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Conserved domains on  [gi|1242013588|ref|NP_001342225|]
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origin recognition complex subunit 4 isoform 1 [Mus musculus]

Protein Classification

origin recognition complex subunit 4( domain architecture ID 13386334)

origin recognition complex subunit 4 is a component of the origin recognition complex (ORC), an ATP-dependent DNA-binding complex that binds origins of replication

CATH:  3.40.50.300
Gene Symbol:  ORC4
Gene Ontology:  GO:0006270|GO:0006260|GO:0005524|GO:0000808|GO:0003688
PubMed:  20130679|18208389|18466635|16828312|15037233|17241905
SCOP:  4000172|4000283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 225-412 1.46e-59

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


:

Pssm-ID: 464223  Cd Length: 212  Bit Score: 193.33  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 225 KIFKEQLSLPAEF----PDKAFAERWNENVHCLSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLM 300
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 301 EAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKP 367
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1242013588 368 VVMKAFEHLQQLELIKPVERTSVNS-------QREYQLVKLLLDNTQIMNAL 412
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 super family cl34277
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-223 9.56e-21

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1474:

Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 93.37  E-value: 9.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474    34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 118 DNVVEDKvfG-SFAENLSFLLEALQKGDRtsscPVIFILDEFDIFAHQKNQTLLYNLFDISQS-AQTPVAVIGLTCRLDI 195
Cdd:COG1474   113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDLEF 186

                         170       180
                  ....*....|....*....|....*...
gi 1242013588 196 LELLEKRVKSRFSHRQIHlmnsfdFPQY 223
Cdd:COG1474   187 LENLDPRVKSSLGEEEIV------FPPY 208
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 225-412 1.46e-59

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 193.33  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 225 KIFKEQLSLPAEF----PDKAFAERWNENVHCLSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLM 300
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 301 EAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKP 367
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1242013588 368 VVMKAFEHLQQLELIKPVERTSVNS-------QREYQLVKLLLDNTQIMNAL 412
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-223 9.56e-21

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 93.37  E-value: 9.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474    34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 118 DNVVEDKvfG-SFAENLSFLLEALQKGDRtsscPVIFILDEFDIFAHQKNQTLLYNLFDISQS-AQTPVAVIGLTCRLDI 195
Cdd:COG1474   113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDLEF 186

                         170       180
                  ....*....|....*....|....*...
gi 1242013588 196 LELLEKRVKSRFSHRQIHlmnsfdFPQY 223
Cdd:COG1474   187 LENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 56-223 1.38e-13

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 71.51  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  56 GESNSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNldnVVEDKV--FG-SFA 130
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaeDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 131 ENLSFLLEALQKGDRTsscpVIFILDEFDIFAhQKNQTLLYNLFDISQSAQT---PVAVIGLTCRLDILELLEKRVKSRF 207
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGISNDLKFRENLDPRVKSSL 189

                         170
                  ....*....|....*.
gi 1242013588 208 SHRQIHlmnsfdFPQY 223
Cdd:TIGR02928 190 CEEEII------FPPY 199
cdc6 PRK00411
ORC1-type DNA replication protein;
46-223 7.09e-13

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 69.88  E-value: 7.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  46 IELLK---RTAIYGESNS-VLIVGPRGSGKTTLLNHALKELMEIevSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVV 121
Cdd:PRK00411   39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI--AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPPP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 122 EDKVfgSFAENLSFLLEALQKGDRTsscpVIFILDEFDIFAHQKNQTLLYNLFDISQSAQ-TPVAVIGLTCRLDILELLE 200
Cdd:PRK00411  117 SSGL--SFDELFDKIAEYLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHEEYPgARIGVIGISSDLTFLYILD 190

                         170       180
                  ....*....|....*....|...
gi 1242013588 201 KRVKSRFSHRQIHlmnsfdFPQY 223
Cdd:PRK00411  191 PRVKSVFRPEEIY------FPPY 207
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-210 1.66e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 59.08  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  44 HLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQTNekialkeitrqlnldnvVED 123
Cdd:cd00009     5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLEGL-----------------VVA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 124 KVFGSFAENLSFLLEALQKGDrtsscpvIFILDEFDIFAHQKNQTLLYNL--FDISQSAQTPVAVIGLTCRLDILELLEK 201
Cdd:cd00009    66 ELFGHFLVRLLFELAEKAKPG-------VLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNRPLLGDLDRA 138


                  ....*....
gi 1242013588 202 RvKSRFSHR 210
Cdd:cd00009   139 L-YDRLDIR 146
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-187 8.05e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 51.74  E-value: 8.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL-------MEIEVSENVIQVHLNGLLQTN--- 103
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRALerdggyfLRGKCDENLPYSPLLEALTREgll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 104 EKIALKEITRQLNLDNVVEDKVFGSFAE----NLSFLLEALQK---GDRTSSCPVIFILDEFDIFAHQkNQTLLYNLFDI 176
Cdd:pfam13191  80 RQLLDELESSLLEAWRAALLEALAPVPElpgdLAERLLDLLLRlldLLARGERPLVLVLDDLQWADEA-SLQLLAALLRL 158

                         170
                  ....*....|.
gi 1242013588 177 SQsaQTPVAVI 187
Cdd:pfam13191 159 LE--SLPLLVV 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-214 3.39e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.68  E-value: 3.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588   59 NSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQtnekialkEITRQLNLDNVVEDKVFGSFAENLSFLLE 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALAREL--GPPGGGVIYIDGEDILE--------EVLDQLLLIIVGGKKASGSGELRLRLALA 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  139 ALQKgdrtsSCPVIFILDEF----DIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTcrLDILELLEKRVKSRFSHRQIHL 214
Cdd:smart00382  73 LARK-----LKPDVLILDEItsllDAEQEALLLLLEELRLLLLLKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVLL 145
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 225-412 1.46e-59

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 193.33  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 225 KIFKEQLSLPAEF----PDKAFAERWNENVHCLSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLM 300
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 301 EAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKP 367
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1242013588 368 VVMKAFEHLQQLELIKPVERTSVNS-------QREYQLVKLLLDNTQIMNAL 412
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-223 9.56e-21

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 93.37  E-value: 9.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474    34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 118 DNVVEDKvfG-SFAENLSFLLEALQKGDRtsscPVIFILDEFDIFAHQKNQTLLYNLFDISQS-AQTPVAVIGLTCRLDI 195
Cdd:COG1474   113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDLEF 186

                         170       180
                  ....*....|....*....|....*...
gi 1242013588 196 LELLEKRVKSRFSHRQIHlmnsfdFPQY 223
Cdd:COG1474   187 LENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 56-223 1.38e-13

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 71.51  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  56 GESNSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNldnVVEDKV--FG-SFA 130
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaeDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 131 ENLSFLLEALQKGDRTsscpVIFILDEFDIFAhQKNQTLLYNLFDISQSAQT---PVAVIGLTCRLDILELLEKRVKSRF 207
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGISNDLKFRENLDPRVKSSL 189

                         170
                  ....*....|....*.
gi 1242013588 208 SHRQIHlmnsfdFPQY 223
Cdd:TIGR02928 190 CEEEII------FPPY 199
cdc6 PRK00411
ORC1-type DNA replication protein;
46-223 7.09e-13

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 69.88  E-value: 7.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  46 IELLK---RTAIYGESNS-VLIVGPRGSGKTTLLNHALKELMEIevSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVV 121
Cdd:PRK00411   39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI--AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPPP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 122 EDKVfgSFAENLSFLLEALQKGDRTsscpVIFILDEFDIFAHQKNQTLLYNLFDISQSAQ-TPVAVIGLTCRLDILELLE 200
Cdd:PRK00411  117 SSGL--SFDELFDKIAEYLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHEEYPgARIGVIGISSDLTFLYILD 190

                         170       180
                  ....*....|....*....|...
gi 1242013588 201 KRVKSRFSHRQIHlmnsfdFPQY 223
Cdd:PRK00411  191 PRVKSVFRPEEIY------FPPY 207
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-210 1.66e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 59.08  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  44 HLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQTNekialkeitrqlnldnvVED 123
Cdd:cd00009     5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLEGL-----------------VVA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 124 KVFGSFAENLSFLLEALQKGDrtsscpvIFILDEFDIFAHQKNQTLLYNL--FDISQSAQTPVAVIGLTCRLDILELLEK 201
Cdd:cd00009    66 ELFGHFLVRLLFELAEKAKPG-------VLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNRPLLGDLDRA 138


                  ....*....
gi 1242013588 202 RvKSRFSHR 210
Cdd:cd00009   139 L-YDRLDIR 146
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
57-284 2.35e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 56.35  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  57 ESNSVLIVGPRGSGKTTLLNHALKELMEIEVSENVIQVHLngllqtnekIALKEITRQLNLDNVVEDKVFGSFAENLSFL 136
Cdd:COG5635   179 KKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPIL---------IELRDLAEEASLEDLLAEALEKRGGEPEDAL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 137 LEALQKGdrtsscPVIFILDEFD-IFAHQKNQTLLYNLFDISQSAQtPVAVIgLTCRLDILEllekrvKSRFSHRQIHLM 215
Cdd:COG5635   250 ERLLRNG------RLLLLLDGLDeVPDEADRDEVLNQLRRFLERYP-KARVI-ITSRPEGYD------SSELEGFEVLEL 315

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1242013588 216 NSFDFPQylkIfkeqlslpaefpdKAFAERWNENVHCLSEDstvlevLQKHFSVNKNLQSL----HMLLMLAL 284
Cdd:COG5635   316 APLSDEQ---I-------------EEFLKKWFEATERKAER------LLEALEENPELRELarnpLLLTLLAL 366
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-187 8.05e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 51.74  E-value: 8.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL-------MEIEVSENVIQVHLNGLLQTN--- 103
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRALerdggyfLRGKCDENLPYSPLLEALTREgll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 104 EKIALKEITRQLNLDNVVEDKVFGSFAE----NLSFLLEALQK---GDRTSSCPVIFILDEFDIFAHQkNQTLLYNLFDI 176
Cdd:pfam13191  80 RQLLDELESSLLEAWRAALLEALAPVPElpgdLAERLLDLLLRlldLLARGERPLVLVLDDLQWADEA-SLQLLAALLRL 158

                         170
                  ....*....|.
gi 1242013588 177 SQsaQTPVAVI 187
Cdd:pfam13191 159 LE--SLPLLVV 167
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
46-158 1.32e-07

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 53.00  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  46 IELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIEVSenviqvhlngLLQTNEKIALKEITRQLN--LDNVVED 123
Cdd:COG1672     9 LEELEKLYESDGGELVVVYGRRRVGKTSLIKEFLKEKPAIYFD----------AREESERESLRDFSEALAeaLGDPLSK 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1242013588 124 KVFGSFAENLSFLLEALQKGdrtsscPVIFILDEF 158
Cdd:COG1672    79 KEFESWEEAFEYLAELAEGK------RLVIVIDEF 107
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-214 3.39e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.68  E-value: 3.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588   59 NSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQtnekialkEITRQLNLDNVVEDKVFGSFAENLSFLLE 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALAREL--GPPGGGVIYIDGEDILE--------EVLDQLLLIIVGGKKASGSGELRLRLALA 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  139 ALQKgdrtsSCPVIFILDEF----DIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTcrLDILELLEKRVKSRFSHRQIHL 214
Cdd:smart00382  73 LARK-----LKPDVLILDEItsllDAEQEALLLLLEELRLLLLLKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVLL 145
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 61-211 5.08e-06

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 45.66  E-value: 5.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  61 VLIVGPRGSGKTTLL----NHALKELMEIEVSEnviqvhlngllqtnekialkeitrqlnldnvVEDKVFGSFAENLSFL 136
Cdd:pfam00004   1 LLLYGPPGTGKTTLAkavaKELGAPFIEISGSE-------------------------------LVSKYVGESEKRLREL 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588 137 LEALqkgdRTSSCPVIFIlDEFDIFA----------HQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDileLLEKRVKSR 206
Cdd:pfam00004  50 FEAA----KKLAPCVIFI-DEIDALAgsrgsggdseSRRVVNQLLTELDGFTSSNSKVIVIAATNRPD---KLDPALLGR 121


                  ....*
gi 1242013588 207 FSHRQ 211
Cdd:pfam00004 122 FDRII 126
AAA_22 pfam13401
AAA domain;
60-188 1.30e-05

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 44.64  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  60 SVLIVGPRGSGKTTLlnhaLKELMEIEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDnvvedkvfGSFAENLSFLLEA 139
Cdd:pfam13401   7 ILVLTGESGTGKTTL----LRRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLP--------LSGRLSKEELLAA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1242013588 140 LQKGDRTSSCPVIFILDEFDiFAHQKNQTLLYNLFDISQSAqTPVAVIG 188
Cdd:pfam13401  75 LQQLLLALAVAVVLIIDEAQ-HLSLEALEELRDLLNLSSKL-LQLILVG 121
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 61-114 4.94e-05

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 45.57  E-value: 4.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1242013588  61 VLIVGPRGSGKTTLLNHALKELMEIEVseNVIQV------HLNGLLQT--NEKI------ALKEITRQ 114
Cdd:COG2804   316 ILVTGPTGSGKTTTLYAALNELNTPER--NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 61-114 1.10e-04

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 42.47  E-value: 1.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1242013588  61 VLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQ 114
Cdd:cd01129    14 ILVTGPTGSGKTTTLYAMLRELNGPERNiitiEDPVEYQIPGINQSqvNEKIgltfadALRAILRQ 79
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
42-157 1.93e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 43.39  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  42 YKHLIELLKRTAIygesnsVLIVGPRGSGKTTLLNHALKELMEIEVsenviqvhlngllqtnekialkeitrqLNLDNvv 121
Cdd:COG1373    10 LDKLLKLLDNRKA------VVITGPRQVGKTTLLKQLAKELENILY---------------------------INLDD-- 54

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1242013588 122 eDKVFGSFAENLSFLLEALQKGDRTsscPVIFILDE 157
Cdd:COG1373    55 -PRLRALAEEDPDDLLEALKELYPG---KTYLFLDE 86
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 60-143 4.86e-04

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 41.89  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  60 SVLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQlNLDNVVEDKVFG 127
Cdd:pfam00437 132 NILVTGPTGSGKTTTLYAALGELNTRDENivtvEDPVEIQLEGINQVqlNARAgvtfadLLRAILRQ-DPDRIMVGEIRD 210

                          90
                  ....*....|....*.
gi 1242013588 128 sfAENLSFLLEALQKG 143
Cdd:pfam00437 211 --LETAEIALQAANTG 224
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 61-86 8.73e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 39.11  E-value: 8.73e-04
                          10        20
                  ....*....|....*....|....*.
gi 1242013588  61 VLIVGPRGSGKTTLLNHALKELMEIE 86
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKELLPPE 30
LolD COG1136
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
56-76 1.57e-03

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440751 [Multi-domain]  Cd Length: 227  Bit Score: 39.64  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|.
gi 1242013588  56 GESnsVLIVGPRGSGKTTLLN 76
Cdd:COG1136    34 GEF--VAIVGPSGSGKSTLLN 52
ABC_MJ0796_LolCDE_FtsE cd03255
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...
 61-76 2.32e-03

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.


Pssm-ID: 213222 [Multi-domain]  Cd Length: 218  Bit Score: 39.40  E-value: 2.32e-03
                          10
                  ....*....|....*.
gi 1242013588  61 VLIVGPRGSGKTTLLN 76
Cdd:cd03255    33 VAIVGPSGSGKSTLLN 48
PTZ00112 PTZ00112
origin recognition complex 1 protein; Provisional
 58-231 3.04e-03

origin recognition complex 1 protein; Provisional


Pssm-ID: 240274 [Multi-domain]  Cd Length: 1164  Bit Score: 39.97  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588   58 SNSVL-IVGPRGSGKTT-------LLNHALKELMEieVSENVIQVhlNGLLQTNEKIALKEITRQLNldNVVEDKVFGSF 129
Cdd:PTZ00112   780 SNQILyISGMPGTGKTAtvysviqLLQHKTKQKLL--PSFNVFEI--NGMNVVHPNAAYQVLYKQLF--NKKPPNALNSF 853

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  130 aENLSFLLEALQKGDRTSScpvIFILDEFDiFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSH 209
Cdd:PTZ00112   854 -KILDRLFNQNKKDNRNVS---ILIIDEID-YLITKTQKVLFTLFDWPTKINSKLVLIAISNTMDLPERLIPRCRSRLAF 928

                          170       180
                   ....*....|....*....|..
gi 1242013588  210 RQIhLMNSFDFPQYLKIFKEQL 231
Cdd:PTZ00112   929 GRL-VFSPYKGDEIEKIIKERL 949
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 61-84 3.66e-03

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 38.39  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|....
gi 1242013588  61 VLIVGPRGSGKTTLLNHALKELME 84
Cdd:pfam02492   3 TVITGFLGSGKTTLLNHLLKQNRA 26
COG3899 COG3899
Predicted ATPase [General function prediction only];
10-82 3.95e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 39.84  E-value: 3.95e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1242013588   10 AHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRtAIYGESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:COG3899    264 LLLLGLLAAAAAGRRLLARRLIPQPLVGREAELAALLAALER-ARAGRGELVLVSGEAGIGKSRLVRELARRA 335
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
 45-79 4.73e-03

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 38.82  E-value: 4.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1242013588  45 LIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHAL 79
Cdd:pfam10236  10 LIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAM 44
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 61-95 5.42e-03

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 37.83  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1242013588  61 VLIVGPRGSGKTTLLNhALkeLMEIEVSENVIQVH 95
Cdd:cd03250    34 VAIVGPVGSGKSSLLS-AL--LGELEKLSGSVSVP 65
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 60-76 6.04e-03

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 38.91  E-value: 6.04e-03
                          10
                  ....*....|....*..
gi 1242013588  60 SVLIVGPRGSGKTTLLN 76
Cdd:COG0630   292 SVLVAGGTASGKTTLLN 308
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
 61-177 7.59e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 36.86  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  61 VLIVGPRGSGKTTLLNHALKELMEIEVSenvIQVHLNGLLQTNEKIALKEI---TRQLNLDNvvedkvFGSFAENLSFLL 137
Cdd:pfam00005  14 LALVGPNGAGKSTLLKLIAGLLSPTEGT---ILLDGQDLTDDERKSLRKEIgyvFQDPQLFP------RLTVRENLRLGL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1242013588 138 EALQKGDRTSSCPVIFILDEFDIFaHQKNQTLLYNLFDIS 177
Cdd:pfam00005  85 LLKGLSKREKDARAEEALEKLGLG-DLADRPVGERPGTLS 123
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 60-92 8.50e-03

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 38.22  E-value: 8.50e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1242013588  60 SVLIVGPRGSGKTTLLNhALkeLMEIEVSENVI 92
Cdd:COG4962   184 NILVSGGTGSGKTTLLN-AL--SGFIPPDERIV 213
AAA_35 pfam14516
AAA-like domain; This family of proteins are part of the AAA superfamily.
 63-163 9.80e-03

AAA-like domain; This family of proteins are part of the AAA superfamily.


Pssm-ID: 373105  Cd Length: 331  Bit Score: 37.88  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013588  63 IVGPRGSGKTTLLNHALKELmeieVSENVIQVHLNglLQTNEKIALK-----------EITRQLNLDNVVE---DKVFGS 128
Cdd:pfam14516  36 IKAPRQMGKTSLLLRILAYA----QQQGYRTVYLD--FQLADKAILTdldkflrwfcaNISRQLGLPPKLDdywDEDLGS 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1242013588 129 faeNLS-------FLLEALQKgdrtsscPVIFILDEFD-IFAH 163
Cdd:pfam14516 110 ---KVSctiyfedYLLPQIDR-------PLVLALDEVDrLFEY 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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