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Conserved domains on  [gi|1201920900|ref|NP_001339077|]
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zinc finger protein 415 isoform 9 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-526 3.37e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 231 YKCDLCGKVFSQKSNLARHWRVHTGEKPYKCN--ECDRSFSRNSCLALHRRVHTGEKPYKC-YECDKVFSRNSCLALHQK 307
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 308 THIGEKPYTCKECGKAFSVRSTLTN--HQVIHSGKKPYK-CNECGKVFSQTSSLA-------------------THQRIH 365
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 366 TGEKPYKCNECGKVFSQTSSLARHWRIHTGEKPYKCNECGKVF------SYNSHLASHRRVHTGEKPYKCNECGKAFSVH 439
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 440 SNLTTHQVIHTG-EKPYKCNQCGKGFSVHSSLTTHQ--VIHTGE--KPYKCNE--CGKSFSVRPNLTRHQIIHTGKKPYK 512
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330
                  ....*....|....
gi 1201920900 513 CSDCGKSFSVRPNL 526
Cdd:COG5048   354 EKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-361 3.48e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900  99 TAPKENLTCRRDQRDRRGIGNKSIKHQLGLSFLPHPHELQQFQaegkIYECNHVEKSVNHGSSVSPPQIISSTIKTHVSN 178
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS----LLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 179 KygtdficSSLLTQEQKSCIREKPYRYIECDKALNHGSH--MTVRQVSHSGE--KGYKCD--LCGKVFSQKSNLARHWRV 252
Cdd:COG5048   273 S-------SPNESDSSSEKGFSLPIKSKQCNISFSRSSPltRHLRSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 253 HTGEKPYKCNECDRSFSR----NSCLALHRRVHTGEKPYKCYECD-----KVFSRNSCLALHQKTHIGEKPYTCK--ECG 321
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFspllNNEPPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1201920900 322 KAFSVRSTLTNHQVIHSGKKPYkCNECGKVFSQTSSLATH 361
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-526 3.37e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 231 YKCDLCGKVFSQKSNLARHWRVHTGEKPYKCN--ECDRSFSRNSCLALHRRVHTGEKPYKC-YECDKVFSRNSCLALHQK 307
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 308 THIGEKPYTCKECGKAFSVRSTLTN--HQVIHSGKKPYK-CNECGKVFSQTSSLA-------------------THQRIH 365
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 366 TGEKPYKCNECGKVFSQTSSLARHWRIHTGEKPYKCNECGKVF------SYNSHLASHRRVHTGEKPYKCNECGKAFSVH 439
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 440 SNLTTHQVIHTG-EKPYKCNQCGKGFSVHSSLTTHQ--VIHTGE--KPYKCNE--CGKSFSVRPNLTRHQIIHTGKKPYK 512
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330
                  ....*....|....
gi 1201920900 513 CSDCGKSFSVRPNL 526
Cdd:COG5048   354 EKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-361 3.48e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900  99 TAPKENLTCRRDQRDRRGIGNKSIKHQLGLSFLPHPHELQQFQaegkIYECNHVEKSVNHGSSVSPPQIISSTIKTHVSN 178
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS----LLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 179 KygtdficSSLLTQEQKSCIREKPYRYIECDKALNHGSH--MTVRQVSHSGE--KGYKCD--LCGKVFSQKSNLARHWRV 252
Cdd:COG5048   273 S-------SPNESDSSSEKGFSLPIKSKQCNISFSRSSPltRHLRSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 253 HTGEKPYKCNECDRSFSR----NSCLALHRRVHTGEKPYKCYECD-----KVFSRNSCLALHQKTHIGEKPYTCK--ECG 321
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFspllNNEPPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1201920900 322 KAFSVRSTLTNHQVIHSGKKPYkCNECGKVFSQTSSLATH 361
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 5.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1201920900 357 SLATHQRIHTGEKPYKCNECGKVFSQ 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 341-393 8.97e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1201920900 341 KPYkCNECGKVFSQTSSLATHQRIHTgekpYKCNECGKVFSQTSSLARH-WRIH 393
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-526 3.37e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 231 YKCDLCGKVFSQKSNLARHWRVHTGEKPYKCN--ECDRSFSRNSCLALHRRVHTGEKPYKC-YECDKVFSRNSCLALHQK 307
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 308 THIGEKPYTCKECGKAFSVRSTLTN--HQVIHSGKKPYK-CNECGKVFSQTSSLA-------------------THQRIH 365
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 366 TGEKPYKCNECGKVFSQTSSLARHWRIHTGEKPYKCNECGKVF------SYNSHLASHRRVHTGEKPYKCNECGKAFSVH 439
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 440 SNLTTHQVIHTG-EKPYKCNQCGKGFSVHSSLTTHQ--VIHTGE--KPYKCNE--CGKSFSVRPNLTRHQIIHTGKKPYK 512
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330
                  ....*....|....
gi 1201920900 513 CSDCGKSFSVRPNL 526
Cdd:COG5048   354 EKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-529 1.56e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 249 HWRVHTGEKPYKCNECDRSFSRNSCLALHRRVHTGEKPYKCYECDKVFSRNSCLALHQKTHIGEKPYTCKECGKAF--SV 326
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 327 RSTLTNHQVIHSGK-----KPYKCNECGKVFSQTSSLATHQR--IHTGE--KPYKCNE--CGKVFSQTSSLARHWRIHTG 395
Cdd:COG5048   269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 396 EKPYKC--NECGKVFSYNSHLASHRRV--HTGEKPYKCNECGKAFSVHSNLTTHQVIhtgekpykcnqcgKGFSVHSSLT 471
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNLS-------------LHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1201920900 472 THQvihtgekpYKCNECGKSFSVRPNLTRHQIIHTGKKPYKCSDCgKSFSVRPNLFRH 529
Cdd:COG5048   416 PYN--------CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-361 3.48e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900  99 TAPKENLTCRRDQRDRRGIGNKSIKHQLGLSFLPHPHELQQFQaegkIYECNHVEKSVNHGSSVSPPQIISSTIKTHVSN 178
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS----LLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 179 KygtdficSSLLTQEQKSCIREKPYRYIECDKALNHGSH--MTVRQVSHSGE--KGYKCD--LCGKVFSQKSNLARHWRV 252
Cdd:COG5048   273 S-------SPNESDSSSEKGFSLPIKSKQCNISFSRSSPltRHLRSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201920900 253 HTGEKPYKCNECDRSFSR----NSCLALHRRVHTGEKPYKCYECD-----KVFSRNSCLALHQKTHIGEKPYTCK--ECG 321
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFspllNNEPPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1201920900 322 KAFSVRSTLTNHQVIHSGKKPYkCNECGKVFSQTSSLATH 361
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
465-538 1.86e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201920900 465 SVHSSLTTHQVIHTGEKPYKCNECGKSFSVRPNLTRHQIIHTGKKPYKCSD--CGKSFSVRPNLFRHQIIHTKEKP 538
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 5.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1201920900 357 SLATHQRIHTGEKPYKCNECGKVFSQ 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-437 6.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.22e-04
                          10        20
                  ....*....|....*....|....*
gi 1201920900 413 HLASHRRVHTGEKPYKCNECGKAFS 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
497-521 6.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1201920900 497 NLTRHQIIHTGKKPYKCSDCGKSFS 521
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
340-413 1.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1201920900 340 KKPYKCNECGKVFSQTSSLATHQRIHTGEKPYKCN--ECGKVFSQTSSLARHWRIHTGEKPYKCN-ECGKVFSYNSH 413
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 1201920900 245 NLARHWRVHTGEKPYKCNECDRSFSR 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-410 1.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 1201920900 385 SLARHWRIHTGEKPYKCNECGKVFSY 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 231-253 2.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|...
gi 1201920900 231 YKCDLCGKVFSQKSNLARHWRVH 253
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-298 3.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.11e-03
                          10        20
                  ....*....|....*....|....*
gi 1201920900 274 LALHRRVHTGEKPYKCYECDKVFSR 298
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-493 3.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|....*
gi 1201920900 469 SLTTHQVIHTGEKPYKCNECGKSFS 493
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 399-421 5.27e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.27e-03
                          10        20
                  ....*....|....*....|...
gi 1201920900 399 YKCNECGKVFSYNSHLASHRRVH 421
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-465 6.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.08e-03
                          10        20
                  ....*....|....*....|....*
gi 1201920900 441 NLTTHQVIHTGEKPYKCNQCGKGFS 465
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-325 7.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.62e-03
                          10        20
                  ....*....|....*....|....
gi 1201920900 302 LALHQKTHIGEKPYTCKECGKAFS 325
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 341-393 8.97e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1201920900 341 KPYkCNECGKVFSQTSSLATHQRIHTgekpYKCNECGKVFSQTSSLARH-WRIH 393
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 343-365 9.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.59e-03
                          10        20
                  ....*....|....*....|...
gi 1201920900 343 YKCNECGKVFSQTSSLATHQRIH 365
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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