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Conserved domains on  [gi|1230839380|ref|NP_001341380|]
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sodium-driven chloride bicarbonate exchanger isoform 15 [Homo sapiens]

Protein Classification

anion exchanger family transporter( domain architecture ID 705853)

anion exchanger family transporter similar to human SLC4 proteins which function as bicarbonate transporters

Gene Ontology:  GO:0005452|GO:0022857|GO:0055085
SCOP:  4003612
TCDB:  2.A.31

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Band_3_cyto super family cl26877
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
118-1030 0e+00

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


The actual alignment was detected with superfamily member TIGR00834:

Pssm-ID: 452680 [Multi-domain]  Cd Length: 900  Bit Score: 1130.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  118 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 197
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  198 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSP--QSAPACVENKNDVS 275
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKTLSHDASEMPNPDNGAPllPHQPLTEMQLLSVP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  276 RENSTVDFSKvdLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHE 355
Cdd:TIGR00834  161 GDIGSREKSK--LKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHE 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  356 IGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK----IPAVPNGTAAH 431
Cdd:TIGR00834  239 IGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKryepSTVRPENPTMG 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  432 GEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATE 505
Cdd:TIGR00834  319 GDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYFAALSPAITFGGLLGEKTR 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  506 GRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 585
Cdd:TIGR00834  399 NMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFL 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  586 VCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSCNCVEPHNPSNGTLKEwresnisasdiiwe 665
Cdd:TIGR00834  479 VRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNTLFCVPPKPQGPSVSA-------------- 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  666 nLTVSECKSLHGEYVGRACGhdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLID 745
Cdd:TIGR00834  537 -LLEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVD 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  746 YAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCG 820
Cdd:TIGR00834  612 IFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSG 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  821 YHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILK 900
Cdd:TIGR00834  692 FHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILK 771
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  901 FIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPM 980
Cdd:TIGR00834  772 RIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPF 851
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1230839380  981 MVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1030
Cdd:TIGR00834  852 VLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
118-1030 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1130.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  118 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 197
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  198 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSP--QSAPACVENKNDVS 275
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKTLSHDASEMPNPDNGAPllPHQPLTEMQLLSVP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  276 RENSTVDFSKvdLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHE 355
Cdd:TIGR00834  161 GDIGSREKSK--LKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHE 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  356 IGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK----IPAVPNGTAAH 431
Cdd:TIGR00834  239 IGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKryepSTVRPENPTMG 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  432 GEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATE 505
Cdd:TIGR00834  319 GDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYFAALSPAITFGGLLGEKTR 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  506 GRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 585
Cdd:TIGR00834  399 NMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFL 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  586 VCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSCNCVEPHNPSNGTLKEwresnisasdiiwe 665
Cdd:TIGR00834  479 VRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNTLFCVPPKPQGPSVSA-------------- 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  666 nLTVSECKSLHGEYVGRACGhdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLID 745
Cdd:TIGR00834  537 -LLEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVD 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  746 YAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCG 820
Cdd:TIGR00834  612 IFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSG 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  821 YHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILK 900
Cdd:TIGR00834  692 FHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILK 771
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  901 FIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPM 980
Cdd:TIGR00834  772 RIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPF 851
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1230839380  981 MVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1030
Cdd:TIGR00834  852 VLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
450-958 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 913.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  450 RIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGG 529
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  530 QPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEA 609
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  610 LEKLFELSEAYPINMHndlelltqYSCNCVEP--HNPSNGTLKEWRESNIsasdIIWEN-LTVSECK-SLHGEYVGRACG 685
Cdd:pfam00955  161 FKKLIKIFKKYPLYLN--------YDCTCVPPssNNTTNSTLSLSTESSS----INWSSlLTNSECTeSYGGTLVGSGCG 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  686 hdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTR 765
Cdd:pfam00955  229 ----YVPDTALLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  766 DDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVA 845
Cdd:pfam00955  305 PDRGWIINPFGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVA 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  846 ATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 925
Cdd:pfam00955  385 ATVRSITHVNSLKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFF 464
                          490       500       510
                   ....*....|....*....|....*....|...
gi 1230839380  926 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTII 958
Cdd:pfam00955  465 DRILLLFMPQKHQPDTHYLRHVPLRKVHLFTLI 497
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
820-973 1.12e-03

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 42.60  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  820 GYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNS-LKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSV----- 893
Cdd:cd17484    152 GYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPhRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSsgsam 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  894 --FMTSILKFIPMpvlygvflYMG-------ASSLKGIQFFDRiklfwmpakhqpdfiYLRHVPLRKVHLFTIIQMSCLG 964
Cdd:cd17484    232 fyFMTNELGFSPE--------FLGrlrvigsIASLLGVLLYNR---------------FLKHVPFRKIFFWTTVLLVLLG 288

                   ....*....
gi 1230839380  965 LLWIIKVSR 973
Cdd:cd17484    289 LTDLILVTR 297
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
306-390 7.15e-03

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 38.29  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  306 GELEFLDRTVVAFVRLSPAVLLQGLAEVPIptRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSG 385
Cdd:COG1762     68 ARPEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILEL 145

                   ....*
gi 1230839380  386 IDEFL 390
Cdd:COG1762    146 LKEAE 150
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
118-1030 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1130.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  118 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 197
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  198 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSP--QSAPACVENKNDVS 275
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKTLSHDASEMPNPDNGAPllPHQPLTEMQLLSVP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  276 RENSTVDFSKvdLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHE 355
Cdd:TIGR00834  161 GDIGSREKSK--LKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHE 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  356 IGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK----IPAVPNGTAAH 431
Cdd:TIGR00834  239 IGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKryepSTVRPENPTMG 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  432 GEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATE 505
Cdd:TIGR00834  319 GDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYFAALSPAITFGGLLGEKTR 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  506 GRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 585
Cdd:TIGR00834  399 NMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFL 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  586 VCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSCNCVEPHNPSNGTLKEwresnisasdiiwe 665
Cdd:TIGR00834  479 VRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNTLFCVPPKPQGPSVSA-------------- 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  666 nLTVSECKSLHGEYVGRACGhdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLID 745
Cdd:TIGR00834  537 -LLEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVD 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  746 YAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCG 820
Cdd:TIGR00834  612 IFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSG 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  821 YHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILK 900
Cdd:TIGR00834  692 FHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILK 771
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  901 FIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPM 980
Cdd:TIGR00834  772 RIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPF 851
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1230839380  981 MVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1030
Cdd:TIGR00834  852 VLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
450-958 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 913.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  450 RIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGG 529
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  530 QPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEA 609
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  610 LEKLFELSEAYPINMHndlelltqYSCNCVEP--HNPSNGTLKEWRESNIsasdIIWEN-LTVSECK-SLHGEYVGRACG 685
Cdd:pfam00955  161 FKKLIKIFKKYPLYLN--------YDCTCVPPssNNTTNSTLSLSTESSS----INWSSlLTNSECTeSYGGTLVGSGCG 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  686 hdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTR 765
Cdd:pfam00955  229 ----YVPDTALLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  766 DDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVA 845
Cdd:pfam00955  305 PDRGWIINPFGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVA 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  846 ATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 925
Cdd:pfam00955  385 ATVRSITHVNSLKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFF 464
                          490       500       510
                   ....*....|....*....|....*....|...
gi 1230839380  926 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTII 958
Cdd:pfam00955  465 DRILLLFMPQKHQPDTHYLRHVPLRKVHLFTLI 497
Band_3_cyto pfam07565
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
146-397 2.18e-128

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


Pssm-ID: 429542  Cd Length: 255  Bit Score: 390.93  E-value: 2.18e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  146 DVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQN 225
Cdd:pfam07565    1 DVEEEGGRWGKPHVATLSFHSLLELRRCLAKGTVLLDLEATSLPGVAHLVLDQMIYSGQIRPEDREEVLRALLLKHSHQN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  226 -QKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSPQSA--PACVENKNDVSRENSTVDFSKVDLHFMKKIPPGAEASN 302
Cdd:pfam07565   81 eLKELGGVKPAVRSLSSIGSSLSHGHDDSKPLLPQQSSLEggLLCEQGEGPNSDEQLTVSESKSPLHFLKKIPEDAEATN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  303 ILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDL 382
Cdd:pfam07565  161 VLVGEVDFLERPVLAFVRLKEAVPLEGVTEVPVPVRFLFILLGPSGPGLDYHEIGRAIATLMSDEVFHDVAYKADDREDL 240
                          250
                   ....*....|....*
gi 1230839380  383 VSGIDEFLDQVTVLP 397
Cdd:pfam07565  241 LAGIDEFLDCSIVLP 255
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
820-973 1.12e-03

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 42.60  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  820 GYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNS-LKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSV----- 893
Cdd:cd17484    152 GYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPhRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSsgsam 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  894 --FMTSILKFIPMpvlygvflYMG-------ASSLKGIQFFDRiklfwmpakhqpdfiYLRHVPLRKVHLFTIIQMSCLG 964
Cdd:cd17484    232 fyFMTNELGFSPE--------FLGrlrvigsIASLLGVLLYNR---------------FLKHVPFRKIFFWTTVLLVLLG 288

                   ....*....
gi 1230839380  965 LLWIIKVSR 973
Cdd:cd17484    289 LTDLILVTR 297
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
306-390 7.15e-03

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 38.29  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230839380  306 GELEFLDRTVVAFVRLSPAVLLQGLAEVPIptRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSG 385
Cdd:COG1762     68 ARPEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILEL 145

                   ....*
gi 1230839380  386 IDEFL 390
Cdd:COG1762    146 LKEAE 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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