPPALKPLSSLsthHPPSAHPPPLQLMPQSQQlpppPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQh 465
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  751 STIPGAVPV-----TPPITTIAATPTLSAPVGGTPST------VLGPPVPEIKVKEEAePVDITRPVSTVPPLATNTVSP 819
Cdd:pfam03154  466 PFVPGGPPPitppsGPPTSTSSAMPGIQPPSSASVSSsgpvpaAVSCPLPPVQIKEEA-LDEAEEPESPPPPPRSPSPEP 544
                          410
                   ....*....|
gi 1274095713  820 SLALLASNLS 829
Cdd:pfam03154  545 TVVNTPSHAS 554
 
Name Accession Description Interval E-value
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
635-1040 0e+00

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 549.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  635 AQGSSPRPSILRKKPATDGmavrktllppqppdvatprvessmrsasgsprpagAKPKSEVHVSIATPVTVSLETISNQN 714
Cdd:pfam16014    1 ALGSSPRPSILRKKPATEG-----------------------------------AKPKPDIHVAVAPPVTVAVEALPGQN 45
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  715 AEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVTPP----ITTIAATPTLSApVGGTPSTVLGPPVPE 790
Cdd:pfam16014   46 SEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLPAAMAVTPPipasMANVVAPPTQPA-ASSTAACAVSSVLPE 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  791 IKVKEEAEPVDITRpvsTVPPLATNTVSPSLALLASNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKS 870
Cdd:pfam16014  125 IKIKQEAEPMDTSQ---SVPPLTPTSISPALTSLANNLSVPAGDLLPGASPRKKPRKQQHVISTEEGEMMETNSTDEEKS 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  871 AAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSC 950
Cdd:pfam16014  202 APKPLTSRAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKGTLQDMANQKGVTC 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  951 RAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLD 1030
Cdd:pfam16014  282 RAQGWKIHLCAAQLLQLTNLEHDVYSRLTTLQEGLIPKKKAGTDDDLHRINELIQGNMQRCKLVMDQITEARDSMMKVLD 361
                          410
                   ....*....|
gi 1274095713 1031 HKDRVLKLLN 1040
Cdd:pfam16014  362 HKDRVLKLLN 371
PHA03247 PHA03247
large tegument protein UL36; Provisional
417-886 1.20e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  417 PRIQPDYPPERSSLIPiSGHRASPNPVAMETRNDNRPSVPVQfqyflPTYPPSAYPlaahTYTPITSSVSTIRQYPVSAQ 496
Cdd:PHA03247  2641 HPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQ-----RPRRRAARP----TVGSLTSLADPPPPPPTPEP 2710
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  497 APNSTITAqtgvgvastvhlNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGtsgiqPAPIGTPGIHSAAPINTQGL 576
Cdd:PHA03247  2711 APHALVSA------------TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTTAGPPAPAPPA 2773
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  577 QPAAmanqQPQPEGKTSAVVLADGATivaNPISNPFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATdgmav 656
Cdd:PHA03247  2774 APAA----GPPRRLTRPAVASLSESR---ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP----- 2841
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  657 rktllPPQPPDVATPR----VESSMRSASGSPRPAGAKPKSEVHVSIATPVTVSLETiSNQNAEQPTVAVPPTAQQPPPT 732
Cdd:PHA03247  2842 -----PPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPP 2915
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  733 IPSMIAAASPPSQPAIALSTIPGAVPVTPPITTIAATPtlsAPVGGTPSTVLGP------PVPEIKVKEEAEPVDItrPV 806
Cdd:PHA03247  2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG---EPSGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREA--PA 2990
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  807 STVPPLaTNTVSPSLALLASNLSMPPSDLPPGASprkkpRKQQHVIS--TEEGDMMETNSTDDEKSAAKSLLVKAEKRKS 884
Cdd:PHA03247  2991 SSTPPL-TGHSLSRVSSWASSLALHEETDPPPVS-----LKQTLWPPddTEDSDADSLFDSDSERSDLEALDPLPPEPHD 3064

                   ..
gi 1274095713  885 PP 886
Cdd:PHA03247  3065 PF 3066
PHA03247 PHA03247
large tegument protein UL36; Provisional
558-849 3.00e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  558 APIGTPGiHSAAPINTQGLQPAAMANQQPQPEGKTSAVVLADGATIVANPISNPFSAApaATTVVQTHSQSASTNTPAQG 637
Cdd:PHA03247  2600 APVDDRG-DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDP--APGRVSRPRRARRLGRAAQA 2676
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  638 SSPrPSILRKKPATDGMAVRKTLLPPQPPdvatprvessmrsasgsPRPAGAKPKSEVHVSIATPVTVSletiSNQNAEQ 717
Cdd:PHA03247  2677 SSP-PQRPRRRAARPTVGSLTSLADPPPP-----------------PPTPEPAPHALVSATPLPPGPAA----ARQASPA 2734
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  718 PTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVT--PPITTIAATPTLSAPVGGTPSTVLGPPVPEIKVKE 795
Cdd:PHA03247  2735 LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgpPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1274095713  796 EAEPVDITRPVSTVPPLATNT-VSPSLALLASNLSMPP-SDLPPGASPRKKPRKQQ 849
Cdd:PHA03247  2815 AAALPPAASPAGPLPPPTSAQpTAPPPPPGPPPPSLPLgGSVAPGGDVRRRPPSRS 2870
PHA03247 PHA03247
large tegument protein UL36; Provisional
98-492 1.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713   98 PPAHLTPA---------VPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSLPPKVPGQVTVTMESS-IPQASAIPVATISG 167
Cdd:PHA03247  2551 PPPPLPPAappaapdrsVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSpLPPDTHAPDPPPPS 2630
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  168 QQGHPSNLHHIMTTNVQMSIIRSNAPGPP------------LHIGASHLPRGAAAAAVMSS-SKVTTVLRPTSQLPNAAT 234
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlgRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEP 2710
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  235 AQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPV-ITTTAAHAADSTLSRPTLSIQHPPSAAISIQRPAQSR 313
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  314 DVTTRITLPS------HPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTLPSTTTAGSVSHTQAPtstiVTMTM 387
Cdd:PHA03247  2791 LSESRESLPSpwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD----VRRRP 2866
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  388 PSHSSHATAVTTSNIPVAKVvpqqithtsPRIQPDYPPERSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPTYP 467
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRL---------ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          410       420
                   ....*....|....*....|....*
gi 1274095713  468 PSAYPLAAHTYTPITSSVSTIRQYP 492
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQP 2962
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
453-829 4.23e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 4.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  453 PSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQ-YPVSAQAPNSTI-TAQTGVGVASTVHLNPMQLMTvdashar 530
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQgSPATSQPPNQTQsTAAPHTLIQQTPTLHPQRLPS------- 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  531 hiqgiqPAPISTQGIQPAPIGTSGIQPAPigTPGIHSAAPINTQGLQPAAMANQQPQPEgktsavvladgATIVANPISN 610
Cdd:pfam03154  245 ------PHPPLQPMTQPPPPSQVSPQPLP--QPSLHGQMPPMPHSLQTGPSHMQHPVPP-----------QPFPLTPQSS 305
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  611 PFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATDG-MAVRKTLLPPQPPDVATPRVESSMRSASGS------ 683
Cdd:pfam03154  306 QSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPApLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSgpspfq 385
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  684 -----PRPAGAKPKSEV---HVSIATPVTVSLETISNQ----NAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIAL- 750
Cdd:pfam03154  386 mnsnlPPPPALKPLSSLsthHPPSAHPPPLQLMPQSQQlpppPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQh 465
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  751 STIPGAVPV-----TPPITTIAATPTLSAPVGGTPST------VLGPPVPEIKVKEEAePVDITRPVSTVPPLATNTVSP 819
Cdd:pfam03154  466 PFVPGGPPPitppsGPPTSTSSAMPGIQPPSSASVSSsgpvpaAVSCPLPPVQIKEEA-LDEAEEPESPPPPPRSPSPEP 544
                          410
                   ....*....|
gi 1274095713  820 SLALLASNLS 829
Cdd:pfam03154  545 TVVNTPSHAS 554
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
741-861 4.32e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 4.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  741 SPPSQPAIALSTIPGAVPVTPPITTIAATPTLSAPVGGTPSTVLGPPVPEIKVKEEAEPV--DITRPVSTVPPLATNTVS 818
Cdd:PRK14950   344 TSYGQLPLELAVIEALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVreTATPPPVPPRPVAPPVPH 423
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1274095713  819 PSLALLASNLSMPPSDLPPGASPrKKPRKQQHVISTEEGDMME 861
Cdd:PRK14950   424 TPESAPKLTRAAIPVDEKPKYTP-PAPPKEEEKALIADGDVLE 465
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
531-846 4.96e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 4.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  531 HIQGIQPAPISTQGIQPAPIGTSGIQPAPIGTPGihSAAPINTQGLQPAAMANQQPQPEGKTSAVVLADGATIVANPISN 610
Cdd:PHA03307    91 SLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA--SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAAS 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  611 PFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSilrkkpatdgmavrktlLPPQPPDVATPRVESSMRSASGSPRPAGAK 690
Cdd:PHA03307   169 SRQAALPLSSPEETARAPSSPPAEPPPSTPPAA-----------------ASPRPPRRSSPISASASSPAPAPGRSAADD 231
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  691 PKSEVHVSIATPVTVSLETISNQNAEQPtvavpptaqqppptiPSMIAAASPPSQPAIALSTIPGAVPVTPPITTIAATP 770
Cdd:PHA03307   232 AGASSSDSSSSESSGCGWGPENECPLPR---------------PAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSP 296
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1274095713  771 TLSAPVGGTPSTVLGPPVPEIKVKEEAEPVDITRPVSTVPPLATNTVSPSLALLASnlSMPPSDLPPGASPRKKPR 846
Cdd:PHA03307   297 SPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPS--PSRPPPPADPSSPRKRPR 370
PHA02732 PHA02732
hypothetical protein; Provisional
237-466 7.04e-03

hypothetical protein; Provisional


Pssm-ID: 165099 [Multi-domain]  Cd Length: 1467  Bit Score: 40.51  E-value: 7.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  237 PAVQHLIHQPIQSRPPVTTSST--IPPAVVA----TVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSAAISIQrPA 310
Cdd:PHA02732  1182 PAPQLLSSYIPTGSVLYQDPIFtyIPPGIIGmsgtNTFTFKAAQLQLSAASSPPAATTPTPPPSSSSSSSAQSISTS-PG 1260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  311 QSR-----DVTTRITLPSHPALGTPKqqlhtmaqktifsTGTPVAAATVapilatntlpSTTTAGSVSHTQAPTSTIVTM 385
Cdd:PHA02732  1261 QIQivlngSTTIHINFLFFPALSTPK-------------IGQILAMPIV----------NSSGAFISLYVNSAISANFNV 1317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095713  386 TMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPPErSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPT 465
Cdd:PHA02732  1318 TIEYVFSNGTVIKRFTDEPGQIFPLPLINGDEEVIISVENE-STTFNISANNLGSAQLALQLRNAISASLPGPFAFFGPI 1396

                   .
gi 1274095713  466 Y 466
Cdd:PHA02732  1397 L 1397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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