NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1212621744|ref|NP_001340029|]
View 

phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 4 [Homo sapiens]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-277 1.18e-111

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 319.84  E-value: 1.18e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  93 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 173 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKT 252
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1212621744 253 VDISMILSEAIRRIHNGESMSYLFR 277
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 1.47e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 84.39  E-value: 1.47e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-277 1.18e-111

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 319.84  E-value: 1.18e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  93 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 173 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKT 252
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1212621744 253 VDISMILSEAIRRIHNGESMSYLFR 277
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-277 4.90e-77

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 236.49  E-value: 4.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:COG0462    68 MELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYA 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHPSLEI 157
Cdd:COG0462   148 APLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMNIIGDV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 158 pmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 234
Cdd:COG0462   210 -----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVV 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1212621744 235 TNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:COG0462   270 TDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-277 1.08e-71

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 222.69  E-value: 1.08e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK01259   65 MELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaihpslei 157
Cdd:PRK01259  145 SPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV--------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 158 pmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNT 237
Cdd:PRK01259  200 ----------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDS 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1212621744 238 IPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK01259  270 IPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-277 9.86e-71

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 220.23  E-value: 9.86e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:TIGR01251  66 MELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhpsleipm 159
Cdd:TIGR01251 146 SPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL-------- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:TIGR01251 205 -----------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIP 273

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1212621744 240 HEVqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:TIGR01251 274 HEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 1.47e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 84.39  E-value: 1.47e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-277 1.18e-111

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 319.84  E-value: 1.18e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  93 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 173 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKT 252
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1212621744 253 VDISMILSEAIRRIHNGESMSYLFR 277
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-277 4.90e-77

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 236.49  E-value: 4.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:COG0462    68 MELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYA 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHPSLEI 157
Cdd:COG0462   148 APLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMNIIGDV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 158 pmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 234
Cdd:COG0462   210 -----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVV 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1212621744 235 TNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:COG0462   270 TDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-277 1.08e-71

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 222.69  E-value: 1.08e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK01259   65 MELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaihpslei 157
Cdd:PRK01259  145 SPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV--------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 158 pmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNT 237
Cdd:PRK01259  200 ----------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDS 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1212621744 238 IPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK01259  270 IPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-277 9.86e-71

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 220.23  E-value: 9.86e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:TIGR01251  66 MELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhpsleipm 159
Cdd:TIGR01251 146 SPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL-------- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:TIGR01251 205 -----------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIP 273

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1212621744 240 HEVqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:TIGR01251 274 HEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
1-276 1.86e-52

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 173.96  E-value: 1.86e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLR 78
Cdd:PRK04923   71 MELLVLIDALKRASAASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVY 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  79 ASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPPMVRSVaaihpsleip 158
Cdd:PRK04923  151 ASPLLLADIWRAY-GTDNLIVVSPDVGGVVRARAVAKRL-----------DDADLAIIDKRRPRANVATV---------- 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 159 mlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTI 238
Cdd:PRK04923  209 ---------MNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTI 279

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1212621744 239 PHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK04923  280 PLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 1-277 1.01e-48

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 163.71  E-value: 1.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PLN02369   56 MELLIMIDACRRASAKRITAVIPYFGYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPpmvrsvaaiHPSLEipm 159
Cdd:PLN02369  136 QPVILDYLASKTISSPDLVVVSPDVGGVARARAFAKKL-----------SDAPLAIVDKRRQG---------HNVAE--- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:PLN02369  193 -------VMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIVTNTIP 265

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1212621744 240 HEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PLN02369  266 VSEKN-YFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
1-276 2.53e-48

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 163.04  E-value: 2.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK02269   70 MEILIMVDALKRASAESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMG 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSppmvrsvaaihpslEIPM 159
Cdd:PRK02269  150 APLIADYFDRRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAII------------DKRRS--------------VDKM 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 LIPKekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:PRK02269  204 NTSE---VMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIY 280

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1212621744 240 HEVQKLqCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK02269  281 LPEERL-IDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
1-276 3.69e-47

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 159.73  E-value: 3.69e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK03092   54 MEQLIMIDALKRASAKRITVVLPFYPYARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIPDyRNAVIVAKSPASAKRAQSFAERLrlgiavihGEAqdaesdlvdgrhspPMvrsvAAIHPSLEIpm 159
Cdd:PRK03092  134 MPLLADYVRDKYDL-DNVTVVSPDAGRVRVAEQWADRL--------GGA--------------PL----AFIHKTRDP-- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 LIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:PRK03092  185 TVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVVTDTLP 264

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1212621744 240 HEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK03092  265 IPEEK-RFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 1-277 2.66e-46

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 157.98  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSK-QCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK02812   86 MELLIMVDACRRASARQITAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYG 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLRlgiavihgeaqDAESDLVDGRHSPPMVRSVaaihpsleipm 159
Cdd:PRK02812  166 SPVLLDYLASK--NLEDIVVVSPDVGGVARARAFAKKLN-----------DAPLAIIDKRRQAHNVAEV----------- 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:PRK02812  222 --------LNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIP 293

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1212621744 240 HEvQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK02812  294 VP-EERRFPQLKVLSVANMLGEAIWRIHEESSVSSMFR 330
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-277 5.07e-44

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 152.20  E-value: 5.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK02458   74 WELLIMIDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFT 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDlvDGrhsppmvrsvaaihpsleipm 159
Cdd:PRK02458  154 VPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSERE--EG--------------------- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekppiTVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIp 239
Cdd:PRK02458  211 ---------YIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSV- 280

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1212621744 240 heVQKLQCPK-IKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK02458  281 --ATKERVPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-276 1.98e-43

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 153.10  E-value: 1.98e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFN--IPVDNL 77
Cdd:PTZ00145  184 IELLLMISTCRRASAKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  78 RASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLrlgiavIHGEAQDAEsdlvdgrhsppmvrsvaaihpsleI 157
Cdd:PTZ00145  264 EAQLIGLDYFTKK--DLYKPVIVSPDAGGVYRARKFQDGL------NHRGISDCG------------------------I 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 158 PMLI-----PKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEV 232
Cdd:PTZ00145  312 AMLIkqrtkPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEV 391

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1212621744 233 VVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PTZ00145  392 VVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 1-276 8.14e-41

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 143.90  E-value: 8.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK00553   74 MELLIAIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRT 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSvaaihpsleipm 159
Cdd:PRK00553  154 YHVFLSRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAII------------DKRRPKHNVAE------------ 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEES----AIDEVVVT 235
Cdd:PRK00553  209 -------SINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLIDKLFVS 281

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1212621744 236 NTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK00553  282 NSIPQTKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 1-245 6.51e-27

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 105.77  E-value: 6.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMcKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK00934   63 VELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGePISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFINLDA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  80 SPFLLQYIQEeipDYRNAVIVAKSPASAKRAQSFAERLrlGIAVIHGEAQdaesdlvdgRHSPPMVRsvaaIHPSlEIpm 159
Cdd:PRK00934  142 APLIAEYIGD---KLDDPLVLAPDKGALELAKEAAEIL--GCEYDYLEKT---------RISPTEVE----IAPK-NL-- 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 160 lipkekppitvvgDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIP 239
Cdd:PRK00934  201 -------------DVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLE 267


                  ....*.
gi 1212621744 240 HEVQKL 245
Cdd:PRK00934  268 SEVSKI 273
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 1.47e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 84.39  E-value: 1.47e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1212621744   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 15-278 9.65e-19

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 85.00  E-value: 9.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  15 AKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIP-VDNLRASPFLLQYIQEEIPD 93
Cdd:PRK06827  122 ARRITVIMPFLYESRQHKRKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgFENLYPSYQIIKALLKNEKD 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  94 YR----NAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaQDaESDLVDGRHsppmvrsvaaihpsleipmlipkekpPIT 169
Cdd:PRK06827  202 LEidkdHLMVISPDTGAMDRAKYYASVLGVDLGLFYKR-RD-YSRVVNGRN--------------------------PIV 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 170 VV----GDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLsSDAPRRI----EESAIDEVVVTNTIPHE 241
Cdd:PRK06827  254 AHeflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFGFF-TNGLEKFdkayEEGYFDRIIGTNLVYHP 332

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1212621744 242 VQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFRN 278
Cdd:PRK06827  333 EELLSKPWYIEVDMSKLIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
2-265 2.12e-07

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 51.09  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744   2 ELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVS-----KLLAsmmckAGLTHLITMD--LHQ-KEIQGFFNIP 73
Cdd:PRK07199   67 PLLFAAEAARELGARRVGLVAPYLAYMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSEVYPIP 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744  74 VDNLRASPFLLQYIQEEIPDyrnAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVaaihp 153
Cdd:PRK07199  142 AVVLSAAPAIAAWIRAHVPR---PLLIGPDEESEQWVAAVAERAGAPHAVLRKT-----------RHGD---RDV----- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212621744 154 slEIPMlipkekPPITVVGdvgGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVV 233
Cdd:PRK07199  200 --EISL------PDAAPWA---GRTPVLVDDIVSTGRTLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVV 268

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1212621744 234 VTNTIPHEVQklqcpkikTVDISMILSEAIRR 265
Cdd:PRK07199  269 STDTVPHPSN--------AISLAPLLAEALRR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH