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Conserved domains on  [gi|1167803501|ref|NP_001336675|]
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transmembrane and coiled-coil domain-containing protein 3 isoform 7 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 268-347 5.88e-19

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


:

Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 89.05  E-value: 5.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 268 HHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKH 347
Cdd:COG0475     3 ASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
50-201 3.29e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  50 VRDSCRKLSGLLRQknAVLNKLKTAIGAVEKDVGLSDEEKLFQVHT----FEIFQKELNESENSVFQAVYGLQRALQGDY 125
Cdd:COG4717   349 LQELLREAEELEEE--LQLEELEQEIAALLAEAGVEDEEELRAALEqaeeYQELKEELEELEEQLEELLGELEELLEALD 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 126 KDVVNMK--------ESSRQRLEALRE--AAIKEE-------TEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVR 188
Cdd:COG4717   427 EEELEEEleeleeelEELEEELEELREelAELEAEleqleedGELAELLQELEELKAELRELAEEWAALKLALELLEEAR 506

                         170
                  ....*....|....*...
gi 1167803501 189 KAA-----DRLEEEIEEH 201
Cdd:COG4717   507 EEYreerlPPVLERASEY 524
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 268-347 5.88e-19

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 89.05  E-value: 5.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 268 HHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKH 347
Cdd:COG0475     3 ASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 274-373 3.60e-16

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 80.38  E-value: 3.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 274 IVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSI-VQVETLGEFGVFFTLFLVGLEFSPEKLRKHcRGSS 352
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVdEDLEVLSNLGLPPLLFLAGLELDLRELRKN-GGSI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1167803501 353 ---------------------PNPGFDWSDSFFTSGGFSFMS 373
Cdd:pfam00999  80 lllallgvlipfvliglllylLGLGIPLLEALLFGAILSATS 121
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 284-347 5.50e-12

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 66.52  E-value: 5.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1167803501 284 CGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKH 347
Cdd:TIGR00932   7 AVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKL 70
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 292-344 1.60e-07

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 54.26  E-value: 1.60e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1167803501 292 GLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKL 344
Cdd:PRK03659   28 GIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKL 80
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
50-201 3.29e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  50 VRDSCRKLSGLLRQknAVLNKLKTAIGAVEKDVGLSDEEKLFQVHT----FEIFQKELNESENSVFQAVYGLQRALQGDY 125
Cdd:COG4717   349 LQELLREAEELEEE--LQLEELEQEIAALLAEAGVEDEEELRAALEqaeeYQELKEELEELEEQLEELLGELEELLEALD 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 126 KDVVNMK--------ESSRQRLEALRE--AAIKEE-------TEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVR 188
Cdd:COG4717   427 EEELEEEleeleeelEELEEELEELREelAELEAEleqleedGELAELLQELEELKAELRELAEEWAALKLALELLEEAR 506

                         170
                  ....*....|....*...
gi 1167803501 189 KAA-----DRLEEEIEEH 201
Cdd:COG4717   507 EEYreerlPPVLERASEY 524
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 50-252 3.88e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 3.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501   50 VRDSCRKLSGLLRQKNAVLNKL--------KTAIGAVEKDVGLSDEEKLF--QVHTFEIFQKELNESENSVFQAVYGLQR 119
Cdd:TIGR02169  803 LEEEVSRIEARLREIEQKLNRLtlekeyleKEIQELQEQRIDLKEQIKSIekEIENLNGKKEELEEELEELEAALRDLES 882

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  120 ALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMEL------LAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADR 193
Cdd:TIGR02169  883 RLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLselkakLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQR 962

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1167803501  194 LEEEIEehAFDDnksvkgVNFEAVLRVEEEEANSKQNITKREV--EDDLGLSMLIDSQNNQ 252
Cdd:TIGR02169  963 VEEEIR--ALEP------VNMLAIQEYEEVLKRLDELKEKRAKleEERKAILERIEEYEKK 1015
Com_YlbF pfam06133
Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and ...
 144-201 6.84e-03

Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, pfam04468, interact directly with one another forming a stable ternary complex, in vitro. All three proteins are required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated form of Spo0A, as Spo0A-P.


Pssm-ID: 428784 [Multi-domain]  Cd Length: 103  Bit Score: 36.36  E-value: 6.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1167803501 144 EAAIKEETEYMELLAAEKhQVEA-------LKNMQHQNQSLSML----DEILEDVRKAADRLEEEIEEH 201
Cdd:pfam06133   7 AKAIKESEEYKRYKEAEE-ALEAdeeaqklIKEFRKLQEELQEKqmqgEELTEEEKQELQELYEELDQN 74
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 268-347 5.88e-19

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 89.05  E-value: 5.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 268 HHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKH 347
Cdd:COG0475     3 ASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 274-373 3.60e-16

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 80.38  E-value: 3.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 274 IVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSI-VQVETLGEFGVFFTLFLVGLEFSPEKLRKHcRGSS 352
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVdEDLEVLSNLGLPPLLFLAGLELDLRELRKN-GGSI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1167803501 353 ---------------------PNPGFDWSDSFFTSGGFSFMS 373
Cdd:pfam00999  80 lllallgvlipfvliglllylLGLGIPLLEALLFGAILSATS 121
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 284-347 5.50e-12

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 66.52  E-value: 5.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1167803501 284 CGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKH 347
Cdd:TIGR00932   7 AVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKL 70
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 292-344 1.60e-07

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 54.26  E-value: 1.60e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1167803501 292 GLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKL 344
Cdd:PRK03659   28 GIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKL 80
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 290-344 4.44e-06

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 49.61  E-value: 4.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1167803501 290 AIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKL 344
Cdd:PRK03562   26 RLGLGSVLGYLIAGCIIGPWGLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRL 80
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
274-347 1.29e-03

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 41.49  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1167803501 274 IVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPsGLNSI--KSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKH 347
Cdd:COG0025     7 ILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGP-GLGLEldPELGDLEPLLELFLPPLLFEAALNLDLRELRRN 81
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
50-201 3.29e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  50 VRDSCRKLSGLLRQknAVLNKLKTAIGAVEKDVGLSDEEKLFQVHT----FEIFQKELNESENSVFQAVYGLQRALQGDY 125
Cdd:COG4717   349 LQELLREAEELEEE--LQLEELEQEIAALLAEAGVEDEEELRAALEqaeeYQELKEELEELEEQLEELLGELEELLEALD 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501 126 KDVVNMK--------ESSRQRLEALRE--AAIKEE-------TEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVR 188
Cdd:COG4717   427 EEELEEEleeleeelEELEEELEELREelAELEAEleqleedGELAELLQELEELKAELRELAEEWAALKLALELLEEAR 506

                         170
                  ....*....|....*...
gi 1167803501 189 KAA-----DRLEEEIEEH 201
Cdd:COG4717   507 EEYreerlPPVLERASEY 524
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 50-252 3.88e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 3.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501   50 VRDSCRKLSGLLRQKNAVLNKL--------KTAIGAVEKDVGLSDEEKLF--QVHTFEIFQKELNESENSVFQAVYGLQR 119
Cdd:TIGR02169  803 LEEEVSRIEARLREIEQKLNRLtlekeyleKEIQELQEQRIDLKEQIKSIekEIENLNGKKEELEEELEELEAALRDLES 882

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  120 ALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMEL------LAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADR 193
Cdd:TIGR02169  883 RLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLselkakLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQR 962

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1167803501  194 LEEEIEehAFDDnksvkgVNFEAVLRVEEEEANSKQNITKREV--EDDLGLSMLIDSQNNQ 252
Cdd:TIGR02169  963 VEEEIR--ALEP------VNMLAIQEYEEVLKRLDELKEKRAKleEERKAILERIEEYEKK 1015
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
18-200 3.94e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  18 WAVQAVEHEEVAQRVIKLHRGRGV-------------AAMQSRQWVRDSCRKLSGLLRQKNAVLNKLKTAIGAVEKDvgL 84
Cdd:COG4717    41 AFIRAMLLERLEKEADELFKPQGRkpelnlkelkeleEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREE--L 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803501  85 SDEEKLFQVHTFEIFQKELNESENSVFQAVYGLQRALQgDYKDVVNMKESSRQRLEALREAAikEETEYMELLAAEKHQV 164
Cdd:COG4717   119 EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLE-ELRELEEELEELEAELAELQEEL--EELLEQLSLATEEELQ 195

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1167803501 165 EALKNMQHQNQSLSMLDEILEDVRKAADRLEEEIEE 200
Cdd:COG4717   196 DLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 294-346 5.12e-03

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 39.87  E-value: 5.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1167803501 294 PTMFGYIICGVLLGPSGLNSIK----------SIVQVETLGEFGVFFTLFLVGLEFSPEKLRK 346
Cdd:PLN03159   68 PRVISEILGGVILGPSVLGQSEvfantifplrSVMVLETMANLGLLYFLFLVGVEMDISVIRR 130
Com_YlbF pfam06133
Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and ...
 144-201 6.84e-03

Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, pfam04468, interact directly with one another forming a stable ternary complex, in vitro. All three proteins are required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated form of Spo0A, as Spo0A-P.


Pssm-ID: 428784 [Multi-domain]  Cd Length: 103  Bit Score: 36.36  E-value: 6.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1167803501 144 EAAIKEETEYMELLAAEKhQVEA-------LKNMQHQNQSLSML----DEILEDVRKAADRLEEEIEEH 201
Cdd:pfam06133   7 AKAIKESEEYKRYKEAEE-ALEAdeeaqklIKEFRKLQEELQEKqmqgEELTEEEKQELQELYEELDQN 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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