NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1246743238|ref|NP_001342815|]
View 

gluconokinase [Schizosaccharomyces pombe]

Protein Classification

nucleoside/nucleotide kinase family protein; thymidylate kinase( domain architecture ID 10796813)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars| thymidylate kinase with a major facilitator superfamily (MFS) transporter domain may function in the phosphorylation of thymidine monophosphate and the transport across cytoplasmic or internal membranes of various substrates including sugar phosphates

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
therm_gnt_kin TIGR01313
carbohydrate kinase, thermoresistant glucokinase family; This model represents a subfamily of ...
 17-185 2.63e-97

carbohydrate kinase, thermoresistant glucokinase family; This model represents a subfamily of proteins that includes thermoresistant and thermosensitve isozymes of gluconate kinase (gluconokinase) in E. coli and other related proteins; members of this family are often named by similarity to the thermostable isozyme. These proteins show homology to shikimate kinases and adenylate kinases but not to gluconate kinases from the FGGY family of carbohydrate kinases.


:

Pssm-ID: 273551  Cd Length: 163  Bit Score: 278.90  E-value: 2.63e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  17 FVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKESIkgVVLTCS 96
Cdd:TIGR01313   1 FVLMGVAGSGKSTIASALAHRLGAKFIEGDDLHPAANIEKMSAGIPLNDDDRWPWLQNLNDASTAAAAKNKV--GIITCS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  97 ALKRSYRDILRssleHRPAILRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISVENGKEQSE 176
Cdd:TIGR01313  79 ALKRHYRDILR----EAEPNLHFIYLSGDKDVILERMKARKGHFMKADMLESQFAALEEPLADETDVLRVDIDQPLEGVE 154


                  ....*....
gi 1246743238 177 EECLDIVHK 185
Cdd:TIGR01313 155 EDCIAVVLK 163
 
Name Accession Description Interval E-value
therm_gnt_kin TIGR01313
carbohydrate kinase, thermoresistant glucokinase family; This model represents a subfamily of ...
 17-185 2.63e-97

carbohydrate kinase, thermoresistant glucokinase family; This model represents a subfamily of proteins that includes thermoresistant and thermosensitve isozymes of gluconate kinase (gluconokinase) in E. coli and other related proteins; members of this family are often named by similarity to the thermostable isozyme. These proteins show homology to shikimate kinases and adenylate kinases but not to gluconate kinases from the FGGY family of carbohydrate kinases.


Pssm-ID: 273551  Cd Length: 163  Bit Score: 278.90  E-value: 2.63e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  17 FVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKESIkgVVLTCS 96
Cdd:TIGR01313   1 FVLMGVAGSGKSTIASALAHRLGAKFIEGDDLHPAANIEKMSAGIPLNDDDRWPWLQNLNDASTAAAAKNKV--GIITCS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  97 ALKRSYRDILRssleHRPAILRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISVENGKEQSE 176
Cdd:TIGR01313  79 ALKRHYRDILR----EAEPNLHFIYLSGDKDVILERMKARKGHFMKADMLESQFAALEEPLADETDVLRVDIDQPLEGVE 154


                  ....*....
gi 1246743238 177 EECLDIVHK 185
Cdd:TIGR01313 155 EDCIAVVLK 163
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 16-184 9.81e-76

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 224.24  E-value: 9.81e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKEsiKGVVLTC 95
Cdd:COG3265     3 VIVVMGVSGSGKSTVGQALAERLGWPFIDGDDFHPPANIAKMAAGIPLTDEDRAPWLEALADAIAAHLAAG--EGAVLAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  96 SALKRSYRDILRSSLEHrpaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEkDVITISVENGKEQS 175
Cdd:COG3265    81 SALKRSYRDRLREGNPD----VRFVYLDGSRELIAERLAARKGHFMPASLLDSQFATLEPPGPDE-DAIVVDIDQPPEEI 155


                  ....*....
gi 1246743238 176 EEECLDIVH 184
Cdd:COG3265   156 VAQILAALG 164
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 16-168 5.56e-74

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 219.43  E-value: 5.56e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELdKESIKGVVLTC 95
Cdd:cd02021     1 IIVVMGVSGSGKSTVGKALAERLGAPFIDGDDLHPPANIAKMAAGIPLNDEDRWPWLQALTDALLAKL-ASAGEGVVVAC 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246743238  96 SALKRSYRDILRSSLEHRPaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISV 168
Cdd:cd02021    80 SALKRIYRDILRGGAANPR--VRFVHLDGPREVLAERLAARKGHFMPADLLDSQFETLEPPGEDEEDVIVIDV 150
gntK PRK11545
gluconokinase;
20-170 3.56e-45

gluconokinase;


Pssm-ID: 236926  Cd Length: 163  Bit Score: 146.78  E-value: 3.56e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  20 IGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGAC-AME-LDKESIkgvvLTCSA 97
Cdd:PRK11545    1 MGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMASGEPLNDDDRKPWLQALNDAAfAMQrTNKVSL----IVCSA 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246743238  98 LKRSYRDILRSSLEHrpaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISVEN 170
Cdd:PRK11545   77 LKKHYRDLLREGNPN----LSFIYLKGDFDVIESRLKARKGHFFKTQMLVTQFETLQEPGADETDVLVVDIDQ 145
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 16-156 2.01e-09

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 53.47  E-value: 2.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHpkANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKESiKGVVLTC 95
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELGAVRLSSDDER--KRLFGEGRPSISYYTDATDRTYERLHELARIALRAG-RPVILDA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743238  96 SALKRSYRDILRSSLEHRPAILRFIYLAASRETLIKRTTSR---KNHYMKADM--VESQLAILEAP 156
Cdd:pfam13671  78 TNLRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARaraGGDPSDVPEevLDRQKARFEPP 143
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 13-43 3.60e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 36.32  E-value: 3.60e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1246743238  13 YKYVfVVIGPAGSGKTTMAKAVSEKLGFEYI 43
Cdd:NF033453   16 YKLI-LLVGPPGSGKTALLRELAAKRGAPVI 45
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 16-49 5.25e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 35.81  E-value: 5.25e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1246743238   16 VFVVIGPAGSGKTTMAKAVSEKL-----GFEYIEGDDLH 49
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELgppggGVIYIDGEDIL 42
 
Name Accession Description Interval E-value
therm_gnt_kin TIGR01313
carbohydrate kinase, thermoresistant glucokinase family; This model represents a subfamily of ...
 17-185 2.63e-97

carbohydrate kinase, thermoresistant glucokinase family; This model represents a subfamily of proteins that includes thermoresistant and thermosensitve isozymes of gluconate kinase (gluconokinase) in E. coli and other related proteins; members of this family are often named by similarity to the thermostable isozyme. These proteins show homology to shikimate kinases and adenylate kinases but not to gluconate kinases from the FGGY family of carbohydrate kinases.


Pssm-ID: 273551  Cd Length: 163  Bit Score: 278.90  E-value: 2.63e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  17 FVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKESIkgVVLTCS 96
Cdd:TIGR01313   1 FVLMGVAGSGKSTIASALAHRLGAKFIEGDDLHPAANIEKMSAGIPLNDDDRWPWLQNLNDASTAAAAKNKV--GIITCS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  97 ALKRSYRDILRssleHRPAILRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISVENGKEQSE 176
Cdd:TIGR01313  79 ALKRHYRDILR----EAEPNLHFIYLSGDKDVILERMKARKGHFMKADMLESQFAALEEPLADETDVLRVDIDQPLEGVE 154


                  ....*....
gi 1246743238 177 EECLDIVHK 185
Cdd:TIGR01313 155 EDCIAVVLK 163
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 16-184 9.81e-76

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 224.24  E-value: 9.81e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKEsiKGVVLTC 95
Cdd:COG3265     3 VIVVMGVSGSGKSTVGQALAERLGWPFIDGDDFHPPANIAKMAAGIPLTDEDRAPWLEALADAIAAHLAAG--EGAVLAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  96 SALKRSYRDILRSSLEHrpaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEkDVITISVENGKEQS 175
Cdd:COG3265    81 SALKRSYRDRLREGNPD----VRFVYLDGSRELIAERLAARKGHFMPASLLDSQFATLEPPGPDE-DAIVVDIDQPPEEI 155


                  ....*....
gi 1246743238 176 EEECLDIVH 184
Cdd:COG3265   156 VAQILAALG 164
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 16-168 5.56e-74

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 219.43  E-value: 5.56e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGACAMELdKESIKGVVLTC 95
Cdd:cd02021     1 IIVVMGVSGSGKSTVGKALAERLGAPFIDGDDLHPPANIAKMAAGIPLNDEDRWPWLQALTDALLAKL-ASAGEGVVVAC 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246743238  96 SALKRSYRDILRSSLEHRPaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISV 168
Cdd:cd02021    80 SALKRIYRDILRGGAANPR--VRFVHLDGPREVLAERLAARKGHFMPADLLDSQFETLEPPGEDEEDVIVIDV 150
gntK PRK11545
gluconokinase;
20-170 3.56e-45

gluconokinase;


Pssm-ID: 236926  Cd Length: 163  Bit Score: 146.78  E-value: 3.56e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  20 IGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGAC-AME-LDKESIkgvvLTCSA 97
Cdd:PRK11545    1 MGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMASGEPLNDDDRKPWLQALNDAAfAMQrTNKVSL----IVCSA 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246743238  98 LKRSYRDILRSSLEHrpaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISVEN 170
Cdd:PRK11545   77 LKKHYRDLLREGNPN----LSFIYLKGDFDVIESRLKARKGHFFKTQMLVTQFETLQEPGADETDVLVVDIDQ 145
idnK PRK09825
gluconokinase;
17-183 7.24e-42

gluconokinase;


Pssm-ID: 182097  Cd Length: 176  Bit Score: 139.01  E-value: 7.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  17 FVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDRWGWLHNCGGAcAMELDKESIKGVVLtCS 96
Cdd:PRK09825    6 YILMGVSGSGKSLIGSKIAALFSAKFIDGDDLHPAKNIDKMSQGIPLTDEDRLPWLERLNDA-SYSLYKKNETGFIV-CS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  97 ALKRSYRDILRSSLEHrpaiLRFIYLAASRETLIKRTTSRKNHYMKADMVESQLAILEAPTADEKDVITISVENGKEQSE 176
Cdd:PRK09825   84 SLKKQYRDILRKSSPN----VHFLWLDGDYETILARMQRRAGHFMPPDLLQSQFDALERPCADEHDIARIDVNHDIENVT 159


                  ....*..
gi 1246743238 177 EECLDIV 183
Cdd:PRK09825  160 EQCRQAV 166
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
16-166 3.76e-13

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 64.16  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDlhpkanIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKESIKG---VV 92
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRSDV------VRKRLFGAGLAPLERSPEATARTYARLLALARELLAAgrsVI 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743238  93 LTCSALKRSYRDILRSSLEHRPAILRFIYLAASRETLIKRTTSRKNHYMKAD----MVESQLAILEAPTADEKDVITI 166
Cdd:COG0645    75 LDATFLRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDatweVLERQLAFEEPLTEDEGFLLVV 152
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 16-156 2.01e-09

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 53.47  E-value: 2.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHpkANIEKMSQGHPLNDNDRWGWLHNCGGACAMELDKESiKGVVLTC 95
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELGAVRLSSDDER--KRLFGEGRPSISYYTDATDRTYERLHELARIALRAG-RPVILDA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743238  96 SALKRSYRDILRSSLEHRPAILRFIYLAASRETLIKRTTSR---KNHYMKADM--VESQLAILEAP 156
Cdd:pfam13671  78 TNLRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARaraGGDPSDVPEevLDRQKARFEPP 143
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 21-43 1.05e-07

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 49.02  E-value: 1.05e-07
                          10        20
                  ....*....|....*....|...
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYI 43
Cdd:cd02020     6 GPAGSGKSTVAKLLAKKLGLPYL 28
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 15-191 2.15e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 48.57  E-value: 2.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  15 YVFVVIGPAGSGKTTMAKAVSEKLGFEYIegDDLHpkaniekmsqghpLNDNDRWGWLHNcgGACAMELDKESIKGVVLT 94
Cdd:COG4088     5 MLLILTGPPGSGKTTFAKALAQRLYAEGI--AVAL-------------LHSDDFRRFLVN--ESFPKETYEEVVEDVRTT 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  95 C--SALK-------------RSYRDILRSSLEHRPAIlRFIYLAASRETLIKRTTSR---------KNHYMKadmvesql 150
Cdd:COG4088    68 TadNALDngysvivdgtfyyRSWQRDFRNLAKHKAPI-HIIYLKAPLETALRRNRERgepiperviARMYRK-------- 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1246743238 151 aiLEAPTADEKDVITISVEngkEQSEEECLDIVHKMVNENK 191
Cdd:COG4088   139 --FDKPGTKDRPDLVIDTT---EDSVSETLDAILKAIETWG 174
SKI pfam01202
Shikimate kinase;
24-138 2.16e-07

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 48.35  E-value: 2.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  24 GSGKTTMAKAVSEKLGFEYIEGDDLHPKAniEKMSQGHPLNDNdrwGWlhncGGACAMELD--KE--SIKGVVLTC---S 96
Cdd:pfam01202   2 GAGKSTIGRLLAKALGLPFIDTDEEIEKR--TGMSIAEIFEEE---GE----EGFRRLESEvlKEllAEHGLVIATgggA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1246743238  97 ALKRSYRDILRSSlehrpaiLRFIYLAASRETLIKRTTSRKN 138
Cdd:pfam01202  73 VLSEENRDLLKER-------GIVIYLDAPLEVLLERLKRDKT 107
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 16-139 2.26e-07

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 48.77  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIE-GDDLhpKANIEK-----------MSQGHPLNDNDRWGWLHNcggacamEL 83
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHIStGDLL--REEIASgtelgkkakeyIDSGKLVPDEIVIKLLKE-------RL 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743238  84 DK-ESIKGVVLtcSALKRSYR--DILRSSLEHRPAILRFIYLAASRETLIKRTTSRKNH 139
Cdd:cd01428    72 KKpDCKKGFIL--DGFPRTVDqaEALDELLDEGIKPDKVIELDVPDEVLIERILGRRIC 128
AAA_18 pfam13238
AAA domain;
18-142 6.71e-07

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 46.65  E-value: 6.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIEGdDLHPKANI-----EKMSQGHPLnDNDRWGWLHNcggaCAMELDKESIKGVV 92
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFGDNVR-DLALENGLvlgddPETRESKRL-DEDKLDRLLD----LLEENAALEEGGNL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1246743238  93 LTcsalkrsyrDILRSSLE-HRPAILRFIYLAASRETLIKRTTSRKNHYMK 142
Cdd:pfam13238  76 II---------DGHLAELEpERAKDLVGIVLRASPEELLERLEKRGYEEAK 117
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
21-43 8.50e-07

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 47.33  E-value: 8.50e-07
                          10        20
                  ....*....|....*....|...
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYI 43
Cdd:COG0283     7 GPAGSGKSTVAKALAKRLGYHYL 29
PRK06547 PRK06547
hypothetical protein; Provisional
 18-77 9.01e-07

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 47.04  E-value: 9.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743238  18 VVI-GPAGSGKTTMAKAVSEKLGFEYIEGDDLHPK----ANIEKMSQGHPLNDND----RWGWLHNCGG 77
Cdd:PRK06547   18 VLIdGRSGSGKTTLAGALAARTGFQLVHLDDLYPGwhglAAASEHVAEAVLDEGRpgrwRWDWANNRPG 86
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 18-138 7.38e-06

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 44.08  E-value: 7.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLhpkanIEKMSqGHPLNDN-DRWGWlhncGGACAME----LDKESIKGVV 92
Cdd:cd00464     3 VLIGMMGAGKTTVGRLLAKALGLPFVDLDEL-----IEQRA-GMSIPEIfAEEGE----EGFRELErevlLLLLTKENAV 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1246743238  93 LTC--SALKRSyrDILRSSLEHRPAilrfIYLAASRETLIKRTTSRKN 138
Cdd:cd00464    73 IATggGAVLRE--ENRRLLLENGIV----VWLDASPEELLERLARDKT 114
AAA_17 pfam13207
AAA domain;
21-138 1.17e-05

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 43.00  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYIEGDDL--------HPKANIEKMSQGhPLNDNDRWgwlhncgGACAME-LDKESI-KG 90
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLlreeakerGLVEDRDEMRKL-PLEPQKEL-------QKLAAErIAEEAGeGG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1246743238  91 VVLTCSALKRSYRDILRSSLEHRPAILR---FIYLAASRETLIKRTTSRKN 138
Cdd:pfam13207  74 VIVDGHPRIKTPAGYLPGLPVEVLRELKpdaIILLEADPEEILERRLKDRT 124
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 18-56 1.35e-05

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 43.58  E-value: 1.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLhpkanIEK 56
Cdd:COG0703     2 VLIGMMGAGKSTVGRLLAKRLGLPFVDTDAE-----IEE 35
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 21-44 3.29e-05

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 42.68  E-value: 3.29e-05
                          10        20
                  ....*....|....*....|....
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYIE 44
Cdd:pfam02224   5 GPSGSGKSTVARILARKLGYKYLD 28
PRK04182 PRK04182
cytidylate kinase; Provisional
 21-48 3.70e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 42.49  E-value: 3.70e-05
                          10        20
                  ....*....|....*....|....*...
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYIEGDDL 48
Cdd:PRK04182    7 GPPGSGKTTVARLLAEKLGLKHVSAGEI 34
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 16-48 5.46e-05

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 42.02  E-value: 5.46e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDL 48
Cdd:TIGR02173   2 IITISGPPGSGKTTVAKILAEKLSLKLISAGDI 34
aroK PRK00131
shikimate kinase; Reviewed
 18-56 7.92e-05

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 41.33  E-value: 7.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLhpkanIEK 56
Cdd:PRK00131    8 VLIGFMGAGKSTIGRLLAKRLGYDFIDTDHL-----IEA 41
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 21-43 8.59e-05

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 41.64  E-value: 8.59e-05
                          10        20
                  ....*....|....*....|...
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYI 43
Cdd:TIGR00017   9 GPSGAGKSTVAKAVAEKLGYAYL 31
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 19-44 1.51e-04

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 39.88  E-value: 1.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 1246743238  19 VIGPAGSGKTTMAKAVSEKLGFEYIE 44
Cdd:pfam00004   3 LYGPPGTGKTTLAKAVAKELGAPFIE 28
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
21-49 2.11e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 40.19  E-value: 2.11e-04
                          10        20
                  ....*....|....*....|....*....
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYIEGDDLH 49
Cdd:COG1102     7 REPGSGGTTIAKRLAEKLGLPLYDGEILR 35
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 16-49 2.47e-04

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 40.42  E-value: 2.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLH 49
Cdd:cd02030     1 VITVDGNIASGKGKLAKELAEKLGMKYFPEAGIH 34
PRK13768 PRK13768
GTPase; Provisional
 13-38 2.59e-04

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 40.62  E-value: 2.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 1246743238  13 YKYVFVViGPAGSGKTTMAKAVSEKL 38
Cdd:PRK13768    2 MYIVFFL-GTAGSGKTTLTKALSDWL 26
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
21-43 3.82e-04

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 40.25  E-value: 3.82e-04
                          10        20
                  ....*....|....*....|...
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYI 43
Cdd:PRK13477  291 GPAGAGKSTVTRAVAKKLGLLYL 313
PRK05541 PRK05541
adenylylsulfate kinase; Provisional
 15-144 3.92e-04

adenylylsulfate kinase; Provisional


Pssm-ID: 235498  Cd Length: 176  Bit Score: 39.27  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  15 YVFVVIGPAGSGKTTMAKAVSEKLGFE-----YIEGDDLHpkaNIEKMSqGHplndnDRWGWLHNC---GGACAMeLDKE 86
Cdd:PRK05541    8 YVIWITGLAGSGKTTIAKALYERLKLKysnviYLDGDELR---EILGHY-GY-----DKQSRIEMAlkrAKLAKF-LADQ 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  87 SIKGVVLTCSALKRSYRdilrsslEHRPAILRF--IYLAASRETLIKRttSRKNHYMKAD 144
Cdd:PRK05541   78 GMIVIVTTISMFDEIYA-------YNRKHLPNYfeVYLKCDMEELIRR--DQKGLYTKAL 128
PRK08118 PRK08118
DNA topology modulation protein;
18-53 7.00e-04

DNA topology modulation protein;


Pssm-ID: 181235  Cd Length: 167  Bit Score: 38.44  E-value: 7.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKAN 53
Cdd:PRK08118    5 ILIGSGGSGKSTLARQLGEKLNIPVHHLDALFWKPN 40
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 16-140 9.78e-04

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 38.36  E-value: 9.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYI-EGDDLHPKAN--IEKMsqghpLNDNDRWG------------------WLHN 74
Cdd:cd01673     1 VIVVEGNIGAGKSTLAKELAEHLGYEVVpEPVEPDVEGNpfLEKF-----YEDPKRWAfpfqlyfllsrlkqykdaLEHL 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246743238  75 CGGACAMeLDKESIKGVVLTCSALKRS---------YRDILRSSLEHRPAILRFIYLAASRETLIKRTTSRKNHY 140
Cdd:cd01673    76 STGQGVI-LERSIFSDRVFAEANLKEGgimkteydlYNELFDNLIPELLPPDLVIYLDASPETCLKRIKKRGRPE 149
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 17-46 1.28e-03

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 38.18  E-value: 1.28e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1246743238  17 FVVIGPAGSGKTTMAKAVSEKLGFEYIE-GD 46
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYGIPHIStGD 33
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
18-44 1.59e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 37.49  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*..
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIE 44
Cdd:COG1936     4 AITGTPGTGKTTVAKLLAERLGLEVIH 30
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 11-48 2.15e-03

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 37.97  E-value: 2.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1246743238  11 QPYKYVFVviGPAGSGKTTMAKAVSEKLGFEYIE--GDDL 48
Cdd:COG0464   190 PPRGLLLY--GPPGTGKTLLARALAGELGLPLIEvdLSDL 227
Srp102 COG2229
Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, ...
 1-37 2.37e-03

Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441830 [Multi-domain]  Cd Length: 189  Bit Score: 37.11  E-value: 2.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1246743238   1 MTVTPINPTNQPYKYVFVviGPAGSGKTTMAKAVSEK 37
Cdd:COG2229     1 MAFINVAAREITVKIVYA--GPFGAGKTTFVRSISEI 35
PRK13947 PRK13947
shikimate kinase; Provisional
 18-58 3.26e-03

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 36.61  E-value: 3.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLhpkanIEKMS 58
Cdd:PRK13947    5 VLIGFMGTGKTTVGKRVATTLSFGFIDTDKE-----IEKMT 40
PRK04195 PRK04195
replication factor C large subunit; Provisional
 21-44 3.48e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 37.59  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|....
gi 1246743238  21 GPAGSGKTTMAKAVSEKLGFEYIE 44
Cdd:PRK04195   46 GPPGVGKTSLAHALANDYGWEVIE 69
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 13-43 3.60e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 36.32  E-value: 3.60e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1246743238  13 YKYVfVVIGPAGSGKTTMAKAVSEKLGFEYI 43
Cdd:NF033453   16 YKLI-LLVGPPGSGKTALLRELAAKRGAPVI 45
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 19-36 3.60e-03

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 36.97  E-value: 3.60e-03
                          10
                  ....*....|....*...
gi 1246743238  19 VIGPAGSGKTTMAKAVSE 36
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSE 18
AAA_28 pfam13521
AAA domain;
17-44 3.65e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 36.47  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*...
gi 1246743238  17 FVVIGPAGSGKTTMAKAVSEKLGFEYIE 44
Cdd:pfam13521   2 IVITGGPSTGKTTLAEALAARFGYPVVP 29
DEXSc_RecD-like cd17933
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ...
 16-38 4.61e-03

DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350691 [Multi-domain]  Cd Length: 155  Bit Score: 35.99  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|...
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKL 38
Cdd:cd17933    14 VSVLTGGAGTGKTTTLKALLAAL 36
NadR3 COG3172
Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase ...
 18-61 4.77e-03

Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 442405 [Multi-domain]  Cd Length: 178  Bit Score: 36.34  E-value: 4.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKL--------GFEYIEGDDLHPKAN-IEKMSQGH 61
Cdd:COG3172    12 VLLGAESTGKTTLARALAAHYntpwvpeyGREYLEEKGRALTYDdLLAIARGQ 64
AAA_30 pfam13604
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 16-36 4.82e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.


Pssm-ID: 433343 [Multi-domain]  Cd Length: 191  Bit Score: 36.39  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|.
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSE 36
Cdd:pfam13604  20 VAVLVGPAGTGKTTALKALRE 40
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 18-38 5.10e-03

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


Pssm-ID: 349780  Cd Length: 196  Bit Score: 36.36  E-value: 5.10e-03
                          10        20
                  ....*....|....*....|.
gi 1246743238  18 VVIGPAGSGKTTMAKAVSEKL 38
Cdd:cd17871     4 VVIGPPGSGKTTYCKGMQQFL 24
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 16-49 5.25e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 35.81  E-value: 5.25e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1246743238   16 VFVVIGPAGSGKTTMAKAVSEKL-----GFEYIEGDDLH 49
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELgppggGVIYIDGEDIL 42
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
16-68 5.92e-03

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 36.95  E-value: 5.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLHPKANIEKMSQGHPLNDNDR 68
Cdd:PRK11860  444 VICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAA 496
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 19-73 7.67e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 35.97  E-value: 7.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743238  19 VIGPAGSGKTTMAKAVSEKLGFEY---IEGDDLHpkanieKMSQGHPLNDNDRWGWLH 73
Cdd:COG0572    12 IAGPSGSGKTTFARRLAEQLGADKvvvISLDDYY------KDREHLPLDERGKPNFDH 63
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 16-43 7.79e-03

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 36.49  E-value: 7.79e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1246743238  16 VFVVIGPAGSGKTTMAKAVS---EKLGFEYI 43
Cdd:COG0507   142 VSVLTGGAGTGKTTTLRALLaalEALGLRVA 172
aroL PRK03731
shikimate kinase AroL;
20-46 7.82e-03

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 35.69  E-value: 7.82e-03
                          10        20
                  ....*....|....*....|....*..
gi 1246743238  20 IGPAGSGKTTMAKAVSEKLGFEYIEGD 46
Cdd:PRK03731    8 VGARGCGKTTVGMALAQALGYRFVDTD 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH