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Conserved domains on  [gi|1199303279|ref|NP_001338797|]
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Potassium/chloride cotransporter 3 [Caenorhabditis elegans]

Protein Classification

APC family permease( domain architecture ID 1903533)

APC (amino acid/polyamine/organocation) family permease is involved in the uptake of a specific amino acid and/or polyamine substrate with the concomitant import of a proton

Gene Ontology:  GO:0055085|GO:0022857
TCDB:  2.A.3

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
AA_permease_2 super family cl45918
Amino acid permease;
50-1070 0e+00

Amino acid permease;


The actual alignment was detected with superfamily member TIGR00930:

Pssm-ID: 459263 [Multi-domain]  Cd Length: 953  Bit Score: 681.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279   50 SLGHLALYKEDEGIGTQASfisgyTTPGPKERATSEHVKAN-----LGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVA 124
Cdd:TIGR00930   37 KVVSLLGPLADYTNNGQGM-----KEHEEAEDAEGTKEKPPagavkFGWVMGVLVPCLLNIWGVILFLRLSWIVGQAGIG 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  125 WTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLWPE 204
Cdd:TIGR00930  112 LSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLREN 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  205 MAIGGADALHDtemfgslynnLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACIGGGIekqITMegmkvca 284
Cdd:TIGR00930  192 GSKIMVDPIND----------IRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTI---IPA------- 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  285 idnhllqssivTHPIHKnqtswfnetvdfcnlcdkslylesvfcanvnndeasaeddvfcthytskkmtcqlAFPGFNMK 364
Cdd:TIGR00930  252 -----------FDKPAK-------------------------------------------------------GFFGLGNE 265
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  365 TLNDNMwpeymeksevVPGVRGKEtaevvqdesSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSA 444
Cdd:TIGR00930  266 IFSENF----------IPGIPGPE---------GGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTV 326
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  445 IYYILAILFGGSITRSVLRDKFG---------------------RSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCL 503
Cdd:TIGR00930  327 VYLGSVVLFGACVVRDATGDKNDtlvtnctsaacfsecahntcsYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASL 406
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  504 CSAPRLLQSIAKDDVIPILAPFAR-VTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVL 582
Cdd:TIGR00930  407 VSAPRLFQALCKDNIYPFLQFFGKgYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLL 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  583 KSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVED 662
Cdd:TIGR00930  487 RSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEE 566
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  663 KDPHPKNWRPQVLIlLTSQWSKemidRRAvsMLNLGAQLKAGRGLAIAcaflkGSVDSQKDKNRARDVKT---TLVKDMS 739
Cdd:TIGR00930  567 VEDHVKNWRPQCLV-LTGPPVC----RPA--LLDFASQFTKGKGLMIC-----GSVIQGPRLECVKEAQAaeaKIQTWLE 634
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  740 SVRLRGFAKTMFYNNhqINGTISGLYQSIGIGGLRPNTILLNWPN---EKNPDELVLFAeEIIHGA-ANDNCLIVTKGIT 815
Cdd:TIGR00930  635 KNKVKAFYAVVVADD--LREGVRHLIQASGLGRMKPNTLVMGYKKdwrQAEPRAWETYI-GIIHDAfDAHLAVVVVRNSE 711
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  816 DFP--------------------------------------EYSER-LTGFIDIWWIVQDGGILMLIAYLLRQHKVWKGC 856
Cdd:TIGR00930  712 GLPisvlqvqeelendcsedsielndgkistqpdmhleastQFQKKqGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKC 791
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  857 TLRIFAVSEQDStKSEDMKAGLQKYIYMLRIDAElfivdlldmevsDEVVEkaaeverkqkereemrrsksgylndgfME 936
Cdd:TIGR00930  792 KIRIFVGAQKDD-RSEQEKKDMATLLYKFRIDAE------------VIVVL---------------------------MD 831
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  937 DNGKPRQVMMRH-SDSARSFSpqpgahtsinldETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRE 1015
Cdd:TIGR00930  832 INAKPQTESMEAfEEMIRPFR------------LHKTEKDREAKDPKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLE 899
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1199303279 1016 NSPDSQLILLNLPSPPRNRLAFNNsYMTYLDVLTEDLPRVLFIGGSGREVITIDS 1070
Cdd:TIGR00930  900 YSRDAALVVLSLPVPRKGSIPDEL-YMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
50-1070 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 681.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279   50 SLGHLALYKEDEGIGTQASfisgyTTPGPKERATSEHVKAN-----LGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVA 124
Cdd:TIGR00930   37 KVVSLLGPLADYTNNGQGM-----KEHEEAEDAEGTKEKPPagavkFGWVMGVLVPCLLNIWGVILFLRLSWIVGQAGIG 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  125 WTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLWPE 204
Cdd:TIGR00930  112 LSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLREN 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  205 MAIGGADALHDtemfgslynnLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACIGGGIekqITMegmkvca 284
Cdd:TIGR00930  192 GSKIMVDPIND----------IRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTI---IPA------- 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  285 idnhllqssivTHPIHKnqtswfnetvdfcnlcdkslylesvfcanvnndeasaeddvfcthytskkmtcqlAFPGFNMK 364
Cdd:TIGR00930  252 -----------FDKPAK-------------------------------------------------------GFFGLGNE 265
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  365 TLNDNMwpeymeksevVPGVRGKEtaevvqdesSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSA 444
Cdd:TIGR00930  266 IFSENF----------IPGIPGPE---------GGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTV 326
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  445 IYYILAILFGGSITRSVLRDKFG---------------------RSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCL 503
Cdd:TIGR00930  327 VYLGSVVLFGACVVRDATGDKNDtlvtnctsaacfsecahntcsYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASL 406
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  504 CSAPRLLQSIAKDDVIPILAPFAR-VTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVL 582
Cdd:TIGR00930  407 VSAPRLFQALCKDNIYPFLQFFGKgYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLL 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  583 KSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVED 662
Cdd:TIGR00930  487 RSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEE 566
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  663 KDPHPKNWRPQVLIlLTSQWSKemidRRAvsMLNLGAQLKAGRGLAIAcaflkGSVDSQKDKNRARDVKT---TLVKDMS 739
Cdd:TIGR00930  567 VEDHVKNWRPQCLV-LTGPPVC----RPA--LLDFASQFTKGKGLMIC-----GSVIQGPRLECVKEAQAaeaKIQTWLE 634
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  740 SVRLRGFAKTMFYNNhqINGTISGLYQSIGIGGLRPNTILLNWPN---EKNPDELVLFAeEIIHGA-ANDNCLIVTKGIT 815
Cdd:TIGR00930  635 KNKVKAFYAVVVADD--LREGVRHLIQASGLGRMKPNTLVMGYKKdwrQAEPRAWETYI-GIIHDAfDAHLAVVVVRNSE 711
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  816 DFP--------------------------------------EYSER-LTGFIDIWWIVQDGGILMLIAYLLRQHKVWKGC 856
Cdd:TIGR00930  712 GLPisvlqvqeelendcsedsielndgkistqpdmhleastQFQKKqGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKC 791
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  857 TLRIFAVSEQDStKSEDMKAGLQKYIYMLRIDAElfivdlldmevsDEVVEkaaeverkqkereemrrsksgylndgfME 936
Cdd:TIGR00930  792 KIRIFVGAQKDD-RSEQEKKDMATLLYKFRIDAE------------VIVVL---------------------------MD 831
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  937 DNGKPRQVMMRH-SDSARSFSpqpgahtsinldETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRE 1015
Cdd:TIGR00930  832 INAKPQTESMEAfEEMIRPFR------------LHKTEKDREAKDPKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLE 899
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1199303279 1016 NSPDSQLILLNLPSPPRNRLAFNNsYMTYLDVLTEDLPRVLFIGGSGREVITIDS 1070
Cdd:TIGR00930  900 YSRDAALVVLSLPVPRKGSIPDEL-YMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
96-675 2.46e-37

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 147.08  E-value: 2.46e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279   96 GVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLSTLLTSISLSAVATNGVVeSGGAYFIISRNLGAEFGSAVG 175
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  176 IL------FYLANTVAASMYIVGGVEVI--LMYLWpemaiggadalhdtemfgslynnlrLYGTVFLLIQALIVAMGVKF 247
Cdd:pfam00324   80 WNywlswiTVLALELTAASILIQFWELVpdIPYLW-------------------------VWGAVFLVLLTIINLVGVKW 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  248 ---VQLLApvsLMCVILAIAACIGGGIekqitmegmkvcaidnhllqssivthpihknqtswfnetvdfcnlcdkslyle 324
Cdd:pfam00324  135 ygeAEFWF---ALIKIIAIIGFIIVGI----------------------------------------------------- 158
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  325 SVFCANVNNDEASAeddvfctHYTSKKMTCQLAFPGFnmktlndnmwpeymeksevvpgvrgketaevvqdeSSTFFMLM 404
Cdd:pfam00324  159 ILLSGGNPNDGAIF-------RYLGDNGGKNNFPPGF-----------------------------------GKGFISVF 196
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  405 AIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTsAIYYILAILFGGSIT-RSVLRDKFGRSIGNTMVVAALS--- 480
Cdd:pfam00324  197 VIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRI-TIFYILSLLAIGLLVpWNDPGLLNDSASAASPFVIFFKflg 275
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  481 WPH-PAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPilAPFARVTKNNEPFLGLVLTVIIAECGILLGAVdkIAE 559
Cdd:pfam00324  276 ISGlAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP--KFLKKVDKRGVPLRAILVSMVISLLALLLASL--NPA 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  560 VLDFFFLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKK 639
Cdd:pfam00324  352 IVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPK 431
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 1199303279  640 EWGDGMRGLA-LTTAQYSLLKVEDKDpHPKNWRPQVL 675
Cdd:pfam00324  432 NWGAGSFAAAyLIVLLFLIILIGVKL-HVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
105-629 3.31e-28

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 119.23  E-value: 3.31e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  105 ILGVTMFIRLFWVVGMSGVAWTMALLaICCLSTLLTSISLSAVATNgVVESGGAYFIISRNLGAEFGSAVGILFYLANTV 184
Cdd:COG0531     26 IIGAGIFVLPGLAAGLAGPAAILAWL-IAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYVL 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  185 AASMYIVGGVEViLMYLWPemaiGGADALhdtemfgslynnlrlYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIA 264
Cdd:COG0531    104 AVAAVAVAFGGY-LSSLFP----AGGSVL---------------IALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  265 ACIGGGIekqitmegmkvcaidnhllqssivTHPIHKNQTSWFNETVDFcnlcdkslylesvfcanvnndeasaeddvfc 344
Cdd:COG0531    164 LFIVVGL------------------------FAFDPANFTPFLPAGGGL------------------------------- 188
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  345 thytskkmtcqlafpgfnmktlndnmwpeymeksevvpgvrgketaevvqdesSTFFMLMAIYFPAVTGIFTGTNMSGDL 424
Cdd:COG0531    189 -----------------------------------------------------SGVLAALALAFFAFTGFEAIANLAEEA 215
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  425 RDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDkfgrSIGNTMVVAALSWPHPA--VVTVGAFLSTFGAALQC 502
Cdd:COG0531    216 KNPKRNIPRAIILSLLIVGVLYILVSLALTGVVPYDELAA----SGAPLADAAEAVFGPWGaiLIALGALLSLLGALNAS 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  503 LCSAPRLLQSIAKDDVIPilAPFARV-TKNNEPFLGLVLTVIIAECGILLG--AVDKIAEVLDFFFLMCYAFVNlIAVLH 579
Cdd:COG0531    292 ILGASRLLYAMARDGLLP--KVFAKVhPRFGTPVNAILLTGVIALLLLLLGaaSFTALASLASVGVLLAYLLVA-LAVIV 368
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1199303279  580 SVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASS--VPLACIACTATAVIY 629
Cdd:COG0531    369 LRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGpgALLIGLVLLAIGLLL 420
frlA PRK11357
amino acid permease;
412-628 9.61e-05

amino acid permease;


Pssm-ID: 183096 [Multi-domain]  Cd Length: 445  Bit Score: 46.00  E-value: 9.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  412 TGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLrdkfgrSIGNTMVVAALSWPhPA------ 485
Cdd:PRK11357   209 TGMASICYMTGEIKNPGKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKL------ANSETPISDALTWI-PAlgstag 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  486 -VVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVipILAPFARV-TKNNEPFLGLVLTVIIaecGILLGAVDKIAEVLDF 563
Cdd:PRK11357   282 iFVAITAMIVILGSLSSCVMYQPRLEYAMAKDNL--FFKCFGHVhPKYNTPDVSIILQGAL---GIFFIFVSDLTSLLGY 356
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1199303279  564 F-FLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSV---PLACIACTATAVI 628
Cdd:PRK11357   357 FtLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTTLAIASSLILVASTFvwaPIPGLICAVIVIA 425
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
50-1070 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 681.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279   50 SLGHLALYKEDEGIGTQASfisgyTTPGPKERATSEHVKAN-----LGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVA 124
Cdd:TIGR00930   37 KVVSLLGPLADYTNNGQGM-----KEHEEAEDAEGTKEKPPagavkFGWVMGVLVPCLLNIWGVILFLRLSWIVGQAGIG 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  125 WTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLWPE 204
Cdd:TIGR00930  112 LSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLREN 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  205 MAIGGADALHDtemfgslynnLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACIGGGIekqITMegmkvca 284
Cdd:TIGR00930  192 GSKIMVDPIND----------IRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTI---IPA------- 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  285 idnhllqssivTHPIHKnqtswfnetvdfcnlcdkslylesvfcanvnndeasaeddvfcthytskkmtcqlAFPGFNMK 364
Cdd:TIGR00930  252 -----------FDKPAK-------------------------------------------------------GFFGLGNE 265
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  365 TLNDNMwpeymeksevVPGVRGKEtaevvqdesSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSA 444
Cdd:TIGR00930  266 IFSENF----------IPGIPGPE---------GGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTV 326
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  445 IYYILAILFGGSITRSVLRDKFG---------------------RSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCL 503
Cdd:TIGR00930  327 VYLGSVVLFGACVVRDATGDKNDtlvtnctsaacfsecahntcsYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASL 406
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  504 CSAPRLLQSIAKDDVIPILAPFAR-VTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVL 582
Cdd:TIGR00930  407 VSAPRLFQALCKDNIYPFLQFFGKgYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLL 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  583 KSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVED 662
Cdd:TIGR00930  487 RSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEE 566
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  663 KDPHPKNWRPQVLIlLTSQWSKemidRRAvsMLNLGAQLKAGRGLAIAcaflkGSVDSQKDKNRARDVKT---TLVKDMS 739
Cdd:TIGR00930  567 VEDHVKNWRPQCLV-LTGPPVC----RPA--LLDFASQFTKGKGLMIC-----GSVIQGPRLECVKEAQAaeaKIQTWLE 634
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  740 SVRLRGFAKTMFYNNhqINGTISGLYQSIGIGGLRPNTILLNWPN---EKNPDELVLFAeEIIHGA-ANDNCLIVTKGIT 815
Cdd:TIGR00930  635 KNKVKAFYAVVVADD--LREGVRHLIQASGLGRMKPNTLVMGYKKdwrQAEPRAWETYI-GIIHDAfDAHLAVVVVRNSE 711
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  816 DFP--------------------------------------EYSER-LTGFIDIWWIVQDGGILMLIAYLLRQHKVWKGC 856
Cdd:TIGR00930  712 GLPisvlqvqeelendcsedsielndgkistqpdmhleastQFQKKqGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKC 791
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  857 TLRIFAVSEQDStKSEDMKAGLQKYIYMLRIDAElfivdlldmevsDEVVEkaaeverkqkereemrrsksgylndgfME 936
Cdd:TIGR00930  792 KIRIFVGAQKDD-RSEQEKKDMATLLYKFRIDAE------------VIVVL---------------------------MD 831
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  937 DNGKPRQVMMRH-SDSARSFSpqpgahtsinldETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRE 1015
Cdd:TIGR00930  832 INAKPQTESMEAfEEMIRPFR------------LHKTEKDREAKDPKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLE 899
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1199303279 1016 NSPDSQLILLNLPSPPRNRLAFNNsYMTYLDVLTEDLPRVLFIGGSGREVITIDS 1070
Cdd:TIGR00930  900 YSRDAALVVLSLPVPRKGSIPDEL-YMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
96-675 2.46e-37

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 147.08  E-value: 2.46e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279   96 GVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLSTLLTSISLSAVATNGVVeSGGAYFIISRNLGAEFGSAVG 175
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  176 IL------FYLANTVAASMYIVGGVEVI--LMYLWpemaiggadalhdtemfgslynnlrLYGTVFLLIQALIVAMGVKF 247
Cdd:pfam00324   80 WNywlswiTVLALELTAASILIQFWELVpdIPYLW-------------------------VWGAVFLVLLTIINLVGVKW 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  248 ---VQLLApvsLMCVILAIAACIGGGIekqitmegmkvcaidnhllqssivthpihknqtswfnetvdfcnlcdkslyle 324
Cdd:pfam00324  135 ygeAEFWF---ALIKIIAIIGFIIVGI----------------------------------------------------- 158
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  325 SVFCANVNNDEASAeddvfctHYTSKKMTCQLAFPGFnmktlndnmwpeymeksevvpgvrgketaevvqdeSSTFFMLM 404
Cdd:pfam00324  159 ILLSGGNPNDGAIF-------RYLGDNGGKNNFPPGF-----------------------------------GKGFISVF 196
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  405 AIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTsAIYYILAILFGGSIT-RSVLRDKFGRSIGNTMVVAALS--- 480
Cdd:pfam00324  197 VIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRI-TIFYILSLLAIGLLVpWNDPGLLNDSASAASPFVIFFKflg 275
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  481 WPH-PAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPilAPFARVTKNNEPFLGLVLTVIIAECGILLGAVdkIAE 559
Cdd:pfam00324  276 ISGlAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP--KFLKKVDKRGVPLRAILVSMVISLLALLLASL--NPA 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  560 VLDFFFLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKK 639
Cdd:pfam00324  352 IVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPK 431
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 1199303279  640 EWGDGMRGLA-LTTAQYSLLKVEDKDpHPKNWRPQVL 675
Cdd:pfam00324  432 NWGAGSFAAAyLIVLLFLIILIGVKL-HVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
105-629 3.31e-28

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 119.23  E-value: 3.31e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  105 ILGVTMFIRLFWVVGMSGVAWTMALLaICCLSTLLTSISLSAVATNgVVESGGAYFIISRNLGAEFGSAVGILFYLANTV 184
Cdd:COG0531     26 IIGAGIFVLPGLAAGLAGPAAILAWL-IAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYVL 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  185 AASMYIVGGVEViLMYLWPemaiGGADALhdtemfgslynnlrlYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIA 264
Cdd:COG0531    104 AVAAVAVAFGGY-LSSLFP----AGGSVL---------------IALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  265 ACIGGGIekqitmegmkvcaidnhllqssivTHPIHKNQTSWFNETVDFcnlcdkslylesvfcanvnndeasaeddvfc 344
Cdd:COG0531    164 LFIVVGL------------------------FAFDPANFTPFLPAGGGL------------------------------- 188
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  345 thytskkmtcqlafpgfnmktlndnmwpeymeksevvpgvrgketaevvqdesSTFFMLMAIYFPAVTGIFTGTNMSGDL 424
Cdd:COG0531    189 -----------------------------------------------------SGVLAALALAFFAFTGFEAIANLAEEA 215
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  425 RDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDkfgrSIGNTMVVAALSWPHPA--VVTVGAFLSTFGAALQC 502
Cdd:COG0531    216 KNPKRNIPRAIILSLLIVGVLYILVSLALTGVVPYDELAA----SGAPLADAAEAVFGPWGaiLIALGALLSLLGALNAS 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  503 LCSAPRLLQSIAKDDVIPilAPFARV-TKNNEPFLGLVLTVIIAECGILLG--AVDKIAEVLDFFFLMCYAFVNlIAVLH 579
Cdd:COG0531    292 ILGASRLLYAMARDGLLP--KVFAKVhPRFGTPVNAILLTGVIALLLLLLGaaSFTALASLASVGVLLAYLLVA-LAVIV 368
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1199303279  580 SVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASS--VPLACIACTATAVIY 629
Cdd:COG0531    369 LRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGpgALLIGLVLLAIGLLL 420
SLC12 pfam03522
Solute carrier family 12;
826-1070 3.01e-18

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 88.44  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  826 GFIDIWWIVQDGGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSED---MKAGLQKyiymLRIDAElfivdllDMEVS 902
Cdd:pfam03522  231 GTIDVWWLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEqrnMASLLSK----FRIDYS-------DLTVI 299
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  903 DEVVEKAaeverkqkeREEMrrsksgylndgfmedngkprqvMMRHSDSARSFspqpgahtsinLDETETSFTESlfddf 982
Cdd:pfam03522  300 PDITKKP---------KKET----------------------KKFFDELIEPF-----------RLHEDDKEEES----- 332
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  983 yRSGTPNEDLEgAMKlniHKMNTSVRLNRVIRENSPDSQLILLNLPSPPRNrlAFNNS-YMTYLDVLTEDLPRVLFIGGS 1061
Cdd:pfam03522  333 -AEKITDSELE-ALK---EKTNRQLRLRELLLEHSSDANLIVMTLPMPRKG--TVSAPlYMAWLETLTKDLPPFLLVRGN 405

                   ....*....
gi 1199303279 1062 GREVITIDS 1070
Cdd:pfam03522  406 QTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
395-629 3.44e-15

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 79.28  E-value: 3.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  395 DESSTFFMLMAIYFPAVTGIFTGTNMSGdlRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLrdKFGRSIGNTM 474
Cdd:pfam13520  185 DGWPGVFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEI--ALSSGLGQVA 260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  475 VVAALSWPHPA---VVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPFLGLVLTVIIaeCGILL 551
Cdd:pfam13520  261 ALLFQAVGGKWgaiIVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSPIRAIILTAIL--SLILL 338
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  552 GAVDKIAEVLDF------FFLMCYAFVNLIAVLHSVLKSPNWRPRFKYfhWTLSLLGAALCFFIMFASSVPLACIAcTAT 625
Cdd:pfam13520  339 LLFLLSPAAYNAllslsaYGYLLSYLLPIIGLLILRKKRPDLGRIPGR--WPVAIFGILFSLFLIVALFFPPVGPA-TGS 415

                   ....
gi 1199303279  626 AVIY 629
Cdd:pfam13520  416 SLNY 419
frlA PRK11357
amino acid permease;
412-628 9.61e-05

amino acid permease;


Pssm-ID: 183096 [Multi-domain]  Cd Length: 445  Bit Score: 46.00  E-value: 9.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  412 TGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLrdkfgrSIGNTMVVAALSWPhPA------ 485
Cdd:PRK11357   209 TGMASICYMTGEIKNPGKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKL------ANSETPISDALTWI-PAlgstag 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199303279  486 -VVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVipILAPFARV-TKNNEPFLGLVLTVIIaecGILLGAVDKIAEVLDF 563
Cdd:PRK11357   282 iFVAITAMIVILGSLSSCVMYQPRLEYAMAKDNL--FFKCFGHVhPKYNTPDVSIILQGAL---GIFFIFVSDLTSLLGY 356
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1199303279  564 F-FLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSV---PLACIACTATAVI 628
Cdd:PRK11357   357 FtLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTTLAIASSLILVASTFvwaPIPGLICAVIVIA 425
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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