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Conserved domains on  [gi|1241781300|ref|NP_001342186|]
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probable G-protein coupled receptor 162 isoform a [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11610354)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_GPR162 cd15906
G protein-coupled receptor 162, member of the class A family of seven-transmembrane G ...
14-335 0e+00

G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the orphan G-protein coupled receptor 162 (GPR162), also called A-2 or GRCA, with unknown endogenous ligand and function. Phylogenetic analysis indicates that GPR162 and GPR153 share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320572  Cd Length: 315  Bit Score: 569.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  14 RSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQaSSDYDWNESICKVF 93
Cdd:cd15906     1 QNNSLSWLACGALALLANGWIILSIAAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRK-HSGYDWNESICKVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  94 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 173
Cdd:cd15906    80 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 174 KIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRAGgsvgtkAGGLGGLGTRPAFEVPAIVVEDTRGKR 253
Cdd:cd15906   160 KIGLGFGVCFSLLLLGGIVMGLVCVGITFYQTLWAPARRQRGGHQRP------EEAAGEGGVEGKFEVPAIVVEDARGKR 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 254 RSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 333
Cdd:cd15906   234 RSSLDGSESAKTSLQVTNLVSAIVFLYDALTGVPILVVSFFSLRYDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 313

                  ..
gi 1241781300 334 VR 335
Cdd:cd15906   314 LR 315
 
Name Accession Description Interval E-value
7tmA_GPR162 cd15906
G protein-coupled receptor 162, member of the class A family of seven-transmembrane G ...
14-335 0e+00

G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the orphan G-protein coupled receptor 162 (GPR162), also called A-2 or GRCA, with unknown endogenous ligand and function. Phylogenetic analysis indicates that GPR162 and GPR153 share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320572  Cd Length: 315  Bit Score: 569.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  14 RSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQaSSDYDWNESICKVF 93
Cdd:cd15906     1 QNNSLSWLACGALALLANGWIILSIAAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRK-HSGYDWNESICKVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  94 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 173
Cdd:cd15906    80 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 174 KIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRAGgsvgtkAGGLGGLGTRPAFEVPAIVVEDTRGKR 253
Cdd:cd15906   160 KIGLGFGVCFSLLLLGGIVMGLVCVGITFYQTLWAPARRQRGGHQRP------EEAAGEGGVEGKFEVPAIVVEDARGKR 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 254 RSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 333
Cdd:cd15906   234 RSSLDGSESAKTSLQVTNLVSAIVFLYDALTGVPILVVSFFSLRYDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 313

                  ..
gi 1241781300 334 VR 335
Cdd:cd15906   314 LR 315
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
34-207 1.77e-10

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 61.54  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVvqlrrQASSDYDW--NESICKVFVSTYYTLALATCFTVASL 111
Cdd:pfam00001   5 VILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLV-----YYLNHGDWpfGSALCKIVGALFVVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 112 SYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSI-GWHNNGERYYARGCQF---IVSKIGLGFGVCFSLLL 187
Cdd:pfam00001  80 SIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfGWTLTVPEGNVTVCFIdfpEDLSKPVSYTLLISVLG 159
                         170       180
                  ....*....|....*....|.
gi 1241781300 188 LgGIVMGLVCVAITF-YQTLW 207
Cdd:pfam00001 160 F-LLPLLVILVCYTLiIRTLR 179
 
Name Accession Description Interval E-value
7tmA_GPR162 cd15906
G protein-coupled receptor 162, member of the class A family of seven-transmembrane G ...
14-335 0e+00

G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the orphan G-protein coupled receptor 162 (GPR162), also called A-2 or GRCA, with unknown endogenous ligand and function. Phylogenetic analysis indicates that GPR162 and GPR153 share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320572  Cd Length: 315  Bit Score: 569.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  14 RSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQaSSDYDWNESICKVF 93
Cdd:cd15906     1 QNNSLSWLACGALALLANGWIILSIAAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRK-HSGYDWNESICKVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  94 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 173
Cdd:cd15906    80 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 174 KIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRAGgsvgtkAGGLGGLGTRPAFEVPAIVVEDTRGKR 253
Cdd:cd15906   160 KIGLGFGVCFSLLLLGGIVMGLVCVGITFYQTLWAPARRQRGGHQRP------EEAAGEGGVEGKFEVPAIVVEDARGKR 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 254 RSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 333
Cdd:cd15906   234 RSSLDGSESAKTSLQVTNLVSAIVFLYDALTGVPILVVSFFSLRYDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 313

                  ..
gi 1241781300 334 VR 335
Cdd:cd15906   314 LR 315
7tmA_GPR153_GPR162-like cd14998
orphan G protein-coupled receptors 153 and 162, member of the class A family of ...
14-335 0e+00

orphan G protein-coupled receptors 153 and 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This group contains the G-protein coupled receptor 153 (GPR153), GPR162, and similar proteins. These are orphan GCPRs with unknown endogenous ligand and function. GPR153 and GPR163 are widely expressed in the central nervous system (CNS) and share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain an HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in both GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320129  Cd Length: 301  Bit Score: 568.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  14 RSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASsDYDWNESICKVF 93
Cdd:cd14998     1 PGNALSWLACGGLSLLANAWGILSISAKQQKHKPLELLLCFLAGTHMLMVAVPLTTYSVVQLRRQAS-DYDWNEGLCKVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  94 VSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVS 173
Cdd:cd14998    80 VSTFYTLTLATCFTVTSLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHDNSERYYTHGCRFIVS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 174 KIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPrrarqarraggsvgtkagglGGLGTRPAFEVPAIVVEDTRGKR 253
Cdd:cd14998   160 KIGLGFGVCFSLLLGGGIAMGVVCVAITFFQTLAAQV--------------------RRQADRRAFTVPTIVVEDAQGKR 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 254 RSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRAD 333
Cdd:cd14998   220 RSSIDGSESAKTSLQTTNLVTAIVFIYDSLTGFPILVVSFSSLKADAAPPWMVLCVLWCSMAQTLLLPSFLWSCERYRAD 299

                  ..
gi 1241781300 334 VR 335
Cdd:cd14998   300 VK 301
7tmA_GPR153 cd15907
orphan G protein-coupled receptor 153, member of the class A family of seven-transmembrane G ...
15-335 5.48e-157

orphan G protein-coupled receptor 153, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 153 (GPR153) with unknown endogenous ligand and function. GPR153 shares a common evolutionary origin with GPR162 and is highly expressed in central nervous system (CNS) including the thalamus, cerebellum, and the arcuate nucleus. Although categorized as a member of the rhodopsin-like class A GPCRs, GPR153 contains HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxFL motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320573  Cd Length: 301  Bit Score: 451.32  E-value: 5.48e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  15 SNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQaSSDYDWNESICKVFV 94
Cdd:cd15907     2 NNAVAWLVCSGVSLLANTWGILSVSAKQKKWKPLEFLICTLAGTHILNVAIPITMYSVIQLRRQ-HSDYEWNEGLCKVFV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  95 STYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSK 174
Cdd:cd15907    81 STFYTLTLVTCFSVTSLSYHRMWMVRWPVNYRLSNTKKQAVHTVMGIWMVSFILSTLPAVGWHDTTERFYTRDCRFIVTE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 175 IGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLwarprrarqarraggSVGTkagglGGLGTRPAFEVPAIVVEDTRGKRR 254
Cdd:cd15907   161 IGLGFGVCFLLLISGSVAMGVVCIGIALFQTF---------------SIQT-----GHNIDKNKFNVPTIVVEDAQGKRR 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 255 SSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADV 334
Cdd:cd15907   221 SSIDGSEPIKTSLQITYLISGIVFIYDFLMGFPILVVSFASLKADKSYNWMVLCVLWCSVAQSLLLPMFLWACDRYRADI 300

                  .
gi 1241781300 335 R 335
Cdd:cd15907   301 K 301
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
33-327 3.23e-26

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 108.28  E-value: 3.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  33 WIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRqassDYDWNESICKVFVSTYYTLALATCFTVASLS 112
Cdd:cd14964    18 LVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTE----ASSRPQALCYLIYLLWYGANLASIWTTLVLT 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 113 YHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARG-CQFIVSKIGLGFGVCFSLLLLGGI 191
Cdd:cd14964    94 YHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGsCYLICTTIYLTWGFLLVSFLLPLV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 192 VMGLVCVAITFYQTLwarprrarqarraggsvgtkagglgglgtrpafevpaivvedtRGKRRSSLDGSESAKTSLQVTN 271
Cdd:cd14964   174 AFLVIFSRIVLRLRR-------------------------------------------RVRAIRSAASLNTDKNLKATKS 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1241781300 272 LVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSC 327
Cdd:cd14964   211 LLILVITFLLCWLPFSIVFILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLG 266
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
33-207 3.26e-15

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 76.17  E-value: 3.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  33 WIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLrrqaSSDYDWNESICKVFVSTYYTLALATCFTVASLS 112
Cdd:cd00637    18 LVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLL----LGRWWFGDALCKLLGFLQSVSLLASILTLTAIS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 113 YHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWH---NNGERYYARGCQFIVSKIGLGFGVCFSLLLLG 189
Cdd:cd00637    94 VDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGvydYGGYCCCCLCWPDLTLSKAYTIFLFVLLFLLP 173
                         170
                  ....*....|....*...
gi 1241781300 190 GIVMGLVCVAItfYQTLW 207
Cdd:cd00637   174 LLVIIVCYVRI--FRKLR 189
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
34-187 2.48e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 64.12  E-value: 2.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLrrqaSSDYDWNESICKVFVSTYYTLALATCFTVASLSY 113
Cdd:cd14967    20 VILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTL----LGYWPFGPVLCRFWIALDVLCCTASILNLCAISL 95
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1241781300 114 HRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYY-ARGCQFIVSKIGLGFGVCFSLLL 187
Cdd:cd14967    96 DRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVvDCECEFTPNKIYVLVSSVISFFI 170
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
34-207 1.77e-10

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 61.54  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVvqlrrQASSDYDW--NESICKVFVSTYYTLALATCFTVASL 111
Cdd:pfam00001   5 VILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLV-----YYLNHGDWpfGSALCKIVGALFVVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 112 SYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSI-GWHNNGERYYARGCQF---IVSKIGLGFGVCFSLLL 187
Cdd:pfam00001  80 SIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfGWTLTVPEGNVTVCFIdfpEDLSKPVSYTLLISVLG 159
                         170       180
                  ....*....|....*....|.
gi 1241781300 188 LgGIVMGLVCVAITF-YQTLW 207
Cdd:pfam00001 160 F-LLPLLVILVCYTLiIRTLR 179
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
35-156 6.35e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 48.36  E-value: 6.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  35 ILSISAKQQKHKPLELLLCFLAGTHILMAAV--PLTTFAVVQLRrqassdYDWNESICKVFVSTYYTLALATCFTVASLS 112
Cdd:cd14969    22 IIVFLKKKKLRTPLNLFLLNLALADLLMSVVgyPLSFYSNLSGR------WSFGDPGCVIYGFAVTFLGLVSISTLAALA 95
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1241781300 113 YHRMWMVRWPVNYRLSNaKKQALHAVMGIWMVSFILSTLPSIGW 156
Cdd:cd14969    96 FERYLVIVRPLKAFRLS-KRRALILIAFIWLYGLFWALPPLFGW 138
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
87-156 3.42e-05

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 46.14  E-value: 3.42e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  87 ESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGW 156
Cdd:cd15048    70 KVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGW 139
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
34-157 4.53e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 45.36  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVStyytlALATCFTVASLSY 113
Cdd:cd14972    19 VLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS-----LLASAYSLLAIAV 93
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781300 114 HRMWMVRWPVNY--RLSNakKQALHAVMGIWMVSFILSTLPSIGWH 157
Cdd:cd14972    94 DRYISIVHGLTYvnNVTN--KRVKVLIALVWVWSVLLALLPVLGWN 137
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
64-171 2.84e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 43.01  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  64 AVPLTTFAVVQLRRQASSdydwnesiCKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWM 143
Cdd:cd14968    53 AIPLAILISLGLPTNFHG--------CLFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWV 124
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1241781300 144 VSFILSTLPSIGWHNNGERYYARG-----CQFI 171
Cdd:cd14968   125 LSFLVGLTPMFGWNNGAPLESGCGeggiqCLFE 157
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
34-203 3.84e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 42.69  E-value: 3.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQassdydWNES--ICKVFVSTYYTLALATCFTVASL 111
Cdd:cd15049    21 VILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGY------WPLGplLCDLWLALDYVASNASVMNLLLI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 112 SYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWhnngeryyargcQFIVSKIGLGFGVCFsLLLLGGI 191
Cdd:cd15049    95 SFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGW------------QYFVGERTVPDGQCY-IQFLDDP 161
                         170
                  ....*....|..
gi 1241781300 192 VMGLVCVAITFY 203
Cdd:cd15049   162 AITFGTAIAAFY 173
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
34-161 5.29e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.22  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMA--AVPLTTFAVVqlrrqaSSDYDWNESICKVFVSTYYTLALATCFTVASL 111
Cdd:cd15335    21 VIAAICTTKKLHQPANYLICSLAVTDFLVAvlVMPLSITYIV------MDTWTLGYFICEIWLSVDMTCCTCSILHLCVI 94
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1241781300 112 SYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILStLPSIGWHNNGE 161
Cdd:cd15335    95 ALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFIS-IPPLFWRNHHD 143
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
89-167 5.65e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 42.03  E-value: 5.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781300  89 ICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFiLSTLPSIGWHnngerYYARG 167
Cdd:cd15050    72 VCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSF-LWVIPILGWH-----HFARG 144
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
34-161 6.97e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 41.86  E-value: 6.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMaAVPLTTFAVVQLRRQAssdYDWNESICKVFVSTYYTLALATCFTVASLSY 113
Cdd:cd15334    21 VITAIIVTRKLHHPANYLICSLAVTDFLV-AVLVMPFSIMYIVKET---WIMGQVVCDIWLSVDITCCTCSILHLSAIAL 96
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1241781300 114 HRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILStLPSIGWHNNGE 161
Cdd:cd15334    97 DRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFIS-MPPLFWRHQTT 143
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
34-156 7.38e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 41.80  E-value: 7.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLrrqaSSDYDWNESICKVFVSTYYTLALATCFTVASLSY 113
Cdd:cd15326    21 VILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEI----LGYWVFGRIFCDIWAAVDVLCCTASILSLCAISI 96
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1241781300 114 HRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGW 156
Cdd:cd15326    97 DRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGW 139
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
34-159 1.32e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 40.78  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQassdydWN--ESICKVFVSTYYTLALATCFTVASL 111
Cdd:cd15064    21 VIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGR------WIlgQVLCDIWISLDVTCCTASILHLCVI 94
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1241781300 112 SYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNN 159
Cdd:cd15064    95 ALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTP 142
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
34-200 2.92e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 39.92  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTtfavVQLRRQASSDYDWNESICKVFVSTYYTLALATCFTVASLSY 113
Cdd:cd15323    21 VVIAVLTSRALRAPQNLFLVSLASADILVATLVMP----FSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300 114 HRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQF-------IVSKIGLGFGVCfsll 186
Cdd:cd15323    97 DRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYPQCKLndetwyiLSSCIGSFFAPC---- 172
                         170
                  ....*....|....
gi 1241781300 187 llggIVMGLVCVAI 200
Cdd:cd15323   173 ----LIMILVYIRI 182
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
34-168 3.53e-03

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 39.58  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  34 IILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQassdYDWNESICKVFVSTYYTLALATCFTVASLSY 113
Cdd:cd15330    21 VVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK----WTLGQVTCDLFIALDVLCCTSSILHLCAIAL 96
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1241781300 114 HRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGC 168
Cdd:cd15330    97 DRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDAC 151
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
90-158 4.22e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 39.45  E-value: 4.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781300  90 CKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHN 158
Cdd:cd15071    71 CLMVACPVLILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNN 139
7tmA_GPR149 cd15011
G protein-coupled receptor 149, member of the class A family of seven-transmembrane G ...
61-156 8.38e-03

G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR149 is predominantly expressed in the ovary and is present at low levels in the brain and the digestive tract (stomach and small intestine). GPR149-null mice are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. Additionally, the null mice showed increased expression levels of growth differentiation factor 9 (Gdf9) in oocytes, and upregulated expression of cyclin D2, a downstream target of FSH (follicle-stimulating hormone) receptor signaling pathways that promotes granulosa cell proliferation. GPR149 is an orphan receptor with no known endogenous ligand as yet identified. Although categorized as a member of the class A GPCRs, GPR149 lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the transmembrane domains and carboxyl terminus of GPR149 show low similarities to other GPCRs. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320139  Cd Length: 256  Bit Score: 38.20  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781300  61 LMAAVPLTTFAVVQLRRQASSdydwnESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMG 140
Cdd:cd15011    45 LLSVVPVSIFMLMQWETDGLP-----QPLCTTSALLYLFQGLSSNLKASLIASYNFYTTKKLGWLQTTKRSVRVPWAVLT 119
                          90
                  ....*....|....*.
gi 1241781300 141 IWMVSFILSTLPSIGW 156
Cdd:cd15011   120 IWAASLLLSALPLCGW 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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