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Conserved domains on  [gi|1269208460|ref|NP_001344190|]
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sortilin-related receptor isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS10 super family cl33391
VPS10 domain;
1-419 2.69e-177

VPS10 domain;


The actual alignment was detected with superfamily member smart00602:

Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 550.47  E-value: 2.69e-177
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460     1 MRAAQFVTKHPINE---YYIADAAEDQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfane 75
Cdd:smart00602  204 FAMAKFPKYHALGKqqaYTILDSDEDSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG-------------- 269

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460    76 pFADFHRVEGLQGVYIATLINGsmNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNl 153
Cdd:smart00602  270 -YIDFYKVEGLKGIYIANIVSK--VDKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY- 345

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   154 qlrRMPILSKESAPGLIIATGSVGKNLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYST 231
Cdd:smart00602  346 ---SGDIASSKSAPGIIIASGNVGDGLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYST 422

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   232 NEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--EC 309
Cdd:smart00602  423 DEGKTWKTYTFTSTPVFVKGLLTEPGGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGC 502

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   310 LLGHKTVFKRRTPHATCFNGE-DFDRPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKPYspPVPCPVGSSY 388
Cdd:smart00602  503 LLGHKTIFKRRKPTSQCLVGKsDYDLSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSY 579

                           410       420       430
                    ....*....|....*....|....*....|....
gi 1269208460   389 RR---TRGYRKISGDTCSGGdVEARLEGELVPCP 419
Cdd:smart00602  580 TEyvkSLGYRKIPGDKCKGG-VKLEAEDIPHPCP 612
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1317-1408 7.33e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.54  E-value: 7.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1317 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGLIREYIVEYSRSGSKMW---ASQRAASNSTEIKNLLLNALYTVRVAAVT 1393
Cdd:cd00063      1 PSPPTNLRVTDVTSTS-VTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1269208460 1394 SRGIGNWSDSKSITT 1408
Cdd:cd00063     79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
823-858 6.44e-14

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 67.27  E-value: 6.44e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460  823 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 858
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 991-1025 5.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.06e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  991 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1025
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1039-1069 6.09e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.09e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1269208460 1039 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1069
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
864-896 6.78e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.50  E-value: 6.78e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1269208460  864 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 896
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 744-778 1.85e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.85e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  744 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 778
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1223-1296 2.58e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 2.58e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460 1223 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 1296
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 906-937 2.88e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 2.88e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1269208460  906 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 937
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1085-1119 9.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 9.03e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460 1085 CLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1119
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 490-532 5.94e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 5.94e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   490 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 532
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1356-1766 4.26e-09

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1356 YSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPnihidSYDENSLSFTLTM 1435
Cdd:COG3401      5 YLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGG-----LGTGGRAGTTSGV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1436 DGDIKVNGYVVNLFWSFDAHKQEKKTlSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSl 1515
Cdd:COG3401     80 AAVAVAAAPPTATGLTTLTGSGSVGG-ATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASG- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1516 kaKAINQTAVECIWTGPKNVVYGIFYATSFldlyrnpKSVTTSLHNKTVIVSKDEQYLFLVRVL-IPYQGPSSDYVVVKM 1594
Cdd:COG3401    158 --TTASSVAGAGVVVSPDTSATAAVATTSL-------TVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1595 IPDSRLPPRHLHAVHIGKTSALIKWEspyDSPDQDL-FYAIAVKDlirKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIV 1673
Cdd:COG3401    229 PTTPPSAPTGLTATADTPGSVTLSWD---PVTESDAtGYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRV 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1674 QL----GNMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFWKSLAlkekQFNETrGYEIHMSDSAVNLTAYLGNT- 1744
Cdd:COG3401    303 TAvdaaGNESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWTASS----DADVT-GYNVYRSTSGGGTYTKIAETv 377

                          410       420
                   ....*....|....*....|..
gi 1269208460 1745 TDNFFKVSNLKMGHNYTFTVQA 1766
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTA 399
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 783-819 4.92e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.92e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460  783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 819
Cdd:cd00112      1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 579-619 8.34e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 8.34e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   579 YRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQR 619
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1172 3.42e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 3.42e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460 1137 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1172
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1180-1215 1.43e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 1.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460 1180 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1215
Cdd:cd00112      1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 556-595 9.10e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 9.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1269208460  556 MFWTDWGdLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD 595
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 947-974 6.24e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 6.24e-05
                            10        20
                    ....*....|....*....|....*...
gi 1269208460   947 FVCKNRQqCLFHSMVCDGIVQCRDGSDE 974
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 534-576 1.92e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.92e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   534 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSYMDGS 576
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.58e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.58e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1269208460   446 EQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 487
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 619-653 8.33e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 8.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1269208460   619 RSVILDSLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 653
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
1-419 2.69e-177

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 550.47  E-value: 2.69e-177
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460     1 MRAAQFVTKHPINE---YYIADAAEDQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfane 75
Cdd:smart00602  204 FAMAKFPKYHALGKqqaYTILDSDEDSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG-------------- 269

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460    76 pFADFHRVEGLQGVYIATLINGsmNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNl 153
Cdd:smart00602  270 -YIDFYKVEGLKGIYIANIVSK--VDKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY- 345

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   154 qlrRMPILSKESAPGLIIATGSVGKNLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYST 231
Cdd:smart00602  346 ---SGDIASSKSAPGIIIASGNVGDGLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYST 422

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   232 NEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--EC 309
Cdd:smart00602  423 DEGKTWKTYTFTSTPVFVKGLLTEPGGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGC 502

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   310 LLGHKTVFKRRTPHATCFNGE-DFDRPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKPYspPVPCPVGSSY 388
Cdd:smart00602  503 LLGHKTIFKRRKPTSQCLVGKsDYDLSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSY 579

                           410       420       430
                    ....*....|....*....|....*....|....
gi 1269208460   389 RR---TRGYRKISGDTCSGGdVEARLEGELVPCP 419
Cdd:smart00602  580 TEyvkSLGYRKIPGDKCKGG-VKLEAEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 4-252 9.54e-80

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 271.00  E-value: 9.54e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460    4 AQFVTKHPINEYYIADAAEDQVFVCVSHSNNS--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFH 81
Cdd:pfam15902  205 AQFPHVLEQQAYTVLESSTHSIFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   82 RVEGLQGVYIA-TLIN----GSMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlR 156
Cdd:pfam15902  270 KVAGLEGVYLAnVVSNaeevGKGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---I 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  157 RMPILSKESAPGLIIATGSVGKNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNE 233
Cdd:pfam15902  346 GRDTFSSPSAPGLIMGVGNVGDSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDE 425

                          250
                   ....*....|....*....
gi 1269208460  234 GETWKTFVFSEKPVFVYGL 252
Cdd:pfam15902  426 GKTWETYKFADEKIRVLDL 444
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1317-1408 7.33e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.54  E-value: 7.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1317 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGLIREYIVEYSRSGSKMW---ASQRAASNSTEIKNLLLNALYTVRVAAVT 1393
Cdd:cd00063      1 PSPPTNLRVTDVTSTS-VTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1269208460 1394 SRGIGNWSDSKSITT 1408
Cdd:cd00063     79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
823-858 6.44e-14

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 67.27  E-value: 6.44e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460  823 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 858
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 824-858 1.22e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.22e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  824 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 858
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 991-1025 5.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.06e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  991 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1025
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1039-1069 6.09e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.09e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1269208460 1039 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1069
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
864-896 6.78e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.50  E-value: 6.78e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1269208460  864 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 896
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 864-896 7.65e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 61.11  E-value: 7.65e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   864 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 896
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 744-778 1.85e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.85e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  744 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 778
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 865-897 2.13e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 2.13e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1269208460  865 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 897
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1223-1296 2.58e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 2.58e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460 1223 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 1296
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 906-937 2.88e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 2.88e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1269208460  906 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 937
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 823-855 5.45e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 5.45e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   823 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 855
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1085-1119 9.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 9.03e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460 1085 CLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1119
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
fn3 pfam00041
Fibronectin type III domain;
1318-1401 9.44e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 9.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1318 DAPRNLQLSLNSEEEGVIlgHWAPPVHTHGLIREYIVEYSRSGS-KMWASQRAASN--STEIKNLLLNALYTVRVAAVTS 1394
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTV--SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1269208460 1395 RGIGNWS 1401
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1208-1419 1.03e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1208 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 1280
Cdd:COG3401    213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1281 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNSEEEGVILGhWAPPvhTHGLIREYIVEYS 1357
Cdd:COG3401    290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460 1358 RSGSKMWASQRAASNSTE--IKNLLLNALYTVRVAAVTSRgiGNWSD-SKSITTIKGKVIQAPNI 1419
Cdd:COG3401    364 TSGGGTYTKIAETVTTTSytDTGLTPGTTYYYKVTAVDAA--GNESApSEEVSATTASAASGESL 426
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1039-1069 2.33e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 2.33e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1269208460 1039 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1069
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
991-1025 2.75e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 2.75e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  991 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1025
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 990-1022 3.01e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 3.01e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   990 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1022
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1224-1296 3.05e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 3.05e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1269208460  1224 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTSTVLKVLKPDTTYQVKVQVH 1296
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1039-1066 3.52e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 3.52e-10
                            10        20
                    ....*....|....*....|....*...
gi 1269208460  1039 QFHCENGHCIPNRWKCDRENDCGDWSDE 1066
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
906-937 5.20e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 5.20e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1269208460  906 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 937
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 743-775 5.74e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 5.74e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   743 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE 775
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 490-532 5.94e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 5.94e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   490 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 532
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1083-1119 9.08e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 9.08e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460 1083 STCLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1119
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 905-934 9.36e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 9.36e-10
                            10        20        30
                    ....*....|....*....|....*....|
gi 1269208460   905 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 934
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1084-1116 1.00e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.00e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460  1084 TCLPNYFHCSSGACVMGTWVCDGYRDCADGSDE 1116
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1317-1398 2.61e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.61e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  1317 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGL--IREYIVEYSRSGSKmWASQRAASNSTE--IKNLLLNALYTVRVAAV 1392
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTL-SWEPPPDDGITgyIVGYRVEYREEGSE-WKEVNVTPSSTSytLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1269208460  1393 TSRGIG 1398
Cdd:smart00060   78 NGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1356-1766 4.26e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1356 YSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPnihidSYDENSLSFTLTM 1435
Cdd:COG3401      5 YLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGG-----LGTGGRAGTTSGV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1436 DGDIKVNGYVVNLFWSFDAHKQEKKTlSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSl 1515
Cdd:COG3401     80 AAVAVAAAPPTATGLTTLTGSGSVGG-ATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASG- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1516 kaKAINQTAVECIWTGPKNVVYGIFYATSFldlyrnpKSVTTSLHNKTVIVSKDEQYLFLVRVL-IPYQGPSSDYVVVKM 1594
Cdd:COG3401    158 --TTASSVAGAGVVVSPDTSATAAVATTSL-------TVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1595 IPDSRLPPRHLHAVHIGKTSALIKWEspyDSPDQDL-FYAIAVKDlirKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIV 1673
Cdd:COG3401    229 PTTPPSAPTGLTATADTPGSVTLSWD---PVTESDAtGYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRV 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1674 QL----GNMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFWKSLAlkekQFNETrGYEIHMSDSAVNLTAYLGNT- 1744
Cdd:COG3401    303 TAvdaaGNESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWTASS----DADVT-GYNVYRSTSGGGTYTKIAETv 377

                          410       420
                   ....*....|....*....|..
gi 1269208460 1745 TDNFFKVSNLKMGHNYTFTVQA 1766
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTA 399
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 783-819 4.92e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.92e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460  783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 819
Cdd:cd00112      1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 579-619 8.34e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 8.34e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   579 YRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQR 619
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
743-778 9.59e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 9.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460  743 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 778
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
fn3 pfam00041
Fibronectin type III domain;
1223-1294 2.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1269208460 1223 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQ 1294
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1172 3.42e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 3.42e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460 1137 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1172
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1601-1688 6.17e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 6.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1601 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTvEYSLSKLEPGGKYHIIVQLGNMSK 1680
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1269208460 1681 DS----SIKITT 1688
Cdd:cd00063     82 ESppseSVTVTT 93
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 783-816 1.12e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 1.12e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1269208460   783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 816
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1180-1215 1.43e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 1.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460 1180 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1215
Cdd:cd00112      1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1136-1172 2.03e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 2.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460 1136 QCDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1172
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1179-1212 3.70e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 3.70e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1269208460  1179 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDE 1212
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1601-1674 5.27e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 5.27e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460  1601 PPRHLHAVHIGKTSALIKWESPYDspDQDLFYAIAVKDLIRKTDRSYK-VRSRNSTVEYSLSKLEPGGKYHIIVQ 1674
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVEYREEGSEWKeVNVTPSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1601-1674 6.63e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 6.63e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1269208460 1601 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLiRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQ 1674
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1136-1169 1.21e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 1.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1269208460  1136 QCDRFEFECHqPKKCIPNWKRCDGHQDCQDGQDE 1169
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
783-819 2.14e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460  783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 819
Cdd:pfam00057    3 CSPN-EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 556-595 9.10e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 9.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1269208460  556 MFWTDWGdLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD 595
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1179-1215 2.00e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 2.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460 1179 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1215
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 947-974 6.24e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 6.24e-05
                            10        20
                    ....*....|....*....|....*...
gi 1269208460   947 FVCKNRQqCLFHSMVCDGIVQCRDGSDE 974
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 947-975 1.87e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 1.87e-04
                           10        20
                   ....*....|....*....|....*....
gi 1269208460  947 FVCKNRQqCLFHSMVCDGIVQCRDGSDED 975
Cdd:cd00112      6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 534-576 1.92e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.92e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   534 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSYMDGS 576
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.58e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.58e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1269208460   446 EQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 487
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 619-653 8.33e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 8.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1269208460   619 RSVILDSLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 653
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 599-635 8.71e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.98  E-value: 8.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1269208460  599 IYWTDAYLDC-IERITFSGQQRSVILDS-LPHPYAIAVF 635
Cdd:pfam00058    3 LYWTDSSLRAsISSADLNGSDRKTLFTDdLQHPNAIAVD 41
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
1-419 2.69e-177

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 550.47  E-value: 2.69e-177
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460     1 MRAAQFVTKHPINE---YYIADAAEDQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfane 75
Cdd:smart00602  204 FAMAKFPKYHALGKqqaYTILDSDEDSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG-------------- 269

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460    76 pFADFHRVEGLQGVYIATLINGsmNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNl 153
Cdd:smart00602  270 -YIDFYKVEGLKGIYIANIVSK--VDKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY- 345

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   154 qlrRMPILSKESAPGLIIATGSVGKNLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYST 231
Cdd:smart00602  346 ---SGDIASSKSAPGIIIASGNVGDGLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYST 422

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   232 NEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--EC 309
Cdd:smart00602  423 DEGKTWKTYTFTSTPVFVKGLLTEPGGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGC 502

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   310 LLGHKTVFKRRTPHATCFNGE-DFDRPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKPYspPVPCPVGSSY 388
Cdd:smart00602  503 LLGHKTIFKRRKPTSQCLVGKsDYDLSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSY 579

                           410       420       430
                    ....*....|....*....|....*....|....
gi 1269208460   389 RR---TRGYRKISGDTCSGGdVEARLEGELVPCP 419
Cdd:smart00602  580 TEyvkSLGYRKIPGDKCKGG-VKLEAEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 4-252 9.54e-80

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 271.00  E-value: 9.54e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460    4 AQFVTKHPINEYYIADAAEDQVFVCVSHSNNS--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFH 81
Cdd:pfam15902  205 AQFPHVLEQQAYTVLESSTHSIFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460   82 RVEGLQGVYIA-TLIN----GSMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlR 156
Cdd:pfam15902  270 KVAGLEGVYLAnVVSNaeevGKGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---I 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  157 RMPILSKESAPGLIIATGSVGKNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNE 233
Cdd:pfam15902  346 GRDTFSSPSAPGLIMGVGNVGDSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDE 425

                          250
                   ....*....|....*....
gi 1269208460  234 GETWKTFVFSEKPVFVYGL 252
Cdd:pfam15902  426 GKTWETYKFADEKIRVLDL 444
Sortilin_C pfam15901
Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of ...
 254-418 2.68e-57

Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarization to modulate cell survival and synaptic plasticity.


Pssm-ID: 464928 [Multi-domain]  Cd Length: 164  Bit Score: 195.62  E-value: 2.68e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  254 TEPGEKSTVFTIFGSNKESVHSWLIL-QVNATDALGVPCTENDYKLWSPS-DERGNECLLGHKTVFKRRTPHATCFNGED 331
Cdd:pfam15901    1 TEPDDTSLKFLLFGSSSSSRSDWEVVyTIDFSGLFDRKCTDDDYELWSPRhDQDGPKCLLGHKQKYRRRKPDADCFNGKD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  332 FDRPVVVSNCSCTREDYECDFGFKMSEDLSleVCVPDPEFSgKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARL 411
Cdd:pfam15901   81 FKDPKIEENCECTREDFECDYGFERSANDG--KCVLVPGLL-PPDGPKEDCKPGTYYLGSSGYRKIPGNTCEGGLELDKD 157


                   ....*..
gi 1269208460  412 EGELVPC 418
Cdd:pfam15901  158 EPVEHPC 164
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1317-1408 7.33e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.54  E-value: 7.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1317 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGLIREYIVEYSRSGSKMW---ASQRAASNSTEIKNLLLNALYTVRVAAVT 1393
Cdd:cd00063      1 PSPPTNLRVTDVTSTS-VTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1269208460 1394 SRGIGNWSDSKSITT 1408
Cdd:cd00063     79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
823-858 6.44e-14

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 67.27  E-value: 6.44e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460  823 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 858
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 824-858 1.22e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.22e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  824 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 858
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 991-1025 5.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.06e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  991 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1025
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1039-1069 6.09e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.09e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1269208460 1039 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1069
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
864-896 6.78e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.50  E-value: 6.78e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1269208460  864 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 896
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 864-896 7.65e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 61.11  E-value: 7.65e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   864 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 896
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 744-778 1.85e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 1.85e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  744 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 778
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 865-897 2.13e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 2.13e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1269208460  865 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 897
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1223-1296 2.58e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 2.58e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460 1223 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 1296
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 906-937 2.88e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 2.88e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1269208460  906 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 937
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 823-855 5.45e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 5.45e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   823 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 855
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1085-1119 9.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 9.03e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460 1085 CLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1119
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
fn3 pfam00041
Fibronectin type III domain;
1318-1401 9.44e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 9.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1318 DAPRNLQLSLNSEEEGVIlgHWAPPVHTHGLIREYIVEYSRSGS-KMWASQRAASN--STEIKNLLLNALYTVRVAAVTS 1394
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTV--SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1269208460 1395 RGIGNWS 1401
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1208-1419 1.03e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1208 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 1280
Cdd:COG3401    213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1281 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNSEEEGVILGhWAPPvhTHGLIREYIVEYS 1357
Cdd:COG3401    290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460 1358 RSGSKMWASQRAASNSTE--IKNLLLNALYTVRVAAVTSRgiGNWSD-SKSITTIKGKVIQAPNI 1419
Cdd:COG3401    364 TSGGGTYTKIAETVTTTSytDTGLTPGTTYYYKVTAVDAA--GNESApSEEVSATTASAASGESL 426
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1039-1069 2.33e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 2.33e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1269208460 1039 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1069
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
991-1025 2.75e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 2.75e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1269208460  991 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1025
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 990-1022 3.01e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 3.01e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   990 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1022
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1224-1296 3.05e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 3.05e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1269208460  1224 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTSTVLKVLKPDTTYQVKVQVH 1296
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1039-1066 3.52e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 3.52e-10
                            10        20
                    ....*....|....*....|....*...
gi 1269208460  1039 QFHCENGHCIPNRWKCDRENDCGDWSDE 1066
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
906-937 5.20e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 5.20e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1269208460  906 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 937
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 743-775 5.74e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 5.74e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460   743 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE 775
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 490-532 5.94e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 5.94e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   490 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 532
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1083-1119 9.08e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 9.08e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460 1083 STCLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1119
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 905-934 9.36e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 9.36e-10
                            10        20        30
                    ....*....|....*....|....*....|
gi 1269208460   905 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 934
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1084-1116 1.00e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.00e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1269208460  1084 TCLPNYFHCSSGACVMGTWVCDGYRDCADGSDE 1116
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1317-1398 2.61e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.61e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  1317 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGL--IREYIVEYSRSGSKmWASQRAASNSTE--IKNLLLNALYTVRVAAV 1392
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTL-SWEPPPDDGITgyIVGYRVEYREEGSE-WKEVNVTPSSTSytLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1269208460  1393 TSRGIG 1398
Cdd:smart00060   78 NGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1356-1766 4.26e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1356 YSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPnihidSYDENSLSFTLTM 1435
Cdd:COG3401      5 YLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGG-----LGTGGRAGTTSGV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1436 DGDIKVNGYVVNLFWSFDAHKQEKKTlSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSl 1515
Cdd:COG3401     80 AAVAVAAAPPTATGLTTLTGSGSVGG-ATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASG- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1516 kaKAINQTAVECIWTGPKNVVYGIFYATSFldlyrnpKSVTTSLHNKTVIVSKDEQYLFLVRVL-IPYQGPSSDYVVVKM 1594
Cdd:COG3401    158 --TTASSVAGAGVVVSPDTSATAAVATTSL-------TVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1595 IPDSRLPPRHLHAVHIGKTSALIKWEspyDSPDQDL-FYAIAVKDlirKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIV 1673
Cdd:COG3401    229 PTTPPSAPTGLTATADTPGSVTLSWD---PVTESDAtGYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRV 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1674 QL----GNMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFWKSLAlkekQFNETrGYEIHMSDSAVNLTAYLGNT- 1744
Cdd:COG3401    303 TAvdaaGNESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWTASS----DADVT-GYNVYRSTSGGGTYTKIAETv 377

                          410       420
                   ....*....|....*....|..
gi 1269208460 1745 TDNFFKVSNLKMGHNYTFTVQA 1766
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTA 399
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 783-819 4.92e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.92e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460  783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 819
Cdd:cd00112      1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 579-619 8.34e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 8.34e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   579 YRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQR 619
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
743-778 9.59e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 9.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460  743 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 778
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1260-1580 1.40e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 1.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1260 VVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEgVILgHW 1339
Cdd:COG3401    176 ATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGS-VTL-SW 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1340 APpvHTHGLIREYIVEYSRSGSKMWaSQRAASNSTEI--KNLLLNALYTVRVAAVTSRGI-GNWSDSKSITTIKGKVIQA 1416
Cdd:COG3401    254 DP--VTESDATGYRVYRSNSGDGPF-TKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAP 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1417 PNIHIDSYDENSLSFTLTMDGDIKVNGYVVnlfwsfdaHKQEKKTLSFRG----GSALSHRVSNLTAHTS--YEISAWAK 1490
Cdd:COG3401    331 SGLTATAVGSSSITLSWTASSDADVTGYNV--------YRSTSGGGTYTKiaetVTTTSYTDTGLTPGTTyyYKVTAVDA 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1491 TDLGdSPLAFEHILTRGSSPPAPSLKA--KAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSVTTSLHNKTVIVSK 1568
Cdd:COG3401    403 AGNE-SAPSEEVSATTASAASGESLTAsvDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481

                          330
                   ....*....|..
gi 1269208460 1569 DEQYLFLVRVLI 1580
Cdd:COG3401    482 TDTTTANLSVTT 493
fn3 pfam00041
Fibronectin type III domain;
1223-1294 2.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1269208460 1223 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQ 1294
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1172 3.42e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 3.42e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460 1137 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1172
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1601-1688 6.17e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 6.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1601 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTvEYSLSKLEPGGKYHIIVQLGNMSK 1680
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1269208460 1681 DS----SIKITT 1688
Cdd:cd00063     82 ESppseSVTVTT 93
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 783-816 1.12e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 1.12e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1269208460   783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 816
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1180-1215 1.43e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 1.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1269208460 1180 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1215
Cdd:cd00112      1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1136-1172 2.03e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 2.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460 1136 QCDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1172
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1179-1212 3.70e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 3.70e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1269208460  1179 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDE 1212
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1601-1674 5.27e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 5.27e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208460  1601 PPRHLHAVHIGKTSALIKWESPYDspDQDLFYAIAVKDLIRKTDRSYK-VRSRNSTVEYSLSKLEPGGKYHIIVQ 1674
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVEYREEGSEWKeVNVTPSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1601-1674 6.63e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 6.63e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1269208460 1601 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLiRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQ 1674
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1136-1169 1.21e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 1.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1269208460  1136 QCDRFEFECHqPKKCIPNWKRCDGHQDCQDGQDE 1169
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
783-819 2.14e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460  783 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 819
Cdd:pfam00057    3 CSPN-EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 556-595 9.10e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 9.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1269208460  556 MFWTDWGdLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD 595
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1179-1215 2.00e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 2.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1269208460 1179 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1215
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 947-974 6.24e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 6.24e-05
                            10        20
                    ....*....|....*....|....*...
gi 1269208460   947 FVCKNRQqCLFHSMVCDGIVQCRDGSDE 974
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1692-1779 1.81e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1692 SAPDALKII-TENDHVLLFWKSLALKEKQFnetRGYEIHMSDSAVN--LTAYLGNTTDNFFKVSNLKMGHNYTFTVQARC 1768
Cdd:cd00063      2 SPPTNLRVTdVTSTSVTLSWTPPEDDGGPI---TGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|.
gi 1269208460 1769 LFGsqiCGEPA 1779
Cdd:cd00063     79 GGG---ESPPS 86
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 947-975 1.87e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 1.87e-04
                           10        20
                   ....*....|....*....|....*....
gi 1269208460  947 FVCKNRQqCLFHSMVCDGIVQCRDGSDED 975
Cdd:cd00112      6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 534-576 1.92e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.92e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1269208460   534 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSYMDGS 576
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1692-1772 2.34e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.34e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  1692 SAPDALKII-TENDHVLLFWKSlALKEKQFNETRGYEIHMSDSAVNLTAYLGNTTDNFFKVSNLKMGHNYTFTVQARCLF 1770
Cdd:smart00060    2 SPPSNLRVTdVTSTSVTLSWEP-PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ..
gi 1269208460  1771 GS 1772
Cdd:smart00060   81 GE 82
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.58e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.58e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1269208460   446 EQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 487
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 832-906 2.61e-04

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 43.62  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  832 SSGMCIRSSWVCDGDNDCRDWSDEANCTAiyhtCEASNFQCHN-GHC---IPQRWACDGDAD---CQDGSDEDPVSCEKK 904
Cdd:pfam12999   43 HSEIKLSFDQVNDDYCDCPDGSDEPGTNA----CSNGKFYCANeGFIpgyIPSFKVDDGVCDydiCCDGSDEALGKCPNK 118


                   ..
gi 1269208460  905 CN 906
Cdd:pfam12999  119 CG 120
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1418-1497 1.27e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460 1418 NIHIDSYDENS--LSFTLTMDGDIKVNGYVVNLFwsfDAHKQEKKTLSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGD 1495
Cdd:cd00063      6 NLRVTDVTSTSvtLSWTPPEDDGGPITGYVVEYR---EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82


                   ..
gi 1269208460 1496 SP 1497
Cdd:cd00063     83 SP 84
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 464-603 2.23e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  464 ERNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLetVEALAFEPLSQL--------LYWVDAGFKKIEVANPDGDFRLTI 535
Cdd:COG3386     17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGR--PNGLAFDPDGRLlvadhgrgLVRFDPADGEVTVLADEYGKPLNR 94

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269208460  536 VNSSVLDRpralvlvpqEGVMFWTDWGDLKP--GIYRsyMDGSAAYRLVSEDVKWPNGI--SVDSQWIYWTD 603
Cdd:COG3386     95 PNDGVVDP---------DGRLYFTDMGEYLPtgALYR--VDPDGSLRVLADGLTFPNGIafSPDGRTLYVAD 155
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1417-1496 2.48e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 2.48e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208460  1417 PNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHKQEKKTLSfRGGSALSHRVSNLTAHTSYEISAWAKTDLGDS 1496
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVN-VTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 619-653 8.33e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 8.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1269208460   619 RSVILDSLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 653
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 599-635 8.71e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.98  E-value: 8.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1269208460  599 IYWTDAYLDC-IERITFSGQQRSVILDS-LPHPYAIAVF 635
Cdd:pfam00058    3 LYWTDSSLRAsISSADLNGSDRKTLFTDdLQHPNAIAVD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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