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Conserved domains on  [gi|1215897544|ref|NP_001340462|]
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zinc finger protein 532 isoform c [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13676732)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 1142-1168 5.66e-11

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


:

Pssm-ID: 465205  Cd Length: 27  Bit Score: 58.21  E-value: 5.66e-11
                           10        20
                   ....*....|....*....|....*..
gi 1215897544 1142 SSYQCRECGLCYTSHVSLSRHLFIVHK 1168
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 308-613 1.60e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.19  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  308 PRAADKSPESQNLIDGTKKPS---LKQPDSPRSI-SSENSSKGSPSSPAGSTPAipkvriktikTSSGEIKRTVTRVLPE 383
Cdd:pfam17823   48 PRADNKSSEQ*NFCAATAAPApvtLTKGTSAAHLnSTEVTAEHTPHGTDLSEPA----------TREGAADGAASRALAA 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  384 VDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSP----PRAPLQSAVVTNAVSPAELT-----------------PKQ 442
Cdd:pfam17823  118 AASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANasaaPRAAIAAASAPHAASPAPRTaassttaassttaassaPTT 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  443 VTIKPVATaFLPVSAVKTAGSQVINLKLA-------NNTTVKATVISAASVQSASSAIIKAANAiqqQTVVVPASS---- 511
Cdd:pfam17823  198 AASSAPAT-LTPARGISTAATATGHPAAGtalaavgNSSPAAGTVTAAVGTVTPAALATLAAAA---GTVASAAGTinmg 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  512 ------LANAKLVPkTVHLANLNLLPQGAQATSELRQVLTkpqqqiKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFN 585
Cdd:pfam17823  274 dpharrLSPAKHMP-SDTMARNPAAPMGAQAQGPIIQVST------DQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLA 346

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1215897544  586 KVLS--------SVNPVPVYIPNLSPPANAgiTLPT 613
Cdd:pfam17823  347 VVTTtkaqakepSASPVPVLHTSMIPEVEA--TSPT 380
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1206-1227 3.49e-03

C2H2-type zinc finger;


:

Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.07  E-value: 3.49e-03
                           10        20
                   ....*....|....*....|..
gi 1215897544 1206 KCKVCAKTFETEAALNTHMRTH 1227
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-RING_7 pfam02591
C4-type zinc ribbon domain; Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively ...
 784-819 5.33e-03

C4-type zinc ribbon domain; Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively charged amino acid residues. This C-terminal Zn-ribbon domain consists of two beta-strands acting as a scaffold for the two Zn knuckles. Both pairs of cysteines making up the two Zn knuckles are situated at highly conserved sharp beta-turns, an arrangement that facilitates the tetrahedral coordination of the divalent Zn ion. The two Zn-knuckle cysteine motifs are separated by 20 residues, 9 of which form an alpha-helix (helix 4).Structural modelling suggests this domain may bind nucleic acids. The domain appears to bind flaA-mRNA, thus contributing to flagellum formation and motility.


:

Pssm-ID: 426857 [Multi-domain]  Cd Length: 33  Bit Score: 35.57  E-value: 5.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1215897544  784 TCTICQMLLPNQcsyaSHQRIHQHKSPYTCPECGAI 819
Cdd:pfam02591    1 RCGGCRMELPPQ----LLNEIRAAAEIVRCPECGRI 32
transpos_ISL3 super family cl41316
ISL3 family transposase;
810-859 8.84e-03

ISL3 family transposase;


The actual alignment was detected with superfamily member NF033550:

Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.88  E-value: 8.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215897544  810 PYTCPECGAICRSVHFqthvtknclHYTRRV------GFRII-------YKCSMCDTVFTLQT 859
Cdd:NF033550    10 DATCPECGKPSRRVHD---------TGKRRIrhlpifGRPVYlelrvrrFKCPECGKTFTEEL 63
 
Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 1142-1168 5.66e-11

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


Pssm-ID: 465205  Cd Length: 27  Bit Score: 58.21  E-value: 5.66e-11
                           10        20
                   ....*....|....*....|....*..
gi 1215897544 1142 SSYQCRECGLCYTSHVSLSRHLFIVHK 1168
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 308-613 1.60e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.19  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  308 PRAADKSPESQNLIDGTKKPS---LKQPDSPRSI-SSENSSKGSPSSPAGSTPAipkvriktikTSSGEIKRTVTRVLPE 383
Cdd:pfam17823   48 PRADNKSSEQ*NFCAATAAPApvtLTKGTSAAHLnSTEVTAEHTPHGTDLSEPA----------TREGAADGAASRALAA 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  384 VDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSP----PRAPLQSAVVTNAVSPAELT-----------------PKQ 442
Cdd:pfam17823  118 AASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANasaaPRAAIAAASAPHAASPAPRTaassttaassttaassaPTT 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  443 VTIKPVATaFLPVSAVKTAGSQVINLKLA-------NNTTVKATVISAASVQSASSAIIKAANAiqqQTVVVPASS---- 511
Cdd:pfam17823  198 AASSAPAT-LTPARGISTAATATGHPAAGtalaavgNSSPAAGTVTAAVGTVTPAALATLAAAA---GTVASAAGTinmg 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  512 ------LANAKLVPkTVHLANLNLLPQGAQATSELRQVLTkpqqqiKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFN 585
Cdd:pfam17823  274 dpharrLSPAKHMP-SDTMARNPAAPMGAQAQGPIIQVST------DQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLA 346

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1215897544  586 KVLS--------SVNPVPVYIPNLSPPANAgiTLPT 613
Cdd:pfam17823  347 VVTTtkaqakepSASPVPVLHTSMIPEVEA--TSPT 380
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1206-1227 3.49e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.07  E-value: 3.49e-03
                           10        20
                   ....*....|....*....|..
gi 1215897544 1206 KCKVCAKTFETEAALNTHMRTH 1227
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-RING_7 pfam02591
C4-type zinc ribbon domain; Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively ...
 784-819 5.33e-03

C4-type zinc ribbon domain; Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively charged amino acid residues. This C-terminal Zn-ribbon domain consists of two beta-strands acting as a scaffold for the two Zn knuckles. Both pairs of cysteines making up the two Zn knuckles are situated at highly conserved sharp beta-turns, an arrangement that facilitates the tetrahedral coordination of the divalent Zn ion. The two Zn-knuckle cysteine motifs are separated by 20 residues, 9 of which form an alpha-helix (helix 4).Structural modelling suggests this domain may bind nucleic acids. The domain appears to bind flaA-mRNA, thus contributing to flagellum formation and motility.


Pssm-ID: 426857 [Multi-domain]  Cd Length: 33  Bit Score: 35.57  E-value: 5.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1215897544  784 TCTICQMLLPNQcsyaSHQRIHQHKSPYTCPECGAI 819
Cdd:pfam02591    1 RCGGCRMELPPQ----LLNEIRAAAEIVRCPECGRI 32
transpos_ISL3 NF033550
ISL3 family transposase;
810-859 8.84e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.88  E-value: 8.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215897544  810 PYTCPECGAICRSVHFqthvtknclHYTRRV------GFRII-------YKCSMCDTVFTLQT 859
Cdd:NF033550    10 DATCPECGKPSRRVHD---------TGKRRIrhlpifGRPVYlelrvrrFKCPECGKTFTEEL 63
 
Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 1142-1168 5.66e-11

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


Pssm-ID: 465205  Cd Length: 27  Bit Score: 58.21  E-value: 5.66e-11
                           10        20
                   ....*....|....*....|....*..
gi 1215897544 1142 SSYQCRECGLCYTSHVSLSRHLFIVHK 1168
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 308-613 1.60e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.19  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  308 PRAADKSPESQNLIDGTKKPS---LKQPDSPRSI-SSENSSKGSPSSPAGSTPAipkvriktikTSSGEIKRTVTRVLPE 383
Cdd:pfam17823   48 PRADNKSSEQ*NFCAATAAPApvtLTKGTSAAHLnSTEVTAEHTPHGTDLSEPA----------TREGAADGAASRALAA 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  384 VDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSP----PRAPLQSAVVTNAVSPAELT-----------------PKQ 442
Cdd:pfam17823  118 AASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANasaaPRAAIAAASAPHAASPAPRTaassttaassttaassaPTT 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  443 VTIKPVATaFLPVSAVKTAGSQVINLKLA-------NNTTVKATVISAASVQSASSAIIKAANAiqqQTVVVPASS---- 511
Cdd:pfam17823  198 AASSAPAT-LTPARGISTAATATGHPAAGtalaavgNSSPAAGTVTAAVGTVTPAALATLAAAA---GTVASAAGTinmg 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215897544  512 ------LANAKLVPkTVHLANLNLLPQGAQATSELRQVLTkpqqqiKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFN 585
Cdd:pfam17823  274 dpharrLSPAKHMP-SDTMARNPAAPMGAQAQGPIIQVST------DQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLA 346

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1215897544  586 KVLS--------SVNPVPVYIPNLSPPANAgiTLPT 613
Cdd:pfam17823  347 VVTTtkaqakepSASPVPVLHTSMIPEVEA--TSPT 380
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1206-1227 3.49e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.07  E-value: 3.49e-03
                           10        20
                   ....*....|....*....|..
gi 1215897544 1206 KCKVCAKTFETEAALNTHMRTH 1227
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-RING_7 pfam02591
C4-type zinc ribbon domain; Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively ...
 784-819 5.33e-03

C4-type zinc ribbon domain; Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively charged amino acid residues. This C-terminal Zn-ribbon domain consists of two beta-strands acting as a scaffold for the two Zn knuckles. Both pairs of cysteines making up the two Zn knuckles are situated at highly conserved sharp beta-turns, an arrangement that facilitates the tetrahedral coordination of the divalent Zn ion. The two Zn-knuckle cysteine motifs are separated by 20 residues, 9 of which form an alpha-helix (helix 4).Structural modelling suggests this domain may bind nucleic acids. The domain appears to bind flaA-mRNA, thus contributing to flagellum formation and motility.


Pssm-ID: 426857 [Multi-domain]  Cd Length: 33  Bit Score: 35.57  E-value: 5.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1215897544  784 TCTICQMLLPNQcsyaSHQRIHQHKSPYTCPECGAI 819
Cdd:pfam02591    1 RCGGCRMELPPQ----LLNEIRAAAEIVRCPECGRI 32
transpos_ISL3 NF033550
ISL3 family transposase;
810-859 8.84e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.88  E-value: 8.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215897544  810 PYTCPECGAICRSVHFqthvtknclHYTRRV------GFRII-------YKCSMCDTVFTLQT 859
Cdd:NF033550    10 DATCPECGKPSRRVHD---------TGKRRIrhlpifGRPVYlelrvrrFKCPECGKTFTEEL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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