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Conserved domains on  [gi|1199277045|ref|NP_001338775|]
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telomere length regulation protein TEL2 homolog [Homo sapiens]

Protein Classification

telomere length regulation TEL2 family protein( domain architecture ID 10562851)

TEL2 family protein similar to Saccharomyces cerevisiae telomere length regulation protein TEL2 that is required for telomere length regulation and telomere position effect

CATH:  1.25.40.720
Gene Ontology:  GO:0000723|GO:0042162
PubMed:  20801936|18160036|8649421

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Telomere_reg-2 pfam10193
Telomere length regulation protein; This family is the central conserved 110 amino acid region ...
 512-620 3.42e-39

Telomere length regulation protein; This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.


:

Pssm-ID: 462990  Cd Length: 112  Bit Score: 140.72  E-value: 3.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199277045 512 PAYVRDCVEALTTSEDIERWEAALRALEGLVYRSP---TATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDP 588
Cdd:pfam10193   1 PVYIRDLLEYLRDSEDYERFELALKTAEELIRRKAdfgTEVDEYAEELAKLLLGLQDKFDLENFEELRLNALVALLVADP 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1199277045 589 APVADYLTSQFYALNYSLRQRMDILDVLTLAA 620
Cdd:pfam10193  81 EKVAPYLTEEFFSGDYSLQQRISILSALGLAA 112
 
Name Accession Description Interval E-value
Telomere_reg-2 pfam10193
Telomere length regulation protein; This family is the central conserved 110 amino acid region ...
 512-620 3.42e-39

Telomere length regulation protein; This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.


Pssm-ID: 462990  Cd Length: 112  Bit Score: 140.72  E-value: 3.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199277045 512 PAYVRDCVEALTTSEDIERWEAALRALEGLVYRSP---TATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDP 588
Cdd:pfam10193   1 PVYIRDLLEYLRDSEDYERFELALKTAEELIRRKAdfgTEVDEYAEELAKLLLGLQDKFDLENFEELRLNALVALLVADP 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1199277045 589 APVADYLTSQFYALNYSLRQRMDILDVLTLAA 620
Cdd:pfam10193  81 EKVAPYLTEEFFSGDYSLQQRISILSALGLAA 112
 
Name Accession Description Interval E-value
Telomere_reg-2 pfam10193
Telomere length regulation protein; This family is the central conserved 110 amino acid region ...
 512-620 3.42e-39

Telomere length regulation protein; This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.


Pssm-ID: 462990  Cd Length: 112  Bit Score: 140.72  E-value: 3.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199277045 512 PAYVRDCVEALTTSEDIERWEAALRALEGLVYRSP---TATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDP 588
Cdd:pfam10193   1 PVYIRDLLEYLRDSEDYERFELALKTAEELIRRKAdfgTEVDEYAEELAKLLLGLQDKFDLENFEELRLNALVALLVADP 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1199277045 589 APVADYLTSQFYALNYSLRQRMDILDVLTLAA 620
Cdd:pfam10193  81 EKVAPYLTEEFFSGDYSLQQRISILSALGLAA 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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