NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1143466190|ref|NP_001335544|]
View 

Transmembrane protein 33 [Caenorhabditis elegans]

Protein Classification

TMEM33/Pom33 family protein( domain architecture ID 10508436)

TMEM33/Pom33 family protein similar to Homo sapiens transmembrane protein 33 (TMEM33) and Drosophila melanogaster Krueppel homolog 2

Gene Ontology:  GO:0061024|GO:0071786

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 1-223 1.54e-91

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


:

Pssm-ID: 461009  Cd Length: 237  Bit Score: 268.38  E-value: 1.54e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143466190   1 MECVLFAARVLTVFFALNYMIPFIGLVPAHSAYYKIFAASAATFALRLHTRIqGQFALNAQFIQRLIIEDSFHYLVYSVV 80
Cdd:pfam03661  15 IELALWATRLLTIIFTILYIIPIFGSSHPYSAYYKALLANAATSALRLHQRL-PQFQLSREFLQRLLLEDSCHYLMYSLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143466190  81 FLMAAPVSMAALPVTIYAALHACTFMTKILRETGHTSSIIPKLE-QFTAHQTQNALGIIACSEIFLVPLLVSLIFSGKGS 159
Cdd:pfam03661  94 FLFSAPVTLALLPVFLFALLHSASYTLTLLDVLGSNSWWGARLLiSLVEFQSQNILRLIAFTEIFIMPLTIVLLFSGRAS 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1143466190 160 LLLPFAYYRFLSLRYASRRNPSTRQAFAQMRGSLQNVAMSSSCPRPISSLIYRAIDFISARAPP 223
Cdd:pfam03661 174 LLTPFIYYQFLSLRYSSRRNPYTRNAFSELRILLEHLANHPRCPAFIRSLILKLISFVSRLAPP 237
 
Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 1-223 1.54e-91

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


Pssm-ID: 461009  Cd Length: 237  Bit Score: 268.38  E-value: 1.54e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143466190   1 MECVLFAARVLTVFFALNYMIPFIGLVPAHSAYYKIFAASAATFALRLHTRIqGQFALNAQFIQRLIIEDSFHYLVYSVV 80
Cdd:pfam03661  15 IELALWATRLLTIIFTILYIIPIFGSSHPYSAYYKALLANAATSALRLHQRL-PQFQLSREFLQRLLLEDSCHYLMYSLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143466190  81 FLMAAPVSMAALPVTIYAALHACTFMTKILRETGHTSSIIPKLE-QFTAHQTQNALGIIACSEIFLVPLLVSLIFSGKGS 159
Cdd:pfam03661  94 FLFSAPVTLALLPVFLFALLHSASYTLTLLDVLGSNSWWGARLLiSLVEFQSQNILRLIAFTEIFIMPLTIVLLFSGRAS 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1143466190 160 LLLPFAYYRFLSLRYASRRNPSTRQAFAQMRGSLQNVAMSSSCPRPISSLIYRAIDFISARAPP 223
Cdd:pfam03661 174 LLTPFIYYQFLSLRYSSRRNPYTRNAFSELRILLEHLANHPRCPAFIRSLILKLISFVSRLAPP 237
 
Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 1-223 1.54e-91

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


Pssm-ID: 461009  Cd Length: 237  Bit Score: 268.38  E-value: 1.54e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143466190   1 MECVLFAARVLTVFFALNYMIPFIGLVPAHSAYYKIFAASAATFALRLHTRIqGQFALNAQFIQRLIIEDSFHYLVYSVV 80
Cdd:pfam03661  15 IELALWATRLLTIIFTILYIIPIFGSSHPYSAYYKALLANAATSALRLHQRL-PQFQLSREFLQRLLLEDSCHYLMYSLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143466190  81 FLMAAPVSMAALPVTIYAALHACTFMTKILRETGHTSSIIPKLE-QFTAHQTQNALGIIACSEIFLVPLLVSLIFSGKGS 159
Cdd:pfam03661  94 FLFSAPVTLALLPVFLFALLHSASYTLTLLDVLGSNSWWGARLLiSLVEFQSQNILRLIAFTEIFIMPLTIVLLFSGRAS 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1143466190 160 LLLPFAYYRFLSLRYASRRNPSTRQAFAQMRGSLQNVAMSSSCPRPISSLIYRAIDFISARAPP 223
Cdd:pfam03661 174 LLTPFIYYQFLSLRYSSRRNPYTRNAFSELRILLEHLANHPRCPAFIRSLILKLISFVSRLAPP 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH