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Conserved domains on  [gi|1191017794|ref|NP_001338488|]
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coiled-coil domain-containing protein 138 isoform 13 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000037)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK12704 super family cl36166
phosphodiesterase; Provisional
 177-301 2.17e-04

phosphodiesterase; Provisional


The actual alignment was detected with superfamily member PRK12704:

Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 177 ISQIYDELFQihLKLQCETAAQQKFaEELQKRERFLLEREQLLFRHENALSKIkgvEEEVLTRFQIIKEQHDaEVEHLTE 256
Cdd:PRK12704   59 LLEAKEEIHK--LRNEFEKELRERR-NELQKLEKRLLQKEENLDRKLELLEKR---EEELEKKEKELEQKQQ-ELEKKEE 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191017794 257 VLKEK-NKETKRLR-----SSFDALKELNDTLKKQL-NEASEENRKIDIQAK 301
Cdd:PRK12704  132 ELEELiEEQLQELErisglTAEEAKEILLEKVEEEArHEAAVLIKEIEEEAK 183
 
Name Accession Description Interval E-value
PRK12704 PRK12704
phosphodiesterase; Provisional
 177-301 2.17e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 177 ISQIYDELFQihLKLQCETAAQQKFaEELQKRERFLLEREQLLFRHENALSKIkgvEEEVLTRFQIIKEQHDaEVEHLTE 256
Cdd:PRK12704   59 LLEAKEEIHK--LRNEFEKELRERR-NELQKLEKRLLQKEENLDRKLELLEKR---EEELEKKEKELEQKQQ-ELEKKEE 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191017794 257 VLKEK-NKETKRLR-----SSFDALKELNDTLKKQL-NEASEENRKIDIQAK 301
Cdd:PRK12704  132 ELEELiEEQLQELErisglTAEEAKEILLEKVEEEArHEAAVLIKEIEEEAK 183
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 197-312 4.32e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 197 AQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTrfqiIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALK 276
Cdd:COG1196   307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEE----AEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1191017794 277 ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 312
Cdd:COG1196   383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 194-312 6.75e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 6.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  194 ETAAQQKFAE-ELQKRERFLLEREQLLFRHE--NALSKIKGVEEEVLTRFQII----KEQHDAEVEHLTEVLKEKNKETK 266
Cdd:TIGR02168  371 ESRLEELEEQlETLRSKVAQLELQIASLNNEieRLEARLERLEDRRERLQQEIeellKKLEEAELKELQAELEELEEELE 450

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1191017794  267 RLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 312
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 190-340 8.21e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.75  E-value: 8.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  190 KLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLkEKNKETKRL- 268
Cdd:pfam12128  331 HGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKL-AKIREARDRq 409

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191017794  269 ----RSSFDALK-ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSshAVHEMKSlKQEKA 340
Cdd:pfam12128  410 lavaEDDLQALEsELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDE--RIERARE-EQEAA 483
 
Name Accession Description Interval E-value
PRK12704 PRK12704
phosphodiesterase; Provisional
 177-301 2.17e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 177 ISQIYDELFQihLKLQCETAAQQKFaEELQKRERFLLEREQLLFRHENALSKIkgvEEEVLTRFQIIKEQHDaEVEHLTE 256
Cdd:PRK12704   59 LLEAKEEIHK--LRNEFEKELRERR-NELQKLEKRLLQKEENLDRKLELLEKR---EEELEKKEKELEQKQQ-ELEKKEE 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191017794 257 VLKEK-NKETKRLR-----SSFDALKELNDTLKKQL-NEASEENRKIDIQAK 301
Cdd:PRK12704  132 ELEELiEEQLQELErisglTAEEAKEILLEKVEEEArHEAAVLIKEIEEEAK 183
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 197-312 4.32e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 197 AQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTrfqiIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALK 276
Cdd:COG1196   307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEE----AEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1191017794 277 ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 312
Cdd:COG1196   383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 194-312 6.75e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 6.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  194 ETAAQQKFAE-ELQKRERFLLEREQLLFRHE--NALSKIKGVEEEVLTRFQII----KEQHDAEVEHLTEVLKEKNKETK 266
Cdd:TIGR02168  371 ESRLEELEEQlETLRSKVAQLELQIASLNNEieRLEARLERLEDRRERLQQEIeellKKLEEAELKELQAELEELEEELE 450

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1191017794  267 RLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 312
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 186-338 7.60e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.86  E-value: 7.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  186 QIHLkLQCETAAQQkfAEELQKRERFLLEREQLLFRHENALSKIkgveEEVLTRFQIIKEQHDAevehLTEVLKEKNKET 265
Cdd:COG3096    882 QANL-LADETLADR--LEELREELDAAQEAQAFIQQHGKALAQL----EPLVAVLQSDPEQFEQ----LQADYLQAKEQQ 950

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  266 KRLRSSFDALKE----------------------LNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRkyefmTIQRLK 323
Cdd:COG3096    951 RRLKQQIFALSEvvqrrphfsyedavgllgensdLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQ-----VLASLK 1025

                          170
                   ....*....|....*.
gi 1191017794  324 GSSHAVHEM-KSLKQE 338
Cdd:COG3096   1026 SSRDAKQQTlQELEQE 1041
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 190-340 8.21e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.75  E-value: 8.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  190 KLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLkEKNKETKRL- 268
Cdd:pfam12128  331 HGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKL-AKIREARDRq 409

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191017794  269 ----RSSFDALK-ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSshAVHEMKSlKQEKA 340
Cdd:pfam12128  410 lavaEDDLQALEsELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDE--RIERARE-EQEAA 483
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 186-340 1.36e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 186 QIHLKLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEvLTRFQIIKEQHDAEVEHLTEVLKEKNKET 265
Cdd:COG1196   289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEE-LEELEEELEEAEEELEEAEAELAEAEEAL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191017794 266 KRLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSSHAVHEMKSLKQEKA 340
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEE 442
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
176-322 1.41e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 176 QISQIYDELFQIHLKLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAevehLT 255
Cdd:COG4372    39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEE----LQ 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191017794 256 EVLKEKNKETKRLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRL 322
Cdd:COG4372   115 EELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEA 181
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 200-403 3.35e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 40.03  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  200 KFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLT--RFQIIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKE 277
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDeiKAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKN 1187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  278 LNDTLKKQLNEAS---------EENRKIDIQ-----AKRVQARLDNLQRKYEFMtiqrLKGSSHAVHEMKSLKQEKAPVS 343
Cdd:TIGR01612 1188 IYDEIKKLLNEIAeiekdktslEEVKGINLSygknlGKLFLEKIDEEKKKSEHM----IKAMEAYIEDLDEIKEKSPEIE 1263

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191017794  344 KTYKVPLNGQV-YELLTVFMDWISDHHLSKVKHEESGMDGKKPQLKFA------SQRNDIQEKCVKN 403
Cdd:TIGR01612 1264 NEMGIEMDIKAeMETFNISHDDDKDHHIISKKHDENISDIREKSLKIIedfseeSDINDIKKELQKN 1330
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 176-316 3.54e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 176 QISQIYDELFQIHLKLQcetAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVltrfQIIKEQHDAEVEHLT 255
Cdd:COG1196   268 ELEELRLELEELELELE---EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL----AELEEELEELEEELE 340

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191017794 256 EVLKEKNKETKRLRSsfdALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEF 316
Cdd:COG1196   341 ELEEELEEAEEELEE---AEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 188-315 3.60e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 188 HLKLQCETAAQQKFAEELQKRErfLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLKEKNKETKR 267
Cdd:COG1196   264 ELEAELEELRLELEELELELEE--AQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1191017794 268 LRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYE 315
Cdd:COG1196   342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELL 389
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 162-321 5.67e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 38.90  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 162 PKSKASDKRSLLPHQISQIYDELFQIH-----LKLQCETaaQQKFAEELQKR---------ERFLLEREQLLFRHENalS 227
Cdd:pfam05622  53 SGTPGGKKYLLLQKQLEQLQEENFRLEtarddYRIKCEE--LEKEVLELQHRneeltslaeEAQALKDEMDILRESS--D 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794 228 KIKGVEEEVLT-----------RFQI-IKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKELNDTLKKQLNEASEENRK 295
Cdd:pfam05622 129 KVKKLEATVETykkkledlgdlRRQVkLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQVQELHGKLSEESKKADK 208

                         170       180
                  ....*....|....*....|....*.
gi 1191017794 296 IDIQAKRVQARLDNLQRKYEFMTIQR 321
Cdd:pfam05622 209 LEFEYKKLEEKLEALQKEKERLIIER 234
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 178-311 8.60e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 38.67  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017794  178 SQIYDELFQIHLKL--QCETAAQQKFAEE--LQKRERFLleREQLL----------FRHENALSKIKG------VEEEVL 237
Cdd:pfam12128  386 EQNNRDIAGIKDKLakIREARDRQLAVAEddLQALESEL--REQLEagklefneeeYRLKSRLGELKLrlnqatATPELL 463

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191017794  238 TRfqiiKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKELNDtlkkqlnEASEENRKIDIQAKRVQARLDNLQ 311
Cdd:pfam12128  464 LQ----LENFDERIERAREEQEAANAEVERLQSELRQARKRRD-------QASEALRQASRRLEERQSALDELE 526
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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