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Conserved domains on  [gi|1246742781|ref|NP_001342803|]
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GTPase-activating protein [Schizosaccharomyces pombe]

Protein Classification

tuberin( domain architecture ID 10570870)

tuberin such as human tuberin, encoded by TSC2, that with hamartin (TSC1), form a tumor suppressor heterodimer that inhibits the mammalian target of rapamycin (mTOR) nutrient signaling input; contains an N-terminal DUF3384 domain and a C-terminal RapGAP homology domain responsible for inactivation of Rheb

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3384 pfam11864
Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain ...
 19-422 4.24e-90

Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.


:

Pssm-ID: 463376  Cd Length: 407  Bit Score: 297.64  E-value: 4.24e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781   19 LDKRYKRIKRLIN--NEQFCKNVIlqKLVDSTKDIIENKVHGNILAATISLWTHAAeKHKEMSSDDRALLFNELSKVPNS 96
Cdd:pfam11864    1 LNERIKAAEKLAEalEEYPLSSVL--EIWYAAKDLIDPENPAEARRAGLRLLTACI-KQQDLSDIERLEFFNDISSYCNP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781   97 EY-YPATVDALIVITSQGERTESFSNDILKVLSEWLTDLFTIIDDMRAQSRKSFKGSAELRNYTRCFRQIILLLTNMFRV 175
Cdd:pfam11864   78 DDaFPLRLEALIALTDHGRDIEGFEYDILPLLTSWLEPAYDRIADRSRASKSKSKKKSSLDGEEKNLSQLFQFLTNVIKF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  176 GFNLFDEMEVSSMLANCVWVSKSTTDEEDIALVFSLLNCIISYGRISSAVLYSIVEVVCRAKFGLVASSQSAQQIVEKLL 255
Cdd:pfam11864  158 NFKVLDEEEVEGLLDNLLTICKKTSVEDDLKSCLSVLDAIITYGHIPSESLPPCIEVLCSIYCSVPSLSKPAWRTIRNLL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  256 KTATKYEALNSLKRIMEETDEGSY---IAIMGGIQIVSALFTDIPRSVYCTRGMLLGFLQRSLKNKSSRIALETTRSLYN 332
Cdd:pfam11864  238 KSHTGQAAVRTLLDILRDPPLSQKrnaNVLRGAVFVLRKLLWKSGGYPSVPFSLLLPSLKNALKSNSPRVDLEILQLINN 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  333 ALERRSFVEVLYADEWISLLDLLVEISSSLPKSLNYRPGTWQHIEpNIIESIASYQLQHLLLFNEILKPDSNHFVLEKFH 412
Cdd:pfam11864  318 LLDKESIDKLLPEEDWSSLLDILIECSRRLEDSPNTSKASSSSSD-DVDDSIAANLHRLLSSLESLLESSLDFGQKEKLI 396

                          410
                   ....*....|
gi 1246742781  413 EFLKINFSYL 422
Cdd:pfam11864  397 DFFERVHSYL 406
 
Name Accession Description Interval E-value
DUF3384 pfam11864
Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain ...
 19-422 4.24e-90

Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.


Pssm-ID: 463376  Cd Length: 407  Bit Score: 297.64  E-value: 4.24e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781   19 LDKRYKRIKRLIN--NEQFCKNVIlqKLVDSTKDIIENKVHGNILAATISLWTHAAeKHKEMSSDDRALLFNELSKVPNS 96
Cdd:pfam11864    1 LNERIKAAEKLAEalEEYPLSSVL--EIWYAAKDLIDPENPAEARRAGLRLLTACI-KQQDLSDIERLEFFNDISSYCNP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781   97 EY-YPATVDALIVITSQGERTESFSNDILKVLSEWLTDLFTIIDDMRAQSRKSFKGSAELRNYTRCFRQIILLLTNMFRV 175
Cdd:pfam11864   78 DDaFPLRLEALIALTDHGRDIEGFEYDILPLLTSWLEPAYDRIADRSRASKSKSKKKSSLDGEEKNLSQLFQFLTNVIKF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  176 GFNLFDEMEVSSMLANCVWVSKSTTDEEDIALVFSLLNCIISYGRISSAVLYSIVEVVCRAKFGLVASSQSAQQIVEKLL 255
Cdd:pfam11864  158 NFKVLDEEEVEGLLDNLLTICKKTSVEDDLKSCLSVLDAIITYGHIPSESLPPCIEVLCSIYCSVPSLSKPAWRTIRNLL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  256 KTATKYEALNSLKRIMEETDEGSY---IAIMGGIQIVSALFTDIPRSVYCTRGMLLGFLQRSLKNKSSRIALETTRSLYN 332
Cdd:pfam11864  238 KSHTGQAAVRTLLDILRDPPLSQKrnaNVLRGAVFVLRKLLWKSGGYPSVPFSLLLPSLKNALKSNSPRVDLEILQLINN 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  333 ALERRSFVEVLYADEWISLLDLLVEISSSLPKSLNYRPGTWQHIEpNIIESIASYQLQHLLLFNEILKPDSNHFVLEKFH 412
Cdd:pfam11864  318 LLDKESIDKLLPEEDWSSLLDILIECSRRLEDSPNTSKASSSSSD-DVDDSIAANLHRLLSSLESLLESSLDFGQKEKLI 396

                          410
                   ....*....|
gi 1246742781  413 EFLKINFSYL 422
Cdd:pfam11864  397 DFFERVHSYL 406
 
Name Accession Description Interval E-value
DUF3384 pfam11864
Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain ...
 19-422 4.24e-90

Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.


Pssm-ID: 463376  Cd Length: 407  Bit Score: 297.64  E-value: 4.24e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781   19 LDKRYKRIKRLIN--NEQFCKNVIlqKLVDSTKDIIENKVHGNILAATISLWTHAAeKHKEMSSDDRALLFNELSKVPNS 96
Cdd:pfam11864    1 LNERIKAAEKLAEalEEYPLSSVL--EIWYAAKDLIDPENPAEARRAGLRLLTACI-KQQDLSDIERLEFFNDISSYCNP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781   97 EY-YPATVDALIVITSQGERTESFSNDILKVLSEWLTDLFTIIDDMRAQSRKSFKGSAELRNYTRCFRQIILLLTNMFRV 175
Cdd:pfam11864   78 DDaFPLRLEALIALTDHGRDIEGFEYDILPLLTSWLEPAYDRIADRSRASKSKSKKKSSLDGEEKNLSQLFQFLTNVIKF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  176 GFNLFDEMEVSSMLANCVWVSKSTTDEEDIALVFSLLNCIISYGRISSAVLYSIVEVVCRAKFGLVASSQSAQQIVEKLL 255
Cdd:pfam11864  158 NFKVLDEEEVEGLLDNLLTICKKTSVEDDLKSCLSVLDAIITYGHIPSESLPPCIEVLCSIYCSVPSLSKPAWRTIRNLL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  256 KTATKYEALNSLKRIMEETDEGSY---IAIMGGIQIVSALFTDIPRSVYCTRGMLLGFLQRSLKNKSSRIALETTRSLYN 332
Cdd:pfam11864  238 KSHTGQAAVRTLLDILRDPPLSQKrnaNVLRGAVFVLRKLLWKSGGYPSVPFSLLLPSLKNALKSNSPRVDLEILQLINN 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742781  333 ALERRSFVEVLYADEWISLLDLLVEISSSLPKSLNYRPGTWQHIEpNIIESIASYQLQHLLLFNEILKPDSNHFVLEKFH 412
Cdd:pfam11864  318 LLDKESIDKLLPEEDWSSLLDILIECSRRLEDSPNTSKASSSSSD-DVDDSIAANLHRLLSSLESLLESSLDFGQKEKLI 396

                          410
                   ....*....|
gi 1246742781  413 EFLKINFSYL 422
Cdd:pfam11864  397 DFFERVHSYL 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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