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Conserved domains on  [gi|1254004697|ref|NP_001343778|]
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Apple domain-containing protein [Caenorhabditis elegans]

Protein Classification

PAN/Apple domain-containing protein( domain architecture ID 2422)

PAN/Apple domain-containing protein contains a conserved core of three disulphide bridges and may mediate protein-protein or protein-carbohydrate interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAN_APPLE super family cl00112
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 88-132 2.86e-03

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


The actual alignment was detected with superfamily member cd01100:

Pssm-ID: 469620  Cd Length: 73  Bit Score: 35.49  E-value: 2.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1254004697  88 ECAKECIEDFSCFGYEWNSEEKICYLKsrSTSGKLIAKPNTMVGF 132
Cdd:cd01100    29 QCQAACTADPGCLAFTYNTKSKKCFLK--SSEGTLTKSTGAVSGP 71
 
Name Accession Description Interval E-value
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 88-132 2.86e-03

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 35.49  E-value: 2.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1254004697  88 ECAKECIEDFSCFGYEWNSEEKICYLKsrSTSGKLIAKPNTMVGF 132
Cdd:cd01100    29 QCQAACTADPGCLAFTYNTKSKKCFLK--SSEGTLTKSTGAVSGP 71
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 87-132 3.53e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 35.22  E-value: 3.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1254004697  87 RECAKECIEDFSCFGYEWNSEEKICYLK--SRSTSGKLIAKPNTMVGF 132
Cdd:pfam00024  25 EECAQRCTNEPRCRSFTYNPKSKKCHLKssSSGSLPRLKRSDNKVDYY 72
 
Name Accession Description Interval E-value
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 88-132 2.86e-03

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 35.49  E-value: 2.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1254004697  88 ECAKECIEDFSCFGYEWNSEEKICYLKsrSTSGKLIAKPNTMVGF 132
Cdd:cd01100    29 QCQAACTADPGCLAFTYNTKSKKCFLK--SSEGTLTKSTGAVSGP 71
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 87-132 3.53e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 35.22  E-value: 3.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1254004697  87 RECAKECIEDFSCFGYEWNSEEKICYLK--SRSTSGKLIAKPNTMVGF 132
Cdd:pfam00024  25 EECAQRCTNEPRCRSFTYNPKSKKCHLKssSSGSLPRLKRSDNKVDYY 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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