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Conserved domains on  [gi|1237125288|ref|NP_001340493|]
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plasma membrane calcium-transporting ATPase 2 isoform 2 [Homo sapiens]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1042 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1334.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaamemqplksaeggdadd 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG---------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  328 rkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLV 407
Cdd:TIGR01517  273 --------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVV 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  408 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSI 485
Cdd:TIGR01517  342 VAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNL 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  486 NTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSM 564
Cdd:TIGR01517  422 PAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFM 496
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  565 STVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN 644
Cdd:TIGR01517  497 SVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDY 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  645 ENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNE 724
Cdd:TIGR01517  576 PN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  725 kgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 804
Cdd:TIGR01517  651 --------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEAS 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALAT 882
Cdd:TIGR01517  718 DIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALAT 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  883 EPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQL 962
Cdd:TIGR01517  798 EPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQL 876
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  963 FNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1042
Cdd:TIGR01517  877 FNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1081-1127 1.16e-26

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 103.25  E-value: 1.16e-26
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1237125288 1081 GQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPE 1127
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1042 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1334.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaamemqplksaeggdadd 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG---------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  328 rkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLV 407
Cdd:TIGR01517  273 --------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVV 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  408 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSI 485
Cdd:TIGR01517  342 VAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNL 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  486 NTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSM 564
Cdd:TIGR01517  422 PAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFM 496
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  565 STVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN 644
Cdd:TIGR01517  497 SVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDY 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  645 ENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNE 724
Cdd:TIGR01517  576 PN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  725 kgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 804
Cdd:TIGR01517  651 --------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEAS 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALAT 882
Cdd:TIGR01517  718 DIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALAT 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  883 EPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQL 962
Cdd:TIGR01517  798 EPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQL 876
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  963 FNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1042
Cdd:TIGR01517  877 FNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-906 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1324.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081     66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaa 311
Cdd:cd02081    145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------ 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  312 memqplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWlpecTPVY 391
Cdd:cd02081    207 ------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAED 258
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  392 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV 471
Cdd:cd02081    259 LQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYI 338
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  472 GdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgNKTECGLLGFVLDLKQDYePVRSQMPEEKL 551
Cdd:cd02081    339 G-------------------------------------------------NKTECALLGFVLELGGDY-RYREKRPEEKV 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  552 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVAY 631
Cdd:cd02081    369 LKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAY 447
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  632 RDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE 707
Cdd:cd02081    448 RDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGE 527
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  708 DFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSthteqRQVVAVTGDGTNDGPALKKAD 787
Cdd:cd02081    528 DGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKAD 602
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  788 VGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLW 867
Cdd:cd02081    603 VGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLW 682
                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 1237125288  868 VNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM 906
Cdd:cd02081    683 VNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1036 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 681.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474     12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474     77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474    132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  274 TAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaAAMemqpLKSAEggdaddrkkasmhkKEKSVLQGKLTKLAVQIG 353
Cdd:COG0474    212 VATGMNTEFGKI------------------------AKL----LQEAE--------------EEKTPLQKQLDRLGKLLA 249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  354 KAGLVMSAITVIILVLYftvdtfvvnKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:COG0474    250 IIALVLAALVFLIGLLR---------GGPLL------------EALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRN 308
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipDPSSINTKTMELLINAIAINSAYTtkiLPPEKE 513
Cdd:COG0474    309 AIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ---LEEETG 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  514 galprqVGNKTECGLLGFVLDLKQDYEPVRSQMPeekLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI 593
Cdd:COG0474    382 ------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRV 452
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  594 LNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEPDwdnENDILNELTCICVVGIEDPVRPEVPEAIR 673
Cdd:COG0474    453 LTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPRPEAKEAIA 527
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  674 KCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDflCLEGKEFNRrirneKGEIE-QERIDKIwpklRVLARSSPTDKH 752
Cdd:COG0474    528 ECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSDEElAEAVEDV----DVFARVSPEHKL 596
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  753 TLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 830
Cdd:COG0474    597 RIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNI 669
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  831 SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNI 910
Cdd:COG0474    670 RKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRI 749
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  911 LGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCT 989
Cdd:COG0474    750 LLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLL 816
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*....
gi 1237125288  990 IVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVI 1036
Cdd:COG0474    817 AVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
858-1036 1.73e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 173.19  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  858 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 937
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  938 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1015
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1237125288 1016 LDQWMWCIFIGLGELVWGQVI 1036
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-848 9.14e-44

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 172.56  E-value: 9.14e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517    53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517   118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517   173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  267 GSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaaamemqplksAEGGDADDRkkasmhkkEKSVLQGKLT 346
Cdd:PRK10517   253 GTAQAVVIATGANTWFGQL----------------------------------AGRVSEQDS--------EPNAFQQGIS 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  347 KLAVQIGKAGLVMSAitVIILVLYFTvdtfvvnKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:PRK10517   291 RVSWLLIRFMLVMAP--VVLLINGYT-------KGDW------------WEAALFALSVAVGLTPEMLPMIVTSTLARGA 349
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVgDVHYKeipdpssintKTMELLINAIaINSAYTTK 506
Cdd:PRK10517   350 VKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-VLENHT-DISGK----------TSERVLHSAW-LNSHYQTG 416
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  507 IlppekEGALPRQVgnkTECGLLGFVLDLKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIV 586
Cdd:PRK10517   417 L-----KNLLDTAV---LEGVDEESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEI 478
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  587 LKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEpDWD--NENDilneLTCICVVGIEDP 663
Cdd:PRK10517   479 LNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDESD----LILEGYIAFLDP 550
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  664 VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGedflCLEGkefnrrirnekGEIEQ---ERIDKIWPKL 740
Cdd:PRK10517   551 PKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE----VLIG-----------SDIETlsdDELANLAERT 615
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  741 RVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 820
Cdd:PRK10517   616 TLFARLTPMHKERIVTLLKREGH-----VVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGV 689
                          810       820       830
                   ....*....|....*....|....*....|...
gi 1237125288  821 MWGRNVYDSISKFLqfQLTV-----NVVAVIVA 848
Cdd:PRK10517   690 IEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1081-1127 1.16e-26

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 103.25  E-value: 1.16e-26
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1237125288 1081 GQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPE 1127
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1042 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1334.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaamemqplksaeggdadd 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG---------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  328 rkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLV 407
Cdd:TIGR01517  273 --------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVV 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  408 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSI 485
Cdd:TIGR01517  342 VAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNL 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  486 NTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSM 564
Cdd:TIGR01517  422 PAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFM 496
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  565 STVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN 644
Cdd:TIGR01517  497 SVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDY 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  645 ENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNE 724
Cdd:TIGR01517  576 PN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  725 kgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 804
Cdd:TIGR01517  651 --------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEAS 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALAT 882
Cdd:TIGR01517  718 DIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALAT 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  883 EPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQL 962
Cdd:TIGR01517  798 EPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQL 876
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  963 FNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1042
Cdd:TIGR01517  877 FNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-906 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1324.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081     66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaa 311
Cdd:cd02081    145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------ 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  312 memqplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWlpecTPVY 391
Cdd:cd02081    207 ------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAED 258
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  392 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV 471
Cdd:cd02081    259 LQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYI 338
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  472 GdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgNKTECGLLGFVLDLKQDYePVRSQMPEEKL 551
Cdd:cd02081    339 G-------------------------------------------------NKTECALLGFVLELGGDY-RYREKRPEEKV 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  552 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVAY 631
Cdd:cd02081    369 LKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAY 447
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  632 RDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE 707
Cdd:cd02081    448 RDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGE 527
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  708 DFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSthteqRQVVAVTGDGTNDGPALKKAD 787
Cdd:cd02081    528 DGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKAD 602
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  788 VGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLW 867
Cdd:cd02081    603 VGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLW 682
                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 1237125288  868 VNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM 906
Cdd:cd02081    683 VNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1036 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 681.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474     12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474     77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474    132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  274 TAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaAAMemqpLKSAEggdaddrkkasmhkKEKSVLQGKLTKLAVQIG 353
Cdd:COG0474    212 VATGMNTEFGKI------------------------AKL----LQEAE--------------EEKTPLQKQLDRLGKLLA 249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  354 KAGLVMSAITVIILVLYftvdtfvvnKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:COG0474    250 IIALVLAALVFLIGLLR---------GGPLL------------EALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRN 308
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipDPSSINTKTMELLINAIAINSAYTtkiLPPEKE 513
Cdd:COG0474    309 AIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ---LEEETG 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  514 galprqVGNKTECGLLGFVLDLKQDYEPVRSQMPeekLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI 593
Cdd:COG0474    382 ------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRV 452
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  594 LNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEPDwdnENDILNELTCICVVGIEDPVRPEVPEAIR 673
Cdd:COG0474    453 LTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPRPEAKEAIA 527
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  674 KCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDflCLEGKEFNRrirneKGEIE-QERIDKIwpklRVLARSSPTDKH 752
Cdd:COG0474    528 ECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSDEElAEAVEDV----DVFARVSPEHKL 596
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  753 TLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 830
Cdd:COG0474    597 RIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNI 669
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  831 SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNI 910
Cdd:COG0474    670 RKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRI 749
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  911 LGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCT 989
Cdd:COG0474    750 LLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLL 816
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*....
gi 1237125288  990 IVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVI 1036
Cdd:COG0474    817 AVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
76-894 2.26e-159

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 490.97  E-value: 2.26e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   76 EKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedegeaeAGWIEGA 155
Cdd:cd02089      8 ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL---------------------------GEYVDAI 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02089     61 VIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLR 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  236 IDESSLTGESDQVRKSVDKDP-----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkak 304
Cdd:cd02089    139 VEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEE------------- 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  305 qqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLTKLAVQIGKAGLvmsAITVIILVLYftvdtfVVNKKPWL 384
Cdd:cd02089    206 -----------------------------TEEEKTPLQKRLDQLGKRLAIAAL---IICALVFALG------LLRGEDLL 247
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  385 PEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRM 464
Cdd:cd02089    248 DM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKM 315
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  465 TVVQAYVgdvhykeIPDPSSIntktmellinAIaINSAYTTKILPPEKEGALPRQvgnktecgllgfvldlkqdyepvrS 544
Cdd:cd02089    316 TVEKIYT-------IGDPTET----------AL-IRAARKAGLDKEELEKKYPRI------------------------A 353
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  545 QMPeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEmVKKVIEPMACDGL 624
Cdd:cd02089    354 EIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCTYIYIN-GQVRPLTEEDRAK-ILAVNEEFSEEAL 421
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  625 RTICVAYRDFPSSPEPDWDN-ENDilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII 703
Cdd:cd02089    422 RVLAVAYKPLDEDPTESSEDlEND----LIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGIL 497
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  704 HPGEdfLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGP 781
Cdd:cd02089    498 EDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEHKLRIVKAL-------QRKgkIVAMTGDGVNDAP 560
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  782 ALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLK 861
Cdd:cd02089    561 ALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLL 640
                          810       820       830
                   ....*....|....*....|....*....|...
gi 1237125288  862 AVQMLWVNLIMDTFASLALATEPPTETLLLRKP 894
Cdd:cd02089    641 PIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
157-880 1.51e-149

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 460.25  E-value: 1.51e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  157 ILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVvQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKI 236
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  237 DESSLTGESDQVRKSVDKDP-MLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkakqqdgAAAMemq 315
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI-----------------------AVVV--- 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  316 plksaeggdaddrkKASMHkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFvvnkkpwlpectpvyvqYF 395
Cdd:TIGR01494  134 --------------YTGFS--TKTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWDGN-----------------SI 180
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  396 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVH 475
Cdd:TIGR01494  181 YKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGV 260
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  476 YKEIPDPSSINtktmellinaiainsayttkilppekeGALPRQVGNKTECGLLGFV-LDLKQDYEPVrsqmpEEKLYKV 554
Cdd:TIGR01494  261 EEASLALALLA---------------------------ASLEYLSGHPLERAIVKSAeGVIKSDEINV-----EYKILDV 308
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  555 YTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNgageprvfrprdrdemVKKVIEPMACDGLRTICVAYRDF 634
Cdd:TIGR01494  309 FPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNEND----------------YDEKVDEYARQGLRVLAFASKKL 372
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  635 PsspepdwdnendilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflcleg 714
Cdd:TIGR01494  373 P--------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID----------- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  715 kefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGI 794
Cdd:TIGR01494  428 ---------------------------VFARVKPEEKAAIVEALQEKGRT-----VAMTGDGVNDAPALKKADVGIAMGS 475
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  795 AgtDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdsplkavqmlwvNLIMDT 874
Cdd:TIGR01494  476 G--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI--------------ILLPPL 539

                   ....*.
gi 1237125288  875 FASLAL 880
Cdd:TIGR01494  540 LAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
151-1027 4.27e-142

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 450.18  E-value: 4.27e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQkfTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02080     56 WVDAIVIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIE 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  231 GNDLKIDESSLTGESDQVRKSVDKDP----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkd 300
Cdd:cd02080    134 ARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLLA---------- 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  301 kkakqqdgaaamEMQPLKSAeggdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdTFVVNK 380
Cdd:cd02080    204 ------------EVEQLATP--------------------LTRQIAKFSKALLIVILVLAALTFVF--------GLLRGD 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  381 KPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 460
Cdd:cd02080    244 YSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLT 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  461 TNRMTVVQAYvgdvhykeipdpssintktmeLLINAIAInsayttkilppEKEGALPRQVGNKTECGLLGFVLDLKQDYE 540
Cdd:cd02080    312 RNEMTVQAIV---------------------TLCNDAQL-----------HQEDGHWKITGDPTEGALLVLAAKAGLDPD 359
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  541 PVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDESfRMYSKGASEIVLKKCCKILNGAGEprvfRPRDRDEMVKKViEPMA 620
Cdd:cd02080    360 RLASSYPRVD---KIPFDSAYRYMATLHRDDGQR-VIYVKGAPERLLDMCDQELLDGGV----SPLDRAYWEAEA-EDLA 430
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  621 CDGLRTICVAYRDFPssPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKC 700
Cdd:cd02080    431 KQGLRVLAFAYREVD--SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQL 508
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  701 GIIHPGEdflCLEGKEFNRRIRNEKGEIEQERidkiwpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDG 780
Cdd:cd02080    509 GLGDGKK---VLTGAELDALDDEELAEAVDEV--------DVFARTSPEHKLRLVRAL-----QARGEVVAMTGDGVNDA 572
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  781 PALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV---VAVIVA-FTGACItq 856
Cdd:cd02080    573 PALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLgegLVIIVAiLFGVTL-- 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  857 dsPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTL-LFVGEKMFQID 935
Cdd:cd02080    651 --PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLfLWALDRGYSLE 728
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  936 SGRnaplhsppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCS 1012
Cdd:cd02080    729 TAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKILFLGIGALILLQLAFTYlpFMNSLFGTA 794
                          890
                   ....*....|....*
gi 1237125288 1013 PLQLDQWMWCIFIGL 1027
Cdd:cd02080    795 PIDLVDWAIILLVGI 809
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
52-903 6.54e-132

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 427.86  E-value: 6.54e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   52 DTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYhppgegn 131
Cdd:cd02083      4 TVEEVLAYFGVDPTRGL--SDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF------- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  132 egcataqggaEDEGEAEAGWIEGAAILLSVIC--VVLVtafndWskekQFRGLQSRIEQEQKF-----TVVRAGQVVQ-I 203
Cdd:cd02083     75 ----------EEGEEGVTAFVEPFVILLILIAnaVVGV-----W----QERNAEKAIEALKEYepemaKVLRNGKGVQrI 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  204 PVAEIVVGDIAQVKYGDLLPADG--LFIQGNDLKIDESSLTGESDQVRKSVD--KDP---------MLLSGTHVMEGSGR 270
Cdd:cd02083    136 RARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKAR 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  271 MLVTAVGVNSQTGIIftllgaggeeeekkdkkakqQDGAAAMEmqplksaeggdaddrkkasmhkKEKSVLQGKLTKLAV 350
Cdd:cd02083    216 GVVVGTGLNTEIGKI--------------------RDEMAETE----------------------EEKTPLQQKLDEFGE 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  351 QIGKAglvmsaITVI-ILVlyftvdtFVVNKKPWlpeCTPVYVQYFVK----FFIIGVTVLVVAVPEGLPLAVTISLAYS 425
Cdd:cd02083    254 QLSKV------ISVIcVAV-------WAINIGHF---NDPAHGGSWIKgaiyYFKIAVALAVAAIPEGLPAVITTCLALG 317
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  426 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-----GDVHYKEIP--------------DPSSIN 486
Cdd:cd02083    318 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIldkveDDSSLNEFEvtgstyapegevfkNGKKVK 397
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  487 TKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFV------------LDLKQDYEPVRSQMpEEKLYKV 554
Cdd:cd02083    398 AGQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVekmnvfntdksgLSKRERANACNDVI-EQLWKKE 476
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  555 YT--FNSVRKSMSTVIKLPDESF--RMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVA 630
Cdd:cd02083    477 FTleFSRDRKSMSVYCSPTKASGgnKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILILKKVWG-YGTDTLRCLALA 555
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  631 YRDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG 706
Cdd:cd02083    556 TKDTPPKPEDmdleDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGED 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  707 EDFlclEGKEFNRRIRNEKGEIEQEridKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKA 786
Cdd:cd02083    636 EDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVELL-----QSQGEITAMTGDGVNDAPALKKA 704
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  787 DVGFAMGIaGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQML 866
Cdd:cd02083    705 EIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLL 783
                          890       900       910
                   ....*....|....*....|....*....|....*..
gi 1237125288  867 WVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLIS 903
Cdd:cd02083    784 WVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
142-1027 1.56e-126

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 411.48  E-value: 1.56e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  142 EDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSrIEQEQKfTVVRAGQVVQIPVAEIVVGDIAQVKYGDL 221
Cdd:TIGR01116   27 EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDK 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  222 LPADGLFIQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllg 290
Cdd:TIGR01116  105 VPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKI----- 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  291 aggeeeekkdkkakqqdgaaamemqplksaeggdaddRKKASMHKKEKSVLQGKLTKLAVQIGKaglVMSAITVIIlvly 370
Cdd:TIGR01116  180 -------------------------------------RDEMRAAEQEDTPLQKKLDEFGELLSK---VIGLICILV---- 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  371 ftvdtFVVNKKPWLPECTPV-YVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 449
Cdd:TIGR01116  216 -----WVINIGHFNDPALGGgWIQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTT 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  450 AICSDKTGTLTTNRMTVV----------QAYVGDVH----------YKEIPDPSSINTKTMELLINAIAINSayTTKILP 509
Cdd:TIGR01116  291 VICSDKTGTLTTNQMSVCkvvaldpsssSLNEFCVTgttyapeggvIKDDGPVAGGQDAGLEELATIAALCN--DSSLDF 368
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  510 PEKEGALPRqVGNKTECGLLGFV--LDLKQDYEPVRS---------QMPEEKLYKVYT--FNSVRKSMSTVIKlPDESFR 576
Cdd:TIGR01116  369 NERKGVYEK-VGEATEAALKVLVekMGLPATKNGVSSkrrpalgcnSVWNDKFKKLATleFSRDRKSMSVLCK-PSTGNK 446
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  577 MYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPE----PDWDNENDILNEL 652
Cdd:TIGR01116  447 LFVKGAPEGVLERCTHILNGDGRAVPLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPDPREedllSDPANFEAIESDL 526
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  653 TCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGED--FLCLEGKEFNrrirnekgEIEQ 730
Cdd:TIGR01116  527 TFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGP 598
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  731 ERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTD 810
Cdd:TIGR01116  599 AKQRAACRSAVLFSRVEPSHKSELVELL-----QEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLAD 672
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  811 DNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLL 890
Cdd:TIGR01116  673 DNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIM 752
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  891 LRKPYGRNKPLIS-----RTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAP--------LHSPPSEHYTIIFNTF 957
Cdd:TIGR01116  753 WKPPRRPDEPLITgwlffRYLVVGVYVGLATVGGFVWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVL 832
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1237125288  958 VMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVI--VQFGGKPFSCSPLQLDQWMWCIFIGL 1027
Cdd:TIGR01116  833 VVIEMFNALNALSEDQSLLRM-PPWVNKWLIGAICLSMALHFLIlyVPFLSRIFGVTPLSLTDWLMVLKLSL 903
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
151-1001 1.59e-124

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 406.46  E-value: 1.59e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02086     56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeee 297
Cdd:cd02086    134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL-------- 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  298 kkdkkakqQDGAAAMEMQPLKSAEGGDADDRKKASMH---KKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFTVD 374
Cdd:cd02086    206 --------RGKGGLISRDRVKSWLYGTLIVTWDAVGRflgTNVGTPLQRKLSKLAY-------LLFFIAVILAIIVFAVN 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  375 TFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSD 454
Cdd:cd02086    271 KFDVDNE----------------VIIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSD 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  455 KTGTLTTNRMTVVQAYVgdvhykeipdPSSintktmelLINAIAINSAyttkilppeKEGALPRQVGNKTECGLLGFV-- 532
Cdd:cd02086    335 KTGTLTQGKMVVRQVWI----------PAA--------LCNIATVFKD---------EETDCWKAHGDPTEIALQVFAtk 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  533 LDLKQDYEPVRSQmPEEKLYKVYTFNSVRKSMSTVI--KLPDESFrMYSKGASEIVLKkCCKILNGAGEPRVFRPRDRDE 610
Cdd:cd02086    388 FDMGKNALTKGGS-AQFQHVAEFPFDSTVKRMSVVYynNQAGDYY-AYMKGAVERVLE-CCSSMYGKDGIIPLDDEFRKT 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  611 MVKKViEPMACDGLRTICVAYRDF-------PSSPEPDWDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVR 683
Cdd:cd02086    465 IIKNV-ESLASQGLRVLAFASRSFtkaqfndDQLKNITLSRA-DAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVH 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  684 MVTGDNINTARAIAIKCGIIHPGE--------DFLCLEGKEFNRrirnekgeIEQERIDKIwPKL-RVLARSSPTDKhtl 754
Cdd:cd02086    543 MLTGDHPGTAKAIAREVGILPPNSyhysqeimDSMVMTASQFDG--------LSDEEVDAL-PVLpLVIARCSPQTK--- 610
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  755 VKgIIDSTHTEQRqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFL 834
Cdd:cd02086    611 VR-MIEALHRRKK-FCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFV 688
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  835 QFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKN 909
Cdd:cd02086    689 LHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIID 768
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  910 ILghaVYQLALIFTLL--FVGeKMFQIDSGRnapLHSPPSEHYTI-----------IFNTFVMMQLF---NEINARK--- 970
Cdd:cd02086    769 TF---VYGTFMGVLCLasFTL-VIYGIGNGD---LGSDCNESYNSscedvfraraaVFATLTWCALIlawEVVDMRRsff 841
                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 1237125288  971 -IHGE-----RNVFDGIFRNP-IFCTIVLGTFAIQIVI 1001
Cdd:cd02086    842 nMHPDtdspvKSFFKTLWKNKfLFWSVVLGFVSVFPTL 879
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
156-1015 2.77e-119

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 388.68  E-value: 2.77e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEqkFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02085     52 SITVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLS 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  236 IDESSLTGESDQVRKSVD-------KDPMLLS-----GTHVMEGSGRMLVTAVGVNSQTGIIFtllgaggeeeekkdkka 303
Cdd:cd02085    130 IDESSLTGETEPCSKTTEvipkasnGDLTTRSniafmGTLVRCGHGKGIVIGTGENSEFGEVF----------------- 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  304 kqqdgaaamEMqplksaeggdaddrkkasMHKKE--KSVLQGKLTKLAVQigkaglvMSAITVIILVLYFTVDTFvvNKK 381
Cdd:cd02085    193 ---------KM------------------MQAEEapKTPLQKSMDKLGKQ-------LSLYSFIIIGVIMLIGWL--QGK 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  382 PWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT 461
Cdd:cd02085    237 NLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTK 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  462 NRMTVVQAYVGDVhykeipdpssintktmellinaiaINSAYTTKILPPekegalprqvGNKTECGLLgfVLDLKQDYEP 541
Cdd:cd02085    305 NEMTVTKIVTGCV------------------------CNNAVIRNNTLM----------GQPTEGALI--ALAMKMGLSD 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  542 VRSqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFR---MYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEP 618
Cdd:cd02085    349 IRE---TYIRKQEIPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALPLTQQQRSE-INEEEKE 424
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  619 MACDGLRTICVAyrdfpSSPEpdwdnendiLNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 698
Cdd:cd02085    425 MGSKGLRVLALA-----SGPE---------LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGS 490
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  699 KCGIIHPGEdfLCLEGKEFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTN 778
Cdd:cd02085    491 SLGLYSPSL--QALSGEEVDQ--------MSDSQLASVVRKVTVFYRASPRHKLKIVKAL-----QKSGAVVAMTGDGVN 555
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  779 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS 858
Cdd:cd02085    556 DAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPN 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  859 PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAvyqlALIFT-LLFVGEKmfQIDSG 937
Cdd:cd02085    636 PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSA----AIIVSgTLWVFWK--EMSDD 709
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237125288  938 RNAPLHSppsehyTIIFNTFVMMQLFNEINARkiHGERNVFD-GIFRNPIFCTIVLGTFAIQIVIVQFggkpfscSPLQ 1015
Cdd:cd02085    710 NVTPRDT------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVIYF-------PPLQ 773
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
451-880 9.36e-97

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 311.31  E-value: 9.36e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  451 ICSDKTGTLTTNRMTVVqayvgDVHYKEIPdpssintktmellinaiainsayttkilppekegalprqvgnktecgllg 530
Cdd:cd01431      2 ICSDKTGTLTKNGMTVT-----KLFIEEIP-------------------------------------------------- 26
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  531 fvldlkqdyepvrsqmpeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILngageprvfrPRDRDE 610
Cdd:cd01431     27 --------------------------FNSTRKRMSVVVRLPGR-YRAIVKGAPETILSRCSHAL----------TEEDRN 69
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  611 MVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 690
Cdd:cd01431     70 KIEKAQEESAREGLRVLALAYREFDPETSKEAVELN-----LVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  691 NTARAIAIKCGIIHPGEDFLCLEgkefnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVV 770
Cdd:cd01431    145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGE-----VV 209
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  771 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 850
Cdd:cd01431    210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                          410       420       430
                   ....*....|....*....|....*....|
gi 1237125288  851 GACITQDSPLKAVQMLWVNLIMDTFASLAL 880
Cdd:cd01431    290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
155-883 2.67e-96

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 321.29  E-value: 2.67e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  155 AAILLSVICV-VLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRA--GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQG 231
Cdd:cd07539     60 AVLIVGVLTVnAVIGGVQRLRAERALAAL--LAQQQQPARVVRApaGRTQTVPAESLVPGDVIELRAGEVVPADARLLEA 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  232 NDLKIDESSLTGESDQVRKSVDKDP---------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkdkk 302
Cdd:cd07539    138 DDLEVDESALTGESLPVDKQVAPTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA------------ 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  303 akqqdgaaamemqPLKSAEGgdaddrkkasmhkkeksvLQGKLTKLAVQigkaglvMSAITVIILVLYFTVDtfVVNKKP 382
Cdd:cd07539    206 -------------PVETATG------------------VQAQLRELTSQ-------LLPLSLGGGAAVTGLG--LLRGAP 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  383 WLPectpvyvqyFVKffiIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTN 462
Cdd:cd07539    246 LRQ---------AVA---DGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTEN 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  463 RMTVVQayvgdvhykeipdpssintktmellinaiainsayttkILPPEKEgaLPrqvgnktecgllgfvldlkqdyepv 542
Cdd:cd07539    314 RLRVVQ--------------------------------------VRPPLAE--LP------------------------- 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  543 rsqmpeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGePRVFRPRDRDeMVKKVIEPMACD 622
Cdd:cd07539    329 --------------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTGGQ-VVPLTEADRQ-AIEEVNELLAGQ 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  623 GLRTICVAYRDFPSSPEPDWDNENDilnELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI 702
Cdd:cd07539    393 GLRVLAVAYRTLDAGTTHAVEAVVD---DLELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL 469
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  703 ihpGEDFLCLEGKEFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPA 782
Cdd:cd07539    470 ---PRDAEVVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIVQALQAAGR-----VVAMTGDGANDAAA 533
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  783 LKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKA 862
Cdd:cd07539    534 IRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNT 613
                          730       740
                   ....*....|....*....|.
gi 1237125288  863 VQMLWVNLIMDTFASLALATE 883
Cdd:cd07539    614 RQLLLVNLLTDMFPALALAVE 634
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
156-927 6.92e-93

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 318.91  E-value: 6.92e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  156 AILLSVicVVLVTAFNDWSKEKQfrglQSRIEQE------QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd02608     72 GIVLAA--VVIVTGCFSYYQEAK----SSKIMDSfknmvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRII 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  230 QGNDLKIDESSLTGESDQVRKSVD---KDPM------LLSgTHVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkd 300
Cdd:cd02608    146 SAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS-TNCVEGTARGIVINTGDRTVMGRIATL------------ 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  301 kkakqqdgAAAMEMQPlksaeggdaddrkkasmhkkeksvlqgklTKLAVQIGKAGLVMSAITVIILVLYFTVDtfVVNK 380
Cdd:cd02608    213 --------ASGLEVGK-----------------------------TPIAREIEHFIHIITGVAVFLGVSFFILS--LILG 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  381 KPWLPECtpvyvqyfvkFFIIGVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 459
Cdd:cd02608    254 YTWLEAV----------IFLIGI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  460 TTNRMTVVQA-YVGDVHYKEIPDPSSINTKT------MELLINAIAINSAyttKILPPEKEGALPRQV--GNKTECGLLG 530
Cdd:cd02608    321 TQNRMTVAHMwFDNQIHEADTTEDQSGASFDkssatwLALSRIAGLCNRA---EFKAGQENVPILKRDvnGDASESALLK 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  531 FVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRK---SMSTVIKLPDESFRMYSKGASEIVLKKCCKIL-NGAGEPrvfrpr 606
Cdd:cd02608    398 CIELSCGSVMEMRERNP--KVAEI-PFNSTNKyqlSIHENEDPGDPRYLLVMKGAPERILDRCSTILiNGKEQP------ 468
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  607 dRDEMVKKVIEP--MACDGL--RTI--CVAY---RDFPSSPEPDWDNENDILNELtciCVVGIE---DPVRPEVPEAIRK 674
Cdd:cd02608    469 -LDEEMKEAFQNayLELGGLgeRVLgfCHLYlpdDKFPEGFKFDTDEVNFPTENL---CFVGLMsmiDPPRAAVPDAVGK 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  675 CQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTL 754
Cdd:cd02608    545 CRSAGIKVIMVTGDHPITAKAIAKGVGII--------------------------------------VFARTSPQQKLII 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  755 VKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISK 832
Cdd:cd02608    587 VEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 659
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  833 FLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQMLWVNLIMDTFASLALATEPPTETLLLRKPygRNkPLISRTMMKNI 910
Cdd:cd02608    660 SIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAYEKAESDIMKRQP--RN-PKTDKLVNERL 734
                          810       820
                   ....*....|....*....|..
gi 1237125288  911 LGHAVYQLALI-----FTLLFV 927
Cdd:cd02608    735 ISMAYGQIGMIqalagFFTYFV 756
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
71-917 1.92e-92

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 311.30  E-value: 1.92e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedeGEAEag 150
Cdd:cd07538      3 TEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-----------------------GDPR-- 57
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 wiEGAAILLSVICVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd07538     58 --EGLILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLE 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  231 GNDLKIDESSLTGESDQVRKSVD----------KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkd 300
Cdd:cd07538    134 NDDLGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI--------------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  301 kkakqqdGAAAMEMQplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtFVVNK 380
Cdd:cd07538    199 -------GKSLAEMD--------------------DEPTPLQKQTGRLVKLCALAALVFCALIVAV---------YGVTR 242
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  381 KPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 460
Cdd:cd07538    243 GDWI------------QAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLT 310
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  461 TNRMTVVQAYVgdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgnktecgllgfvldlkqdye 540
Cdd:cd07538    311 KNQMEVVELTS--------------------------------------------------------------------- 321
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  541 PVRSqmpeeklykvYTFNSVRKSMSTVIKLPDESFrMYSKGASEIVLKKCckilngageprVFRPRDRDEMVKKVIEpMA 620
Cdd:cd07538    322 LVRE----------YPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLC-----------RLNPDEKAAIEDAVSE-MA 378
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  621 CDGLRTICVAyrdfpsSPEPDWDNENDILNELTCICV--VGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 698
Cdd:cd07538    379 GEGLRVLAVA------ACRIDESFLPDDLEDAVFIFVglIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAK 452
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  699 KCGIIH-----PGEDFLCLEGKEFNRRIRNekgeieqeridkiwpkLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVT 773
Cdd:cd07538    453 QIGLDNtdnviTGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQAF-----KANGEIVAMT 511
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  774 GDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGAC 853
Cdd:cd07538    512 GDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPL 591
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1237125288  854 ITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISrtmmKNILGHAVYQ 917
Cdd:cd07538    592 LGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
190-920 4.71e-88

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 307.49  E-value: 4.71e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVD---KDPM-----LLSG 261
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  262 THVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkdkkakqqdgaaamemqplksAEGgdaddrkkasmhkkeksvL 341
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL-------------------------------ASG------------------L 251
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  342 QGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDtfVVNKKPWLPECtpvyvqyfvkFFIIGVtvLVVAVPEGLPLAVTIS 421
Cdd:TIGR01106  252 ENGKTPIAIEIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI--IVANVPEGLLATVTVC 317
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  422 LAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV------QAYVGDV---HYKEIPDPSSINTKTMEL 492
Cdd:TIGR01106  318 LTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAhmwfdnQIHEADTtedQSGVSFDKSSATWLALSR 397
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  493 LinAIAINSAyttkILPPEKEGA--LPRQV-GNKTECGLLGFVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRKSMSTVIK 569
Cdd:TIGR01106  398 I--AGLCNRA----VFKAGQENVpiLKRAVaGDASESALLKCIELCLGSVMEMRERNP--KVVEI-PFNSTNKYQLSIHE 468
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  570 LPDES---FRMYSKGASEIVLKKCCKIL-NGAGEPRvfrprdrDEMVKKVIEP--MACDGL--RTI--CVAY---RDFPS 636
Cdd:TIGR01106  469 NEDPRdprHLLVMKGAPERILERCSSILiHGKEQPL-------DEELKEAFQNayLELGGLgeRVLgfCHLYlpdEQFPE 541
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  637 SPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG----EDF--- 709
Cdd:TIGR01106  542 GFQFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvEDIaar 621
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  710 LCLEGKEFNRRIRN-------EKGEIEQERIDKIwpkLR-----VLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGD 775
Cdd:TIGR01106  622 LNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEGC-------QRQgaIVAVTGD 691
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  776 GTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGAC 853
Cdd:TIGR01106  692 GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIpeITPFLIFIIAN 771
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237125288  854 ITQdsPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGR------NKPLISRT-----MMKNILGHAVYQLAL 920
Cdd:TIGR01106  772 IPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPktdklvNERLISMAygqigMIQALGGFFTYFVIL 847
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
151-938 5.54e-84

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 296.54  E-value: 5.54e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:TIGR01523   81 WIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAH--VIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIE 158
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeee 297
Cdd:TIGR01523  159 TKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAAGL-------- 230
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  298 kkdkkakQQDGAAamemqpLKSAEGGDADDRKKASMH--KKEKSV------------LQGKLTKLAVqigkaglVMSAIT 363
Cdd:TIGR01523  231 -------QGDGGL------FQRPEKDDPNKRRKLNKWilKVTKKVtgaflglnvgtpLHRKLSKLAV-------ILFCIA 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  364 VIILVLYFTVDTFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 443
Cdd:TIGR01523  291 IIFAIIVMAAHKFDVDKE----------------VAIYAICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALE 354
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  444 TMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEI---PDPSSINTKTMELLIN----AIAINSAYTTKILPPEK---- 512
Cdd:TIGR01523  355 ALGAVNDICSDKTGTITQGKMIARQIWIPRFGTISIdnsDDAFNPNEGNVSGIPRfspyEYSHNEAADQDILKEFKdelk 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  513 EGALPRQV--------------------------------GNKTECGLlgFVLDLKQDYePVRSQMPEEKLYKV------ 554
Cdd:TIGR01523  435 EIDLPEDIdmdlfiklletaalaniatvfkddatdcwkahGDPTEIAI--HVFAKKFDL-PHNALTGEEDLLKSnendqs 511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  555 -------------------YTFNSVRKSMSTVIK-LPDESFRMYSKGASEIVLKkCCKILNGAGEPRVFRPRDRD-EMVK 613
Cdd:TIGR01523  512 slsqhnekpgsaqfefiaeFPFDSEIKRMASIYEdNHGETYNIYAKGAFERIIE-CCSSSNGKDGVKISPLEDCDrELII 590
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  614 KVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILN------ELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 687
Cdd:TIGR01523  591 ANMESLAAEGLRVLAFASKSFDKADNNDDQLKNETLNrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTG 670
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  688 DNINTARAIAIKCGII--------HPGEDFLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKhtlVKgII 759
Cdd:TIGR01523  671 DFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTGSQFD--------ALSDEEVDDLKALCLVIARCAPQTK---VK-MI 738
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  760 DSTHtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 839
Cdd:TIGR01523  739 EALH-RRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLA 817
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  840 VNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHA 914
Cdd:TIGR01523  818 ENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYG 897
                          890       900
                   ....*....|....*....|....
gi 1237125288  915 VYqLALIFTLLFVGeKMFQIDSGR 938
Cdd:TIGR01523  898 FF-LGGSCLASFTG-ILYGFGSGN 919
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
152-888 3.81e-74

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 262.93  E-value: 3.81e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  152 IEGAAIL---------LSVICVVLVT-AFNDWSKEKQFRGLQSRIEQ--EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYG 219
Cdd:cd02076     42 LEAAAILaaalgdwvdFAIILLLLLInAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIG 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  220 DLLPADGLFIQGNDLKIDESSLTGESDQVRKSvdKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekk 299
Cdd:cd02076    122 DIVPADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVA--------- 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  300 dkkakqqdgaaamemqplkSAEGgdaddrkkasmhkkeksvlQGKLTKLAVQIGKAGLVMSAITV--IILVLYFTVDTFV 377
Cdd:cd02076    191 -------------------SAEE-------------------QGHLQKVLNKIGNFLILLALILVliIVIVALYRHDPFL 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  378 vnkkpwlpectpvyvqYFVKFFIIgvtVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 457
Cdd:cd02076    233 ----------------EILQFVLV---LLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTG 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  458 TLTTNRMTVVQAYVGDVHYKEipdpssintktmELLINAiainsAYTTKilpPEKEGALPRQVgnktecglLGFVldlkQ 537
Cdd:cd02076    294 TLTLNKLSLDEPYSLEGDGKD------------ELLLLA-----ALASD---TENPDAIDTAI--------LNAL----D 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  538 DYEPVRSQMPEEKLYKvytFNSVRK-SMSTVIKLPDESFRmYSKGASEIVLKKCCKilngageprvfrPRDRDEMVKKVI 616
Cdd:cd02076    342 DYKPDLAGYKQLKFTP---FDPVDKrTEATVEDPDGERFK-VTKGAPQVILELVGN------------DEAIRQAVEEKI 405
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  617 EPMACDGLRTICVAYRDfpssPEPDWDnendILNELTCIcvvgieDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 696
Cdd:cd02076    406 DELASRGYRSLGVARKE----DGGRWE----LLGLLPLF------DPPRPDSKATIARAKELGVRVKMITGDQLAIAKET 471
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  697 AIKCGI---IHPGEDFLCLEGKefnrriRNEKGEIEQERIDKiwpkLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVT 773
Cdd:cd02076    472 ARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIED----ADGFAEVFPEHKYRIVEALQQRGH-----LVGMT 536
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  774 GDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVnVVAVIVAFTGAC 853
Cdd:cd02076    537 GDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAE-TLRILVFFTLGI 614
                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 1237125288  854 ITQDSPLKAVQMLWVNLIMDTFASLALATE--PPTET 888
Cdd:cd02076    615 LILNFYPLPLIMIVLIAILNDGATLTIAYDnvPPSPR 651
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
71-882 8.15e-70

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 250.24  E-value: 8.15e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNegcataqggaedegeaeag 150
Cdd:cd02077      3 TNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD------------------- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 wIEGAAILLS-VICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQ-IPVAEIVVGDIAQVKYGDLLPADGLF 228
Cdd:cd02077     64 -LVGALIILLmVLISGLLDFIQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPADVRI 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  229 IQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNsqtgiifTLLGaggeeee 297
Cdd:cd02077    141 IQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFG------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  298 kkdkkakqqdgaaamemqplkSAEGGDADDRKKASMHKKEKSVlqgklTKLavqigkaglvmsaITVIILVLYFTVdtFV 377
Cdd:cd02077    207 ---------------------SIAKSITEKRPETSFDKGINKV-----SKL-------------LIRFMLVMVPVV--FL 245
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  378 VN---KKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSD 454
Cdd:cd02077    246 INgltKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTD 313
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  455 KTGTLTTNRMTVVQAYvgdvhykeipdpsSINTKTMELLINAIAINSAYTTKILPPeKEGALPRQVGNKTECGLlgfvld 534
Cdd:cd02077    314 KTGTLTQDKIVLERHL-------------DVNGKESERVLRLAYLNSYFQTGLKNL-LDKAIIDHAEEANANGL------ 373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  535 lKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI-LNGAGEPRVFRPRdrdEMVK 613
Cdd:cd02077    374 -IQDYTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHVeVNGEVVPLTDTLR---EKIL 439
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  614 KVIEPMACDGLRTICVAYRDFPSspePDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 693
Cdd:cd02077    440 AQVEELNREGLRVLAIAYKKLPA---PEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVT 516
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  694 RAIAIKCGIihPGEDflCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVT 773
Cdd:cd02077    517 KAICKQVGL--DINR--VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKARIIQAL-----KKNGHVVGFM 579
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  774 GDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVN---VVAVIVAft 850
Cdd:cd02077    580 GDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNfgnVFSVLVA-- 656
                          810       820       830
                   ....*....|....*....|....*....|..
gi 1237125288  851 gACITQDSPLKAVQMLWVNLIMDtFASLALAT 882
Cdd:cd02077    657 -SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPF 686
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
191-887 8.74e-68

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 241.80  E-value: 8.74e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  191 KFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGR 270
Cdd:cd02609     93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  271 MLVTAVGVNSQtgiiftllgaggeeeekkdkkakqqdgAAAMEMQplksaeggdaddrkkASMHKKEKSVLQGKLTKLAV 350
Cdd:cd02609    171 ARVTAVGAESY---------------------------AAKLTLE---------------AKKHKLINSELLNSINKILK 208
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  351 qigkaglVMSAITVIILVLYFtVDTFVVNKKPWlpectpvyvqyfvKFFIIG-VTVLVVAVPEGLPLAVTISLAYSVKKM 429
Cdd:cd02609    209 -------FTSFIIIPLGLLLF-VEALFRRGGGW-------------RQAVVStVAALLGMIPEGLVLLTSVALAVGAIRL 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  430 MKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIpdpssiNTKTMELLINAIAINSAyTTKILp 509
Cdd:cd02609    268 AKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAE------AAAALAAFVAASEDNNA-TMQAI- 339
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  510 pekegalprqvgnktecgLLGFVLDLKQdyePVRSQMPeeklykvytFNSVRKsMSTVIKLPDESFRMyskGASEIVLkk 589
Cdd:cd02609    340 ------------------RAAFFGNNRF---EVTSIIP---------FSSARK-WSAVEFRDGGTWVL---GAPEVLL-- 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  590 cckilngageprvfrpRDRDEMVKKVIEPMACDGLRTICVAYrdfpSSPEPDWDNendILNELTCICVVGIEDPVRPEVP 669
Cdd:cd02609    384 ----------------GDLPSEVLSRVNELAAQGYRVLLLAR----SAGALTHEQ---LPVGLEPLALILLTDPIRPEAK 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  670 EAIRKCQRAGITVRMVTGDNINTARAIAIKCGiihpgedflcLEGKEFNRRIRNEKGEIEQERIDKiwpKLRVLARSSPT 749
Cdd:cd02609    441 ETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTDEELAEAVE---NYTVFGRVTPE 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  750 DKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS 829
Cdd:cd02609    508 QKRQLVQALQALGHT-----VAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNN 581
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1237125288  830 ISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTE 887
Cdd:cd02609    582 IERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKR 639
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
193-851 4.92e-54

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 202.30  E-value: 4.92e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRML 272
Cdd:COG2217    216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVR 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  273 VTAVGVNSQ-TGIIftllgaggeeeekkdkkakqqdgaAAMEmqplkSAEGGDAddrkkasmhkkeksvlqgKLTKLAVQ 351
Cdd:COG2217    293 VTKVGSDTTlARII------------------------RLVE-----EAQSSKA------------------PIQRLADR 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  352 IgkaglvmSAI-TVIILVLyfTVDTFVVnkkpWLpectpVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMM 430
Cdd:COG2217    326 I-------ARYfVPAVLAI--AALTFLV----WL-----LFGGDFSTALYRAVAVLVIACPCALGLATPTAIMVGTGRAA 387
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  431 KDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELLIN---AIAINSAYTT 505
Cdd:COG2217    388 RRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVT-----DVVPLDGLDEDELLAlaAALEQGSEhplARAIVAAAKE 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  506 KILPPEKegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskgasei 585
Cdd:COG2217    463 RGLELPE----VEDFEAIPGKGVEATV---------------DGKRVLV------------------------------- 492
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  586 vlkkcckilngaGEPRVFRPR--DRDEMVKKVIEPMACDGLRTICVAyrdfpsspepdWDNEndilneltCICVVGIEDP 663
Cdd:COG2217    493 ------------GSPRLLEEEgiDLPEALEERAEELEAEGKTVVYVA-----------VDGR--------LLGLIALADT 541
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  664 VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeridkiwpklrVL 743
Cdd:COG2217    542 LRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGIDE-------------------------------------VR 584
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  744 ARSSPTDKHTLVKGIIdsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWG 823
Cdd:COG2217    585 AEVLPEDKAAAVRELQ-----AQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLS 658
                          650       660
                   ....*....|....*....|....*...
gi 1237125288  824 RNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:COG2217    659 RATMRIIRQNLFWAFGYNVIGIPLAAGG 686
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
172-851 1.28e-51

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 191.69  E-value: 1.28e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  172 DWSKEKQFRGLQSRIE-QEQKFTVVRA-GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVR 249
Cdd:TIGR01525   36 ERAKSRASDALSALLAlAPSTARVLQGdGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  250 KSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrK 329
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDSTLAQIVELV---------------------------------------E 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  330 KASMHKKEksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFtvdtfvvnkkPWLPECtpvyvqyfvkfFIIGVTVLVVA 409
Cdd:TIGR01525  154 EAQSSKAP---IQRLADRIASYYVPAVLAIALLTFVVWLALG----------ALWREA-----------LYRALTVLVVA 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  410 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-GDVHYKEIPDPSSintk 488
Cdd:TIGR01525  210 CPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPlDDASEEELLALAA---- 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  489 TMELLIN---AIAINSAYTTKILPPekegaLPRQVGNKTECGLLGFVldlkQDYEPVRSQMPEEklykvytfnsvrksms 565
Cdd:TIGR01525  286 ALEQSSShplARAIVRYAKERGLEL-----PPEDVEEVPGKGVEATV----DGGREVRIGNPRF---------------- 340
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  566 tviklpdesfrMYSKGASEIVLKKCCKILNGAGEprvfrprdrdemvkkviepmacdGLRTICVAYRDfpsspepdwdne 645
Cdd:TIGR01525  341 -----------LGNRELAIEPISASPDLLNEGES-----------------------QGKTVVFVAVD------------ 374
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  646 ndilNELtcICVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirne 724
Cdd:TIGR01525  375 ----GEL--LGVIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELGI---------------------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  725 kgeiEQEridkiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 804
Cdd:TIGR01525  427 ----DDE----------VHAELLPEDKLAIVKKL-----QEEGGPVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAA 486
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 1237125288  805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:TIGR01525  487 DIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
858-1036 1.73e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 173.19  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  858 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 937
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  938 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1015
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1237125288 1016 LDQWMWCIFIGLGELVWGQVI 1036
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
172-851 9.00e-48

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 181.64  E-value: 9.00e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  172 DWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd02079    106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  251 SVDkDPmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplKSAEggdaddrkk 330
Cdd:cd02079    185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTLAKIIRLV----------------------------EEAQ--------- 225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  331 asmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtfvvnkkpwlpecTPVYVQYFVKFFIIGVTVLVVAV 410
Cdd:cd02079    226 -----SSKPPLQRLADRFARYFTPAVLVLAALVFLF---------------------WPLVGGPPSLALYRALAVLVVAC 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  411 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQAYVGDVHYKEIPDPSSINTK 488
Cdd:cd02079    280 PCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVteIEPLEGFSEDELLALAAALEQH 359
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  489 TMELLinAIAINSAYTTKILPPEKEGalprQVGNKTECGLLGFVLDlkqdyepvrsqmpeeklykvytfnsvrksmstvi 568
Cdd:cd02079    360 SEHPL--ARAIVEAAEEKGLPPLEVE----DVEEIPGKGISGEVDG---------------------------------- 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  569 klpdesfRMYSKGASEIVlkkcckilngageprvfrprdRDEMVKKVIEPMACDGLRTICVAYRDFpsspepdwdnendi 648
Cdd:cd02079    400 -------REVLIGSLSFA---------------------EEEGLVEAADALSDAGKTSAVYVGRDG-------------- 437
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  649 lnelTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgei 728
Cdd:cd02079    438 ----KLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI-------------------------- 487
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  729 eqeridkiwpkLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 808
Cdd:cd02079    488 -----------DEVHAGLLPEDKLAIVKAL-----QAEGGPVAMVGDGINDAPALAQADVGIAMG-SGTDVAIETADIVL 550
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 1237125288  809 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:cd02079    551 LSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
193-820 1.80e-47

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 181.14  E-value: 1.80e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGThvMEGSGRML 272
Cdd:cd02094    142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGT--INGNGSLL 216
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  273 VTAVGVNSQTgiifTLlgaggeeeekkdkkakqqdgAAAMEMqplksaeggdaddrkkasmhkkeksVLQGKLTKLAVQi 352
Cdd:cd02094    217 VRATRVGADT----TL--------------------AQIIRL-------------------------VEEAQGSKAPIQ- 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  353 gkaGLV--MSAITV-IILVLyfTVDTFVVnkkpWL---PECTPVYVqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:cd02094    247 ---RLAdrVSGVFVpVVIAI--AILTFLV----WLllgPEPALTFA------LVAAVAVLVIACPCALGLATPTAIMVGT 311
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHykeiPDPSSINTKTMEL-----------LIN 495
Cdd:cd02094    312 GRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT-----DVV----PLPGDDEDELLRLaasleqgsehpLAK 382
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  496 AIaINSAYTTKILPPEKEG--ALPrqvGnkteCGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpde 573
Cdd:cd02094    383 AI-VAAAKEKGLELPEVEDfeAIP---G----KGVRGTV---------------DGRRVLV------------------- 420
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  574 sfrmyskGASEIVLKKCCKILNGAGEprvfrprdrdemvkkvIEPMACDGLRTICVAYrdfpsspepdwDNEndilnelt 653
Cdd:cd02094    421 -------GNRRLMEENGIDLSALEAE----------------ALALEEEGKTVVLVAV-----------DGE-------- 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  654 CICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeri 733
Cdd:cd02094    459 LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI------------------------------- 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  734 DKiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNF 813
Cdd:cd02094    508 DE------VIAEVLPEDKAEKVKKL-----QAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDL 575

                   ....*..
gi 1237125288  814 SSIVKAV 820
Cdd:cd02094    576 RGVVTAI 582
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
151-851 6.49e-47

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 177.52  E-value: 6.49e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 WIEGAAILLSVIcvvLVTAFNDWSKEKQFRGLQSRIEQE-QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:TIGR01512   18 YLEGALLLLLFS---IGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdga 309
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNLV-------------------- 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  310 aamemqplKSAEggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtfvvnkkPWLPECTP 389
Cdd:TIGR01512  152 --------EEAQ--------------SRKAPTQRFIDRFARYYTPAVLAIALAAALV---------------PPLLGAGP 194
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  390 vyvqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqa 469
Cdd:TIGR01512  195 -----FLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVT-- 267
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  470 yvgDVHYKEIPDPSSINT--KTMELL---INAIAINSAYTTKILPPEkegalPRQVGNKTECGLLGFVldlkqdyepvrs 544
Cdd:TIGR01512  268 ---DVHPADGHSESEVLRlaAAAEQGsthPLARAIVDYARARELAPP-----VEDVEEVPGEGVRAVV------------ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  545 qmpeeklykvytfnsvrksmstviklpdesfrmyskgaseivlkkcckilnGAGEPRVFRPRDRDEMVKKVIEPMaCDGL 624
Cdd:TIGR01512  328 ---------------------------------------------------DGGEVRIGNPRSLSEAVGASIAVP-ESAG 355
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  625 RTICVAYRDFpsspepdwdnendilnelTCICVVGIEDPVRPEVPEAIRKCQRAGI-TVRMVTGDNINTARAIAIKCGII 703
Cdd:TIGR01512  356 KTIVLVARDG------------------TLLGYIALSDELRPDAAEAIAELKALGIkRLVMLTGDRRAVAEAVARELGID 417
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  704 hpgedflclegkefnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPAL 783
Cdd:TIGR01512  418 -------------------------------------EVHAELLPEDKLEIVKELREKAG-----PVAMVGDGINDAPAL 455
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237125288  784 KKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:TIGR01512  456 AAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILLALFG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
194-848 3.57e-45

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 172.46  E-value: 3.57e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRMLV 273
Cdd:TIGR01511   96 LTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRA 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  274 TAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrKKASMHKKEKSVLQGKLTKLavqig 353
Cdd:TIGR01511  173 TATGEDTTLAQIVRLV---------------------------------------RQAQQSKAPIQRLADKVAGY----- 208
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  354 kagLVMSAITVIILvlyftvdTFVVnkkpWLpectpvyvqyfvkF-FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKD 432
Cdd:TIGR01511  209 ---FVPVVIAIALI-------TFVI----WL-------------FaLEFAVTVLIIACPCALGLATPTVIAVATGLAAKN 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  433 NNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHykeiPDPSSINTKTMELlINAIAINS---------AY 503
Cdd:TIGR01511  262 GVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVT-----DVH----VFGDRDRTELLAL-AAALEAGSehplakaivSY 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  504 TtkilppEKEGALPRQVGN-KTECGLlgfvlDLKQDYEPVRSQMPEEKLYKVYTfnsvrksmstvIKLPDESfrmysKGA 582
Cdd:TIGR01511  332 A------KEKGITLVTVSDfKAIPGI-----GVEGTVEGTKIQLGNEKLLGENA-----------IKIDGKA-----GQG 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  583 SEIVLkkcckilngageprvfrprdrdemvkkviepmacdglrticvayrdfpsspepdwdneNDILNELTCIcvVGIED 662
Cdd:TIGR01511  385 STVVL----------------------------------------------------------VAVNGELAGV--FALED 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  663 PVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeridkiwpklRV 742
Cdd:TIGR01511  405 QLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI--------------------------------------DV 446
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  743 LARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMW 822
Cdd:TIGR01511  447 RAEVLPDDKAALIKKL-----QEKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDL 520
                          650       660
                   ....*....|....*....|....*.
gi 1237125288  823 GRNVYDSISKFLQFQLTVNVVAVIVA 848
Cdd:TIGR01511  521 SRKTLRRIKQNLLWAFGYNVIAIPIA 546
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-848 9.14e-44

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 172.56  E-value: 9.14e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517    53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517   118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517   173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  267 GSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaaamemqplksAEGGDADDRkkasmhkkEKSVLQGKLT 346
Cdd:PRK10517   253 GTAQAVVIATGANTWFGQL----------------------------------AGRVSEQDS--------EPNAFQQGIS 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  347 KLAVQIGKAGLVMSAitVIILVLYFTvdtfvvnKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:PRK10517   291 RVSWLLIRFMLVMAP--VVLLINGYT-------KGDW------------WEAALFALSVAVGLTPEMLPMIVTSTLARGA 349
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVgDVHYKeipdpssintKTMELLINAIaINSAYTTK 506
Cdd:PRK10517   350 VKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-VLENHT-DISGK----------TSERVLHSAW-LNSHYQTG 416
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  507 IlppekEGALPRQVgnkTECGLLGFVLDLKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIV 586
Cdd:PRK10517   417 L-----KNLLDTAV---LEGVDEESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEI 478
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  587 LKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEpDWD--NENDilneLTCICVVGIEDP 663
Cdd:PRK10517   479 LNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDESD----LILEGYIAFLDP 550
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  664 VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGedflCLEGkefnrrirnekGEIEQ---ERIDKIWPKL 740
Cdd:PRK10517   551 PKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE----VLIG-----------SDIETlsdDELANLAERT 615
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  741 RVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 820
Cdd:PRK10517   616 TLFARLTPMHKERIVTLLKREGH-----VVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGV 689
                          810       820       830
                   ....*....|....*....|....*....|...
gi 1237125288  821 MWGRNVYDSISKFLqfQLTV-----NVVAVIVA 848
Cdd:PRK10517   690 IEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
158-922 3.04e-38

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 155.02  E-value: 3.04e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  158 LLSVICVVLVTA----FNDWSKEKQFRGLQSRieqeqKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGND 233
Cdd:cd02073     52 LLPLLFVLGVTAikegYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSE 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  234 LK----IDESSLTGESD-QVRKSVDKDPMLLSGTHVMEGSGRM--------LVTAVG---VNSQTGIIFT----LLGagg 293
Cdd:cd02073    127 PDglcyVETANLDGETNlKIRQALPETALLLSEEDLARFSGEIeceqpnndLYTFNGtleLNGGRELPLSpdnlLLR--- 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  294 eeeekkdkkakqqdGAAamemqpLKSAE---------GGDAddrkKASMHKKEKSVLQGKLTKLAVQIgkagLVMSAITV 364
Cdd:cd02073    204 --------------GCT------LRNTEwvygvvvytGHET----KLMLNSGGTPLKRSSIEKKMNRF----IIAIFCIL 255
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  365 IILVLYFTVDTFVVNKK-----PWL--PECTPVYVQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYSV--------K 427
Cdd:cd02073    256 IVMCLISAIGKGIWLSKhgrdlWYLlpKEERSPALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKFLqsffinwdL 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  428 KMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipdpssintktmeLLINAIAI-NSA 502
Cdd:cd02073    331 DMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY---------------GFFLALALcHTV 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  503 YTTKILPPEK---------EGALPRQvgnkteCGLLGFVLdLKQDYEPV-RSQMPEEKLYK---VYTFNSVRKSMSTVIK 569
Cdd:cd02073    396 VPEKDDHPGQlvyqasspdEAALVEA------ARDLGFVF-LSRTPDTVtINALGEEEEYEilhILEFNSDRKRMSVIVR 468
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  570 LPDESFRMYSKGASEIVLKKCckilngAGEPRVFRprdrdEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE---- 645
Cdd:cd02073    469 DPDGRILLYCKGADSVIFERL------SPSSLELV-----EKTQEHLEDFASEGLRTLCLAYREISEEEYEEWNEKydea 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  646 ---------------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG-EDF 709
Cdd:cd02073    538 stalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDmENL 617
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  710 -LCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLA------RSSPTDKHTLVKGIIDSThteqRQVVAVTGDGTNDGPA 782
Cdd:cd02073    618 aLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSK----KAVTLAIGDGANDVSM 685
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  783 LKKADVGfaMGIAGtdvaKE------ASDIILTddNFSSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV-----AFT 850
Cdd:cd02073    686 IQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYLTqfwyqFFN 757
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  851 GAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TETLLLRKP----YGRNKPLIS-RTMMKNILgHAV 915
Cdd:cd02073    758 GF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLLRYPelykPGQLNELFNwKVFLYWIL-DGI 826

                   ....*..
gi 1237125288  916 YQLALIF 922
Cdd:cd02073    827 YQSLIIF 833
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
193-907 2.48e-36

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 149.02  E-value: 2.48e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVR------AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQV----------RKSVDKDP 256
Cdd:PRK15122   151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVekydtlgavaGKSADALA 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  257 -----------MLLSGTHVMEGSGRMLVTAVGvnSQTgiIFtllgaggeeeekkdkkakqqdGAAAmemqplKSAEGgda 325
Cdd:PRK15122   231 ddegslldlpnICFMGTNVVSGTATAVVVATG--SRT--YF---------------------GSLA------KSIVG--- 276
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  326 dDRKKASMHKKEKSVlqgklTKLAVqigKAGLVMsaITVIILVLYFTvdtfvvnKKPWLPECTpvyvqyfvkfFiigvtV 405
Cdd:PRK15122   277 -TRAQTAFDRGVNSV-----SWLLI---RFMLVM--VPVVLLINGFT-------KGDWLEALL----------F-----A 323
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  406 LVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYvgDVHYKEipdp 482
Cdd:PRK15122   324 LAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHL--DVSGRK---- 397
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  483 ssiNTKTMELlinaIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFvldLKQDYEPvrsqmpeeklykvytFNSVRK 562
Cdd:PRK15122   398 ---DERVLQL----AWLNSFHQSGMKNLMDQAVVAFAEGNPEIVKPAGY---RKVDELP---------------FDFVRR 452
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  563 SMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEPMAcDGLRTICVAYRDFPSSPEPDW 642
Cdd:PRK15122   453 RLSVVVEDAQGQHLLICKGAVEEMLAVATHVRDG-DTVRPLDEARRERLLALAEAYNA-DGFRVLLVATREIPGGESRAQ 530
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  643 ---DNENDILNE--LTCIcvvgieDPVRPEVPEAIRKCQRAGITVRMVTGDN-INTARaIAIKCGIiHPGEDflcLEGKE 716
Cdd:PRK15122   531 ystADERDLVIRgfLTFL------DPPKESAAPAIAALRENGVAVKVLTGDNpIVTAK-ICREVGL-EPGEP---LLGTE 599
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  717 FNRRIRNEKGEIEQERIdkiwpklrVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAG 796
Cdd:PRK15122   600 IEAMDDAALAREVEERT--------VFAKLTPLQKSRVLKALQANGHT-----VGFLGDGINDAPALRDADVGISVD-SG 665
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  797 TDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVAftGACITQdSPLKAVQMLWVNLI 871
Cdd:PRK15122   666 ADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVFSVLVA--SAFIPF-LPMLAIHLLLQNLM 740
                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 1237125288  872 MDtFASLALatepPTETL---LLRKPYGRNKPLISRTMM 907
Cdd:PRK15122   741 YD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
194-848 4.50e-36

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 146.30  E-value: 4.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESdqvrKSVDKDP--MLLSGTHVMEGSGRM 271
Cdd:cd07552    135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  272 LVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrKKAsmhKKEKSVLQGKLTKLAVQ 351
Cdd:cd07552    210 KVTKTGEDSYLSQVMELV---------------------------------------AQA---QASKSRAENLADKVAGW 247
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  352 IGKAGLVMSAITVIILVLYFTVDTFVvnkkpwlpectpvyvqyfvkffIIGVTVLVVAVPEGL----PLAVTISLAYSVK 427
Cdd:cd07552    248 LFYIALGVGIIAFIIWLILGDLAFAL----------------------ERAVTVLVIACPHALglaiPLVVARSTSIAAK 305
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  428 KMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-GDVHYKEIpdpssinTKTMELLIN------AIAIN 500
Cdd:cd07552    306 NGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITfDEYDEDEI-------LSLAAALEAgsehplAQAIV 374
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  501 SAYTTKILPPEKegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVYTFNSVRKSMstvIKLPDESFRMY-S 579
Cdd:cd07552    375 SAAKEKGIRPVE----VENFENIPGVGVEGTV---------------NGKRYQVVSPKYLKELG---LKYDEELVKRLaQ 432
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  580 KGASEIVLkkcckilngageprvfrprdrdemvkkviepmacdglrticvayrdfpsspepdwdnendiLNELTCICVVG 659
Cdd:cd07552    433 QGNTVSFL-------------------------------------------------------------IQDGEVIGAIA 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  660 IEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpk 739
Cdd:cd07552    452 LGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID------------------------------------ 495
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  740 lRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKA 819
Cdd:cd07552    496 -EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESADVVLVKSDPRDIVDF 568
                          650       660
                   ....*....|....*....|....*....
gi 1237125288  820 VMWGRNVYDSISKFLQFQLTVNVVAVIVA 848
Cdd:cd07552    569 LELAKATYRKMKQNLWWGAGYNVIAIPLA 597
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
164-849 5.08e-36

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 148.68  E-value: 5.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  164 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTV-VRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK--- 235
Cdd:TIGR01652   60 VLIVTaikeAIEDIR-----RRRRDKEVNNRLTEVlEGHGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvc 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  236 -IDESSLTGESD-QVRKSVDKDPMLLSGTHVMEGSGRmlVTAVGVNSQtgiIFTLLGaggeeeekkdkkAKQQDGAAAME 313
Cdd:TIGR01652  135 yVETANLDGETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG------------NMTINGDRQYP 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  314 MQP---------LKSAE---------GGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDt 375
Cdd:TIGR01652  198 LSPdnillrgctLRNTDwvigvvvytGHDTKLMRNATQAPSKRSRLEKELNFLIIILFCLLFVLCLISSVGAGIWNDAH- 276
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  376 fvvNKKPW---LPECTPVYVQYFVKFFIIGVTVLVVAVPegLPLAVTISLAYSVKKMMKDNNL------------VRHLD 440
Cdd:TIGR01652  277 ---GKDLWyirLDVSERNAAANGFFSFLTFLILFSSLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtpasVRTSN 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  441 ACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHY-----------------------KEIPDPSSINTKTMELL---- 493
Cdd:TIGR01652  352 LNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgdgfteikdgirerlgsyvenenSMLVESKGFTFVDPRLVdllk 431
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  494 ---INAIAINSAYTT-----KILP---PEKEGALPRQVGNKTECGL------LGFVLDLKQDY-----EPVRSQMPEEKL 551
Cdd:TIGR01652  432 tnkPNAKRINEFFLAlalchTVVPefnDDGPEEITYQAASPDEAALvkaardVGFVFFERTPKsisllIEMHGETKEYEI 511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  552 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKkcckILNGAGeprvfrpRDRDEMVKKVIEPMACDGLRTICVAY 631
Cdd:TIGR01652  512 LNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASEGLRTLCIAY 580
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  632 RDFPSSPEPDW-----------DNENDILNE--------LTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 692
Cdd:TIGR01652  581 RELSEEEYEEWneeyneastalTDREEKLDVvaesiekdLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVET 660
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  693 ARAIAIKCGIIHPGEDFL---------CLEGKEFNRRIRNEKGEIEQERIDK---------------IWPKLR------- 741
Cdd:TIGR01652  661 AINIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDEELEkeflqla 740
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  742 -----VLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNF 813
Cdd:TIGR01652  741 lkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMASDFAIG--QF 812
                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 1237125288  814 SSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 849
Cdd:TIGR01652  813 RFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
160-928 1.10e-33

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 140.96  E-value: 1.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  160 SVICVVLVTAFND---WSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY--GDLLPADGLFIQGnDL 234
Cdd:TIGR01657  196 SLCIVFMSSTSISlsvYQIRKQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SC 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  235 KIDESSLTGESDQVRK----------------SVDKDPMLLSGTHVM-----EGSGRML--VTAVGVN-SQTGIIFTLLg 290
Cdd:TIGR01657  275 IVNESMLTGESVPVLKfpipdngdddedlflyETSKKHVLFGGTKILqirpyPGDTGCLaiVVRTGFStSKGQLVRSIL- 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  291 aggeeeekkdkkakqqdgaaamemqplksaeggdaddrkkasmHKKEKSvlqgklTKLAVQIGKAGLVMSAITVIILVly 370
Cdd:TIGR01657  354 -------------------------------------------YPKPRV------FKFYKDSFKFILFLAVLALIGFI-- 382
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  371 FTVDTFVVNKKPwlpectpvyvqyfVKFFIIGVT-VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 449
Cdd:TIGR01657  383 YTIIELIKDGRP-------------LGKIILRSLdIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKID 449
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  450 AICSDKTGTLTTNRMTV--VQAYVGDVHY-KEIPDPSSINtktMELLINAIAINSAyTTKIlppekEGALprqVGNKTEC 526
Cdd:TIGR01657  450 VCCFDKTGTLTEDGLDLrgVQGLSGNQEFlKIVTEDSSLK---PSITHKALATCHS-LTKL-----EGKL---VGDPLDK 517
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  527 GLLGFV-LDLKQDYE---------PVRSQMPEEKLY--KVYTFNSVRKSMSTVIKLPDESFRM-YSKGASEIVLKKCCKi 593
Cdd:TIGR01657  518 KMFEATgWTLEEDDEsaeptsilaVVRTDDPPQELSiiRRFQFSSALQRMSVIVSTNDERSPDaFVKGAPETIQSLCSP- 596
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  594 lngagePRVfrPRDRDEMVKKVIEpmacDGLRTICVAYRDFPSSPepdWD-----NENDILNELTCICVVGIEDPVRPEV 668
Cdd:TIGR01657  597 ------ETV--PSDYQEVLKSYTR----EGYRVLALAYKELPKLT---LQkaqdlSRDAVESNLTFLGFIVFENPLKPDT 661
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  669 PEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII------------------------HPGEDF--------------- 709
Cdd:TIGR01657  662 KEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnpsntlilaeaeppesgkpnqikfEVIDSIpfastqveipyplgq 741
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  710 ------------LCLEGKEFNRRIRNEKgeieqERIDKIWPKLRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGT 777
Cdd:TIGR01657  742 dsvedllasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDGA 811
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  778 NDGPALKKADVGFAM-----GIAGTDVAKEAS-----DIILTddnfssivkavmwGR-NVYDSISKFlQFQLTVNVVAVI 846
Cdd:TIGR01657  812 NDCGALKQADVGISLseaeaSVAAPFTSKLASiscvpNVIRE-------------GRcALVTSFQMF-KYMALYSLIQFY 877
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  847 VAFTGACItqDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKNILGhavyQLALIFTLLF 926
Cdd:TIGR01657  878 SVSILYLI--GSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVLI----QFVLHILSQV 948

                   ..
gi 1237125288  927 VG 928
Cdd:TIGR01657  949 YL 950
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
172-851 5.76e-33

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 136.25  E-value: 5.76e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  172 DWSKEKQFRGL-QSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd07550     81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  251 SVDKdpMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrKK 330
Cdd:cd07550    160 REGD--LVFASTVVEEGQLVIRAERVGRETRAARIAELI---------------------------------------EQ 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  331 ASMHKKEKsvlQGKLTKLAVQIGKAGLVMSAITviilvlyftvdtfvvnkkpwlpectpvyvqyfvkFFIIG-----VTV 405
Cdd:cd07550    199 SPSLKARI---QNYAERLADRLVPPTLGLAGLV----------------------------------YALTGdisraAAV 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  406 LVV----AVPEGLPLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipd 481
Cdd:cd07550    242 LLVdfscGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI------------ 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  482 pssintktmellinaIAINSAYttkilpPEKEgalprqvgnktecgLLGFVLDLkqdyepvrsqmpEEKLYKVYTFNSVR 561
Cdd:cd07550    306 ---------------ITFDGRL------SEED--------------LLYLAASA------------EEHFPHPVARAIVR 338
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  562 KSMSTVIKLPDESFRMY--SKG-ASEIVLKKcckILngAGEPRVFRPRDRD--EMVKKVIEPMACDGLRTICVAYrdfps 636
Cdd:cd07550    339 EAEERGIEHPEHEEVEYivGHGiASTVDGKR---IR--VGSRHFMEEEEIIliPEVDELIEDLHAEGKSLLYVAI----- 408
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  637 spepdwDNEndilneltCICVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAikcgiihpgedflclegk 715
Cdd:cd07550    409 ------DGR--------LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA------------------ 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  716 efnrrirnekgeiEQERIDkiwpklRVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiA 795
Cdd:cd07550    457 -------------EQLGID------RYHAEALPEDKAEIVEKLQAEGRT-----VAFVGDGINDSPALSYADVGISMR-G 511
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1237125288  796 GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:cd07550    512 GTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
E1-E2_ATPase pfam00122
E1-E2 ATPase;
193-431 8.99e-33

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 125.38  E-value: 8.99e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKsvDKDPMLLSGTHVMEGSGRML 272
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  273 VTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrkkaSMHKKEKSVLQGKLTKLAVQI 352
Cdd:pfam00122   85 VTATGEDTELGRIARLV------------------------------------------EEAKSKKTPLQRLLDRLGKYF 122
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237125288  353 GKAGLVMSAITVIILVLYFTVDTFVvnkkpwlpectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK 431
Cdd:pfam00122  123 SPVVLLIALAVFLLWLFVGGPPLRA---------------------LLRALAVLVAACPCALPLATPLALAVGARRLAK 180
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
151-878 1.42e-32

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 135.24  E-value: 1.42e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  151 WIEGAAIllsVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd07545     59 WPEAAMV---VFLFAISEALEAYSMDRARRSIRSLMDIAPKTaLVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIV 135
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAvgvnsqtgiiftllgaggeeeekkdkkaKQQDGA 309
Cdd:cd07545    136 RGESS-VNQAAITGESLPVEKGVGDE--VFAGTLNGEGALEVRVTK----------------------------PAEDST 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  310 AAMEMQPLKSAEGgdaddrkkasmhkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFvvnkkPWlpectp 389
Cdd:cd07545    185 IARIIHLVEEAQA--------------ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGGAWF-----TW------ 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  390 VYVqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQA 469
Cdd:cd07545    240 IYR---------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDV 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  470 YVgdvhykeipdpssintktmellinaiainsayttkilppekegalprqVGNKTECGLLGFVLDLKQdyepvRSQMPEE 549
Cdd:cd07545    311 VV------------------------------------------------LGGQTEKELLAIAAALEY-----RSEHPLA 337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  550 KLYkvytfnsVRKSMSTVIKLPD-ESFR-MYSKGASEIVLKKCCKIlngaGEPRVFRPRDRDEMV--KKVIEPMACDGlR 625
Cdd:cd07545    338 SAI-------VKKAEQRGLTLSAvEEFTaLTGRGVRGVVNGTTYYI----GSPRLFEELNLSESPalEAKLDALQNQG-K 405
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  626 TICVayrdfpsspepdwdnendILNELTCICVVGIEDPVRPEVPEAIRKCQRAGI--TVrMVTGDNINTARAIAIKCGIi 703
Cdd:cd07545    406 TVMI------------------LGDGERILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTGDNPQTAQAIAAQVGV- 465
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  704 hpgedflclegkefnrrirnekGEIEQERIdkiwpklrvlarssPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPAL 783
Cdd:cd07545    466 ----------------------SDIRAELL--------------PQDKLDAIEAL-----QAEGGRVAMVGDGVNDAPAL 504
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  784 KKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitqdsplkaV 863
Cdd:cd07545    505 AAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLVIPG-----------W 573
                          730
                   ....*....|....*
gi 1237125288  864 QMLWVNLIMDTFASL 878
Cdd:cd07545    574 LTLWMAVFADMGASL 588
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
194-851 1.31e-31

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 132.37  E-value: 1.31e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLV 273
Cdd:cd07551    117 IQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRV 193
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  274 TAVgvNSQTgiIFtllgaggeeeekkdkkakqqdgaaAMEMQPLKSAEGgdaddrkkasmhkkEKSVLQGKLTKLavQIG 353
Cdd:cd07551    194 TKL--SSDT--VF------------------------AKIVQLVEEAQS--------------EKSPTQSFIERF--ERI 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  354 KAGLVMSAITVIILVLYFtvdtfvVNKKPWLPEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:cd07551    230 YVKGVLLAVLLLLLLPPF------LLGWTWADS------------FYRAMVFLVVASPCALVASTPPATLSAIANAARQG 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELLIN---AIAINSAYTTKIL 508
Cdd:cd07551    292 VLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVT-----DVIPAEGVDEEELLQvaAAAESQSEhplAQAIVRYAEERGI 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  509 PPekegALPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskgaseivlk 588
Cdd:cd07551    367 PR----LPAIEVEAVTGKGVTATV---------------DGQTYRI---------------------------------- 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  589 kcckilngaGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDfpsspepdwdnendilnelTCICVVGIEDPVRPEV 668
Cdd:cd07551    394 ---------GKPGFFGEVGIPSEAAALAAELESEGKTVVYVARDD-------------------QVVGLIALMDTPRPEA 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  669 PEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKIWPKLRvlarssP 748
Cdd:cd07551    446 KEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI-------------------------------DEVVANLL------P 488
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  749 TDKhtlVKgIIDSTHTEQRQVvAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYD 828
Cdd:cd07551    489 EDK---VA-IIRELQQEYGTV-AMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRR 562
                          650       660
                   ....*....|....*....|...
gi 1237125288  829 SISKFLQFQLTVNVVAVIVAFTG 851
Cdd:cd07551    563 IIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
157-927 2.38e-31

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 132.76  E-value: 2.38e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  157 ILLSVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY-GDLLPADGLFIQGNDLk 235
Cdd:cd07542     58 VIISVISIFLSL----YETRKQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCI- 132
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  236 IDESSLTGESDQVRKSVDKDP-----------------MLLSGTHVME--GSGRMLVTAVGVnsQTGIIftllgaggeee 296
Cdd:cd07542    133 VNESMLTGESVPVTKTPLPDEsndslwsiysiedhskhTLFCGTKVIQtrAYEGKPVLAVVV--RTGFN----------- 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  297 ekkdkkakqqdgaaamemqplkSAEGgdadDRKKASMHKKEKSVlqgKLTK-----LAVQIGKAGLVMsAITVIILVLYF 371
Cdd:cd07542    200 ----------------------TTKG----QLVRSILYPKPVDF---KFYRdsmkfILFLAIIALIGF-IYTLIILILNG 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  372 TvdtfvvnkkpwlpectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNA 448
Cdd:cd07542    250 E---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINIC 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  449 TAI---CSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILppekegalpRQVGNKte 525
Cdd:cd07542    303 GKInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSL---------TLIDGE-- 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  526 cgLLGFVLDLKQ------DYEPVRSqmpeeklykvYTFNSVRKSMSTVIKLP-DESFRMYSKGASEIVLKKCckilngag 598
Cdd:cd07542    372 --LVGDPLDLKMfeftgwSLEILRQ----------FPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLC-------- 431
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  599 EPRVFrPRDRDEMVKKviepMACDGLRTICVAYRDFPSSPEPDWDNENDIL-NELTCICVVGIEDPVRPEVPEAIRKCQR 677
Cdd:cd07542    432 KPETV-PSNFQEVLNE----YTKQGFRVIALAYKALESKTWLLQKLSREEVeSDLEFLGLIVMENRLKPETAPVINELNR 506
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  678 AGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEfnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKG 757
Cdd:cd07542    507 ANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVK-------PEDDDSASLTWTLLLKGTVFARMSPDQKSELVEE 579
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  758 I--IDSThteqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVakeASDIILTDDNFSSIVKAVMWGRNVYD---SISK 832
Cdd:cd07542    580 LqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPTVIKEGRAALVtsfSCFK 649
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  833 FLqfqltvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKNI 910
Cdd:cd07542    650 YM-------ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVSPPVLVSL 719
                          810
                   ....*....|....*..
gi 1237125288  911 LGHAVYQLALIFTLLFV 927
Cdd:cd07542    720 LGQIVLILLFQVIGFLI 736
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
190-851 2.42e-30

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 128.21  E-value: 2.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSg 269
Cdd:cd07544    110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKR--------PGDRVMSGA- 179
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  270 rmlvtavgVNsqtgiiftllgaggeeeekkdkkakqqdGAAAMEMQPLKSAeggdADDRKK---ASMHKKEKSvlQGKLT 346
Cdd:cd07544    180 --------VN----------------------------GDSALTMVATKLA----ADSQYAgivRLVKEAQAN--PAPFV 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  347 KLAVQIGkaglvmsaitviilvLYFTVDTFVVNKKPWLPECTPVYVqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:cd07544    218 RLADRYA---------------VPFTLLALAIAGVAWAVSGDPVRF----------AAVLVVATPCPLILAAPVAIVSGM 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeIPDPssiNTKTMELL------------I 494
Cdd:cd07544    273 SRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDV---------VPAP---GVDADEVLrlaasveqysshV 340
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  495 NAIAINSAYTTKILPPekegALPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVYTFNSVRKSMSTviklpDES 574
Cdd:cd07544    341 LARAIVAAARERELQL----SAVTELTEVPGAGVTGTV---------------DGHEVKVGKLKFVLARGAW-----APD 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  575 FRMYSKGASEIVLkkcckilngageprvfrprdrdemvkkviepmACDGlrTICVAYRdfpsspepdwdnendilneltc 654
Cdd:cd07544    397 IRNRPLGGTAVYV--------------------------------SVDG--KYAGAIT---------------------- 420
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  655 icvvgIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeri 733
Cdd:cd07544    421 -----LRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGIDE----------------------------- 466
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  734 dkiwpklrVLARSSPTDKHTLVKgiidsTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNF 813
Cdd:cd07544    467 --------VRAELLPEDKLAAVK-----EAPKAGPTIMV-GDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDL 532
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 1237125288  814 SSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 851
Cdd:cd07544    533 DRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1081-1127 1.16e-26

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 103.25  E-value: 1.16e-26
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1237125288 1081 GQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPE 1127
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
160-800 2.80e-26

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 116.54  E-value: 2.80e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  160 SVICVVLVTAFND---WSKEKQFRGLQSRIEQEQKFTVVRAG-QVVQIPVAEIVVGDIAQVKY-GDLLPADGLFIQGNdL 234
Cdd:cd02082     53 AITVVFMTTINSLsciYIRGVMQKELKDACLNNTSVIVQRHGyQEITIASNMIVPGDIVLIKRrEVTLPCDCVLLEGS-C 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  235 KIDESSLTGESDQVRKSVDKDPMllsgthvmegsgrmlVTAVGVNSQTGIIFTLLGaggeeeekkdkkakqqdGAAAMEM 314
Cdd:cd02082    132 IVTEAMLTGESVPIGKCQIPTDS---------------HDDVLFKYESSKSHTLFQ-----------------GTQVMQI 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  315 QPLksaeggdADDRKKASMHKKEKSVLQGKLTKlAVQIGKA---GLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVY 391
Cdd:cd02082    180 IPP-------EDDILKAIVVRTGFGTSKGQLIR-AILYPKPfnkKFQQQAVKFTLLLATLALIGFLYTLIRLLDIELPPL 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  392 vqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYV 471
Cdd:cd02082    252 -----FIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQ 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  472 GDVHYKEIPDPSSINTKTMELLINAIAINSAyTTKIlppekEGALprqVGNKTECGLLGFV-LDLKQDYE----PVRSQM 546
Cdd:cd02082    326 LKGQNQTFDPIQCQDPNNISIEHKLFAICHS-LTKI-----NGKL---LGDPLDVKMAEAStWDLDYDHEakqhYSKSGT 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  547 PEEKLYKVYTFNSVRKSMSTV---IKLPDESFRMYS--KGASEIVLKKCCKIlngageprvfrPRDRdemvKKVIEPMAC 621
Cdd:cd02082    397 KRFYIIQVFQFHSALQRMSVVakeVDMITKDFKHYAfiKGAPEKIQSLFSHV-----------PSDE----KAQLSTLIN 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  622 DGLRTICVAYRDFPSSPEPDWDN--ENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIK 699
Cdd:cd02082    462 EGYRVLALGYKELPQSEIDAFLDlsREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQE 541
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  700 CGIIHPGEDFLCLEGkefnrrIRNEKGEIEQERIDKIwPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTND 779
Cdd:cd02082    542 LEIINRKNPTIIIHL------LIPEIQKDNSTQWILI-IHTNVFARTAPEQKQTIIRLL-----KESDYIVCMCGDGAND 609
                          650       660
                   ....*....|....*....|.
gi 1237125288  780 GPALKKADVGFAMGIAGTDVA 800
Cdd:cd02082    610 CGALKEADVGISLAEADASFA 630
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
193-882 1.48e-24

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 110.19  E-value: 1.48e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSgrml 272
Cdd:cd07546    102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKA--------AGDKVFAGS---- 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  273 vtavgVNSqtgiiftllgaggeeeekkdkkakqqDGAAAMEmqpLKSAEGGDADDRKKASMHKKE--KSVLQGKLTKLAV 350
Cdd:cd07546    169 -----INV--------------------------DGVLRIR---VTSAPGDNAIDRILHLIEEAEerRAPIERFIDRFSR 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  351 QIGKAGLVMSAITVIILVLYFTVDTfvvnkKPWLPEctpvyvqyfvkffiiGVTVLVVAVPEGL----PLAVTISLAYSV 426
Cdd:cd07546    215 WYTPAIMAVALLVIVVPPLLFGADW-----QTWIYR---------------GLALLLIGCPCALvistPAAITSGLAAAA 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  427 KKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSsintktmELLINAIAINSAYT-- 504
Cdd:cd07546    275 RRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVT-----DVVPLTGISEA-------ELLALAAAVEMGSShp 338
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  505 --TKILP-PEKEGALPRQVGNKTecGLLGFVLDLKQDYEPVRsqmpeeklykvytfnsvrksmstviklpdesfrmyskg 581
Cdd:cd07546    339 laQAIVArAQAAGLTIPPAEEAR--ALVGRGIEGQVDGERVL-------------------------------------- 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  582 aseivlkkcckilngAGEPRVFRPRDRDEmVKKVIEPMACDGlRTICVAYRdfpsspepdwdnENDILNeltcicVVGIE 661
Cdd:cd07546    379 ---------------IGAPKFAADRGTLE-VQGRIAALEQAG-KTVVVVLA------------NGRVLG------LIALR 423
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  662 DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirneKGEIeqeridkiwpklr 741
Cdd:cd07546    424 DELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-----DF---------------RAGL------------- 470
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  742 vlarsSPTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVM 821
Cdd:cd07546    471 -----LPEDK---VKAV---RELAQHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIE 538
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1237125288  822 WGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQdsplkavqmLWVNLIMDTFASlALAT 882
Cdd:cd07546    539 LSRATLANIRQNITIALGLKAVFLVTTLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
189-847 4.46e-24

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 109.61  E-value: 4.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  189 EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK----IDESSLTGESD-QVRKSVDKDPMLLSGTH 263
Cdd:cd07536     82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  264 VMEGSGrmLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGgdaddrkkasmhkkeKSVLQG 343
Cdd:cd07536    162 LMKISA--YVECQKPQMDIHSFEGNFTLEDSDPPIHESLSIENTLLRASTLRNTGWVIG---------------VVVYTG 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  344 KLTKLAVQIGKAGLVMS-----------AITVIILVLYFTVDTFVVNKKPWLPEcTPVYVQY----FVKFFIIGVTVLVV 408
Cdd:cd07536    225 KETKLVMNTSNAKNKVGlldlelnrltkALFLALVVLSLVMVTLQGFWGPWYGE-KNWYIKKmdttSDNFGRNLLRFLLL 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  409 ---AVPEGLPLAVTISLAYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVH 475
Cdd:cd07536    304 fsyIIPISLRVNLDMVKAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCHIGGVS 383
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  476 YKeipdpssintktmellinaiainsayttkilppekegalprqvGNKTECGLLgfvldlkqdyepvrsqmpeeklyKVY 555
Cdd:cd07536    384 YG-------------------------------------------GQVLSFCIL-----------------------QLL 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  556 TFNSVRKSMSTVIKLPDES-FRMYSKGASEIVLkkcckilngagePRVfRPRDRDEMVKKVIEPMACDGLRTICVAYRDF 634
Cdd:cd07536    398 EFTSDRKRMSVIVRDESTGeITLYMKGADVAIS------------PIV-SKDSYMEQYNDWLEEECGEGLRTLCVAKKAL 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  635 PSSPEPDW------------DNE-------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARA 695
Cdd:cd07536    465 TENEYQEWesryteaslslhDRSlrvaevvESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAIC 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  696 IAIKCGIIHP-------------GED-----FLCLEGKEFNRR------IRNEKGEI-----EQERID-KIWPKLRVLAR 745
Cdd:cd07536    545 IAKSCHLVSRtqdihllrqdtsrGERaaitqHAHLELNAFRRKhdvalvIDGDSLEValkyyRHEFVElACQCPAVICCR 624
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  746 SSPTDKHTLVKgiIDSTHTEQRQVvaVTGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFSSIVKAVM-W 822
Cdd:cd07536    625 VSPTQKARIVT--LLKQHTGRRTL--AIGDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT--QFRHLGRLLLvH 696
                          730       740
                   ....*....|....*....|....*
gi 1237125288  823 GRNVYDSISKFLQFQLTVNVVAVIV 847
Cdd:cd07536    697 GRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
193-792 6.26e-23

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 105.93  E-value: 6.26e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVRAGQVVQIPVAEIVVGDIAQVKYG---DLLPADGLFIQGNDLkIDESSLTGES-DQVRKSVDkdpmLLSGTHVMEGS 268
Cdd:cd07543     89 QVYRDGKWVPISSDELLPGDLVSIGRSaedNLVPCDLLLLRGSCI-VNEAMLTGESvPLMKEPIE----DRDPEDVLDDD 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  269 GRmlvtavgvnSQTGIIFTllgaggeeeekkdkkakqqdGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTK- 347
Cdd:cd07543    164 GD---------DKLHVLFG--------------------GTKVVQHTPPGKGGLKPPDGGCLAYVLRTGFETSQGKLLRt 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  348 --LAVQIGKAGLVMSAITVIILVLYFTVDTFVVnkkpWLPECTPVYVQYfvKFFIIGVTVLVVAVPEGLP----LAVTIS 421
Cdd:cd07543    215 ilFSTERVTANNLETFIFILFLLVFAIAAAAYV----WIEGTKDGRSRY--KLFLECTLILTSVVPPELPmelsLAVNTS 288
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  422 LAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtVVQAYVGDVHYKE-IPDPSSINTKTmellIN 495
Cdd:cd07543    289 LIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VVEGVAGLNDGKEvIPVSSIEPVET----IL 354
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  496 AIAinSAYTtkiLPPEKEGALprqVGNKTECGLLGFV---LDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTV--IKL 570
Cdd:cd07543    355 VLA--SCHS---LVKLDDGKL---VGDPLEKATLEAVdwtLTKDEKVFPRSKKTKGLKIIQRFHFSSALKRMSVVasYKD 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  571 P---DESFRMYSKGASEIV---LKKCckilngageprvfrPRDRDEMVKKviepMACDGLRTICVAYRDFPS---SPEPD 641
Cdd:cd07543    427 PgstDLKYIVAVKGAPETLksmLSDV--------------PADYDEVYKE----YTRQGSRVLALGYKELGHltkQQARD 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  642 WDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkeFNRRI 721
Cdd:cd07543    489 YKRE-DVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGIV-------------DKPVL 554
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1237125288  722 RNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVkgiidSTHTEQRQVVAVTGDGTNDGPALKKADVGFAM 792
Cdd:cd07543    555 ILILSEEGKSNEWKLIPHVKVFARVAPKQKEFII-----TTLKELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
198-824 1.20e-19

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 95.02  E-value: 1.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  198 GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQV-RKSVDKDPMLLSGTHVMEGSGRMLVTAv 276
Cdd:cd02078    104 GKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPViRESGGDRSSVTGGTKVLSDRIKVRITA- 181
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  277 gvnsQTGIIFTllgaggeeeekkdkkakqqDGAAAMemqplksAEGGDaddRKKASmhkkeksvlqgklTKLAVQIGKAG 356
Cdd:cd02078    182 ----NPGETFL-------------------DRMIAL-------VEGAS---RQKTP-------------NEIALTILLVG 215
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  357 LvmSAITVIILVLYFTVDTFVVNKkpwlpectpvyvqyfvkffiIGVTVLV---VA-VPE---GLPLAVTISlaySVKKM 429
Cdd:cd02078    216 L--TLIFLIVVATLPPFAEYSGAP--------------------VSVTVLVallVClIPTtigGLLSAIGIA---GMDRL 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  430 MKDNNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqayvgdvhyKEIPdpssINTKTMELLINAIAINSAYTTKil 508
Cdd:cd02078    271 LRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQAT----------EFIP----VGGVDEKELADAAQLASLADET-- 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  509 ppeKEG----ALPRQVGNKTecgllgfvldlkqdYEPVRSQmpeeklYKVYTFnSVRKSMSTViKLPDEsfRMYSKGASE 584
Cdd:cd02078    335 ---PEGrsivILAKQLGGTE--------------RDLDLSG------AEFIPF-SAETRMSGV-DLPDG--TEIRKGAVD 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  585 IVLKKcckILNGAGEPrvfrPRDRDEMVKKVIE----PMAcdglrtICVAYRdfpsspepdwdnendILNeltcicVVGI 660
Cdd:cd02078    388 AIRKY---VRSLGGSI----PEELEAIVEEISKqggtPLV------VAEDDR---------------VLG------VIYL 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  661 EDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridkiwpkl 740
Cdd:cd02078    434 KDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL------------------------------ 479
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  741 rvlARSSPTDKHTLVKgiidsthTEQRQ--VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVK 818
Cdd:cd02078    480 ---AEAKPEDKLELIR-------KEQAKgkLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKLIE 548

                   ....*.
gi 1237125288  819 AVMWGR 824
Cdd:cd02078    549 VVEIGK 554
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
497-593 1.28e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 84.58  E-value: 1.28e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  497 IAINSAyttkILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDES-F 575
Cdd:pfam13246    1 ALCNSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLPDDGkY 73
                           90
                   ....*....|....*...
gi 1237125288  576 RMYSKGASEIVLKKCCKI 593
Cdd:pfam13246   74 RLFVKGAPEIILDRCTTI 91
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
164-836 1.85e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 94.40  E-value: 1.85e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  164 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTVVraGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGND------ 233
Cdd:cd07541     58 VLAVTmakeAVDDIR-----RRRRDKEQNYEKLTVR--GETVEIPSSDIKVGDLIIVEKNQRIPADMVLLRTSEksgscf 130
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  234 LKIDEssLTGESD-QVRKSVDKDPMLLSGTHVMEgsgrmlVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGA--- 309
Cdd:cd07541    131 IRTDQ--LDGETDwKLRIAVPCTQKLPEEGILNS------ISAVYAEAPQKDIHSFYGTFTINDDPTSESLSVENTLwan 202
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  310 ---AAMEMQPLKSAEGGDAddrkKASMHKKEKSVLQGKLTKlavQIGKAGLVMSAITVIILVLYFTVDTFvvnKKPWLpe 386
Cdd:cd07541    203 tvvASGTVIGVVVYTGKET----RSVMNTSQPKNKVGLLDL---EINFLTKILFCAVLALSIVMVALQGF---QGPWY-- 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  387 ctpVYVQYFVKFF--IIGVTvlvvavpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGT 458
Cdd:cd07541    271 ---IYLFRFLILFssIIPIS-----------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGT 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  459 LTTNRMTVVQAYVGDVHYkeipdpsSINTKTMELLinaiainsayttkilppekegalprqvgnktecgllgfvldlkqd 538
Cdd:cd07541    337 LTQNEMVFKKLHLGTVSY-------GGQNLNYEIL--------------------------------------------- 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  539 yepvrsqmpeeklyKVYTFNSVRKSMSTVIKLP-DESFRMYSKGAseivlkkcckilngageprvfrprdrDEMVKKVIE 617
Cdd:cd07541    365 --------------QIFPFTSESKRMGIIVREEkTGEITFYMKGA--------------------------DVVMSKIVQ 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  618 P----------MACDGLRTICVAYRDFPSSPEPDWDNEND-------------------ILNELTCICVVGIEDPVRPEV 668
Cdd:cd07541    405 YndwleeecgnMAREGLRTLVVAKKKLSEEEYQAFEKRYNaaklsihdrdlkvaevvesLERELELLCLTGVEDKLQEDV 484
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  669 PEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI------IH-------PGEDFLCLEgkeFNRRIRNEK---------- 725
Cdd:cd07541    485 KPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLvsrgqyIHvfrkvttREEAHLELN---NLRRKHDCAlvidgeslev 561
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  726 --GEIEQERIDKIWPKLRVLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKE 802
Cdd:cd07541    562 clKYYEHEFIELACQLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQ 634
                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 1237125288  803 AS---DIILTDdnFSSIVKAVMW-GRNVYDSISKFLQF 836
Cdd:cd07541    635 ASlaaDFSITQ--FSHIGRLLLWhGRNSYKRSAKLAQF 670
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
194-862 4.94e-17

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 86.26  E-value: 4.94e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRksVDKDPMLLSGTHVMEGSGRMLV 273
Cdd:cd02092    131 LQADGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVT--VAPGDLVQAGAMNLSGPLRLRA 207
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  274 TAVGVNsqtgiifTLLgaggeeeekkdkkakqQDGAAAMEMqplksAEGGDAddrkkasmhkkeksvlqgKLTKLAVQIg 353
Cdd:cd02092    208 TAAGDD-------TLL----------------AEIARLMEA-----AEQGRS------------------RYVRLADRA- 240
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  354 kAGLVMSAITVIILVlyftvdTFVVnkkpWLPECTPVYVQyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:cd02092    241 -ARLYAPVVHLLALL------TFVG----WVAAGGDWRHA-----LLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRG 304
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipdpSSINTKTMELLiNAIAINSAYTTKILPPEKE 513
Cdd:cd02092    305 VLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGA-------------HAISADLLALA-AALAQASRHPLSRALAAAA 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  514 GALPRQVGNKTE---CGLLGFVLDLkqdyePVRSQMPEeklykvytFNSVRKSMSTviklpdesfrmyskgASEIVLKKc 590
Cdd:cd02092    371 GARPVELDDAREvpgRGVEGRIDGA-----RVRLGRPA--------WLGASAGVST---------------ASELALSK- 421
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  591 ckilnGAGEPRVFRprdrdemvkkviepmacdglrticvayrdfpsspepdwdnendilneltcicvvgIEDPVRPEVPE 670
Cdd:cd02092    422 -----GGEEAARFP-------------------------------------------------------FEDRPRPDARE 441
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  671 AIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTD 750
Cdd:cd02092    442 AISALRALGLSVEILSGDREPAVRALARALGIED-------------------------------------WRAGLTPAE 484
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  751 KHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 830
Cdd:cd02092    485 KVARIEEL-----KAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPVPEAIEIARRARRLI 558
                          650       660       670
                   ....*....|....*....|....*....|..
gi 1237125288  831 SKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 862
Cdd:cd02092    559 RQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
197-852 1.43e-16

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 84.93  E-value: 1.43e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  197 AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQVRKSVDKD-PMLLSGTHVMEGsgrMLVTA 275
Cdd:TIGR01497  113 DGAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIKESGGDfASVTGGTRILSD---WLVVE 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  276 VGVNSQTGIIftllgaggeeeekkdkkakqqDGAAAMemqplksAEGGDaddRKKASmhkkeksvlqgklTKLAVQIgka 355
Cdd:TIGR01497  189 CTANPGETFL---------------------DRMIAL-------VEGAQ---RRKTP-------------NEIALTI--- 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  356 glVMSAITVIILVLYFTVDTFVVnkkpWLPECTPVYVQyfvkffiigVTVLVVAVPE---GLPLAVTISlaySVKKMMKD 432
Cdd:TIGR01497  222 --LLIALTLVFLLVTATLWPFAA----YGGNAISVTVL---------VALLVCLIPTtigGLLSAIGIA---GMDRVLGF 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  433 NNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqayvgdvhyKEIPdpssINTKTMELLINAIAINSAYTTKilpPE 511
Cdd:TIGR01497  284 NVIATSGRAVEACGDVDTLLLDKTGTITLgNRLAS----------EFIP----AQGVDEKTLADAAQLASLADDT---PE 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  512 KEGALprqvgnktecgLLGFVLDLKQDYEPVRSQMPEEklykvytfNSVRKSMSTvIKLPDEsfRMYSKGASEiVLKKCC 591
Cdd:TIGR01497  347 GKSIV-----------ILAKQLGIREDDVQSLHATFVE--------FTAQTRMSG-INLDNG--RMIRKGAVD-AIKRHV 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  592 KILNGageprVFrPRDRDEMVKKVIE----PMAcdglrtICVayrdfpsspepdwdnENDILNeltcicVVGIEDPVRPE 667
Cdd:TIGR01497  404 EANGG-----HI-PTDLDQAVDQVARqggtPLV------VCE---------------DNRIYG------VIYLKDIVKGG 450
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  668 VPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridkiwpklrvlARSS 747
Cdd:TIGR01497  451 IKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI---------------------------------AEAT 493
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  748 PTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVY 827
Cdd:TIGR01497  494 PEDKIALIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKLIEVVHIGKQLL 567
                          650       660
                   ....*....|....*....|....*....
gi 1237125288  828 DSISKFLQFQLTVNVV---AVI-VAFTGA 852
Cdd:TIGR01497  568 ITRGALTTFSIANDVAkyfAIIpAIFAAA 596
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
660-824 1.74e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 84.59  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  660 IEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKIWP 738
Cdd:cd07548    426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  739 KLrvlarsSPTDKHTLVKGIIDsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 818
Cdd:cd07548    475 EL------LPEDKVEKVEELKA----ESKGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                   ....*.
gi 1237125288  819 AVMWGR 824
Cdd:cd07548    545 AIKIAR 550
copA PRK10671
copper-exporting P-type ATPase CopA;
194-820 7.57e-16

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 82.87  E-value: 7.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSgrMLV 273
Cdd:PRK10671   327 VVTDEGEKSVPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGEGDS--VHAGTVVQDGS--VLF 401
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  274 TAVGVNSQTG---IIftllgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrkkasmhkkeKSVLQGKLTKlaV 350
Cdd:PRK10671   402 RASAVGSHTTlsrII----------------------------------------------------RMVRQAQSSK--P 427
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  351 QIGKAGLVMSAI---TVIILVLYFTVDTFVVNKKPWLpectpVYVqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVK 427
Cdd:PRK10671   428 EIGQLADKISAVfvpVVVVIALVSAAIWYFFGPAPQI-----VYT------LVIATTVLIIACPCALGLATPMSIISGVG 496
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  428 KMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgdvhykEIPDPSSINTKTMELLINAIAINSAY--TT 505
Cdd:PRK10671   497 RAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVV----------AVKTFNGVDEAQALRLAAALEQGSSHplAR 566
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  506 KILPPEKEGALPRQVGNKTECGLlgfvlDLKQDYEPVRSQMPEEKLYKVYTFNSvrKSMSTVIKlpdesfRMYSKGASEI 585
Cdd:PRK10671   567 AILDKAGDMTLPQVNGFRTLRGL-----GVSGEAEGHALLLGNQALLNEQQVDT--KALEAEIT------AQASQGATPV 633
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  586 VLkkcckilngageprvfrprdrdemvkkviepmACDGlrticvayrdfpsspepdwdnendilnelTCICVVGIEDPVR 665
Cdd:PRK10671   634 LL--------------------------------AVDG-----------------------------KAAALLAIRDPLR 652
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  666 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklRVLAR 745
Cdd:PRK10671   653 SDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGID-------------------------------------EVIAG 695
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237125288  746 SSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 820
Cdd:PRK10671   696 VLPDGKAEAIKRL-----QSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGVADAL 764
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
193-809 2.65e-14

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 77.73  E-value: 2.65e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKIDESSLTGESDQVRKsvdkdpmlLSGTHVMEGSgrml 272
Cdd:PRK11033   246 TRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVER--------ATGEKVPAGA---- 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  273 vTAVgvnsqtgiiftllgaggeeeekkdkkakqqDGAAAMEmqpLKSAEGGDADDRkkaSMHKKE-----KSVLQGKLTK 347
Cdd:PRK11033   313 -TSV------------------------------DRLVTLE---VLSEPGASAIDR---ILHLIEeaeerRAPIERFIDR 355
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  348 LAVQIGKAGLVMSAITVIILVLYFTvdtfvvnkKPWLPEctpVYVqyfvkffiiGVTVLVVAVPEGL----PLAVTISLA 423
Cdd:PRK11033   356 FSRIYTPAIMLVALLVILVPPLLFA--------APWQEW---IYR---------GLTLLLIGCPCALvistPAAITSGLA 415
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  424 YSVKKmmkdNNLVRHLDACETMGNATAICSDKTGTLT--TNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIaINS 501
Cdd:PRK11033   416 AAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTegKPQVTDIHPATGISESELLALAAAVEQGSTHPLAQAI-VRE 490
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  502 AYTTKILPPEKEgALPRQVGNktecGLLGFVldlkqdyepvrsqmpEEKLYKVYtfnsvrkSMSTVIKLPDEsfrmyskG 581
Cdd:PRK11033   491 AQVRGLAIPEAE-SQRALAGS----GIEGQV---------------NGERVLIC-------APGKLPPLADA-------F 536
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  582 ASEIVLkkcckiLNGAGEprvfrprdrdemvkkviepmacdglrTICVAYRDFpsspepdwdnendilnelTCICVVGIE 661
Cdd:PRK11033   537 AGQINE------LESAGK--------------------------TVVLVLRND------------------DVLGLIALQ 566
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  662 DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirnekgeieqeridkiwpklr 741
Cdd:PRK11033   567 DTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF-------------------------------- 609
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  742 vlaRSS--PTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 809
Cdd:PRK11033   610 ---RAGllPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
205-862 6.82e-14

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 76.01  E-value: 6.82e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  205 VAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQVrkSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGI 284
Cdd:cd07553    143 ADQIKSGDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPR--IVERGDKVPAGTSLENQAFEIRVEHSLAESWSGS 219
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  285 IftllgaggeeeekkdkkakqqdgaaameMQPLKSAEggdaddrkkasmHKKEKSVLqgkLTKlavqigKAGLVMSAITV 364
Cdd:cd07553    220 I----------------------------LQKVEAQE------------ARKTPRDL---LAD------KIIHYFTVIAL 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  365 IILVLYFTVdtfvvnkkpWLPECTPVYVQYFVkffiigvTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACET 444
Cdd:cd07553    251 LIAVAGFGV---------WLAIDLSIALKVFT-------SVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLER 314
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  445 MGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipDPSSINTKtmellinaiAINSAYTTkilppekegalprqvgnkt 524
Cdd:cd07553    315 LSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGIDRL---------ALRAISAI------------------- 355
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  525 ecgllgfvldLKQDYEPVrSQMPEEKLYKVytfNSVRKSMSTVIKLPDESFRMYSKGaSEIVLKKCCkilngageprvfr 604
Cdd:cd07553    356 ----------EAHSRHPI-SRAIREHLMAK---GLIKAGASELVEIVGKGVSGNSSG-SLWKLGSAP------------- 407
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  605 prdrdemvkkviepMACDGLRTICVAYRDfpsspepdwdnendilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRM 684
Cdd:cd07553    408 --------------DACGIQESGVVIARD------------------GRQLLDLSFNDLLRPDSNREIEELKKGGLSIAI 455
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  685 VTGDNINTARAIAikcgiihpgeDFLCLEGKEfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsthT 764
Cdd:cd07553    456 LSGDNEEKVRLVG----------DSLGLDPRQ-------------------------LFGNLSPEEKLAWIE-------S 493
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  765 EQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVA 844
Cdd:cd07553    494 HSPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVA 572
                          650
                   ....*....|....*...
gi 1237125288  845 VIVAFTGACitqdSPLKA 862
Cdd:cd07553    573 IGLALSGWI----SPLVA 586
PLN03190 PLN03190
aminophospholipid translocase; Provisional
399-696 3.81e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 67.62  E-value: 3.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  399 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 465
Cdd:PLN03190   394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  466 VVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILP---------PEKEGA----------------LPRQV 520
Cdd:PLN03190   471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPqllelsksgKDTEEAkhvhdfflalaacntiVPIVV 550
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  521 GNKTE---------------------CGLLGFVLDLKQDYEPVRSQMPEEKLYKV---YTFNSVRKSMSTVIKLPDESFR 576
Cdd:PLN03190   551 DDTSDptvklmdyqgespdeqalvyaAAAYGFMLIERTSGHIVIDIHGERQRFNVlglHEFDSDRKRMSVILGCPDKTVK 630
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  577 MYSKGASEIVLKKCCKILNgagePRVFRPrdrdemVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE----------- 645
Cdd:PLN03190   631 VFVKGADTSMFSVIDRSLN----MNVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSfeaastaligr 700
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1237125288  646 --------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 696
Cdd:PLN03190   701 aallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
657-842 1.02e-09

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 62.80  E-value: 1.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  657 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridki 736
Cdd:PRK14010   435 VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------------------- 481
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  737 wpklRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 816
Cdd:PRK14010   482 ----RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAANLIDLDSNPTKL 551
                          170       180
                   ....*....|....*....|....*.
gi 1237125288  817 VKAVMWGRNVYDSISKFLQFQLTVNV 842
Cdd:PRK14010   552 MEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
648-787 5.42e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.13  E-value: 5.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  648 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFnrrirnekge 727
Cdd:pfam00702   83 VLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV---------- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  728 ieqeridkiwpklrvlARSSPTDKHTLVKGIIDSTHteqrQVVAVtGDGTNDGPALKKAD 787
Cdd:pfam00702  153 ----------------GKPKPEIYLAALERLGVKPE----EVLMV-GDGVNDIPAAKAAG 191
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
50-112 6.19e-07

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 47.94  E-value: 6.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237125288   50 YGDTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILE 112
Cdd:pfam00690    3 ALSVEEVLKKLGTDLEKGL--TEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILL 63
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
666-812 4.41e-06

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 48.59  E-value: 4.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  666 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPgedFLCLEGKEfnrrIRNEKGE------IEQERIDKIWPK 739
Cdd:COG0561     22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEvlyerpLDPEDVREILEL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  740 LR-------VLARSSPT---------DKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEA 803
Cdd:COG0561     95 LRehglhlqVVVRSGPGfleilpkgvSKGSALKKLAERLGIPPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEVKAA 172

                   ....*....
gi 1237125288  804 SDIIlTDDN 812
Cdd:COG0561    173 ADYV-TGSN 180
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
721-819 8.55e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 42.61  E-value: 8.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237125288  721 IRNEKGEIEQ--ERIDKIWPKLRVLARSSP---------TDKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVG 789
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 1237125288  790 FAMGIAgTDVAKEASDIILTDDNFSSIVKA 819
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
770-812 9.81e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.26  E-value: 9.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1237125288  770 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 812
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
751-822 9.53e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 38.74  E-value: 9.53e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237125288  751 KHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVaKEASDIIlTDDNFSS-IVKAVMW 822
Cdd:cd07517    142 KAKGIQKVIEHLGIKKEETMAF-GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYV-TKDVDEDgILKALKH 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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