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Conserved domains on  [gi|1168811992|ref|NP_001336740|]
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sterile alpha motif domain-containing protein 12 isoform c [Homo sapiens]

Protein Classification

SAM domain-containing protein( domain architecture ID 81749)

SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAM_superfamily super family cl15755
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 72-136 4.68e-32

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


The actual alignment was detected with superfamily member cd09510:

Pssm-ID: 472832  Cd Length: 75  Bit Score: 108.93  E-value: 4.68e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1168811992  72 KPVALWTQQDVCKWLKKHCPNQYQIYR----------RALLRLTDKKLERMGIAQENLRQHILQQVLQLKVREEV 136
Cdd:cd09510     1 KPVYLWSVQDVCKWLKRHCPDYYLLYAelflqhditgRALLRLNDNKLERMGITDEDHRQDILREILKLRLKTEI 75
 
Name Accession Description Interval E-value
SAM_aveugle-like cd09510
SAM domain of aveugle-like subfamily; SAM (sterile alpha motif) domain of SAM_aveugle-like ...
 72-136 4.68e-32

SAM domain of aveugle-like subfamily; SAM (sterile alpha motif) domain of SAM_aveugle-like subfamily is a protein-protein interaction domain. In Drosophila, the aveugle (AVE) protein (also known as HYP (Hyphen)) is involved in normal photoreceptor differentiation, and required for epidermal growth factor receptor (EGFR) signaling between ras and raf genes during eye development and wing vein formation. SAM domain of the HYP(AVE) protein interacts with SAM domain of CNK, the multidomain scaffold protein connector enhancer of kinase suppressor of ras. CNK/HYP(AVE) complex interacts with KSR (kinase suppressor of Ras) protein. This interaction leads to stimulation of Ras-dependent Raf activation. This subfamily also includes vertebrate AVE homologs - Samd10 and Samd12 proteins. Their exact function is unknown, but they may play a role in signal transduction during embryogenesis.


Pssm-ID: 188909  Cd Length: 75  Bit Score: 108.93  E-value: 4.68e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1168811992  72 KPVALWTQQDVCKWLKKHCPNQYQIYR----------RALLRLTDKKLERMGIAQENLRQHILQQVLQLKVREEV 136
Cdd:cd09510     1 KPVYLWSVQDVCKWLKRHCPDYYLLYAelflqhditgRALLRLNDNKLERMGITDEDHRQDILREILKLRLKTEI 75
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
74-131 1.19e-05

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 40.72  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1168811992  74 VALWTQQDVCKWLK-----KHCPN--QYQIY-RRALLRLTDKKLERMGIAQENLRQHILQQVLQLK 131
Cdd:pfam07647   1 VESWSLESVADWLRsigleQYTDNfrDQGITgAELLLRLTLEDLKRLGITSVGHRRKILKKIQELK 66
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 74-131 6.19e-03

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 33.42  E-value: 6.19e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1168811992   74 VALWTQQDVCKWLKKHCPNQY-------QIYRRALLRLTDK-KLERMGIAQENLRQHILQQVLQLK 131
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYadnfrknGIDGALLLLLTSEeDLKELGITKLGHRKKILKAIQKLK 66
 
Name Accession Description Interval E-value
SAM_aveugle-like cd09510
SAM domain of aveugle-like subfamily; SAM (sterile alpha motif) domain of SAM_aveugle-like ...
 72-136 4.68e-32

SAM domain of aveugle-like subfamily; SAM (sterile alpha motif) domain of SAM_aveugle-like subfamily is a protein-protein interaction domain. In Drosophila, the aveugle (AVE) protein (also known as HYP (Hyphen)) is involved in normal photoreceptor differentiation, and required for epidermal growth factor receptor (EGFR) signaling between ras and raf genes during eye development and wing vein formation. SAM domain of the HYP(AVE) protein interacts with SAM domain of CNK, the multidomain scaffold protein connector enhancer of kinase suppressor of ras. CNK/HYP(AVE) complex interacts with KSR (kinase suppressor of Ras) protein. This interaction leads to stimulation of Ras-dependent Raf activation. This subfamily also includes vertebrate AVE homologs - Samd10 and Samd12 proteins. Their exact function is unknown, but they may play a role in signal transduction during embryogenesis.


Pssm-ID: 188909  Cd Length: 75  Bit Score: 108.93  E-value: 4.68e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1168811992  72 KPVALWTQQDVCKWLKKHCPNQYQIYR----------RALLRLTDKKLERMGIAQENLRQHILQQVLQLKVREEV 136
Cdd:cd09510     1 KPVYLWSVQDVCKWLKRHCPDYYLLYAelflqhditgRALLRLNDNKLERMGITDEDHRQDILREILKLRLKTEI 75
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
74-131 1.19e-05

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 40.72  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1168811992  74 VALWTQQDVCKWLK-----KHCPN--QYQIY-RRALLRLTDKKLERMGIAQENLRQHILQQVLQLK 131
Cdd:pfam07647   1 VESWSLESVADWLRsigleQYTDNfrDQGITgAELLLRLTLEDLKRLGITSVGHRRKILKKIQELK 66
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 81-127 9.12e-04

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 35.68  E-value: 9.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1168811992  81 DVCKWLKKHCPNQY-------QIYRRALLRLTDKKLERMGIAQENLRQHILQQV 127
Cdd:cd09487     1 DVAEWLESLGLEQYadlfrknEIDGDALLLLTDEDLKELGITSPGHRKKILRAI 54
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 77-131 9.75e-04

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 35.71  E-value: 9.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1168811992  77 WTQQDVCKWLKKHCPNQY-------QIYRRALLRLTDKKLERMGIAQENLRQHILQQVLQLK 131
Cdd:pfam00536   3 WSVEDVGEWLESIGLGQYidsfragYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQRLK 64
SAM_Neurabin-like cd09512
SAM domain of SAM_Neurabin-like subfamily; SAM (sterile alpha motif) domain of Neurabin-like ...
 71-131 3.08e-03

SAM domain of SAM_Neurabin-like subfamily; SAM (sterile alpha motif) domain of Neurabin-like (Neural actin-binding) subfamily is a putative protein-protein interaction domain. This group currently includes the SAM domains of neurobin-I, SAMD14 and neurobin-I/SAMD14-like proteins. Most are multidomain proteins and in addition to SAM domain they contain other protein-binding domains such as PDZ and actin-binding domains. Members of this subfamily participate in signal transduction. Neurabin-I is involved in the regulation of Ca signaling intensity in alpha-adrenergic receptors; it forms a functional pair of opposing regulators with neurabin-II. Neurabins are expressed almost exclusively in neuronal cells. They are known to interact with protein phosphatase 1 and inhibit its activity; they also can bind actin filaments; however, the exact role of the SAM domain is unclear, since SAM doesn't participate in these interactions.


Pssm-ID: 188911 [Multi-domain]  Cd Length: 70  Bit Score: 34.55  E-value: 3.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1168811992  71 SKPVALWTQQDVCKWL-----KKHCP--NQYQIYRRALLRLTDKKLERMGIAQENLRQHILQQVLQLK 131
Cdd:cd09512     1 SRPVSEWSVQQVCQWLmglglEQYIPefTANNIDGQQLLQLDSSKLKALGITSSSDRSLLKKKLKELK 68
SAM_HD cd09508
SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily ...
 76-131 4.98e-03

SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily proteins is a putative protein-protein interaction domain. Proteins of this group, additionally to the SAM domain, contain a HD hydrolase domain. Human SAM-HD1 is a nuclear protein involved in innate immune response and may act as a negative regulator of the cell-intrinsic antiviral response. Mutations in this gene lead to Aicardi-Goutieres syndrome (symptoms include cerebral atrophy, leukoencephalopathy, hepatosplenomegaly, and increased production of alpha-interferon).


Pssm-ID: 188907  Cd Length: 70  Bit Score: 33.83  E-value: 4.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1168811992  76 LWTQQDVCKWLKKH---CPNQYQIYRRA------LLRLTDKKLERMGIAQENLRQHILQQVLQLK 131
Cdd:cd09508     4 SWDPEDVCQFLRGNgfgEPELLEIFRENeitgahLPDLTESRLEKLGVSSLGERLKLLKCLQKLS 68
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 74-131 6.19e-03

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 33.42  E-value: 6.19e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1168811992   74 VALWTQQDVCKWLKKHCPNQY-------QIYRRALLRLTDK-KLERMGIAQENLRQHILQQVLQLK 131
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYadnfrknGIDGALLLLLTSEeDLKELGITKLGHRKKILKAIQKLK 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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