|
Name |
Accession |
Description |
Interval |
E-value |
| AMP_deaminase |
TIGR01429 |
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ... |
312-939 |
0e+00 |
|
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.
Pssm-ID: 273618 [Multi-domain] Cd Length: 611 Bit Score: 1116.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 312 EDLKTASGHLIEALHLRSKYMERIGNQFPSTTRNFLSGHYPAnlpkhRVKNTETTqvlfhppsvpdleaVQTSFNPPDPP 391
Cdd:TIGR01429 1 EDLAEAAKSLAKALMLREKYARLAYHRFPDTTAQYLSHQGYP-----ESVPLEEG--------------LPDFHPPPDPQ 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 392 KDHWGKNDPLPKYEKIYHLRRNRGVTEICNDDGSIDQQFKN--VNVTKEEFLNDTEKLTAMIVDGPLKSFCFRRLSYLEN 469
Cdd:TIGR01429 62 EDPYCLDDDAPPIELGYLVRMHGGVLFVYDNDTMLERQEPHflVPPTLETYYVDMEHLLALISDGPTKSFCFRRLQYLES 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 470 KFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEADTVVLNNNGTKVTMKEVFKKMG 549
Cdd:TIGR01429 142 KFNLHELLNEMSELKEQKSVPHRDFYNVRKVDTHIHAAASMNQKHLLRFIKHKLKTEPDETVIERDGKKLTLREVFDSLH 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 550 IDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLKEVLSDLEDSKYQHAEPRLSIY 629
Cdd:TIGR01429 222 LDPYDLSVDTLDVHADRNTFHRFDKFNLKYNPVGESRLREIFLKTDNYIGGKYFAELVKEVFTDLEDSKYQYAEPRLSIY 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 630 GRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFEVTNDPSSHPELHLFLQQISGI 709
Cdd:TIGR01429 302 GRSPKEWDSLARWIIDHDVFSPNVRWLIQVPRLYDVYRSKKLVPNFGDMLENVFLPLFEVTKDPSSHPELHLFLQQVTGF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 710 DSVDDESKHEFVNFDRSTPCPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFALRPHCGEAGHVSHLLTGYLTS 789
Cdd:TIGR01429 382 DSVDDESKHEDHMFSRKFPSPDEWTSEQNPPYSYYLYYMYANIMVLNNFRRERGLNTFLLRPHCGEAGSVDHLVSAFLTS 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 790 ESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTKEALMEEFSIAA 869
Cdd:TIGR01429 462 HGINHGILLRKVPVLQYLYYLTQIPIAMSPLSNNSLFLEYSKNPLPEYLHKGLNVSLSTDDPLQFHYTKEALMEEYAIAA 541
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 870 QVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFRHEALVDELYNL 939
Cdd:TIGR01429 542 QVWKLSTCDMCELARNSVLQSGFEHQVKQHWLGPNYYKEGPEGNDIRRTNVPDIRVAFRYETLCNELSLL 611
|
|
| AMPD |
cd01319 |
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ... |
440-936 |
0e+00 |
|
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644 Cd Length: 496 Bit Score: 968.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 440 FLNDTEKLTAMIVDGPLKSFCFRRLSYLENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFI 519
Cdd:cd01319 1 FYLDLEFLLALISDGPAKSFCYRRLQYLESKFQLHVLLNEDRELKEQKTVPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 520 KKKIKTEADTVVLNNNGTKVTMKEVFKKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVG 599
Cdd:cd01319 81 KKKLRTEPDEVVIFRDGKKLTLKEVFDSLKLTAYDLSVDTLDVHADRNTFHRFDKFNLKYNPIGESRLREIFLKTDNYIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 600 GKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDML 679
Cdd:cd01319 161 GRYLAEITKEVFSDLEESKYQHAEYRLSIYGRSKDEWDKLASWVVDNDLFSPNVRWLIQIPRLYDVYKKSGIVNSFQEML 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 680 DNLFTPLFEVTNDPSSHPELHLFLQQISGIDSVDDESKhEFVNFDRSTPCPPEYTDLENPPYNYYLFYMYRNICALNAFR 759
Cdd:cd01319 241 ENIFEPLFEATKDPSSHPELHVFLQQVIGFDSVDDESK-SERRFTRKFPKPEEWTSEENPPYSYYLYYMYANITTLNSFR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 760 RARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQ 839
Cdd:cd01319 320 KARGFNTFVLRPHCGEAGDIDHLASAFLLAHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLSYEKNPFPEFFK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 840 KGLNVSLSTDDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTN 919
Cdd:cd01319 400 RGLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHSIKRHWLGPNYLKRGVAGNDIRRTN 479
|
490
....*....|....*..
gi 1254003956 920 VPDIRVSFRHEALVDEL 936
Cdd:cd01319 480 VPQIRMAYRYETLCEEL 496
|
|
| AMP_deaminase |
pfam19326 |
AMP deaminase; |
296-936 |
0e+00 |
|
AMP deaminase;
Pssm-ID: 437158 [Multi-domain] Cd Length: 622 Bit Score: 870.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 296 YQRMAITGEELSGVPLEDLKTASGHLIEALHLRSKYMerignqFPSTTRNFL-SGHYPANLPKhrvkntETTQVLFHPPs 374
Cdd:pfam19326 3 VQRVTISGDYKLGVPTEDLEEAYKSLAECLEIREKYM------FPETTAPYLkSVQGEDSTPK------ENDEPVFHPP- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 375 vpdleavqtsfnpPDPPKDHWGKNDPLPKYEkiYHLRRNRGVTEICNDDGSIDQQFKNVNVtkEEFLNDTEKLTAMIVDG 454
Cdd:pfam19326 70 -------------PKKGEDPYELFNFPPDLG--YHLRMQDGVVHVYANKDALEDSLPYPDL--RDFYTDLEHLLALIADG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 455 PLKSFCFRRLSYLENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEADTVVLNN 534
Cdd:pfam19326 133 PIKTFCHRRLQYLESKFNLHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEVVIFR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 535 NGTKVTMKEVFKKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLKEVLSDL 614
Cdd:pfam19326 213 DGKYLTLREVFESLKLTGYDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEVFSDL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 615 EDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFEVTNDPS 694
Cdd:pfam19326 293 EESKYQMAEYRISIYGRSPDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEATVNPQ 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 695 SHPELHLFLQQISGIDSVDDESKHEFVNFDRStPCPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFALRPHCG 774
Cdd:pfam19326 373 SHPELHVFLKRVIGFDSVDDESKPERRMFRKS-PKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRPHCG 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 775 EAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLSTDDPLQF 854
Cdd:pfam19326 452 EAGDIDHLVSAFLLAHGISHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDPLQF 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 855 HYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFRHEALVD 934
Cdd:pfam19326 532 HFTKEPLMEEYSIAAQVWKLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYETLCQ 611
|
..
gi 1254003956 935 EL 936
Cdd:pfam19326 612 EL 613
|
|
| PLN03055 |
PLN03055 |
AMP deaminase; Provisional |
369-941 |
0e+00 |
|
AMP deaminase; Provisional
Pssm-ID: 178613 Cd Length: 602 Bit Score: 716.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 369 LFHPPSVPDLEAVQTSfNPPDPPKDHWgKNDPLPKYEKIYhlRRNRGVTEICNDDGSIDQQFKNVNVTkeEFLNDTEKLT 448
Cdd:PLN03055 26 LFREKLPPWRKGIFES-STSKPNPDPF-RYEPEPPSQHVF--RMVDGVMHVYAPDDAKEELFPVPDAT--TFFTDMHRIL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 449 AMIVDGPLKSFCFRRLSYLENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEAD 528
Cdd:PLN03055 100 RIVSLGNVRTFCHHRLKLLEQKFSLHLMLNADREFLAQKSAPHRDFYNVRKVDTHVHHSSCMNQKHLLRFIKSKLRKEPD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 529 TVVLNNNGTKVTMKEVFKKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLK 608
Cdd:PLN03055 180 EVVIFRDGKYLTLREVFESLDLTGYDLNVDLLDVHADKNTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 609 EVLSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFE 688
Cdd:PLN03055 260 EVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWIVNNRLYSENVVWLIQLPRLYNVYKEMGIVQSFQQILDNIFKPLFE 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 689 VTNDPSSHPELHLFLQQISGIDSVDDESKHEFVNFDRSTPcPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFA 768
Cdd:PLN03055 340 VTVDPSSHPQLHVFLKMVVGFDMVDDESKPERRPTKHMQT-PEQWDIPFNPAYSYWAYYVYANLYTLNKLRESKGLNTIK 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 769 LRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLST 848
Cdd:PLN03055 419 FRPHAGEAGDIDHLAAAFLLAHNIAHGNNLRKSPGLQYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFARGLNVSLST 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 849 DDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFR 928
Cdd:PLN03055 499 DDPLQIHLTKEPLVEEYSIAAQVWKLSSCDLCEIARNSVLQSGFPHASKKHWVGDNYWLRGPAGNDIHKTNVPHMRVEFR 578
|
570
....*....|...
gi 1254003956 929 HEALVDELYNLFR 941
Cdd:PLN03055 579 HEVWKEELQYVFL 591
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
757-901 |
1.06e-15 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 79.36 E-value: 1.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 757 AFRRARGLNtFALRPHCGEAG---HVSHLLTgYLTSESIAHGI-------LLRkvpvlqylyYL--TQIGIAMSPLSNNS 824
Cdd:COG1816 173 AFARAREAG-LHLTAHAGEAGgpeSIWEALD-LLGAERIGHGVraiedpaLVA---------RLadRGIPLEVCPTSNVQ 241
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1254003956 825 L--FISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTkeaLMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWL 901
Cdd:COG1816 242 LgvVPSLAEHPLRRLLDAGVRVTLNTDDPLYFGTT---LTDEYELAAEAFGLSDADLAQLARNAIEASFLPEEEKAALL 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AMP_deaminase |
TIGR01429 |
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ... |
312-939 |
0e+00 |
|
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.
Pssm-ID: 273618 [Multi-domain] Cd Length: 611 Bit Score: 1116.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 312 EDLKTASGHLIEALHLRSKYMERIGNQFPSTTRNFLSGHYPAnlpkhRVKNTETTqvlfhppsvpdleaVQTSFNPPDPP 391
Cdd:TIGR01429 1 EDLAEAAKSLAKALMLREKYARLAYHRFPDTTAQYLSHQGYP-----ESVPLEEG--------------LPDFHPPPDPQ 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 392 KDHWGKNDPLPKYEKIYHLRRNRGVTEICNDDGSIDQQFKN--VNVTKEEFLNDTEKLTAMIVDGPLKSFCFRRLSYLEN 469
Cdd:TIGR01429 62 EDPYCLDDDAPPIELGYLVRMHGGVLFVYDNDTMLERQEPHflVPPTLETYYVDMEHLLALISDGPTKSFCFRRLQYLES 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 470 KFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEADTVVLNNNGTKVTMKEVFKKMG 549
Cdd:TIGR01429 142 KFNLHELLNEMSELKEQKSVPHRDFYNVRKVDTHIHAAASMNQKHLLRFIKHKLKTEPDETVIERDGKKLTLREVFDSLH 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 550 IDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLKEVLSDLEDSKYQHAEPRLSIY 629
Cdd:TIGR01429 222 LDPYDLSVDTLDVHADRNTFHRFDKFNLKYNPVGESRLREIFLKTDNYIGGKYFAELVKEVFTDLEDSKYQYAEPRLSIY 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 630 GRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFEVTNDPSSHPELHLFLQQISGI 709
Cdd:TIGR01429 302 GRSPKEWDSLARWIIDHDVFSPNVRWLIQVPRLYDVYRSKKLVPNFGDMLENVFLPLFEVTKDPSSHPELHLFLQQVTGF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 710 DSVDDESKHEFVNFDRSTPCPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFALRPHCGEAGHVSHLLTGYLTS 789
Cdd:TIGR01429 382 DSVDDESKHEDHMFSRKFPSPDEWTSEQNPPYSYYLYYMYANIMVLNNFRRERGLNTFLLRPHCGEAGSVDHLVSAFLTS 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 790 ESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTKEALMEEFSIAA 869
Cdd:TIGR01429 462 HGINHGILLRKVPVLQYLYYLTQIPIAMSPLSNNSLFLEYSKNPLPEYLHKGLNVSLSTDDPLQFHYTKEALMEEYAIAA 541
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 870 QVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFRHEALVDELYNL 939
Cdd:TIGR01429 542 QVWKLSTCDMCELARNSVLQSGFEHQVKQHWLGPNYYKEGPEGNDIRRTNVPDIRVAFRYETLCNELSLL 611
|
|
| AMPD |
cd01319 |
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ... |
440-936 |
0e+00 |
|
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644 Cd Length: 496 Bit Score: 968.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 440 FLNDTEKLTAMIVDGPLKSFCFRRLSYLENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFI 519
Cdd:cd01319 1 FYLDLEFLLALISDGPAKSFCYRRLQYLESKFQLHVLLNEDRELKEQKTVPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 520 KKKIKTEADTVVLNNNGTKVTMKEVFKKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVG 599
Cdd:cd01319 81 KKKLRTEPDEVVIFRDGKKLTLKEVFDSLKLTAYDLSVDTLDVHADRNTFHRFDKFNLKYNPIGESRLREIFLKTDNYIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 600 GKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDML 679
Cdd:cd01319 161 GRYLAEITKEVFSDLEESKYQHAEYRLSIYGRSKDEWDKLASWVVDNDLFSPNVRWLIQIPRLYDVYKKSGIVNSFQEML 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 680 DNLFTPLFEVTNDPSSHPELHLFLQQISGIDSVDDESKhEFVNFDRSTPCPPEYTDLENPPYNYYLFYMYRNICALNAFR 759
Cdd:cd01319 241 ENIFEPLFEATKDPSSHPELHVFLQQVIGFDSVDDESK-SERRFTRKFPKPEEWTSEENPPYSYYLYYMYANITTLNSFR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 760 RARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQ 839
Cdd:cd01319 320 KARGFNTFVLRPHCGEAGDIDHLASAFLLAHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLSYEKNPFPEFFK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 840 KGLNVSLSTDDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTN 919
Cdd:cd01319 400 RGLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHSIKRHWLGPNYLKRGVAGNDIRRTN 479
|
490
....*....|....*..
gi 1254003956 920 VPDIRVSFRHEALVDEL 936
Cdd:cd01319 480 VPQIRMAYRYETLCEEL 496
|
|
| AMP_deaminase |
pfam19326 |
AMP deaminase; |
296-936 |
0e+00 |
|
AMP deaminase;
Pssm-ID: 437158 [Multi-domain] Cd Length: 622 Bit Score: 870.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 296 YQRMAITGEELSGVPLEDLKTASGHLIEALHLRSKYMerignqFPSTTRNFL-SGHYPANLPKhrvkntETTQVLFHPPs 374
Cdd:pfam19326 3 VQRVTISGDYKLGVPTEDLEEAYKSLAECLEIREKYM------FPETTAPYLkSVQGEDSTPK------ENDEPVFHPP- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 375 vpdleavqtsfnpPDPPKDHWGKNDPLPKYEkiYHLRRNRGVTEICNDDGSIDQQFKNVNVtkEEFLNDTEKLTAMIVDG 454
Cdd:pfam19326 70 -------------PKKGEDPYELFNFPPDLG--YHLRMQDGVVHVYANKDALEDSLPYPDL--RDFYTDLEHLLALIADG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 455 PLKSFCFRRLSYLENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEADTVVLNN 534
Cdd:pfam19326 133 PIKTFCHRRLQYLESKFNLHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEVVIFR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 535 NGTKVTMKEVFKKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLKEVLSDL 614
Cdd:pfam19326 213 DGKYLTLREVFESLKLTGYDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEVFSDL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 615 EDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFEVTNDPS 694
Cdd:pfam19326 293 EESKYQMAEYRISIYGRSPDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEATVNPQ 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 695 SHPELHLFLQQISGIDSVDDESKHEFVNFDRStPCPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFALRPHCG 774
Cdd:pfam19326 373 SHPELHVFLKRVIGFDSVDDESKPERRMFRKS-PKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRPHCG 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 775 EAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLSTDDPLQF 854
Cdd:pfam19326 452 EAGDIDHLVSAFLLAHGISHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDPLQF 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 855 HYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFRHEALVD 934
Cdd:pfam19326 532 HFTKEPLMEEYSIAAQVWKLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYETLCQ 611
|
..
gi 1254003956 935 EL 936
Cdd:pfam19326 612 EL 613
|
|
| PLN03055 |
PLN03055 |
AMP deaminase; Provisional |
369-941 |
0e+00 |
|
AMP deaminase; Provisional
Pssm-ID: 178613 Cd Length: 602 Bit Score: 716.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 369 LFHPPSVPDLEAVQTSfNPPDPPKDHWgKNDPLPKYEKIYhlRRNRGVTEICNDDGSIDQQFKNVNVTkeEFLNDTEKLT 448
Cdd:PLN03055 26 LFREKLPPWRKGIFES-STSKPNPDPF-RYEPEPPSQHVF--RMVDGVMHVYAPDDAKEELFPVPDAT--TFFTDMHRIL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 449 AMIVDGPLKSFCFRRLSYLENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEAD 528
Cdd:PLN03055 100 RIVSLGNVRTFCHHRLKLLEQKFSLHLMLNADREFLAQKSAPHRDFYNVRKVDTHVHHSSCMNQKHLLRFIKSKLRKEPD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 529 TVVLNNNGTKVTMKEVFKKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLK 608
Cdd:PLN03055 180 EVVIFRDGKYLTLREVFESLDLTGYDLNVDLLDVHADKNTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 609 EVLSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFE 688
Cdd:PLN03055 260 EVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWIVNNRLYSENVVWLIQLPRLYNVYKEMGIVQSFQQILDNIFKPLFE 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 689 VTNDPSSHPELHLFLQQISGIDSVDDESKHEFVNFDRSTPcPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFA 768
Cdd:PLN03055 340 VTVDPSSHPQLHVFLKMVVGFDMVDDESKPERRPTKHMQT-PEQWDIPFNPAYSYWAYYVYANLYTLNKLRESKGLNTIK 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 769 LRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLST 848
Cdd:PLN03055 419 FRPHAGEAGDIDHLAAAFLLAHNIAHGNNLRKSPGLQYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFARGLNVSLST 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 849 DDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFR 928
Cdd:PLN03055 499 DDPLQIHLTKEPLVEEYSIAAQVWKLSSCDLCEIARNSVLQSGFPHASKKHWVGDNYWLRGPAGNDIHKTNVPHMRVEFR 578
|
570
....*....|...
gi 1254003956 929 HEALVDELYNLFR 941
Cdd:PLN03055 579 HEVWKEELQYVFL 591
|
|
| PLN02768 |
PLN02768 |
AMP deaminase |
388-936 |
0e+00 |
|
AMP deaminase
Pssm-ID: 215411 Cd Length: 835 Bit Score: 700.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 388 PDP-PKDHWGKNDplpkyekiYHLRRNRGVTEICNDDGSIDQQFKNVNVTKeeFLNDTEKLTAMIVDGPLKSFCFRRLSY 466
Cdd:PLN02768 281 PNPfSYTPEGKSD--------HYFEMQDGVVHVYANKDSKEELFPVADATT--FFTDLHHILRVIAAGNIRTLCHHRLNL 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 467 LENKFQLHVLLNELRELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEADTVVLNNNGTKVTMKEVFK 546
Cdd:PLN02768 351 LEQKFNLHLMLNADREFLAQKSAPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEVVIFRDGTYLTLKEVFE 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 547 KMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLKEVLSDLEDSKYQHAEPRL 626
Cdd:PLN02768 431 SLDLTGYDLNVDLLDVHADKSTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTKQVFSDLEASKYQMAEYRI 510
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 627 SIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNFDDMLDNLFTPLFEVTNDPSSHPELHLFLQQI 706
Cdd:PLN02768 511 SIYGRKQSEWDQLASWIVNNELYSENVVWLIQLPRLYNVYKEMGIVTSFQNILDNIFIPLFEVTVDPDSHPQLHVFLKQV 590
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 707 SGIDSVDDESKHEfvnfDRST---PCPPEYTDLENPPYNYYLFYMYRNICALNAFRRARGLNTFALRPHCGEAGHVSHLL 783
Cdd:PLN02768 591 VGLDLVDDESKPE----RRPTkhmPTPAQWTNVFNPAFSYYVYYCYANLYTLNKLRESKGMTTIKFRPHSGEAGDIDHLA 666
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 784 TGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTKEALME 863
Cdd:PLN02768 667 ATFLTCHNIAHGINLRKSPVLQYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFLRGLNVSLSTDDPLQIHLTKEPLVE 746
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1254003956 864 EFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFRHEALVDEL 936
Cdd:PLN02768 747 EYSIAASVWKLSSCDLCEIARNSVYQSGFSHALKSHWIGKEYYKRGPDGNDIHKTNVPHIRVEFRDTIWKEEM 819
|
|
| PTZ00310 |
PTZ00310 |
AMP deaminase; Provisional |
436-936 |
0e+00 |
|
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain] Cd Length: 1453 Bit Score: 584.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 436 TKEEFLNDTEKLTAMIVDGPLKSFCFRRLSYLENKFQLHVLLNELREL--HEQKGVSHRDFYNIRKVDTHIHAASSMNQK 513
Cdd:PTZ00310 781 TLTEFIRDLSELRDICSSVEVKRLATKRLENLEHKFRLHLALNHSNEAgtTEERESSNRDFYQAYKVDTHIHMAAGMTAR 860
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 514 HLLRFIKKKIKTEADTVVLNNNGTKVTMKEVFKKMGIDAyDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIK 593
Cdd:PTZ00310 861 QLLEFVVDKLLESGDDIAFKRGDHIVTLGQLFSKYGITP-NLTVDQLNVQADHTLFERFDNFNSKYNPMENPDLRSLLLK 939
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 594 TDNYVGGKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVK 673
Cdd:PTZ00310 940 TDNFMKGRYFAELIKDVFEQYSRDRFTYAENRLSIYGINVKEWDDLAHWFDTHGMASKHNKWMIQVPRVYKVFRAQNVIG 1019
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 674 NFDDMLDNLFTPLFEVTNDPSSHPELHLFLQQISGIDSVDDESKhefVNFDRSTPCPPEYTDLENPPYNYYLFYMYRNIC 753
Cdd:PTZ00310 1020 SFGQYLDNIFQPLWEASLHPSKHPKFHYFLNHVSGFDSVDNEAT---IDLPFTDVSPWAWTSVENPPYNYYLYYLYANIR 1096
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 754 ALNAFRRARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSLFISYQRNP 833
Cdd:PTZ00310 1097 TLNEFRASRGFSTFALRPHCGESGSMDHLYGAFLCANSICHGINLRNDPPMQYLYYLAQIGLHVSPLSNNALFLAFLENP 1176
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 834 LPEYLQKGLNVSLSTDDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGN 913
Cdd:PTZ00310 1177 FPVFFHRGLNVSLSTDDPLMFHQTQEPLIEEYSIAARVWGLSLNDLCEIARNSVLQSGFDAAFKRNAIGDRWYLSSSLGN 1256
|
490 500
....*....|....*....|...
gi 1254003956 914 DIHRTNVPDIRVSFRHEALVDEL 936
Cdd:PTZ00310 1257 DSLRTHLSDIRVAFRFETYHTEL 1279
|
|
| ADA_AMPD |
cd00443 |
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ... |
497-904 |
5.78e-88 |
|
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Pssm-ID: 238250 Cd Length: 305 Bit Score: 283.47 E-value: 5.78e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 497 IRKVDTHIHAASSMNQKHLLRFIKKKikteadtvvlnnngtkvtmkevfkkmgidaydlsvdmldvhadrntfhrfdkfn 576
Cdd:cd00443 1 LPKVELHAHLSGSISPETLLELIKKE------------------------------------------------------ 26
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 577 tkynpvgestLREIFIKTDNY-VGGKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNE-WDNLAKWALTHDVWSPNAR 654
Cdd:cd00443 27 ----------FFEKFLLVHNLlQKGEALARALKEVIEEFAEDNVQYLELRTTPRLLETEKgLTKEQYWLLVIEGISEAKQ 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 655 WL--VQIPRLYDVYRAKNMVKNfddmldnlftplfevTNDPSSHPELHLFLQQ-ISGIDSVDDESKHEfvnfdrstpcpp 731
Cdd:cd00443 97 WFppIKVRLILSVDRRGPYVQN---------------YLVASEILELAKFLSNyVVGIDLVGDESKGE------------ 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 732 eytdleNPPYNYYLFYMYRNICALnafrrarglntFALRPHCGEAGHVSHLLTGY-LTSESIAHGILLRKVPVLQYLYYL 810
Cdd:cd00443 150 ------NPLRDFYSYYEYARRLGL-----------LGLTLHCGETGNREELLQALlLLPDRIGHGIFLLKHPELIYLVKL 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 811 TQIGIAMSPLSNNSLFI--SYQRNPLPEYLQKGLNVSLSTDDPLQFHYTkeaLMEEFSIAAQVWKLSSCDMCELARNSVM 888
Cdd:cd00443 213 RNIPIEVCPTSNVVLGTvqSYEKHPFMRFFKAGLPVSLSTDDPGIFGTS---LSEEYSLAAKTFGLTFEDLCELNRNSVL 289
|
410
....*....|....*.
gi 1254003956 889 QSGFEDKVKIHWLGPN 904
Cdd:cd00443 290 SSFAKDEEKKSLLEVL 305
|
|
| PTZ00310 |
PTZ00310 |
AMP deaminase; Provisional |
438-935 |
3.17e-84 |
|
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain] Cd Length: 1453 Bit Score: 297.11 E-value: 3.17e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 438 EEFLNDTEKLTAMIVDGPLKSFCFRRLSYLENKFQLHVLLN----ELRELHEQKGVshrdFYNIRKVDTHIHAASSMNQK 513
Cdd:PTZ00310 146 EQYVRDVQAVYLTVGNGPCLSACRHRLTIIQERSRMFFLLNaeieERADLYKAGGV----FSPCTKVDNAVLLSTSVDAQ 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 514 HLLRFIKKKIKTEADTVVLNNNGTKVTMKEVFKKMGI-DAYDLSVDMLDVHA--DRNTFHRFDKFNTKyNPVGE--STLR 588
Cdd:PTZ00310 222 ELLEFVVTTYREQPRAPLRLRDGSNSTLREYLEAHGVrDPRELTVEGLGWQPtkYRNKYGQYDLFDAK-NPMGAlgAELR 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 589 EIFIKTDNYVGGKyfadLLKEVLSDLEDSKY--QHAEPRLSIYGRSKNEWDNLAKWALTHDVWS-PNARWLVQIprlydv 665
Cdd:PTZ00310 301 QSFLSLHGNLCGK----LLRRELERREYQKQqpQATEYSLPLYGHHPEELTDLAEWVRRQGFGPfSRNRWILAI------ 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 666 yRAK----NMV----KNFDDMLDNLFTPLFEVTNDPS--SHPELHLFLQQISGIdSVDDESKHEFVNFDrSTPCPPEYTD 735
Cdd:PTZ00310 371 -SFKelgpFQVpsscTTVQDQLDNIFLPLFKATLCPSdpQWSDVAWLLCQVGGL-QILTHAVVRSEDFD-ETAPDPDQVP 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 736 LENPPYN-YYLFYMYRNICALNAFRRARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQYLYYLTQIG 814
Cdd:PTZ00310 448 YTAKCSDlYYFYYVYANLAVLNSLRKRKGLNTLQLRPSGEKAPAYDQLISSYLLGDVITRATSIADYPVLQYLCGLHRVG 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 815 IAMSPLSNNSLFI-SYQRNPLPEYLQKGLNVSLSTDDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFE 893
Cdd:PTZ00310 528 LTVSPLRDHALSItAYFDHPLPKFLHRCLRVSISTSDPLYFHHHSQPLIEEYATAMKLFSLSPLDTTELARNSVLNSSFP 607
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1254003956 894 DKVKIHWLGPNYkEEGVLGNDIHRTNVPDIRVSFRHEALVDE 935
Cdd:PTZ00310 608 PEVKQQWLGERF-QLGVEGNDFERSGVTNYRLAFREEAWALE 648
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
757-901 |
1.06e-15 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 79.36 E-value: 1.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 757 AFRRARGLNtFALRPHCGEAG---HVSHLLTgYLTSESIAHGI-------LLRkvpvlqylyYL--TQIGIAMSPLSNNS 824
Cdd:COG1816 173 AFARAREAG-LHLTAHAGEAGgpeSIWEALD-LLGAERIGHGVraiedpaLVA---------RLadRGIPLEVCPTSNVQ 241
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1254003956 825 L--FISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTkeaLMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWL 901
Cdd:COG1816 242 LgvVPSLAEHPLRRLLDAGVRVTLNTDDPLYFGTT---LTDEYELAAEAFGLSDADLAQLARNAIEASFLPEEEKAALL 317
|
|
| metallo-dependent_hydrolases |
cd01292 |
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ... |
593-883 |
2.66e-13 |
|
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
Pssm-ID: 238617 [Multi-domain] Cd Length: 275 Bit Score: 71.21 E-value: 2.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 593 KTDNYVGGKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAknmv 672
Cdd:cd01292 23 KEAEELSPEDLYEDTLRALEALLAGGVTTVVDMGSTPPPTTTKAAIEAVAEAARASAGIRVVLGLGIPGVPAAVDE---- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 673 knfddmldnlftplfevtNDPSSHPELHLFLQQ--ISGIDSVDDeskhefvnfdrstpcppeYTDLENPPYNYYlfymyr 750
Cdd:cd01292 99 ------------------DAEALLLELLRRGLElgAVGLKLAGP------------------YTATGLSDESLR------ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 751 nicalNAFRRARGLNTfALRPHCGEAGHVSH------LLTGYLTSESIAHGILLrkVPVLQYLYYLTQIGIAMSPLSNNS 824
Cdd:cd01292 137 -----RVLEEARKLGL-PVVIHAGELPDPTRaledlvALLRLGGRVVIGHVSHL--DPELLELLKEAGVSLEVCPLSNYL 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1254003956 825 LF-ISYQRNPLPEYLQKGLNVSLSTDDPlqFHYTKEALMEEFSIAAQVWKL--SSCDMCELA 883
Cdd:cd01292 209 LGrDGEGAEALRRLLELGIRVTLGTDGP--PHPLGTDLLALLRLLLKVLRLglSLEEALRLA 268
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
755-901 |
1.21e-12 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 69.92 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 755 LNAFRRAR--GLNtfaLRPHCGEAGHVSHLLTG--YLTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSNNSL--FIS 828
Cdd:cd01320 176 VRAFQRAReaGLR---LTAHAGEAGGPESVRDAldLLGAERIGHGIRAIEDPELVKRLAERNIPLEVCPTSNVQTgaVKS 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1254003956 829 YQRNPLPEYLQKGLNVSLSTDDPLQFHYTkeaLMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWL 901
Cdd:cd01320 253 LAEHPLRELLDAGVKVTINTDDPTVFGTY---LTDEYELLAEAFGLTEEELKKLARNAVEASFLSEEEKAELL 322
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
757-901 |
1.85e-12 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 69.82 E-value: 1.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 757 AFRRARGLNtFALRPHCGEAG---HVSHLLTgYLTSESIAHGI-------LLRkvpvlqylyYL--TQIGIAMSPLSNNS 824
Cdd:PRK09358 187 AFDRARDAG-LRLTAHAGEAGgpeSIWEALD-ELGAERIGHGVraiedpaLMA---------RLadRRIPLEVCPTSNVQ 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1254003956 825 L--FISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTkeaLMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWL 901
Cdd:PRK09358 256 TgaVPSLAEHPLKTLLDAGVRVTINTDDPLVFGTT---LTEEYEALAEAFGLSDEDLAQLARNALEAAFLSEEEKAALL 331
|
|
| ADGF |
cd01321 |
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors ... |
787-897 |
1.89e-05 |
|
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Pssm-ID: 238646 Cd Length: 345 Bit Score: 48.04 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254003956 787 LTSESIAHGILLRKVPVLQYLYYLTQIGIAMSPLSN--NSLFISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTkeALMEE 864
Cdd:cd01321 221 LNTKRIGHGFALPKHPLLMDLVKKKNIAIEVCPISNqvLGLVSDLRNHPAAALLARGVPVVISSDDPGFWGAK--GLSHD 298
|
90 100 110
....*....|....*....|....*....|....*.
gi 1254003956 865 FSIAAQVWKLSSCDMC---ELARNSVMQSGFEDKVK 897
Cdd:cd01321 299 FYQAFMGLAPADAGLRglkQLAENSIRYSALSDQEK 334
|
|
| |
