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Conserved domains on  [gi|1244518226|ref|NP_001342550|]
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tetratricopeptide repeat protein 33 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11469162)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-164 1.16e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                          90       100
                  ....*....|....*....|....*...
gi 1244518226 137 QLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG4783    82 LLKAGDYDEALALLEKALKLDPEHPEAY 109
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-164 1.16e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                          90       100
                  ....*....|....*....|....*...
gi 1244518226 137 QLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG4783    82 LLKAGDYDEALALLEKALKLDPEHPEAY 109
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 38-162 4.84e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  38 GNWLQASKRRKETLQEGCKQRSQQLKDEGAQLAENkRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAE 117
Cdd:TIGR02917 513 GNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG-NEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILN 591

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1244518226 118 MAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPE 162
Cdd:TIGR02917 592 EAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSAL 636
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-164 1.16e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                          90       100
                  ....*....|....*....|....*...
gi 1244518226 137 QLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG4783    82 LLKAGDYDEALALLEKALKLDPEHPEAY 109
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 60-185 1.75e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  60 QQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLG 139
Cdd:COG3914    79 ALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRR 158

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1244518226 140 LGEIVLAIRSFQIALHIYPMNPELWkedLSWARKLQEQQKVAQRIE 185
Cdd:COG3914   159 LGRLEEAIAALRRALELDPDNAEAL---NNLGNALQDLGRLEEAIA 201
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 66-164 1.76e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198

                          90
                  ....*....|....*....
gi 1244518226 146 AIRSFQIALHIYPMNPELW 164
Cdd:COG3914   199 AIAAYRRALELDPDNADAH 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-164 1.92e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                          90
                  ....*....|....*....
gi 1244518226 146 AIRSFQIALHIYPMNPELW 164
Cdd:COG0457    95 ALEDYDKALELDPDDAEAL 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-188 7.03e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 7.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1244518226 146 AIRSFQIALHIYPMNPELWkEDLSWARKLQEQQKVAQRIENKE 188
Cdd:COG0457   129 AIEAYERALELDPDDADAL-YNLGIALEKLGRYEEALELLEKL 170
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 66-160 1.79e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 1.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG4783    45 GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124

                          90
                  ....*....|....*
gi 1244518226 146 AIRSFQIALHIYPMN 160
Cdd:COG4783   125 AIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 69-159 1.92e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.97  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143

                          90
                  ....*....|.
gi 1244518226 149 SFQIALHIYPM 159
Cdd:COG5010   144 ALQRALGTSPL 154
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
57-164 1.05e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 54.15  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4785    71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                          90       100       110
                  ....*....|....*....|....*....|
gi 1244518226 137 QLGLGEIVLAIRSFQIALHIYPMNPE--LW 164
Cdd:COG4785   151 LYYLGRYELAIADLEKALELDPNDPEraLW 180
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 69-162 1.11e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG4235    27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106

                          90
                  ....*....|....
gi 1244518226 149 SFQIALHIYPMNPE 162
Cdd:COG4235   107 AWQKLLALLPADAP 120
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
69-158 5.01e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 5.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEmFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR-YDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                          90
                  ....*....|
gi 1244518226 149 SFQIALHIYP 158
Cdd:COG3063    81 YLERALELDP 90
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 60-186 5.72e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.07  E-value: 5.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  60 QQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLG 139
Cdd:COG3914    45 LLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1244518226 140 LGEIVLAIRSFQIALHIYPMNPELWkedLSWARKLQEQQKVAQRIEN 186
Cdd:COG3914   125 LGRLEEALAALRRALALNPDFAEAY---LNLGEALRRLGRLEEAIAA 168
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 77-164 1.14e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  77 EAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHI 156
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                  ....*...
gi 1244518226 157 YPMNPELW 164
Cdd:COG4235    81 DPDNPEAL 88
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 36-185 1.58e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  36 EDGNWLQASK--RRKETLQEGCKQRSQQLkdeGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAV 113
Cdd:COG2956   122 QEGDWEKAIEvlERLLKLGPENAHAYCEL---AELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1244518226 114 HAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPELwkedLSWARKLQEQQKVAQRIE 185
Cdd:COG2956   199 AALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL----LALADLLERKEGLEAALA 266
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 67-189 3.19e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.80  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  67 AQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLA 146
Cdd:COG5010    28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEA 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1244518226 147 IRSFQIALHIYPMNPELWkEDLSWARKLQEQQKVAQRIENKEM 189
Cdd:COG5010   108 KEYYEKALALSPDNPNAY-SNLAALLLSLGQDDEAKAALQRAL 149
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 38-191 6.51e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 6.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  38 GNWLQASKRRKETLQegCKQRSQQLKDEGAQ--------LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEM 109
Cdd:COG3914   119 GNLLLALGRLEEALA--ALRRALALNPDFAEaylnlgeaLRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226 110 FPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRsFQIALHIYPMNPELWK-------EDLSWARKLQEQQKVAQ 182
Cdd:COG3914   197 EEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALARGPSELSpfallylPDDDPAELLALARAWAQ 275


                  ....*....
gi 1244518226 183 RIENKEMPP 191
Cdd:COG3914   276 LVAAAAAPE 284
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 65-186 1.43e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  65 EGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIV 144
Cdd:COG2956    14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1244518226 145 LAIRSFQIALHIYPMNPELWKEDLSWARKLQEQQK---VAQRIEN 186
Cdd:COG2956    94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKaieVLERLLK 138
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 69-185 2.65e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG2956   120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1244518226 149 SFQIALHIYPMNPELWKEDLSWARKLQEQQKVAQRIE 185
Cdd:COG2956   200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLR 236
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-164 7.09e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 7.09e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1244518226  86 LQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
102-183 2.06e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226 102 VLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRsFQIALHIYPMNPELWKEdLSWARKLQEQQKVA 181
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN-LAELLLELGDYDEA 78


                  ..
gi 1244518226 182 QR 183
Cdd:COG3063    79 LA 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 73-185 4.81e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  73 KRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQI 152
Cdd:COG2956    56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1244518226 153 ALHIYPMNPELWKEdlsWARKLQEQQKVAQRIE 185
Cdd:COG2956   136 LLKLGPENAHAYCE---LAELYLEQGDYDEAIE 165
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 38-162 4.84e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  38 GNWLQASKRRKETLQEGCKQRSQQLKDEGAQLAENkRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAE 117
Cdd:TIGR02917 513 GNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG-NEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILN 591

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1244518226 118 MAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPE 162
Cdd:TIGR02917 592 EAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSAL 636
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-185 7.41e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.91  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244518226  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG0457   120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1244518226 149 SFQIALHIYPMNPELWKEDLSWARKLQEQQKVAQRIE 185
Cdd:COG0457   200 LLALEQALRKKLAILTLAALAELLLLALALLLALRLA 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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