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Conserved domains on  [gi|1246741403|ref|NP_001342729|]
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glucose-6-phosphate 1-dehydrogenase [Schizosaccharomyces pombe]

Protein Classification

glucose-6-phosphate 1-dehydrogenase( domain architecture ID 1000188)

glucose-6-phosphate 1-dehydrogenase (G6PD) catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes

EC:  1.1.1.-
Gene Ontology:  GO:0006006|GO:0050661|GO:0016614

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-472 1.21e-152

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 445.35  E-value: 1.21e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   2 LSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAAnkivtahiPIDDTVGASQKAL-------NTF 74
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVER--------WKKETLARFFKRLddrechlEQF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  75 VEHYKYVPGTYDKPESFEMLNSIIAEKETA---PASECTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFD 151
Cdd:PTZ00309  127 LKHISYISGSYDEDEDFKRLNKLIERMEEAfqgPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 152 YKSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGIL 231
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGII 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 232 RDVVQNHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKVPGYRELDGVADDSEVSTFCA 311
Cdd:PTZ00309  287 RDVMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAA 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 312 LQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVDSS-NVLVLRVYPKEFIALKGHIKQPGFSRQIVPV 390
Cdd:PTZ00309  367 AVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDDTQrNELVIRAQPSEAMYLKITAKVPGLSNDLHQT 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 391 TLDVKYPEAFpDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLSPLPYAFGShHGPDATLEFFK 468
Cdd:PTZ00309  447 ELDLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQidRGEVKPEPYPFGS-RGPKEADELIK 524


                  ....
gi 1246741403 469 KRNL 472
Cdd:PTZ00309  525 KNGF 528
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-472 1.21e-152

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 445.35  E-value: 1.21e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   2 LSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAAnkivtahiPIDDTVGASQKAL-------NTF 74
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVER--------WKKETLARFFKRLddrechlEQF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  75 VEHYKYVPGTYDKPESFEMLNSIIAEKETA---PASECTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFD 151
Cdd:PTZ00309  127 LKHISYISGSYDEDEDFKRLNKLIERMEEAfqgPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 152 YKSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGIL 231
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGII 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 232 RDVVQNHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKVPGYRELDGVADDSEVSTFCA 311
Cdd:PTZ00309  287 RDVMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAA 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 312 LQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVDSS-NVLVLRVYPKEFIALKGHIKQPGFSRQIVPV 390
Cdd:PTZ00309  367 AVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDDTQrNELVIRAQPSEAMYLKITAKVPGLSNDLHQT 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 391 TLDVKYPEAFpDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLSPLPYAFGShHGPDATLEFFK 468
Cdd:PTZ00309  447 ELDLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQidRGEVKPEPYPFGS-RGPKEADELIK 524


                  ....
gi 1246741403 469 KRNL 472
Cdd:PTZ00309  525 KNGF 528
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 4-474 1.45e-142

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 417.49  E-value: 1.45e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIV------TAHIPIDDTvgasqkaLNTFVEH 77
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVreaiikFETDEIDEQ-------WDEFAQR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  78 YKYVPGTYDKPESFEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSE-LIKSKAHPNGMVTRLIVEKPIGFDYKSAD 156
Cdd:TIGR00871  78 LSYVSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKqLKKHGLNEQGKWSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 157 AILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQ 236
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 237 NHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKED--IVYGQYTKSANG--KVPGYRELDGVADDSEVSTFCAL 312
Cdd:TIGR00871 238 NHLLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIGgvSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 313 QLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMF----PTVDSSNVLVLRVYPKEFIALKGHIKQPGFSRQIV 388
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFkaneRDANPRNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 389 PVTLDVKYPEAFPDTwIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT---TGDLSPLPYAFGShHGPDATLE 465
Cdd:TIGR00871 398 PVKLDFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAwaaNKGPSPPNYPAGS-WGPKEADE 475


                  ....*....
gi 1246741403 466 FFKKRNLEW 474
Cdd:TIGR00871 476 LIRKDGRSW 484
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 4-474 1.96e-125

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 374.03  E-value: 1.96e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHI------PIDDTVgasqkaLNTFVEH 77
Cdd:COG0364    12 LVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALeefsrkPFDEEV------WERFLER 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  78 YKYVPGTYDKPESFEMLNSIIAEKETAPASEcTRIFYLVLPPHLFAPVSELIKSkahpNGMVT-----RLIVEKPIGFDY 152
Cdd:COG0364    86 LHYVSGDFTDPEGYERLKELLEELDEERTPG-NRVFYLATPPSLFGPICENLGA----AGLATeggwrRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 153 KSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILR 232
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 233 DVVQNHllqlltllcI---------EEPKSQDAEDIIKCKVDFLKSLHPVSKEDI----VYGQYTKSA-NGK-VPGYREL 297
Cdd:COG0364   241 DMVQNH---------LlqllclvamEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTAGWiGGEpVPGYREE 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 298 DGVADDSEVSTFCALQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVD---SSNVLVLRVYPKEFIAL 374
Cdd:COG0364   312 PGVAPDSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAeelPPNRLVIRIQPDEGISL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 375 KGHIKQPGFSRQIVPVTLDVKYPEAF----PDtwihkAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLS 448
Cdd:COG0364   392 RFNAKVPGLGMRLRPVSLDFSYSDAFgersPE-----AYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAwaEEPEP 466

                         490       500
                  ....*....|....*....|....*.
gi 1246741403 449 PLPYAFGShHGPDATLEFFKKRNLEW 474
Cdd:COG0364   467 PPPYPAGS-WGPEAADALLARDGRSW 491
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
188-474 1.78e-110

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 328.63  E-value: 1.78e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 188 AIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHllqlltllcI---------EEPKSQDAED 258
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNH---------LlqllalvamEPPVSFDAED 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 259 IIKCKVDFLKSLHPVSKEDI----VYGQYTKSANG--KVPGYRELDGVADDSEVSTFCALQLRSEAPRWKGIPIIISAGK 332
Cdd:pfam02781  73 IRDEKVKVLRSLRPITPEDVednvVRGQYGAGWIGgePVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 333 GLDRDYFEARITFKRREGGMFPTVD--SSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVKYPEAFPDtWIHKAYE 410
Cdd:pfam02781 153 RLPERVTEIRIQFKDVPHNLFRDPGtlPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGE-RIPEAYE 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246741403 411 VVIADAINGKHTHFISDDEVRTSWKIFDDVLDTTGDLSPLPYAFGShHGPDATLEFFKKRNLEW 474
Cdd:pfam02781 232 RLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAGS-WGPKAADELLARDGRKW 294
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-472 1.21e-152

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 445.35  E-value: 1.21e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   2 LSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAAnkivtahiPIDDTVGASQKAL-------NTF 74
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVER--------WKKETLARFFKRLddrechlEQF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  75 VEHYKYVPGTYDKPESFEMLNSIIAEKETA---PASECTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFD 151
Cdd:PTZ00309  127 LKHISYISGSYDEDEDFKRLNKLIERMEEAfqgPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 152 YKSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGIL 231
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGII 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 232 RDVVQNHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKVPGYRELDGVADDSEVSTFCA 311
Cdd:PTZ00309  287 RDVMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAA 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 312 LQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVDSS-NVLVLRVYPKEFIALKGHIKQPGFSRQIVPV 390
Cdd:PTZ00309  367 AVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDDTQrNELVIRAQPSEAMYLKITAKVPGLSNDLHQT 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 391 TLDVKYPEAFpDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLSPLPYAFGShHGPDATLEFFK 468
Cdd:PTZ00309  447 ELDLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQidRGEVKPEPYPFGS-RGPKEADELIK 524


                  ....
gi 1246741403 469 KRNL 472
Cdd:PTZ00309  525 KNGF 528
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 4-474 1.45e-142

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 417.49  E-value: 1.45e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIV------TAHIPIDDTvgasqkaLNTFVEH 77
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVreaiikFETDEIDEQ-------WDEFAQR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  78 YKYVPGTYDKPESFEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSE-LIKSKAHPNGMVTRLIVEKPIGFDYKSAD 156
Cdd:TIGR00871  78 LSYVSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKqLKKHGLNEQGKWSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 157 AILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQ 236
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 237 NHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKED--IVYGQYTKSANG--KVPGYRELDGVADDSEVSTFCAL 312
Cdd:TIGR00871 238 NHLLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIGgvSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 313 QLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMF----PTVDSSNVLVLRVYPKEFIALKGHIKQPGFSRQIV 388
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFkaneRDANPRNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 389 PVTLDVKYPEAFPDTwIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT---TGDLSPLPYAFGShHGPDATLE 465
Cdd:TIGR00871 398 PVKLDFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAwaaNKGPSPPNYPAGS-WGPKEADE 475


                  ....*....
gi 1246741403 466 FFKKRNLEW 474
Cdd:TIGR00871 476 LIRKDGRSW 484
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 4-474 7.99e-132

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 390.26  E-value: 7.99e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIPIDDTVGASQKALNTFVEHYKYVPG 83
Cdd:PRK05722   12 LVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTPFDEEVWERFLSRLYYVSG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  84 TYDKPESFEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSELIKSkahpNGMV-----TRLIVEKPIGFDYKSADAI 158
Cdd:PRK05722   92 DVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAA----AGLNegggwRRVVIEKPFGHDLASAREL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 159 LSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNH 238
Cdd:PRK05722  168 NDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNH 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 239 LLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDI----VYGQYTKSANG--KVPGYRELDGVADDSEVSTFCAL 312
Cdd:PRK05722  248 LLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVkentVRGQYTAGWIGgkPVPGYREEEGVNPDSTTETFVAL 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 313 QLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVD---SSNVLVLRVYPKEFIALKGHIKQPGFSRQIVP 389
Cdd:PRK05722  328 KLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAeelGPNKLVIRIQPDEGISLRFNAKVPGEGMELRP 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 390 VTLDVKYPEAFPDTwIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLSPLPYAFGShHGPDATLEFF 467
Cdd:PRK05722  408 VKLDFSYSEAFGEA-SPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAweADGGPPPPYPAGT-WGPEAADALL 485


                  ....*..
gi 1246741403 468 KKRNLEW 474
Cdd:PRK05722  486 ARDGRSW 492
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 4-474 1.96e-125

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 374.03  E-value: 1.96e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHI------PIDDTVgasqkaLNTFVEH 77
Cdd:COG0364    12 LVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALeefsrkPFDEEV------WERFLER 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  78 YKYVPGTYDKPESFEMLNSIIAEKETAPASEcTRIFYLVLPPHLFAPVSELIKSkahpNGMVT-----RLIVEKPIGFDY 152
Cdd:COG0364    86 LHYVSGDFTDPEGYERLKELLEELDEERTPG-NRVFYLATPPSLFGPICENLGA----AGLATeggwrRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 153 KSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILR 232
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 233 DVVQNHllqlltllcI---------EEPKSQDAEDIIKCKVDFLKSLHPVSKEDI----VYGQYTKSA-NGK-VPGYREL 297
Cdd:COG0364   241 DMVQNH---------LlqllclvamEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTAGWiGGEpVPGYREE 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 298 DGVADDSEVSTFCALQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVD---SSNVLVLRVYPKEFIAL 374
Cdd:COG0364   312 PGVAPDSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAeelPPNRLVIRIQPDEGISL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 375 KGHIKQPGFSRQIVPVTLDVKYPEAF----PDtwihkAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLS 448
Cdd:COG0364   392 RFNAKVPGLGMRLRPVSLDFSYSDAFgersPE-----AYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAwaEEPEP 466

                         490       500
                  ....*....|....*....|....*.
gi 1246741403 449 PLPYAFGShHGPDATLEFFKKRNLEW 474
Cdd:COG0364   467 PPPYPAGS-WGPEAADALLARDGRSW 491
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 2-462 3.46e-125

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 373.29  E-value: 3.46e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   2 LSIIVFGASGDLATKMTFPALFALYVRKIIPED-FQIIGYARSKLSQEAANKIVTAHIPIDDTvgASQKALNTFVEHYKY 80
Cdd:PLN02539   18 LSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDeVHIFGYARSKITDEELRDRIRGYLKDEKN--APAEAVSKFLQLIKY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  81 VPGTYDKPESFEMLNSIIAEKETAPASE---CTRIFYLVLPPHLFAPVSELIKSK-AHPNGMVTRLIVEKPIGFDYKSAD 156
Cdd:PLN02539   96 VSGAYDSEEGFRRLDKEISEHEISKNSAegsSRRLFYLALPPSVYPPVCKMIKKCcMNKSGLWTRIVVEKPFGKDLESAE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 157 AILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQ 236
Cdd:PLN02539  176 ELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQ 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 237 NHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYtksangkvPGYRELDGVADDSEVSTFCALQLRS 316
Cdd:PLN02539  256 NHLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEVVLGQY--------EGYRDDPTVPDDSNTPTFASVVLRI 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 317 EAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVDSS-NVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVK 395
Cdd:PLN02539  328 NNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKCQKQGrNEFVIRLQPSEAMYMKLTVKQPGLEMSTVQSELDLS 407

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246741403 396 YPEAFPDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLD--TTGDLSPLPYAFGSHHGPDA 462
Cdd:PLN02539  408 YGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHriDAGKVKPIPYKQGSRGPAEA 476
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
4-474 1.00e-124

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 371.54  E-value: 1.00e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIPIDDTVGASQKALNTFVEHYKYVPG 83
Cdd:PRK12853   11 LVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADGFDDAVWDRLAARLSYVQG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  84 TYDKPESFEMLnsiiaeKETApASECTRIFYLVLPPHLFAPVSE-LIKSKAHPNGmvTRLIVEKPIGFDYKSADAILSDL 162
Cdd:PRK12853   91 DVTDPADYARL------AEAL-GPGGNPVFYLAVPPSLFAPVVEnLGAAGLLPEG--RRVVLEKPFGHDLASARALNATL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 163 SKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHLLQL 242
Cdd:PRK12853  162 AKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 243 LTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDI--VYGQYTKSANG--KVPGYRELDGVADDSEVSTFCALQLRSEA 318
Cdd:PRK12853  242 LALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVhtVRGQYTAGTVGgePVPGYREEPGVDPDSRTETFVALKLEIDN 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 319 PRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFP--TVDSSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVKY 396
Cdd:PRK12853  322 WRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRgtGVEPPNRLVIRLQPDEGISLELNVKRPGPGMRLRPVELDADY 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 397 PEAFPDTwihKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDT--TGDLSPLPYAFGShHGPDATLEFFKKRNLEW 474
Cdd:PRK12853  402 ADDERPL---EAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAwaADPVPPHEYPAGS-WGPAAADALLARDGRGW 477
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
188-474 1.78e-110

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 328.63  E-value: 1.78e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 188 AIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHllqlltllcI---------EEPKSQDAED 258
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNH---------LlqllalvamEPPVSFDAED 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 259 IIKCKVDFLKSLHPVSKEDI----VYGQYTKSANG--KVPGYRELDGVADDSEVSTFCALQLRSEAPRWKGIPIIISAGK 332
Cdd:pfam02781  73 IRDEKVKVLRSLRPITPEDVednvVRGQYGAGWIGgePVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 333 GLDRDYFEARITFKRREGGMFPTVD--SSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVKYPEAFPDtWIHKAYE 410
Cdd:pfam02781 153 RLPERVTEIRIQFKDVPHNLFRDPGtlPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGE-RIPEAYE 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246741403 411 VVIADAINGKHTHFISDDEVRTSWKIFDDVLDTTGDLSPLPYAFGShHGPDATLEFFKKRNLEW 474
Cdd:pfam02781 232 RLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAGS-WGPKAADELLARDGRKW 294
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 2-474 4.50e-109

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 334.68  E-value: 4.50e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   2 LSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIP--IDDTVGASQKaLNTFVEHYK 79
Cdd:PLN02640   89 LSITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLTcrIDQRENCGDK-MDQFLKRCF 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  80 YVPGTYDKPESFEMLNSIIAEKETAPASecTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFDYKSADAIL 159
Cdd:PLN02640  168 YHSGQYDSEEDFAELNKKLKEKEAGKLS--NRLFYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELT 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 160 SDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHL 239
Cdd:PLN02640  246 RCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 240 LQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYT-KSANGKV-PGYRELDGVADDSEVSTFCALQLRSE 317
Cdd:PLN02640  326 LQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKgHSKGGKSyPAYTDDPTVPKHSLTPTFAAAALFIN 405

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 318 APRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFP-----TVD-SSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVT 391
Cdd:PLN02640  406 NARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKrnfgtDLDkATNELVLRVQPDEAIYLKINNKVPGLGMRLDRSD 485

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 392 LDV----KYPEAFPDtwihkAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDTTGDLSPLP--YAFGShHGPDATLE 465
Cdd:PLN02640  486 LNLlyraRYPREIPD-----AYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPelYPYGS-RGPVGAHY 559


                  ....*....
gi 1246741403 466 FFKKRNLEW 474
Cdd:PLN02640  560 LAAKYNVRW 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 2-474 2.30e-106

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 328.47  E-value: 2.30e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   2 LSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIP--IDDTVGASQKaLNTFVEHYK 79
Cdd:PLN02333  118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTcrIDKRENCGEK-MEEFLKRCF 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  80 YVPGTYDKPESFEMLNSIIAEKETAPASecTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFDYKSADAIL 159
Cdd:PLN02333  197 YHSGQYDSQEHFAELDKKLKEHEGGRVS--NRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVEKPFGRDSESSAALT 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 160 SDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHL 239
Cdd:PLN02333  275 KSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHL 354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 240 LQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKV--PGYRELDGVADDSEVSTFCALQLRSE 317
Cdd:PLN02333  355 LQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKGGVtyPAYTDDKTVPKGSLTPTFAAAALFID 434

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 318 APRWKGIPIIISAGKGLDRDYFEARITFKRREGGMF-----PTVD-SSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVT 391
Cdd:PLN02333  435 NARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYnrnfgTDLDqATNELVIRVQPDEAIYLKINNKVPGLGMRLDRSN 514

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 392 LDV----KYPEAFPDtwihkAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDTTGDLSPLP--YAFGShHGPDATLE 465
Cdd:PLN02333  515 LNLlyaaRYSKEIPD-----AYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPeyYPYGS-RGPVGAHY 588


                  ....*....
gi 1246741403 466 FFKKRNLEW 474
Cdd:PLN02333  589 LAARYKVRW 597
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 4-462 1.81e-88

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 278.46  E-value: 1.81e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   4 IIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIPIDDTVGASQKALNTFVEHYKYVPG 83
Cdd:PRK12854   14 FVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARKLDDGEWARFAKRLRYVPG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  84 TYDKPESfEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSELIKskAHpnGMV--TRLIVEKPIGFDYKSADAILSD 161
Cdd:PRK12854   94 GFLSAGP-GALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALG--EA--GLAegSRVVMEKPFGTDLASAEALNAA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 162 LSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHLLQ 241
Cdd:PRK12854  169 VHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHLFQ 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 242 LLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTksangkvpGYRELDGVADDSEVSTFCALQLRSEAPRW 321
Cdd:PRK12854  249 VLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYS--------GYRDEPGVAPDSTTETFVALKVWIDNWRW 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403 322 KGIPIIISAGKGLDRDYFEARITFKRREGGMFP----TVDSSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVKYP 397
Cdd:PRK12854  321 AGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPagsvGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRLDKLSLQFSLK 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246741403 398 EAFPDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDttgDLSPL-PYAFGShHGPDA 462
Cdd:PRK12854  401 DTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLE---DPPPVkPYAPGS-WGPNA 462
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
5-183 1.51e-52

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 174.92  E-value: 1.51e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403   5 IVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEA-ANKIVTAhipIDDTVGASQKALNTFVEHYKYVPG 83
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEfRERVREA---LKEFKELDEEKWDRFLERLHYVSG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246741403  84 TYDKPESFEMLNSIIAEKEtaPASECTRIFYLVLPPHLFAPVSELIKSkahpNGMV-----TRLIVEKPIGFDYKSADAI 158
Cdd:pfam00479  78 DFDDPESYEKLKERLEEHE--DETRGNRLFYLAVPPSLFGPIAENLGR----AGLSeeggwRRVVIEKPFGHDLESAREL 151

                         170       180
                  ....*....|....*....|....*
gi 1246741403 159 LSDLSKHWSAKDTFKVDHFLGEDMI 183
Cdd:pfam00479 152 NDQLAKVFKEEQIYRIDHYLGKETV 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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