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Conserved domains on  [gi|1231293821|ref|NP_001341501|]
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alpha-2-HS-glycoprotein isoform 3 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-132 8.34e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 55.51  E-value: 8.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821   31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQ-PSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 109
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQvVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 1231293821  110 EGDCDFQLLKLDG--KFSVVYAKCD 132
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-232 3.81e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam00031:

Pssm-ID: 447698  Cd Length: 92  Bit Score: 53.11  E-value: 3.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821 148 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKQY 226
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80


                  ....*.
gi 1231293821 227 GFCKAT 232
Cdd:pfam00031  81 GLCSAQ 86
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-132 8.34e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 55.51  E-value: 8.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821   31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQ-PSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 109
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQvVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 1231293821  110 EGDCDFQLLKLDG--KFSVVYAKCD 132
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 148-232 3.81e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.11  E-value: 3.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821 148 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKQY 226
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80


                  ....*.
gi 1231293821 227 GFCKAT 232
Cdd:pfam00031  81 GLCSAQ 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-119 4.98e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 47.85  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821  28 RQPNCDDPETEEAALVAIDYINQNLpwgyKHTLNQIDEVK-----VWpqpSGELFEIEIDTLETTCHVLDPTPVarCSVR 102
Cdd:cd00042     4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVLsaksqVV---AGTNYYITVEAGDTNCKKSSVPLD--CPDC 74

                          90
                  ....*....|....*..
gi 1231293821 103 QLKEHAVEGDCDFQLLK 119
Cdd:cd00042    75 KLLEEGKKKFCTAKVWE 91
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 145-246 9.73e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 47.04  E-value: 9.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821  145 CQDCPLLAPLNDTRVVHAAKAALAAFnaqNNGSN--FQLEEISRA---QLVPLPPSTYVEFTVSGTDCVaKEATEAAKCN 219
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEY---NKKSNdkYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1231293821  220 LLAEKQyGFCKATLSEKLG---GAEVAVTC 246
Cdd:smart00043  78 FLDQGE-KFCTAKVWEKPWenkIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 147-246 1.52e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.31  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821 147 DCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRA--QLVplpPSTYVEFTVSGTDCVAKEA---TEAAKCNLL 221
Cdd:cd00042     1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVV---AGTNYYITVEAGDTNCKKSsvpLDCPDCKLL 77

                          90       100
                  ....*....|....*....|....*...
gi 1231293821 222 AEKQYGFCKATLSEKL---GGAEVAVTC 246
Cdd:cd00042    78 EEGKKKFCTAKVWEKPwenFKELLSFKC 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-132 8.34e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 55.51  E-value: 8.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821   31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQ-PSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 109
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQvVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 1231293821  110 EGDCDFQLLKLDG--KFSVVYAKCD 132
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 148-232 3.81e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.11  E-value: 3.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821 148 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKQY 226
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80


                  ....*.
gi 1231293821 227 GFCKAT 232
Cdd:pfam00031  81 GLCSAQ 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-119 4.98e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 47.85  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821  28 RQPNCDDPETEEAALVAIDYINQNLpwgyKHTLNQIDEVK-----VWpqpSGELFEIEIDTLETTCHVLDPTPVarCSVR 102
Cdd:cd00042     4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVLsaksqVV---AGTNYYITVEAGDTNCKKSSVPLD--CPDC 74

                          90
                  ....*....|....*..
gi 1231293821 103 QLKEHAVEGDCDFQLLK 119
Cdd:cd00042    75 KLLEEGKKKFCTAKVWE 91
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 145-246 9.73e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 47.04  E-value: 9.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821  145 CQDCPLLAPLNDTRVVHAAKAALAAFnaqNNGSN--FQLEEISRA---QLVPLPPSTYVEFTVSGTDCVaKEATEAAKCN 219
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEY---NKKSNdkYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1231293821  220 LLAEKQyGFCKATLSEKLG---GAEVAVTC 246
Cdd:smart00043  78 FLDQGE-KFCTAKVWEKPWenkIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 147-246 1.52e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.31  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293821 147 DCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRA--QLVplpPSTYVEFTVSGTDCVAKEA---TEAAKCNLL 221
Cdd:cd00042     1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVV---AGTNYYITVEAGDTNCKKSsvpLDCPDCKLL 77

                          90       100
                  ....*....|....*....|....*...
gi 1231293821 222 AEKQYGFCKATLSEKL---GGAEVAVTC 246
Cdd:cd00042    78 EEGKKKFCTAKVWEKPwenFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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