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Conserved domains on  [gi|1241781191|ref|NP_001342108|]
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auxilin isoform d [Mus musculus]

Protein Classification

cyclin-G-associated kinase( domain architecture ID 12998567)

cyclin-G-associated kinase (GAK) is a serine/threonine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; it phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2, and associates with cyclin G and CDK5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTP_auxilin_N cd14563
N-terminal protein tyrosine phosphatase-like domain of auxilin; Auxilin, also called auxilin-1 ...
 84-246 6.48e-114

N-terminal protein tyrosine phosphatase-like domain of auxilin; Auxilin, also called auxilin-1 or DnaJ homolog subfamily C member 6 (DNAJC6), is a J-domain containing protein that recruits the ATP-dependent chaperone Hsc70 to newly budded clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles, driving the clathrin assembly#disassembly cycle. Mutations in the DNAJC6 gene, encoding auxilin, are associated with early-onset Parkinson's disease. Auxilin contains an N-terminal protein tyrosine phosphatase (PTP)-like domain similar to the PTP-like domain of PTEN, a phosphoinositide 3-phosphatase, and a C-terminal region with clathrin-binding and J domains.


:

Pssm-ID: 350411 [Multi-domain]  Cd Length: 163  Bit Score: 346.10  E-value: 6.48e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  84 VSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQA 163
Cdd:cd14563     1 VASYTKGELDISYITSRIIVMSYPAEGVELGFRNHIEDVRSFLDSRHLDHYTVFNLSQKSYRSAKFHNRVSECSWPVRQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 164 PSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYM 243
Cdd:cd14563    81 PSLHNLFAVCKNMHNWLQQNPKNVCVIHCMDGRAASAVLVSAMFCFCHLFSNPVPAMQLLNAKRPGIGLWPSHRRYIGYI 160


                  ...
gi 1241781191 244 CDL 246
Cdd:cd14563   161 CDL 163
PTEN_C2 pfam10409
C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key ...
 254-392 4.28e-36

C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.


:

Pssm-ID: 463081  Cd Length: 133  Bit Score: 132.79  E-value: 4.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 254 PHFKPLTIKAITVSPVPFFNKQrNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVIVSMYHLRS 333
Cdd:pfam10409   1 PPPKPLTLHSIILHGIPNFKSG-GGCRPYIRIYQNKKKVFSTSGKYKKLKEYQQDDCVILFPKGIPVQGDVLVEFYHKGS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1241781191 334 TIGSRlqakvtnTQIFQLQFHSGFIPldTTVLKFTKPELDACDVP---EKYPQLFQVTLDIE 392
Cdd:pfam10409  80 DLLSE-------EKMFRFWFNTSFIE--DNTLTLPKNELDKADKDkkdKRFPKDFKVELLFS 132
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 889-934 4.78e-09

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


:

Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 52.93  E-value: 4.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781191 889 TPEQVKKVYRRAVLVVHPDKATGQPyeqYAKMIFMELNDAWSEFEN 934
Cdd:cd06257    13 SDEEIKKAYRKLALKYHPDKNPDDP---EAEEKFKEINEAYEVLSD 55
PPE super family cl35037
PPE-repeat protein [Function unknown];
535-755 6.57e-06

PPE-repeat protein [Function unknown];


The actual alignment was detected with superfamily member COG5651:

Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 49.51  E-value: 6.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 535 VSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVEDVFHPSGPVSAQSTPRRTATSASASPTlrvGEGATFDPFGA 614
Cdd:COG5651   173 TITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAA---GAAAAAAAAAA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 615 PAKPPGQDLLGSFLNTSSASSDPFLQPTRSPS-----PTVHASSTPAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTG 689
Cdd:COG5651   250 AAGAGASAALASLAATLLNASSLGLAATAASSaatnlGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALG 329

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1241781191 690 SSHGTPThqskpqtldpfADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAG 755
Cdd:COG5651   330 AGAAAAA-----------AGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
 
Name Accession Description Interval E-value
PTP_auxilin_N cd14563
N-terminal protein tyrosine phosphatase-like domain of auxilin; Auxilin, also called auxilin-1 ...
 84-246 6.48e-114

N-terminal protein tyrosine phosphatase-like domain of auxilin; Auxilin, also called auxilin-1 or DnaJ homolog subfamily C member 6 (DNAJC6), is a J-domain containing protein that recruits the ATP-dependent chaperone Hsc70 to newly budded clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles, driving the clathrin assembly#disassembly cycle. Mutations in the DNAJC6 gene, encoding auxilin, are associated with early-onset Parkinson's disease. Auxilin contains an N-terminal protein tyrosine phosphatase (PTP)-like domain similar to the PTP-like domain of PTEN, a phosphoinositide 3-phosphatase, and a C-terminal region with clathrin-binding and J domains.


Pssm-ID: 350411 [Multi-domain]  Cd Length: 163  Bit Score: 346.10  E-value: 6.48e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  84 VSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQA 163
Cdd:cd14563     1 VASYTKGELDISYITSRIIVMSYPAEGVELGFRNHIEDVRSFLDSRHLDHYTVFNLSQKSYRSAKFHNRVSECSWPVRQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 164 PSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYM 243
Cdd:cd14563    81 PSLHNLFAVCKNMHNWLQQNPKNVCVIHCMDGRAASAVLVSAMFCFCHLFSNPVPAMQLLNAKRPGIGLWPSHRRYIGYI 160


                  ...
gi 1241781191 244 CDL 246
Cdd:cd14563   161 CDL 163
PTEN_C2 pfam10409
C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key ...
 254-392 4.28e-36

C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.


Pssm-ID: 463081  Cd Length: 133  Bit Score: 132.79  E-value: 4.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 254 PHFKPLTIKAITVSPVPFFNKQrNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVIVSMYHLRS 333
Cdd:pfam10409   1 PPPKPLTLHSIILHGIPNFKSG-GGCRPYIRIYQNKKKVFSTSGKYKKLKEYQQDDCVILFPKGIPVQGDVLVEFYHKGS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1241781191 334 TIGSRlqakvtnTQIFQLQFHSGFIPldTTVLKFTKPELDACDVP---EKYPQLFQVTLDIE 392
Cdd:pfam10409  80 DLLSE-------EKMFRFWFNTSFIE--DNTLTLPKNELDKADKDkkdKRFPKDFKVELLFS 132
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 889-934 4.78e-09

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 52.93  E-value: 4.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781191 889 TPEQVKKVYRRAVLVVHPDKATGQPyeqYAKMIFMELNDAWSEFEN 934
Cdd:cd06257    13 SDEEIKKAYRKLALKYHPDKNPDDP---EAEEKFKEINEAYEVLSD 55
DnaJ smart00271
DnaJ molecular chaperone homology domain;
889-935 3.29e-07

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 48.00  E-value: 3.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1241781191  889 TPEQVKKVYRRAVLVVHPDKATGQPYEqyAKMIFMELNDAWSEFENQ 935
Cdd:smart00271  14 SLDEIKKAYRKLALKYHPDKNPGDKEE--AEEKFKEINEAYEVLSDP 58
PPE COG5651
PPE-repeat protein [Function unknown];
535-755 6.57e-06

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 49.51  E-value: 6.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 535 VSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVEDVFHPSGPVSAQSTPRRTATSASASPTlrvGEGATFDPFGA 614
Cdd:COG5651   173 TITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAA---GAAAAAAAAAA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 615 PAKPPGQDLLGSFLNTSSASSDPFLQPTRSPS-----PTVHASSTPAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTG 689
Cdd:COG5651   250 AAGAGASAALASLAATLLNASSLGLAATAASSaatnlGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALG 329

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1241781191 690 SSHGTPThqskpqtldpfADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAG 755
Cdd:COG5651   330 AGAAAAA-----------AGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 536-821 1.99e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.76  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 536 STNFSSLAAPPSNSELLSDLFGGVGATGPAQAGqagvedvfhPSGPVSAQSTPRRTATSASASPtlrVGEGATFDPFGAP 615
Cdd:pfam05109 433 TLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTG---------PTVSTADVTSPTPAGTTSGASP---VTPSPSPRDNGTE 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 616 AKPPgqdllgSFLNTSSASSDPFLQPTrSPSPTVhasSTPAVNIQPDIAGgwdwHTKPGGFGMGSKSAATSPTGSShGTP 695
Cdd:pfam05109 501 SKAP------DMTSPTSAVTTPTPNAT-SPTPAV---TTPTPNATSPTLG----KTSPTSAVTTPTPNATSPTPAV-TTP 565

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 696 ThqskpqtldPFADLGTLGSSSFASKPTTPTglgggfPPLSSPQKASPQPMGGGWQQPAGynwqQTQSKPQSSMPhssPQ 775
Cdd:pfam05109 566 T---------PNATIPTLGKTSPTSAVTTPT------PNATSPTVGETSPQANTTNHTLG----GTSSTPVVTSP---PK 623

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781191 776 NrpnynvSFSAMPAGQSERGKGSTNLEGKQKAADFEDLLSSQGFNA 821
Cdd:pfam05109 624 N------ATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNS 663
PHA03247 PHA03247
large tegument protein UL36; Provisional
 562-793 2.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  562 TGPAQAGQAGVEDVFHPSGPVSAQST---------PRRTATSASASPTlrvgegATFDPFGAPAK---PPGQDLLGSFLN 629
Cdd:PHA03247  2723 PGPAAARQASPALPAAPAPPAVPAGPatpggparpARPPTTAGPPAPA------PPAAPAAGPPRrltRPAVASLSESRE 2796

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  630 TSSASSDPFLQP--TRSPSPTVHASSTPAVNIQPDIAggwdwhtkpggfgmgskSAATSPTGSSHGTPTHQSKPQTLDPF 707
Cdd:PHA03247  2797 SLPSPWDPADPPaaVLAPAAALPPAASPAGPLPPPTS-----------------AQPTAPPPPPGPPPPSLPLGGSVAPG 2859

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  708 ADLGTLGSS-SFASKPTTPTGLGG---GFPPLSSPQKASPQPMGGGWQQPAGYNWQQTQSKPQ-----SSMPHSSPQNRP 778
Cdd:PHA03247  2860 GDVRRRPPSrSPAAKPAAPARPPVrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQpppppQPQPPPPPPPRP 2939

                          250
                   ....*....|....*
gi 1241781191  779 NYNVSFSAMPAGQSE 793
Cdd:PHA03247  2940 QPPLAPTTDPAGAGE 2954
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 889-930 2.54e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 42.85  E-value: 2.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1241781191 889 TPEQVKKVYRRAVLVVHPDKATGQPyeQYAKMiFMELNDAWS 930
Cdd:pfam00226  13 SDEEIKKAYRKLALKYHPDKNPGDP--EAEEK-FKEINEAYE 51
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
888-929 1.95e-03

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 37.85  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1241781191 888 VTPEQVKKVYRRAVLVVHPDK-ATGQPYEQ--YAKMIFMELNDAW 929
Cdd:COG1076    16 ADDAELKRAYRKLQREHHPDRlAAGLPEEEqrLALQKAAAINEAY 60
 
Name Accession Description Interval E-value
PTP_auxilin_N cd14563
N-terminal protein tyrosine phosphatase-like domain of auxilin; Auxilin, also called auxilin-1 ...
 84-246 6.48e-114

N-terminal protein tyrosine phosphatase-like domain of auxilin; Auxilin, also called auxilin-1 or DnaJ homolog subfamily C member 6 (DNAJC6), is a J-domain containing protein that recruits the ATP-dependent chaperone Hsc70 to newly budded clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles, driving the clathrin assembly#disassembly cycle. Mutations in the DNAJC6 gene, encoding auxilin, are associated with early-onset Parkinson's disease. Auxilin contains an N-terminal protein tyrosine phosphatase (PTP)-like domain similar to the PTP-like domain of PTEN, a phosphoinositide 3-phosphatase, and a C-terminal region with clathrin-binding and J domains.


Pssm-ID: 350411 [Multi-domain]  Cd Length: 163  Bit Score: 346.10  E-value: 6.48e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  84 VSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQA 163
Cdd:cd14563     1 VASYTKGELDISYITSRIIVMSYPAEGVELGFRNHIEDVRSFLDSRHLDHYTVFNLSQKSYRSAKFHNRVSECSWPVRQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 164 PSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYM 243
Cdd:cd14563    81 PSLHNLFAVCKNMHNWLQQNPKNVCVIHCMDGRAASAVLVSAMFCFCHLFSNPVPAMQLLNAKRPGIGLWPSHRRYIGYI 160


                  ...
gi 1241781191 244 CDL 246
Cdd:cd14563   161 CDL 163
PTP_auxilin-like cd14511
protein tyrosine phosphatase-like domain of auxilin and similar proteins; This subfamily ...
 84-246 9.25e-95

protein tyrosine phosphatase-like domain of auxilin and similar proteins; This subfamily contains proteins similar to auxilin, characterized by also containing a J domain. It includes auxilin, also called auxilin-1, and cyclin-G-associated kinase (GAK), also called auxilin-2. Auxilin-1 and -2 facilitate Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, while auxilin-1 which is nerve-specific. Both proteins contain a protein tyrosine phosphatase (PTP)-like domain similar to the PTP-like domain of PTEN (a phosphoinositide 3-phosphatase), and a C-terminal region with clathrin-binding and J domains. In addition, GAK contains an N-terminal protein kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2.


Pssm-ID: 350361 [Multi-domain]  Cd Length: 164  Bit Score: 295.80  E-value: 9.25e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  84 VSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFR-NQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQ 162
Cdd:cd14511     1 QQSYARNDLDISYITSRIIVMPFPAEGIESTYRkNNIEDVRAFLDSRHPQKYSVYNLSPRSYPTLRLPSRVVECSWPYRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 163 APSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGY 242
Cdd:cd14511    81 APSLHALYALCRDIYQWLNKDPKNVIVIHCTDGKAASATVVCALLVYCGLFKTPEDALQMFAVKRCPPGLSPSELRYLYY 160


                  ....
gi 1241781191 243 MCDL 246
Cdd:cd14511   161 FSDI 164
PTP_GAK cd14564
protein tyrosine phosphatase-like domain of cyclin-G-associated kinase; cyclin-G-associated ...
 84-246 1.82e-77

protein tyrosine phosphatase-like domain of cyclin-G-associated kinase; cyclin-G-associated kinase (GAK), also called auxilin-2, contains an N-terminal protein kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of a protein tyrosine phosphatase (PTP)-like domain similar to the PTP-like domain of PTEN (a phosphoinositide 3-phosphatase), and a C-terminal region with clathrin-binding and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor.


Pssm-ID: 350412 [Multi-domain]  Cd Length: 163  Bit Score: 249.43  E-value: 1.82e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  84 VSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQA 163
Cdd:cd14564     1 VANYAKGDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDSRHPGHYAVYNLSQRTYRPSRFHNRVSECGWPARRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 164 PSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYM 243
Cdd:cd14564    81 PNLQNLYSICKNMHLWLKQDQKNICIVHCLDGRAASAVVVCSFLCFCRLFTTAEAAVYMFSMKRCPPGIWPSHKRYIEYM 160


                  ...
gi 1241781191 244 CDL 246
Cdd:cd14564   161 CDM 163
PTP_PTEN-like cd14497
protein tyrosine phosphatase-like domain of phosphatase and tensin homolog and similar ...
 93-246 5.85e-62

protein tyrosine phosphatase-like domain of phosphatase and tensin homolog and similar proteins; Phosphatase and tensin homolog (PTEN) is a tumor suppressor that acts as a dual-specificity protein phosphatase and as a lipid phosphatase. It dephosphorylates phosphoinositide trisphosphate. In addition to PTEN, this family includes tensins, voltage-sensitive phosphatases (VSPs), and auxilins. They all contain a protein tyrosine phosphatase-like domain although not all are active phosphatases. Tensins are intracellular proteins that act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility, and they may or may not have phosphatase activity. VSPs are phosphoinositide phosphatases with substrates that include phosphatidylinositol-4,5-diphosphate and phosphatidylinositol-3,4,5-trisphosphate. Auxilins are J domain-containing proteins that facilitate Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles, and they do not exhibit phosphatase activity.


Pssm-ID: 350347 [Multi-domain]  Cd Length: 160  Bit Score: 207.05  E-value: 5.85e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  93 DFTYVTSRIIVMSFPVDSV-DIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYR-TAKFHSRVSECSWPIRQAPSLHNLF 170
Cdd:cd14497     1 DLSYITPRIIAMSFPATGYpESLYRNSIDDVANFLNTHHPDHYMIFNLSEEEYDdDSKFEGRVLHYGFPDHHPPPLGLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 171 AVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGL----SPSHRRYLGYMCDL 246
Cdd:cd14497    81 EIVDDIDSWLSEDPNNVAVVHCKAGKGRTGTVICAYLLYYGQYSTADEALEYFAKKRFKEGLpgvtIPSQLRYLQYFERL 160
PTEN_C2 pfam10409
C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key ...
 254-392 4.28e-36

C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.


Pssm-ID: 463081  Cd Length: 133  Bit Score: 132.79  E-value: 4.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 254 PHFKPLTIKAITVSPVPFFNKQrNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVIVSMYHLRS 333
Cdd:pfam10409   1 PPPKPLTLHSIILHGIPNFKSG-GGCRPYIRIYQNKKKVFSTSGKYKKLKEYQQDDCVILFPKGIPVQGDVLVEFYHKGS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1241781191 334 TIGSRlqakvtnTQIFQLQFHSGFIPldTTVLKFTKPELDACDVP---EKYPQLFQVTLDIE 392
Cdd:pfam10409  80 DLLSE-------EKMFRFWFNTSFIE--DNTLTLPKNELDKADKDkkdKRFPKDFKVELLFS 132
PTP_PTEN cd14509
protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog; ...
 93-242 4.72e-36

protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog; Phosphatase and tensin homolog (PTEN), also phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN or mutated in multiple advanced cancers 1 (MMAC1), is a tumor suppressor that acts as a dual-specificity protein phosphatase and as a lipid phosphatase. It is a critical endogenous inhibitor of phosphoinositide signaling. It dephosphorylates phosphoinositide trisphosphate, and therefore, has the function of negatively regulating Akt. The PTEN/PI3K/AKT pathway regulates the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation, and cell growth. PTEN contains an N-terminal PIP-binding domain, a protein tyrosine phosphatase (PTP)-like catalytic domain, a regulatory C2 domain responsible for its cellular location, a C-tail containing phosphorylation sites, and a C-terminal PDZ domain.


Pssm-ID: 350359 [Multi-domain]  Cd Length: 158  Bit Score: 133.87  E-value: 4.72e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  93 DFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFA 171
Cdd:cd14509     1 DLTYITPNIIAMGFPAEGVEGVYRNPIDDVQRFLETKHKGHYKVYNLcSERSYDPSKFNGRVAEYPFDDHNPPPLELIKP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1241781191 172 VCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRP--GIGLS-PSHRRYLGY 242
Cdd:cd14509    81 FCEDVDEWLKEDEKNVAAVHCKAGKGRTGVMICCYLLYLGKFPSAKEALDFYGAKRTknKKGVTiPSQRRYVYY 154
PTP_tensin cd14508
protein tyrosine phosphatase-like domain of tensins; The tensin family of intracellular ...
 93-246 1.12e-35

protein tyrosine phosphatase-like domain of tensins; The tensin family of intracellular proteins (tensin-1, -2, -3 and -4) act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of tensin expression has been implicated in human cancer. Tensin-1, -2, and -3 contain an N-terminal region with a protein tyrosine phosphatase (PTP)-like domain followed by a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. In addition, tensin-2 contains a zinc finger N-terminal to its PTP domain. Tensin-4 is not included in this model as it does not contain a PTP-like domain.


Pssm-ID: 350358 [Multi-domain]  Cd Length: 159  Bit Score: 132.51  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  93 DFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAV 172
Cdd:cd14508     1 DLTYITERIIALSFPSTCSEQTYRHNLREAAHLLQSKHGDNYMVFNLSERRHDLRSLNPKVLDFGWPELHAPPLEKLCSI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781191 173 CRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKR-----PGIGLSPSHRRYLGYMCDL 246
Cdd:cd14508    81 CKNMDSWLNADPQNVVVLHCKGGKGRLGVVVSAYMHYSKISATADQALDRFAMKRfyddkVGPLGQPSQKRYVGYFSGL 159
PTP_VSP_TPTE cd14510
protein tyrosine phosphatase-like catalytic domain of voltage-sensitive phosphatase ...
 87-242 9.29e-34

protein tyrosine phosphatase-like catalytic domain of voltage-sensitive phosphatase/transmembrane phosphatase with tensin homology; Voltage-sensitive phosphatase (VSP) proteins comprise a family of phosphoinositide phosphatases with substrates that include phosphatidylinositol-4,5-diphosphate and phosphatidylinositol-3,4,5-trisphosphate. This family is conserved in deuterostomes; VSP was first identified as a sperm flagellar plasma membrane protein in Ciona intestinalis. Gene duplication events in primates resulted in the presence of paralogs, transmembrane phosphatase with tensin homology (TPTE) and TPTE2, that retain protein domain architecture but, in the case of TPTE, have lost catalytic activity. TPTE, also called cancer/testis antigen 44 (CT44), may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. TPTE2, also called TPTE and PTEN homologous inositol lipid phosphatase (TPIP), occurs in several differentially spliced forms; TPIP alpha displays phosphoinositide 3-phosphatase activity and is localized on the endoplasmic reticulum, while TPIP beta is cytosolic and lacks detectable phosphatase activity. VSP/TPTE proteins contain an N-terminal voltage sensor consisting of four transmembrane segments, a protein tyrosine phosphatase (PTP)-like phosphoinositide phosphatase catalytic domain, followed by a regulatory C2 domain.


Pssm-ID: 350360 [Multi-domain]  Cd Length: 177  Bit Score: 127.86  E-value: 9.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  87 YTKG--DLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNL-SPKSYRTAKFHSRVSECSWPIRQA 163
Cdd:cd14510     7 YQKDgfDLDLTYVTDRVIAMSFPSSGKQAFYRNPIEEVVRFLDTKHPDHYKVYNLcSERGYDPKYFHNRVERVPIDDHNV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 164 PSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLS--------PS 235
Cdd:cd14510    87 PTLDEMLSFTAEVREWMAADPKNVVAIHCKGGKGRTGTMVCAWLIYSGQFESAKEALEYFGERRTDKSVSskfqgvetPS 166


                  ....*..
gi 1241781191 236 HRRYLGY 242
Cdd:cd14510   167 QSRYVGY 173
PTP_tensin-3 cd14561
protein tyrosine phosphatase-like domain of tensin-3; Tensin-3 (TNS3) is also called ...
 93-246 5.17e-27

protein tyrosine phosphatase-like domain of tensin-3; Tensin-3 (TNS3) is also called tensin-like SH2 domain-containing protein 1 (TENS1) or tumor endothelial marker (TEM6). It is part of the tensin family of intracellular proteins (tensin-1, -2, -3 and -4), which act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Tensin-3 contributes to cell migration, anchorage-independent growth, tumorigenesis, and metastasis of cancer cells. It cooperates with Dock5, an exchange factor for the small GTPase Rac, for osteoclast activity to ensure the correct organization of podosomes. Tensin-3 contains an N-terminal region with a protein tyrosine phosphatase (PTP)-like domain followed by a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains.


Pssm-ID: 350409 [Multi-domain]  Cd Length: 159  Bit Score: 107.72  E-value: 5.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  93 DFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAV 172
Cdd:cd14561     1 DLTYITERIIAVSFPADCSEETYLHNLQDVTRMLKSKHGDNYLVLNLSEKRYELTKLNPKIMDVGWPDLHAPPLDKMCTI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781191 173 CRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAV-----RLLYAKRPGIGLSPSHRRYLGYMCDL 246
Cdd:cd14561    81 CKAMESWLNSDPLHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALdrfamKKFYDDKVSALMQPSQKRYVQFLSGL 159
PTP_tensin-1 cd14560
protein tyrosine phosphatase-like domain of tensin-1; Tensin-1 (TNS1) is part of the tensin ...
 93-246 2.59e-25

protein tyrosine phosphatase-like domain of tensin-1; Tensin-1 (TNS1) is part of the tensin family of intracellular proteins (tensin-1, -2, -3 and -4), which act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. It plays an essential role in TGF-beta-induced myofibroblast differentiation and myofibroblast-mediated formation of extracellular fibronectin and collagen matrix. It also positively regulates RhoA activity through its interaction with DLC1, a RhoGAP-containing tumor suppressor; the tensin-1-DLC1-RhoA signaling axis is critical in regulating cellular functions that lead to angiogenesis. Tensin-1 contains an N-terminal region with a protein tyrosine phosphatase (PTP)-like domain followed by a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains.


Pssm-ID: 350408 [Multi-domain]  Cd Length: 159  Bit Score: 103.14  E-value: 2.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  93 DFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAV 172
Cdd:cd14560     1 DLVYITERIISVSFPSTAEEPSFRSNLKEVAQMLKSKHGDNYLLFNLSERRHDISKLHPKVLDFGWPDLHAPALEKICSI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 173 CRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKR-------PgIGlSPSHRRYLGYMCD 245
Cdd:cd14560    81 CKAMDTWLNADPHNVVVIHNKGNRGRTGVVIAAYMHYSNISASADQALDRFAMKRfyedkvvP-VG-QPSQKRYVHYFSG 158


                  .
gi 1241781191 246 L 246
Cdd:cd14560   159 L 159
PTP_tensin-2 cd14562
protein tyrosine phosphatase-like domain of tensin-2; Tensin-2 (TNS2) is also called ...
 93-246 2.39e-23

protein tyrosine phosphatase-like domain of tensin-2; Tensin-2 (TNS2) is also called tensin-like C1 domain-containing phosphatase (TENC1) or C1 domain-containing phosphatase and tensin homolog (C1-TEN). It is part of the tensin family of intracellular proteins (tensin-1, -2, -3 and -4), which act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Tensin-2 is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It also modulates cell contractility and remodeling of collagen fibers through the DLC1, a RhoGAP that binds to tensins in focal adhesions. Tensin-2 may have phosphatase activity; it reduces AKT1 phosphorylation. It contains an N-terminal region with a zinc finger, a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains.


Pssm-ID: 350410 [Multi-domain]  Cd Length: 159  Bit Score: 97.33  E-value: 2.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  93 DFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAV 172
Cdd:cd14562     1 DLTYITERIISVFFPPALEEQRYRGNLREVAQMLKSKHEDKYLLFNLSEKRHDITRLNPKVQDFGWPDLHAPPLDKICSI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781191 173 CRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAK-----RPGIGLSPSHRRYLGYMCDL 246
Cdd:cd14562    81 CKAMETWLNADPQHVVVLHCKGNKGKTGVIVAAYMHYSKISAGADQALSTLAMRkfcedKVATSLQPSQRRYISYFGGL 159
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 889-934 4.78e-09

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 52.93  E-value: 4.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781191 889 TPEQVKKVYRRAVLVVHPDKATGQPyeqYAKMIFMELNDAWSEFEN 934
Cdd:cd06257    13 SDEEIKKAYRKLALKYHPDKNPDDP---EAEEKFKEINEAYEVLSD 55
DnaJ smart00271
DnaJ molecular chaperone homology domain;
889-935 3.29e-07

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 48.00  E-value: 3.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1241781191  889 TPEQVKKVYRRAVLVVHPDKATGQPYEqyAKMIFMELNDAWSEFENQ 935
Cdd:smart00271  14 SLDEIKKAYRKLALKYHPDKNPGDKEE--AEEKFKEINEAYEVLSDP 58
PPE COG5651
PPE-repeat protein [Function unknown];
535-755 6.57e-06

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 49.51  E-value: 6.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 535 VSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVEDVFHPSGPVSAQSTPRRTATSASASPTlrvGEGATFDPFGA 614
Cdd:COG5651   173 TITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAA---GAAAAAAAAAA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 615 PAKPPGQDLLGSFLNTSSASSDPFLQPTRSPS-----PTVHASSTPAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTG 689
Cdd:COG5651   250 AAGAGASAALASLAATLLNASSLGLAATAASSaatnlGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALG 329

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1241781191 690 SSHGTPThqskpqtldpfADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAG 755
Cdd:COG5651   330 AGAAAAA-----------AGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 536-821 1.99e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.76  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 536 STNFSSLAAPPSNSELLSDLFGGVGATGPAQAGqagvedvfhPSGPVSAQSTPRRTATSASASPtlrVGEGATFDPFGAP 615
Cdd:pfam05109 433 TLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTG---------PTVSTADVTSPTPAGTTSGASP---VTPSPSPRDNGTE 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 616 AKPPgqdllgSFLNTSSASSDPFLQPTrSPSPTVhasSTPAVNIQPDIAGgwdwHTKPGGFGMGSKSAATSPTGSShGTP 695
Cdd:pfam05109 501 SKAP------DMTSPTSAVTTPTPNAT-SPTPAV---TTPTPNATSPTLG----KTSPTSAVTTPTPNATSPTPAV-TTP 565

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 696 ThqskpqtldPFADLGTLGSSSFASKPTTPTglgggfPPLSSPQKASPQPMGGGWQQPAGynwqQTQSKPQSSMPhssPQ 775
Cdd:pfam05109 566 T---------PNATIPTLGKTSPTSAVTTPT------PNATSPTVGETSPQANTTNHTLG----GTSSTPVVTSP---PK 623

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781191 776 NrpnynvSFSAMPAGQSERGKGSTNLEGKQKAADFEDLLSSQGFNA 821
Cdd:pfam05109 624 N------ATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNS 663
PHA03247 PHA03247
large tegument protein UL36; Provisional
 562-793 2.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  562 TGPAQAGQAGVEDVFHPSGPVSAQST---------PRRTATSASASPTlrvgegATFDPFGAPAK---PPGQDLLGSFLN 629
Cdd:PHA03247  2723 PGPAAARQASPALPAAPAPPAVPAGPatpggparpARPPTTAGPPAPA------PPAAPAAGPPRrltRPAVASLSESRE 2796

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  630 TSSASSDPFLQP--TRSPSPTVHASSTPAVNIQPDIAggwdwhtkpggfgmgskSAATSPTGSSHGTPTHQSKPQTLDPF 707
Cdd:PHA03247  2797 SLPSPWDPADPPaaVLAPAAALPPAASPAGPLPPPTS-----------------AQPTAPPPPPGPPPPSLPLGGSVAPG 2859

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  708 ADLGTLGSS-SFASKPTTPTGLGG---GFPPLSSPQKASPQPMGGGWQQPAGYNWQQTQSKPQ-----SSMPHSSPQNRP 778
Cdd:PHA03247  2860 GDVRRRPPSrSPAAKPAAPARPPVrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQpppppQPQPPPPPPPRP 2939

                          250
                   ....*....|....*
gi 1241781191  779 NYNVSFSAMPAGQSE 793
Cdd:PHA03247  2940 QPPLAPTTDPAGAGE 2954
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 889-930 2.54e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 42.85  E-value: 2.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1241781191 889 TPEQVKKVYRRAVLVVHPDKATGQPyeQYAKMiFMELNDAWS 930
Cdd:pfam00226  13 SDEEIKKAYRKLALKYHPDKNPGDP--EAEEK-FKEINEAYE 51
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 578-794 4.36e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 578 PSGPVSAQSTPRRTATS-ASASPTlrvGEGATFDPFGAPA-KPPGQDLLGSFLNTSSASSDPFLQPTRSPSPtvHASSTP 655
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQaATAGPT---PSAPSVPPQGSPAtSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSP--HPPLQP 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 656 AVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTGsshgtPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPL 735
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTG-----PSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIH 326

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781191 736 SSPQKASPQPmgggwQQPAgynwqqtQSKPQSSMPHSSPQNRPNYNVSFSAMPAGQSER 794
Cdd:pfam03154 327 TPPSQSQLQS-----QQPP-------REQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHK 373
PHA03247 PHA03247
large tegument protein UL36; Provisional
 543-776 5.74e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  543 AAPPSNSELLSDLFGGVGATGPAQAGQAGvedvfhPSGPVSAQSTPRRTATSASASPTLRVGEGATFDPfgAPAKPPGQD 622
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPA------PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPW--DPADPPAAV 2811

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  623 LLGSFLNTSSASSDPFLQPTRSPSPTvhASSTPAVNIQPDIA-GGWdwhTKPGG---FGMGSKSAATSPTGSSHGTPTHQ 698
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPT--APPPPPGPPPPSLPlGGS---VAPGGdvrRRPPSRSPAAKPAAPARPPVRRL 2886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  699 SKP---QTLDPFA----DLGTLGSSSFASKPTTPtglgggfPPLSSPQKASPQPMGGGWQQPAGYNWQQTQSKPQSSMPH 771
Cdd:PHA03247  2887 ARPavsRSTESFAlppdQPERPPQPQAPPPPQPQ-------PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959


                   ....*
gi 1241781191  772 SSPQN 776
Cdd:PHA03247  2960 PQPWL 2964
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
532-737 1.73e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 45.13  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 532 GSDVSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVedvfhpSGPVSAQSTPRRTATSASASPTLRVGEGATFDP 611
Cdd:COG3469    15 ASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASG------SAGSGTGTTAASSTAATSSTTSTTATATAAAAA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 612 FGAPAKPPGQDLLGSFLNTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTGSS 691
Cdd:COG3469    89 ATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTST 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781191 692 HGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSS 737
Cdd:COG3469   169 TTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
888-929 1.95e-03

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 37.85  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1241781191 888 VTPEQVKKVYRRAVLVVHPDK-ATGQPYEQ--YAKMIFMELNDAW 929
Cdd:COG1076    16 ADDAELKRAYRKLQREHHPDRlAAGLPEEEqrLALQKAAAINEAY 60
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
889-929 2.36e-03

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 38.16  E-value: 2.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1241781191 889 TPEQVKKVYRRAVLVVHPDkaTGQPYEQYAKMIFMELNDAW 929
Cdd:COG2214    18 SLEEIRQAYRRLAKLLHPD--RGGELKALAEELFQRLNEAY 56
PTPMT1 cd14524
protein-tyrosine phosphatase mitochondrial 1; Protein-tyrosine phosphatase mitochondrial 1 or ...
 162-240 5.41e-03

protein-tyrosine phosphatase mitochondrial 1; Protein-tyrosine phosphatase mitochondrial 1 or PTP localized to the mitochondrion 1 (PTPMT1), also called phosphoinositide lipid phosphatase (PLIP), phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, or PTEN-like phosphatase, is a lipid phosphatase or phosphatidylglycerophosphatase (EC 3.1.3.27) which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). It is targeted to the mitochondrion by an N-terminal signal sequence and is found anchored to the matrix face of the inner membrane. It is essential for the biosynthesis of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. PTPMT1 also plays a crucial role in hematopoietic stem cell (HSC) function, and has been shown to display activity toward phosphoprotein substrates.


Pssm-ID: 350374 [Multi-domain]  Cd Length: 149  Bit Score: 38.40  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191 162 QAPSLHNLF-AVcrnmyNWLL-QNPKNVCV-VHCLDGRAASSILVGAMFIFCNLYsTPGPAVRLLYAKRPGIGLSPSHRR 238
Cdd:cd14524    68 GVPSLEDLEkGV-----DFILkHREKGKSVyVHCKAGRGRSATIVACYLIQHKGW-SPEEAQEFLRSKRPHILLRLSQRE 141


                  ..
gi 1241781191 239 YL 240
Cdd:cd14524   142 VL 143
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 578-788 6.28e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 6.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  578 PSGPVSAQSTPRRTATSASASPTLRVGEG---ATFDPFGAPAKPPGQDLLGS--------FLNTSSASSDPflqpTRSPS 646
Cdd:PHA03307   222 PAPGRSAADDAGASSSDSSSSESSGCGWGpenECPLPRPAPITLPTRIWEASgwngpssrPGPASSSSSPR----ERSPS 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781191  647 PTVHASSTPAVNIQPDIAGGWDWHTKpggfgmgSKSAATSPTG-SSHGTPTHQSKPQTLDPfADLGTLGSSSFASKPTTP 725
Cdd:PHA03307   298 PSPSSPGSGPAPSSPRASSSSSSSRE-------SSSSSTSSSSeSSRGAAVSPGPSPSRSP-SPSRPPPPADPSSPRKRP 369

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1241781191  726 TGLGGgfPPLSSPQKASPQPMGGGWQQPAGYNWQQ-----TQSKPQSSMPHSS------PQNRPNYNVSFSAMP 788
Cdd:PHA03307   370 RPSRA--PSSPAASAGRPTRRRARAAVAGRARRRDatgrfPAGRPRPSPLDAGaasgafYARYPLLTPSGEPWP 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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