ataxin-7-like protein 2 isoform 3 [Homo sapiens]
Protein Classification
SCA7 domain-containing protein( domain architecture ID 10550843)
SCA7 domain-containing protein similar to protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SCA7 | pfam08313 | SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ... |
261-322 | 9.59e-23 | ||
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain. : Pssm-ID: 462422 Cd Length: 61 Bit Score: 91.89 E-value: 9.59e-23
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| Name | Accession | Description | Interval | E-value | ||
| SCA7 | pfam08313 | SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ... |
261-322 | 9.59e-23 | ||
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain. Pssm-ID: 462422 Cd Length: 61 Bit Score: 91.89 E-value: 9.59e-23
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| Name | Accession | Description | Interval | E-value | ||
| SCA7 | pfam08313 | SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ... |
261-322 | 9.59e-23 | ||
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain. Pssm-ID: 462422 Cd Length: 61 Bit Score: 91.89 E-value: 9.59e-23
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