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Conserved domains on  [gi|1212348565|ref|NP_001340059|]
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pre-B-cell leukemia transcription factor 1 isoform 4 [Homo sapiens]

Protein Classification

TALE/PBX homeobox family transcription factor( domain architecture ID 10510321)

TALE/PBX homeobox family transcription factor similar to human pre-B-cell leukemia transcription factor 1 (PBX1) that binds the sequence 5'-ATCAATCAA-3'

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 4-149 1.26e-81

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


:

Pssm-ID: 461052  Cd Length: 181  Bit Score: 246.14  E-value: 1.26e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565   4 RPVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELE 83
Cdd:pfam03792  48 KTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAGPEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELE 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1212348565  84 KYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 149
Cdd:pfam03792 116 KYEQACNEFTEHVRNLLREQSEFRPITPKEIERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 151-211 1.40e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.74  E-value: 1.40e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212348565 151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKN 211
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 4-149 1.26e-81

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 246.14  E-value: 1.26e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565   4 RPVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELE 83
Cdd:pfam03792  48 KTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAGPEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELE 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1212348565  84 KYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 149
Cdd:pfam03792 116 KYEQACNEFTEHVRNLLREQSEFRPITPKEIERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 151-211 1.40e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.74  E-value: 1.40e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212348565 151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKN 211
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
151-210 5.09e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 5.09e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565 151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKK 210
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 151-209 5.32e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 71.13  E-value: 5.32e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1212348565  151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYK 209
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
108-218 2.08e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 49.74  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565 108 PISPKEIERMVSIIHRKFSSIQMQLKQStcEAVMILrSRFLD----ARRKRRNFNKQATEILNEYFyshLSNPYPSEEAK 183
Cdd:COG5576     8 PLSALESQRMPQIRTIKTTKNKREVEAA--DSEMKL-ERKQDgsspPKSKRRRTTDEQLMVLEREF---EINPYPSSITR 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1212348565 184 EELAKKCGITVSQVSNWFGNKRIRYKKnIGKFQEE 218
Cdd:COG5576    82 IKLSLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVE 115
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 4-149 1.26e-81

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 246.14  E-value: 1.26e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565   4 RPVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELE 83
Cdd:pfam03792  48 KTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAGPEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELE 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1212348565  84 KYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 149
Cdd:pfam03792 116 KYEQACNEFTEHVRNLLREQSEFRPITPKEIERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 151-211 1.40e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.74  E-value: 1.40e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212348565 151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKN 211
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
151-210 5.09e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 5.09e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565 151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKK 210
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 169-207 3.26e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 71.39  E-value: 3.26e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1212348565 169 FYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIR 207
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 151-209 5.32e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 71.13  E-value: 5.32e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1212348565  151 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYK 209
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
108-218 2.08e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 49.74  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212348565 108 PISPKEIERMVSIIHRKFSSIQMQLKQStcEAVMILrSRFLD----ARRKRRNFNKQATEILNEYFyshLSNPYPSEEAK 183
Cdd:COG5576     8 PLSALESQRMPQIRTIKTTKNKREVEAA--DSEMKL-ERKQDgsspPKSKRRRTTDEQLMVLEREF---EINPYPSSITR 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1212348565 184 EELAKKCGITVSQVSNWFGNKRIRYKKnIGKFQEE 218
Cdd:COG5576    82 IKLSLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVE 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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